KEGG   ENZYME: 5.2.1.13Help
Entry
EC 5.2.1.13                 Enzyme                                 

Name
prolycopene isomerase;
CRTISO;
carotene cis-trans isomerase;
ZEBRA2 (gene name);
carotene isomerase;
carotenoid isomerase
Class
Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
7,9,7',9'-tetracis-lycopene cis-trans-isomerase
Reaction(IUBMB)
7,9,7',9'-tetracis-lycopene = all-trans-lycopene [RN:R07512]
Reaction(KEGG)
Substrate
7,9,7',9'-tetracis-lycopene [CPD:C15858]
Product
all-trans-lycopene [CPD:C05432]
Comment
Requires FADH2 [1]. The enzyme is involved in carotenoid biosynthesis.
History
EC 5.2.1.13 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09835  prolycopene isomerase
Genes
ATH: AT1G06820(CRTISO)
ALY: ARALYDRAFT_470704
CRB: 17899122
CSAT: 104739241 104759100 104764727 104764772 104764782 104764820
EUS: EUTSA_v10007141mg
BRP: 103843494(CRTISO1)
BNA: 106420156
BOE: 106307135
THJ: 104823508
CPAP: 110806395
CIT: 102577949
TCC: 18598462
GRA: 105785422
DZI: 111311628
EGR: 104446658
VRA: 106772686
CCAJ: 109813368
CAM: 101494469
ADU: 107476032
AIP: 107626297
LJA: Lj0g3v0245759.1(Lj0g3v0245759.1) Lj0g3v0245759.2(Lj0g3v0245759.2)
LANG: 109336113
FVE: 101297853
PPER: 18770912
PMUM: 103339574
PAVI: 110749117
MDM: 103423243 103449595 103454192(CRTISO-1)
PXB: 103940205
CSV: 101212850
CMO: 103486713(CISO)
MCHA: 111019389
CMAX: 111498600
CMOS: 111445387
CPEP: 111800043
RCU: 8259794
JCU: 105635773
HBR: 110655834
JRE: 109011895
VVI: 100263250
SLY: 101267857(CRTISO)
SPEN: 107002441
SOT: 102591604
CANN: 107854534
NTA: 107791326 107832559(CRTISO)
NSY: 104243683
NTO: 104098775
INI: 109181501
SIND: 105161700
OEU: 111392821
HAN: 110873397
LSV: 111876520
DCR: 108219304
BVG: 104893199
SOE: 110798138
NNU: 104601462
OSA: 4350758
DOSA: Os11t0572700-00(Os11g0572700)
OBR: 102699732
ATS: 109736594(LOC109736594)
SBI: 8071947
ZMA: 100281663(CRTISO2) 100281747
SITA: 101781301
PDA: 103707328
EGU: 105042411
MUS: 103996172
DCT: 110108203
AOF: 109843839
ATR: 18421603
PMK: MDS_3610
PSEM: TO66_25880
DEU: DBW_2504(crtI)
DOL: Dole_2352
DAL: Dalk_3336
BMX: BMS_1442
PPY: PPE_04524
PPM: PPSC2_23590(crtI)
PPO: PPM_4688(crtI)
PPOL: X809_25485
PPOY: RE92_13670
CBK: CLL_A0660
CBT: CLH_0621
NFA: NFA_30910
SBH: SBI_02612
KAL: KALB_6264
SAQ: Sare_1069
SYN: sll0033
SYY: SYNGTS_2835(sll0033)
SYT: SYNGTI_2834(sll0033)
SYS: SYNPCCN_2833(sll0033)
SYQ: SYNPCCP_2833(sll0033)
SYJ: D082_19610(crtH)
SYO: C7I86_14805(crtH)
SYW: SYNW0901(crtH)
SYC: syc0304_c
SYG: sync_1140(crtH)
SYR: SynRCC307_1542(crtH)
SYX: SynWH7803_1380(crtH)
SYP: SYNPCC7002_A1892(crtH)
CYA: CYA_1857(crtH)
CYB: CYB_1298(crtH)
SYNR: KR49_03785
SYND: KR52_07875
SYH: Syncc8109_0960(crtH)
SYNW: SynWH8103_01032(crtH)
CYI: CBM981_1144(crtH)
LET: O77CONTIG1_00409(crtI_1)
PMA: Pro_0584
PMM: PMM1115(crtH)
PMT: PMT_1051
PMB: A9601_12211(crtH)
PMC: P9515_12061(crtH)
PMF: P9303_10011(crtH)
PMG: P9301_12221(crtH)
PMH: P9215_12511(crtH)
PMJ: P9211_05841(crtH)
PME: NATL1_14681(crtH)
PRC: EW14_1255
PRM: EW15_1528
AMR: AM1_1491
MAR: MAE_12360(crtH)
MPK: VL20_3318
CYL: AA637_01480(crtH)
CYT: cce_1534
TER: Tery_2192
ARP: NIES39_C05040(crtH)
ANA: alr2064
NOE: CLI64_01070(crtH)
AVA: Ava_3112
CALH: IJ00_18455
NSP: BMF81_03055(crtH)
CTHE: Chro_4528
CEO: ETSB_1929
KST: KSMBR1_0796(crtI) KSMBR1_3476(ctrI)
LBF: LBF_0864
CTE: CT0649
CPC: Cpar_0650
CCH: Cag_1888
CLI: Clim_0766
PVI: Cvib_1153
PLT: Plut_0626
PPH: Ppha_2151
PAA: Paes_0760
PROC: Ptc2401_01569(crtI)
CTS: Ctha_1262
 » show all
Taxonomy
Reference
1  [PMID:21209101]
  Authors
Yu Q, Ghisla S, Hirschberg J, Mann V, Beyer P
  Title
Plant carotene cis-trans isomerase CRTISO: a new member of the FAD(RED)-dependent flavoproteins catalyzing non-redox reactions.
  Journal
J Biol Chem 286:8666-76 (2011)
DOI:10.1074/jbc.M110.208017
Reference
2  [PMID:20221689]
  Authors
Li Q, Farre G, Naqvi S, Breitenbach J, Sanahuja G, Bai C, Sandmann G, Capell T, Christou P, Zhu C
  Title
Cloning and functional characterization of the maize carotenoid isomerase and beta-carotene hydroxylase genes and their regulation during endosperm maturation.
  Journal
Transgenic Res 19:1053-68 (2010)
DOI:10.1007/s11248-010-9381-x
Reference
3  [PMID:11884678]
  Authors
Isaacson T, Ronen G, Zamir D, Hirschberg J
  Title
Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of beta-carotene and xanthophylls in plants.
  Journal
Plant Cell 14:333-42 (2002)
DOI:10.1105/tpc.010303
  Sequence
[sly:101267857]
Reference
4  [PMID:21161331]
  Authors
Chai C, Fang J, Liu Y, Tong H, Gong Y, Wang Y, Liu M, Wang Y, Qian Q, Cheng Z, Chu C
  Title
ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice.
  Journal
Plant Mol Biol 75:211-21 (2011)
DOI:10.1007/s11103-010-9719-z
Other DBs
ExplorEnz - The Enzyme Database: 5.2.1.13
IUBMB Enzyme Nomenclature: 5.2.1.13
ExPASy - ENZYME nomenclature database: 5.2.1.13
BRENDA, the Enzyme Database: 5.2.1.13

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