KEGG   ENZYME: 5.3.1.29
Entry
EC 5.3.1.29                 Enzyme                                 
Name
ribose-1,5-bisphosphate isomerase;
R15P isomerase;
ribulose 1,5-bisphosphate synthase;
RuBP synthase
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
Sysname
alpha-D-ribose 1,5-bisphosphate aldose-ketose-isomerase
Reaction(IUBMB)
alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate [RN:R10555]
Reaction(KEGG)
R10555
Substrate
alpha-D-ribose 1,5-bisphosphate [CPD:C01151]
Product
D-ribulose 1,5-bisphosphate [CPD:C01182]
Comment
This archaeal enzyme is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The enzyme is activated by cAMP [2].
History
EC 5.3.1.29 created 2013
Orthology
K18237  ribose 1,5-bisphosphate isomerase
Genes
MAQMaqu_0074
MARAD0851_12185
SSESsed_2704
NHLNhal_2211
NTTTAO_1563
ABAWD5400_18205
BACAFAY30_22265
LAGRFJQ98_14765
VNECFK40_04125
EAVEH197_23085
ACOLK5I23_08745 K5I23_13025
SLPSlip_0714
TPZTph_c27250
CIUG4D55_01500 G4D55_02115
LCGL3BBH23_16140
ERBA4V01_03310 A4V01_03935
KBSEPA93_25865
THUGKNN16_00865
BPWWESB_1267(gcn3)
SHYRLA303_13055
SRBP148_SR1C001G0163
MJAMJ_0122
MFEMefer_1167
MVUMetvu_0771
MFSMFS40622_0999
MJHJH146_0745
MESGMLAUSG7_1030
MESAMLASG1_0747
MIGMetig_0446
MAEMaeo_0673
MOKMetok_1427
AFUAF_2037
AFGAFULGI_00023040
APOArcpr_1242
AVEArcve_0806
ASTAsulf_00197
FPLFerp_2476
GACGACE_2136
GAHGAH_00545
PFUPF0122
PFIPFC_07590
PHOPH0208(PH0208)
PABPAB2402
PYNPNA2_0724
PYAPYCH_16630
PYSPy04_0275
PYCTQ32_00430
TKOTK0185
TONTON_1296
TGATGAM_1633
TSITSIB_0548
TBATERMP_01301
THEGQS_08985
THATAM4_1574
THMCL1_1398
TLTOCC_04330
THSTES1_1328
TNUBD01_1733
TEUTEU_00610
TGYX802_01085
THVADU37_CDS05060
TCHCHITON_0339
TPEPA0127_03060
TPIEA7C91_02100
TGGA3K92_02045
TCEA3L02_04540
TBSA3L01_07270
THHCDI07_08305
TSLA3L11_00730
TTDA3L14_09605
TPRFA3L09_05105
TRLA3L10_06685
TPAFA3L08_00550
THYA3L12_02280
TICFH039_10745
TCQTIRI35C_1779
THEMFPV09_10840
THEIK1720_05870
PPACPAP_04815
MBAMbar_A0793
MBYMSBRM_0258
MBWMSBRW_0209
MBARMSBR2_2119
MBAKMSBR3_2069
MACMA_0379(eif2B2)
MMAMM_1606
MMJMSMAS_3063
MMACMSMAC_3082
MVCMSVAZ_3086
MEKMSKOL_3049
MLSMSLAZ_0192
METMMSMTP_2960
MEFMSWH1_0276
MEQMSWHS_0281
MSJMSSAC_0356
MSZMSSIH_0312
MSWMSSIT_0317
MTHRMSTHT_2157
MTHEMSTHC_1125
MHORMSHOH_3785
MFZAOB57_005110
MBUMbur_1938
MMETMCMEM_0162
MELOJ7W08_10875
MMHMmah_0172
MHAZBHR79_02620
MEVMetev_2236
MZHMzhil_1979
MPYMpsy_1650
MZIHWN40_00750
MHZMetho_2361
MTPMthe_1262
MCJMCON_0206
MHIMhar_2272
MHUMhun_2314
MRTJKHC33_16265
MLAMlab_0557
MEMMemar_2067
MBGBN140_1619
MEMAMMAB1_2076
MCHKMchiMG62_23860
MSUMOH143_04615
MPIMpet_0507
MENDL6E24_05325
MBNMboo_2432
MFOMetfor_0217
MPLMpal_0257
MPDMCP_2142
RCIRRC408(eif2b2)
HALVNG_1853G(eif2ba)
HSLOE_3610R
HDLHALDL1_14315
HHBHhub_3205
HAGSJT689_08810
HABOJRZ79_07215
HNOLT974_12750
HLULT972_02130
HANRLJ422_07465
HJEHacjB3_07320 HacjB3_13310
HALHHTSR_1620 HTSR_1864
HHSRHSR6_1688 HSR6_1933
HSUHLASF_0414 HLASF_1916
HSFHLASA_0413 HLASA_1902
SALRFQU85_07280
HALREFA46_000470 EFA46_013245
HALXM0R89_03730
HAXZM0R88_03930
HARAAArcS_1091(gcd22)
HHIHAH_1030(eif2BD1) HAH_2467(eif2BD2)
HHNHISP_05295 HISP_12560
HABSG26_04865 SG26_12965
HTABVU17_12000
HALJG9465_13080
NPHNP_1050A NP_3202A
NMONmlp_1786(tif2Bd) Nmlp_3000(tif2Ba)
NHOHWV23_07735 HWV23_14670
NSALHWV07_10115 HWV07_18135
HUTHuta_1398
HTIHTIA_1280
HALAHrd1104_02275
HMUHmuk_2762
HALZE5139_01105
HALLLC1Hm_2107
HAZPGBQ70_01105
HALIBV210_01305 BV210_10815
HSNDV733_06015 DV733_10460
HDSHSR122_0293(gcd2)
HRRHZS55_15410
HPELHZS54_18445
HLTI7X12_20190
HARCHARCEL1_09145
SSAIN0B31_04365
HWAHQ_2713A
HWCHqrw_3064
HVOHVO_0966
HMEHFX_0963
HGIABY42_04635
HALEG3A49_04815
HLSKU306_09425
HBOHbor_21590
HLMDV707_08745
HALMFCF25_05415
HLAHlac_2269
HALPDOS48_11410
HALBEKH57_13805
HEZZEO776_12580
HALQHrr1229_009495
HSSJ7656_03745
HSAIHPS36_09065
HAZZKI388_11125
SRUBC2R22_06170
HAEhalTADL_0175
HALNB4589_001370
HALGHUG10_03090
HALUHUG12_13770
HMPK6T50_01445
HREK6T36_01245
HRMK6T25_00075
HDFAArcSl_0991
HAHHalar_2167
HTUHtur_0571 Htur_3564
HDABB347_11090 BB347_11970
HSALJMJ58_06260 JMJ58_10535
HLOJ0X27_02120 J0X27_12180
HAKZJ0X25_10240
NMGNmag_2966
HXAHalxa_1680 Halxa_3413
NATNJ7G_4171
NPENatpe_0259 Natpe_3491
NPLFGF80_09535 FGF80_15055
NAYHYG81_12595
HALYHYG82_19630
HJTDVR14_07590
NGENatgr_1133 Natgr_2288
HRUHalru_1540
NOUNatoc_0402 Natoc_2480
HLCCHINAEXTREME02065 CHINAEXTREME06955
NAJB1756_00190 B1756_04360
NAGAArcMg_0285 AArcMg_3194
NANAArc1_3103
NBGDV706_08855
NASGCU68_03210 GCU68_07770
SAWLNGM29_17185
MEAMMU439_02375
TARTALC_00199
MAXMMALV_01860
MERMMINT_06510 MMINT_17710
MEARMpt1_c12760
MEUZKRP56_01045
MARCAR505_1643
ABIAboo_0331
ACFAciM339_0726
SMRSmar_1357
SHCShell_1087 Shell_1088
DKADKAM_0459 DKAM_0460
DFDDesfe_0599
DMUDesmu_0715
TAGTagg_0676 Tagg_0677
THGTCELL_1141
HBUHbut_0498
PDLPyrde_1813 Pyrde_1814
TPETpen_0384
THBN186_02935 N186_02940
TCBTCARB_1655 TCARB_1656
THFMA03_08045 MA03_08050
THELIG193_05630 IG193_05635
CLGCalag_1023
CCAINAS2_1493 NAS2_1494
BARCAOA65_0862 AOA65_0864
FLTSv326_0527
LOKILokiarch_30180
PSYTDSAG12_01252
 » show all
Reference
1  [PMID:17303759]
  Authors
Sato T, Atomi H, Imanaka T
  Title
Archaeal type III RuBisCOs function in a pathway for AMP metabolism.
  Journal
Science 315:1003-6 (2007)
DOI:10.1126/science.1135999
  Sequence
[tko:TK0185]
Reference
2  [PMID:23065974]
  Authors
Aono R, Sato T, Yano A, Yoshida S, Nishitani Y, Miki K, Imanaka T, Atomi H
  Title
Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway.
  Journal
J Bacteriol 194:6847-55 (2012)
DOI:10.1128/JB.01335-12
  Sequence
[tko:TK0185]
Reference
3  [PMID:22511789]
  Authors
Nakamura A, Fujihashi M, Aono R, Sato T, Nishiba Y, Yoshida S, Yano A, Atomi H, Imanaka T, Miki K
  Title
Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1.
  Journal
J Biol Chem 287:20784-96 (2012)
DOI:10.1074/jbc.M112.349423
  Sequence
[tko:TK0185]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.1.29
IUBMB Enzyme Nomenclature: 5.3.1.29
ExPASy - ENZYME nomenclature database: 5.3.1.29
BRENDA, the Enzyme Database: 5.3.1.29

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