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Entry
EC 5.3.2.4                  Enzyme                                 

Name
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming);
TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase (ambiguous);
Tyl1a;
dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase (ambiguous)
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting keto- and enol-groups
BRITE hierarchy
Sysname
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose isomerase
Reaction(IUBMB)
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose [RN:R06424]
Reaction(KEGG)
Substrate
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose [CPD:C11907]
Product
dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose [CPD:C11908]
Comment
The enzyme is involved in biosynthesis of D-mycaminose.
History
EC 5.3.2.4 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K19853  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Genes
SAMB: SAM23877_5623(srm14)
Taxonomy
Reference
1  [PMID:17209568]
  Authors
Melancon CE 3rd, Hong L, White JA, Liu YN, Liu HW
  Title
Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and  substrate specificity studies.
  Journal
Biochemistry 46:577-90 (2007)
DOI:10.1021/bi061907y
Other DBs
ExplorEnz - The Enzyme Database: 5.3.2.4
IUBMB Enzyme Nomenclature: 5.3.2.4
ExPASy - ENZYME nomenclature database: 5.3.2.4
BRENDA, the Enzyme Database: 5.3.2.4

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (13)   

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