KEGG   ENZYME: 5.3.2.4
Entry
EC 5.3.2.4                  Enzyme                                 
Name
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming);
TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase (ambiguous);
Tyl1a;
dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase (ambiguous)
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting keto- and enol-groups
Sysname
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose isomerase
Reaction(IUBMB)
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose [RN:R06424]
Reaction(KEGG)
R06424
Substrate
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose [CPD:C11907]
Product
dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose [CPD:C11908]
Comment
The enzyme is involved in biosynthesis of D-mycaminose.
History
EC 5.3.2.4 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19853  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
K24249  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Genes
CBE: Cbei_2596
CBZ: Cbs_2596
CSR: Cspa_c19620
CAH: CAETHG_2608
CCK: Ccar_14195
CEU: A7L45_16800
CDY: F3K33_13280
CRW: CROST_039220(fdtA)
CGEL: psyc5s11_31550
CLOM: AXY43_01095
CRAS: KVH43_11465
ELM: ELI_1977
ELIM: B2M23_19440
AWO: Awo_c20960
AMIC: Ami3637_06300
THYR: P4S50_04730
SAMB: SAM23877_5623(srm14)
SCAE: IHE65_08870
 » show all
Reference
1  [PMID:17209568]
  Authors
Melancon CE 3rd, Hong L, White JA, Liu YN, Liu HW
  Title
Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies.
  Journal
Biochemistry 46:577-90 (2007)
DOI:10.1021/bi061907y
Other DBs
ExplorEnz - The Enzyme Database: 5.3.2.4
IUBMB Enzyme Nomenclature: 5.3.2.4
ExPASy - ENZYME nomenclature database: 5.3.2.4
BRENDA, the Enzyme Database: 5.3.2.4

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