Entry
Name
5-carboxymethyl-2-hydroxymuconate Delta-isomerase;
CHM isomerase;
5-carboxymethyl-2-hydroxymuconic acid isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
5-carboxymethyl-2-hydroxymuconate Delta2,Delta4-2-oxo,Delta3-isomerase
Reaction(IUBMB)
5-carboxymethyl-2-hydroxymuconate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate [RN:
R04379 ]
Reaction(KEGG)
Substrate
5-carboxymethyl-2-hydroxymuconate [CPD:
C04186 ]
Product
(3E,5R)-5-carboxy-2-oxohept-3-enedioate
Comment
Part of the homoprotocatechuate degradation pathway in Escherichia coli C.
History
EC 5.3.3.10 created 1984
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K01826 5-carboxymethyl-2-hydroxymuconate isomerase
Genes
REE : electrica_04375(hpcD)
RTG : NCTC13098_06421(hpcD)
KIE : NCTC12125_02699(hpcD)
YPG : YpAngola_A1644(hpaF)
YPI : YpsIP31758_2361(hpaF)
SFJ : SAMEA4384070_0656(hpcD)
SOF : NCTC11214_00928(hpcD_2)
PHEI : NCTC12003_00823(hpcD)
PRJ : NCTC6933_00880(hpcD)
PRAG : EKN56_02465 EKN56_03315
PFQ : QQ39_02830 QQ39_14475
VNA : PN96_04565 PN96_12080
VEJ : VEJY3_01200 VEJY3_08805
VNI : VIBNI_A3616 VIBNI_B1975
VCY : IX92_14040 IX92_27595
VCT : JV59_00195 JV59_24385
VSI : MTO69_01160 MTO69_16160
VMI : AL543_08190 AL543_16445
VKA : BTD91_07445 BTD91_16745
VZI : G5S32_01005 G5S32_15630
VGI : MID13_14425 MID13_23080
VSL : LTQ54_09875 LTQ54_17430
VPL : SA104470976_00166(hpcD)
VCRA : IS519_11610 IS519_25150
VLE : ISX51_02785 ISX51_14820
PGH : FH974_00900 FH974_06160
PATE : NNL38_00920 NNL38_17090
PRE : PCA10_16310(hpaF) PCA10_33850
PFUW : KF707C_32060 KF707C_32210
PAEV : N297_2028 N297_4257(hpcD)
PAEI : N296_2028 N296_4257(hpcD)
PAU : PA14_10610(hpcD) PA14_39100
PAG : PLES_08461(hpcD) PLES_33571
PAF : PAM18_0814(hpcD) PAM18_3079
PNC : NCGM2_2938 NCGM2_5326(hpcD)
PAEB : NCGM1900_0835(hpcD) NCGM1900_4522
PSG : G655_04075 G655_15280
PRP : M062_10250 M062_21755
PAEP : PA1S_04195 PA1S_15865
PAEM : U769_04220 U769_15450
PAEL : T223_04130 T223_17145
PAES : SCV20265_0842 SCV20265_3427
PAEU : BN889_04579(hpcD) BN889_06660
PAEG : AI22_17905 AI22_29420
PAEC : M802_2026 M802_4255(hpcD)
PAEO : M801_2027 M801_4123(hpcD)
SECH : B18_03740 B18_21725
PAP : PSPA7_0967(hpcD) PSPA7_3330
PPAA : B7D75_04065 B7D75_15160
PFV : Psefu_1019 Psefu_2859
PMOL : CLJ08_19430 CLJ08_25205
PMOS : O165_002080 O165_009135
PFL : PFL_1486(hpcD_1) PFL_3374(hpcD_2)
PPRC : PFLCHA0_c15250 PFLCHA0_c34040(hpcD)
PPRO : PPC_1539(hpcD_1) PPC_3398(hpcD_2)
PFE : PSF113_1440 PSF113_2547
PZA : HU749_008395 HU749_016625
PFS : PFLU_1499 PFLU_2285 PFLU_3273
PFC : PflA506_1513(hpcD_2) PflA506_3398(hpcD_1)
PTV : AA957_06620 AA957_24910
PCG : AXG94_00015 AXG94_22705
PAZO : AYR47_14755 AYR47_26795
PMED : E3Z27_07095 E3Z27_12215
PMAB : U0037_07480 U0037_11480 U0037_16350
PFW : PF1751_v1c14800(hpcD) PF1751_v1c25990 PF1751_v1c34820(hpcD)
PFF : PFLUOLIPICF700930 PFLUOLIPICF718495 PFLUOLIPICF724035
PEN : PSEEN3096(hpaF) PSEEN4037
PBA : PSEBR_a1361 PSEBR_a2740
PBC : CD58_07625 CD58_13830
PSK : U771_08620 U771_17295
PKC : PKB_2455(hpaF) PKB_3512
PCH : EY04_06875 EY04_16750
PCZ : PCL1606_26990 PCL1606_46380
PCP : JM49_13985 JM49_22990
PCHP : C4K32_1547 C4K32_3450
PSES : PSCI_0281 PSCI_3408
PSEM : TO66_07345 TO66_17405
PSEC : CCOS191_2711 CCOS191_3985
PSOS : POS17_1497(hpcD_1) POS17_3355(hpcD_2)
PANR : A7J50_1622 A7J50_3682
PYM : AK972_3752 AK972_4478
PVK : EPZ47_07390 EPZ47_13755
PBZ : GN234_04550 GN234_11035
PSEP : C4K39_1565 C4K39_5344
PPII : QL104_07805 QL104_17935
PVW : HU752_008500 HU752_019675
PTRT : HU722_0008485 HU722_0018770
PSAM : HU731_005405 HU731_023295
PTZ : HU718_008085 HU718_011215
PQI : KH389_07475 KH389_12125
PXN : HU772_013385 HU772_018120
PASG : KSS96_08140 KSS96_11180 KSS96_11955
PMUY : KSS95_15000 KSS95_20945
PMAM : KSS90_06695 KSS90_12420
PCAS : LOY40_17125 LOY40_21555
PORY : EJA05_07185 EJA05_13155
PTK : EXN22_08190 EXN22_12265
PTW : TUM18999_28810(hpcD)
PGF : J0G10_08200 J0G10_11740
PSIH : LOY51_07075 LOY51_12975
PKK : QQ992_12750 QQ992_17470 QQ992_17625
PCUC : PSH97_06645 PSH97_16050
PPAE : LDL65_00735 LDL65_18825
PRHZ : CRX69_05725 CRX69_11990
PHEF : PSH57_18345 PSH57_21470
PSNC : C0058_07515 C0058_11530
PBEJ : PSH84_11830 PSH84_18055
PCAA : V6L78_14525 V6L78_26560
PSIV : LZ023_16070 LZ023_25785
PKH : JLK41_06100 JLK41_06960
ABAZ : P795_6470 P795_8035
ABK : LX00_09730 LX00_11360
ABAU : IX87_06465 IX87_20470
ABOU : ACBO_11680(hpcD) ACBO_24790
SSEM : JYB85_10495 JYB85_14955
TACT : SG35_013315 SG35_022480
PPHE : PP2015_1456 PP2015_2813
PLZ : S4054249_12890 S4054249_18125
PTD : PTET_a3158(hpaF) PTET_b0400(hpaF)
AGQ : LQZ07_06490 LQZ07_21160
AGAR : OAG1_06620 OAG1_32960(hpcD)
MII : BTJ40_09910 BTJ40_16465
MCEL : LPW13_04310 LPW13_16915
MICZ : GL2_24910 GL2_32780
LJR : NCTC11533_00323(hpcD)
GAI : IMCC3135_16365(hpcD)
ALCA : ASALC70_00931(hpcD)
MMW : Mmwyl1_3173 Mmwyl1_3292
MPRI : MP3633_0968(hpcD1) MP3633_3047(hpcD2)
MRHI : KDW99_14210 KDW99_14960
NJP : NEJAP_0040 NEJAP_1958
AJP : AMJAP_1982 AMJAP_2319
IGN : MMG00_04240 MMG00_10995
CRZ : D1345_06330 D1345_13740
CHAE : CH06BL_13810 CH06BL_29070
AQS : DKK66_02120 DKK66_11035
AQL : BXU06_01555 BXU06_08970
RPF : Rpic12D_1628 Rpic12D_2223
RMN : TK49_12415 TK49_15370
RIN : ACS15_0042 ACS15_1523 ACS15_2661
RWE : KOL96_16015 KOL96_19175
REH : H16_A0624(hpaF) H16_B1250(h16_B1250)
CNC : CNE_2c12210 CNE_BB2p02560
CUH : BJN34_27870 BJN34_30235
CTI : RALTA_A0570 RALTA_B1154
CBW : RR42_m3788 RR42_s1469 RR42_s1739
CCUP : BKK81_18325 BKK81_27590 BKK81_30330
CUP : BKK80_19180 BKK80_26025 BKK80_28735
CUU : BKK79_12865 BKK79_31900 BKK79_34685
CNAN : A2G96_04225 A2G96_26445
BMN : BMA10247_A1509(hpaF)
BPM : BURPS1710b_A2268(hpcD)
BPL : BURPS1106A_A0942(hpaF)
BPD : BURPS668_A1027(hpaF)
BPZ : BP1026B_II0769(hpcD)
BUR : Bcep18194_B0126 Bcep18194_B1779
BMK : DM80_3358 DM80_3367 DM80_3533
BCEP : APZ15_17815 APZ15_24100
BCON : NL30_05810 NL30_17460
BSTG : WT74_25610 WT74_32310
BAEN : L3V59_19975 L3V59_28600
PSAA : QEN71_12045 QEN71_34390
PPAI : E1956_24570 E1956_40335
HYF : DTO96_100050 DTO96_101728(hpcD)
BOJ : CBF45_11020 CBF45_15815
KGY : EHF36_11270 EHF36_15865
AMON : H9L24_01945 H9L24_11005
DEL : DelCs14_0104 DelCs14_4809
DTS : BI380_15500 BI380_22255
DHK : BO996_02480 BO996_08665
DLA : I6G47_15125 I6G47_22205
CODO : LAD35_04295 LAD35_15680
CRJ : QMY55_00330 QMY55_18845
LIM : L103DPR2_00428(hpcD)
LIH : L63ED372_02769(hpcD)
HYN : F9K07_02265 F9K07_10690
DIH : G7047_24990 G7047_29095
DRG : H9K76_08055 H9K76_18650
SMIO : CATMQ487_02920(hpaF)
UPV : EJN92_01885 EJN92_08885
QAU : KI612_13740 KI612_16495
ACOM : CEW83_16270 CEW83_16450
BNU : N3Z17_00610 N3Z17_04175
RHI : NGR_b06010 NGR_b20110
ESJ : SJ05684_b51260 SJ05684_b53910
RLT : Rleg2_3466 Rleg2_4440
RTR : RTCIAT899_PC03865(hpcD) RTCIAT899_PC07920
RBQ : J2J99_09970 J2J99_22475
BIO : BR141012304_20938(hpcD)
BJU : BJ6T_20730 BJ6T_67960
BJP : RN69_10155 RN69_32965
BSEI : KMZ68_03430 KMZ68_09615
RPA : TX73_015475 TX73_019465
RPX : Rpdx1_1585 Rpdx1_2456
RBK : E0H22_18055 E0H22_20135
RHOR : ONR75_09145 ONR75_23010
RHOL : RBJ75_00875 RBJ75_24400
VGO : GJW-30_1_00229(hpcD)
TRB : HB776_13910 HB776_15480
TALZ : RPMA_20170 RPMA_22795
TARD : RSO67_07600 RSO67_09215
MMYR : MXMO3_00063 MXMO3_01288
PSIN : CAK95_00955 CAK95_28340
LAP : ACP90_04040 ACP90_06690
LABT : FIU93_09670(hpcD1) FIU93_12330(hpcD2)
LAGG : B0E33_15595 B0E33_18240
CEH : CEW89_04100 CEW89_10885
SMED : JNX03_11755 JNX03_18445
SPSE : SULPSESMR1_00273(hpcD)
AHT : ANTHELSMS3_04502(hpcD)
OCD : FHY55_12615 FHY55_14420
TGL : HFZ77_01110 HFZ77_15865
PAMO : BAR1_02140 BAR1_11980
NSM : JO391_15470 JO391_17930
FUV : JR347_06910 JR347_06955
AQR : HN014_06575 HN014_11145
CGLE : NCTC11432_02674(hpcD)
BFD : NCTC4823_03854(hpcD)
PARG : PspKH34_04520(hpcD)
STRE : GZL_00818 GZL_08681
SCW : TU94_09615 TU94_29455
SLE : sle_08990(sle_08990) sle_49330(sle_49330)
SNR : SNOUR_03895 SNOUR_39355
SALL : SAZ_03340 SAZ_40455
SPUN : BFF78_30065 BFF78_40315
SKA : CP970_28155 CP970_31400
SBRO : GQF42_04820 GQF42_14125
SXN : IAG42_01640 IAG42_25535
SACT : DMT42_03760 DMT42_11295
SYUN : MOV08_03410 MOV08_40270
SINN : ABB07_27195 ABB07_36125
SLUO : PS467_02495 PS467_12745
SABD : N8I86_12430 N8I86_34940
SCT : SCAT_p0515 SCAT_p0542
SCY : SCATT_p11970 SCATT_p12260
KSK : KSE_03310 KSE_14500 KSE_72990
KIS : HUT16_05920 HUT16_34485 HUT16_35790
» show all
Taxonomy
Reference
Authors
Garrido-Peritierra A, Cooper RA
Title
Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.
Journal
Reference
2
Authors
Johnson WH Jr, Hajipour G, Whitman CP.
Title
Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications.
Journal
J Am Chem Soc 117:8719-8726 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.10
ExPASy - ENZYME nomenclature database: 5.3.3.10
UM-BBD (Biocatalysis/Biodegradation Database): 5.3.3.10