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Entry
EC 5.3.3.12                 Enzyme                                 

Name
L-dopachrome isomerase;
dopachrome tautomerase;
tyrosinase-related protein 2;
TRP-1;
TRP2;
TRP-2;
tyrosinase-related protein-2;
dopachrome Delta7,Delta2-isomerase;
dopachrome Delta-isomerase;
dopachrome conversion factor;
dopachrome isomerase;
dopachrome oxidoreductase;
dopachrome-rearranging enzyme;
DCF;
DCT;
dopachrome keto-enol isomerase;
L-dopachrome-methyl ester tautomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
L-dopachrome keto-enol isomerase
Reaction(IUBMB)
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate [RN:R03673]
Reaction(KEGG)
Substrate
L-dopachrome [CPD:C01693]
Product
5,6-dihydroxyindole-2-carboxylate [CPD:C04185]
Comment
A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).
History
EC 5.3.3.12 created 1992, modified 1999, modified 2005
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K01827  dopachrome tautomerase
K22203  dopachrome tautomerase
Genes
HSA: 1638(DCT)
PTR: 452622(DCT)
PPS: 100975768(DCT)
GGO: 101133130(DCT)
PON: 100438537(DCT)
NLE: 100595345(DCT)
MCC: 694577(DCT)
MCF: 102127456(DCT)
CSAB: 103214664(DCT)
RRO: 104658800(DCT)
RBB: 108519938(DCT)
CJC: 100389709(DCT)
MMU: 13190(Dct)
RNO: 290484(Dct)
CGE: 100764118(Dct)
NGI: 103729035(Dct)
HGL: 101716269(Dct)
CCAN: 109702871(Dct)
OCU: 100353923(DCT)
TUP: 102484655(DCT)
CFA: 485520(DCT)
AML: 100467156(DCT)
UMR: 103657595(DCT)
ORO: 101381485(DCT)
FCA: 101094977(DCT)
PTG: 102953286(DCT)
AJU: 106984228(DCT)
BTA: 280761(DCT)
BOM: 102285590(DCT)
BIU: 109566904(DCT)
PHD: 102334289(DCT)
CHX: 102169882(DCT)
OAS: 100170232(DCT)
SSC: 574066(DCT)
CFR: 102519042(DCT)
CDK: 105089212(DCT)
BACU: 103009988(DCT)
LVE: 103070463(DCT)
OOR: 101273282(DCT)
ECB: 100058776(DCT)
EPZ: 103559368(DCT)
EAI: 106846221(DCT)
MYB: 102258295(DCT)
MYD: 102754085(DCT)
HAI: 109395407(DCT)
RSS: 109450165(DCT)
PALE: 102883222(DCT)
LAV: 100656003(DCT)
TMU: 101340616
MDO: 100027305(DCT)
SHR: 100920202(DCT)
OAA: 100081295(DCT)
GGA: 395775(DCT)
MGP: 100543862(DCT)
CJO: 107308023(DCT)
APLA: 101792699(DCT)
ACYG: 106045352(DCT)
TGU: 100230498(DCT)
GFR: 102032174(DCT)
FAB: 101812075(DCT)
PHI: 102103043(DCT)
PMAJ: 107199948(DCT)
CCW: 104685963(DCT)
FPG: 101918681(DCT)
FCH: 102059594(DCT)
CLV: 102092544(DCT)
EGZ: 104122461(DCT)
AAM: 106491647(DCT)
ASN: 102378044(DCT)
AMJ: 102571729(DCT)
PSS: 102443459(DCT)
CMY: 102934273(DCT)
CPIC: 101935852(DCT)
ACS: 100557746(dct)
PVT: 110073874(DCT)
PBI: 103062097(DCT)
GJA: 107116639(DCT)
XLA: 100381161(dct.L)
XTR: 549915(dct)
NPR: 108786125(DCT)
DRE: 58074(dct)
SRX: 107722116(dct)
SGH: 107558385(dct) 107567421
IPU: 108266888(dct)
AMEX: 103044028(dct)
TRU: 101077388(dct)
LCO: 104922692(dct)
NCC: 104947502(dct)
MZE: 101480314(dct)
OLA: 101166914(dct)
XMA: 102224148(dct)
PRET: 103459953(dct)
NFU: 107389964(dct)
CSEM: 103392019(dct)
LCF: 108901600(dct)
HCQ: 109523392(dct)
BPEC: 110173138(dct)
SFM: 108942570(dct)
LCM: 102360769(DCT)
CMK: 103176933(dct)
CIN: 100187516
DME: Dmel_CG18550(yellow-f) Dmel_CG8063
DSI: Dsimw501_GD20528(Dsim_GD20528) Dsimw501_GD20529(Dsim_GD20529)
MDE: 101889119
TCA: 657666(Y-f)
DPA: 109544651
NVL: 108566790
 » show all
Taxonomy
Reference
1  [PMID:8573077]
  Authors
Solano F, Jimenez-Cervantes C, Martinez-Liarte JH, Garcia-Borron JC, Jara JR, Lozano JA.
  Title
Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase.
  Journal
Biochem J 313 ( Pt 2):447-53 (1996)
  Sequence
[mmu:13190]
Reference
2  [PMID:2106316]
  Authors
Pawelek JM.
  Title
Dopachrome conversion factor functions as an isomerase.
  Journal
Biochem Biophys Res Commun 166:1328-33 (1990)
DOI:10.1016/0006-291X(90)91011-G
Reference
3  [PMID:9794786]
  Authors
Pennock JL, Behnke JM, Bickle QD, Devaney E, Grencis RK, Isaac RE, Joshua GW, Selkirk ME, Zhang Y, Meyer DJ.
  Title
Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi.
  Journal
Biochem J 335 ( Pt 3):495-8 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.12
IUBMB Enzyme Nomenclature: 5.3.3.12
ExPASy - ENZYME nomenclature database: 5.3.3.12
BRENDA, the Enzyme Database: 5.3.3.12
CAS: 130122-81-5

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