Entry |
|
Name |
trans-2,3-dihydro-3-hydroxyanthranilate isomerase;
phzF (gene name);
(5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase (incorrect)
|
Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
|
Sysname |
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate isomerase
|
Reaction(IUBMB) |
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate [RN: R09707]
|
Reaction(KEGG) |
|
Substrate |
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate
|
Product |
(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate [CPD: C19831]
|
Comment |
The enzyme is involved in phenazine biosynthesis. The product probably spontaneously dimerises to 1,4,5a,6,9,10a-hexahydrophenazine-1,6-dicarboxylate
|
History |
EC 5.3.3.17 created 2011
|
Pathway |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K06998 | trans-2,3-dihydro-3-hydroxyanthranilate isomerase |
|
Genes |
» show all
|
Reference |
|
Authors |
Parsons JF, Song F, Parsons L, Calabrese K, Eisenstein E, Ladner JE |
Title |
Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Blankenfeldt W, Kuzin AP, Skarina T, Korniyenko Y, Tong L, Bayer P, Janning P, Thomashow LS, Mavrodi DV |
Title |
Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Parsons JF, Calabrese K, Eisenstein E, Ladner JE |
Title |
Structure of the phenazine biosynthesis enzyme PhzG. |
Journal |
|
Reference |
|
Authors |
Mavrodi DV, Bleimling N, Thomashow LS, Blankenfeldt W |
Title |
The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79. |
Journal |
|
Reference |
|
Authors |
Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W |
Title |
PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 5.3.3.17 |
ExPASy - ENZYME nomenclature database: | 5.3.3.17 |
|