| Entry |
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| Name |
trans-2,3-dihydro-3-hydroxyanthranilate isomerase;
phzF (gene name);
(5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase (incorrect)
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
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| Sysname |
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate isomerase
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| Reaction(IUBMB) |
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate [RN: R09707]
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| Reaction(KEGG) |
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| Substrate |
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate
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| Product |
(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate [CPD: C19831]
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| Comment |
The enzyme is involved in phenazine biosynthesis. The product probably spontaneously dimerises to 1,4,5a,6,9,10a-hexahydrophenazine-1,6-dicarboxylate
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| History |
EC 5.3.3.17 created 2011
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| Pathway |
| ec01130 | Biosynthesis of antibiotics |
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| Orthology |
| K06998 | trans-2,3-dihydro-3-hydroxyanthranilate isomerase |
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| Genes |
» show all
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| Reference |
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| Authors |
Parsons JF, Song F, Parsons L, Calabrese K, Eisenstein E, Ladner JE |
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| Title |
Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Blankenfeldt W, Kuzin AP, Skarina T, Korniyenko Y, Tong L, Bayer P, Janning P, Thomashow LS, Mavrodi DV |
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| Title |
Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Parsons JF, Calabrese K, Eisenstein E, Ladner JE |
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| Title |
Structure of the phenazine biosynthesis enzyme PhzG. |
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| Journal |
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| Reference |
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| Authors |
Mavrodi DV, Bleimling N, Thomashow LS, Blankenfeldt W |
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| Title |
The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79. |
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| Journal |
Acta Crystallogr D Biol Crystallogr 60:184-6 (2004) |
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| Reference |
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| Authors |
Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W |
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| Title |
PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.3.17 |
| ExPASy - ENZYME nomenclature database: | 5.3.3.17 |
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