ENZYME: 5.3.3.21 Help
Entry
Name
Delta3,5-Delta2,4-dienoyl-CoA isomerase;
3,5-tetradecadienoyl-CoA isomerase;
DCI1 (gene name)
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
(3E,5Z)-alka-3,5-dienoyl-CoA Delta3,5-Delta2,4 isomerase
Reaction(IUBMB)
a (3E,5Z)-alka-3,5-dienoyl-CoA = a (2E,4E)-alka-2,4-dienoyl-CoA
Substrate
(3E,5Z)-alka-3,5-dienoyl-CoA
Product
(2E,4E)-alka-2,4-dienoyl-CoA
Comment
The enzyme participates in an alternative degradation route of fatty acids with cis-double bonds on odd-number carbons such as oleate and linoleate. The main physiological substrate is (3E,5Z)-tetradeca-3,5-dienoyl-CoA, but other (3E,5Z)-dienoyl-CoAs with varying carbon chain lengths are also substrates.
History
EC 5.3.3.21 created 2018
Orthology
K12663 Delta3,5-Delta2,4-dienoyl-CoA isomerase
K22587 Delta3,5-Delta2,4-dienoyl-CoA isomerase
Genes
PON : 100171488(ECH1) 100449591
PPYG : 129019632 134738847
MLEU : 105534633 105534634
TFN : 117078242 117092488(ECH1)
DORD : 105993166 105993180
PLOP : 125338629 125338830
LLV : 125084075 125088500 125092368
NVS : 122899831 122911645(ECH1)
ZCA : 113927250 113936612(ECH1)
MJV : 108389637(ECH1) 118972999
LAV : 100655872 100656445 100656730
TMU : 101352322 101352581 101352835 101353098 111822758
DNM : 101432906(ECH1) 101437967
MGP : 100550981(ECH1) 104909213
ACHC : 115338167 115338172
NPR : 108804971 108804972(ECH1)
BBUF : 121009241 121009242
SRX : 107736640 107747316(ech1)
SGH : 107567253 107598793 107598808
PPRM : 120464709 120464722
MASI : 127422285 127429509
TROS : 130565112 130565113
IFU : 128615146 128623952(ech1)
AMEX : 103040042 103040349
CMAO : 118797074 118797075 118797078
LCO : 104938714 109137402(ech1)
MSAM : 119882016 119882249
ONL : 100709616 100709888(ech1)
OGO : 123992936(ech1) 124005634
ONE : 115136942(ech1) 115141655
CCLU : 121564011(ech1) 121567518
PSPA : 121304867 121304901(ech1)
PMRN : 116947863 116947864(ECH1)
LRJ : 133341300 133341303(ECH1)
SCLV : 120345418 120345420
LPIC : 129264728 129265900
APLC : 110988065 110988088
DSI : Dsimw501_GD28939(Dsim_GD28939)
RZE : 108366865 108375582 108376525
CLON : 129605351 129605530
CFEL : 113389079 113389213
DCI : 103518652 103523550 108251806
PPOI : 119093172 119093174 119094558 119114574 119114575
PTEP : 107444488 107457486
ABRU : 129958738 129962044
UDV : 129217211 129219095 129219343
LPOL : 106461158 106463343 106472857
CEL : CELE_F58A6.1(F58A6.1) CELE_Y25C1A.13(Y25C1A.13)
CBR : CBG_02334 CBG_19637 CBG_25649
CRQ : GCK72_005962 GCK72_006747
NAI : NECAME_04904 NECAME_15165
PMAX : 117324206 117324208
TAD : TRIADDRAFT_19479 TRIADDRAFT_20308 TRIADDRAFT_34632
CSAT : 104725139 104760625 104771473
HSYR : 120121475 120123046 120164502 120164503
ADU : 107458788 107461773 107467677 107474293
AIP : 107616276 107617815 107640222 107640470
AHF : 112701432 112705227 112712411 112722601 112747977 112748227 112775267
CSAV : 115714493 115714555
CILL : 122311899 122313985
SSPL : 121767521 121769806
CSIN : 114278791 114300552
TDC : 119270157 119270158 119278219
TAES : 123063160 123063162 123072066 123080349 123080350
LPER : 127345442 127345443
LRD : 124661443 124661444 124667471
MFLO : 136453950 136459756 136500775 136509436
PVIR : 120709121 120709123
MSIN : 131246711 131247428
SMO : SELMODRAFT_106195 SELMODRAFT_430350
NCS : NCAS_0F00380(NCAS0F00380)
NDI : NDAI_0D02720(NDAI0D02720)
TPF : TPHA_0F02640(TPHA0F02640)
TDL : TDEL_0G03960(TDEL0G03960)
KAF : KAFR_0G02430(KAFR0G02430)
KNG : KNAG_0M00960(KNAG0M00960)
LBG : 92208401(LODBEIA_P32050)
CAL : CAALFM_C306730WA(CaO19.6830)
CTEN : 18247161(PSN45_004070)
YLI : 2906089(YALI2_A00111g)
NTE : NEUTE1DRAFT144029(NEUTE1DRAFT_144029)
SMP : 10803377(SMAC4_06561)
FKR : NCS57_00752300 NCS57_00970100 NCS57_01492300 NCS57_01492700
TATV : 25785651(TrAtP1_006809)
TASP : 36618196(TrAFT101_006026)
MAW : 19246910(J3458_005720)
MBRN : 26241469(Ech1_0) 26245318(Ech1_1)
PLJ : 90642979(PLICBS_005014)
AOR : AO090103000285 AO090701000555
AFV : AFLA_005084 AFLA_013239
APUU : APUU_20756A APUU_30206S
PTRR : 6339025(PtrM4_021720)
PFJ : MYCFIDRAFT_47012 MYCFIDRAFT_47359
FFU : CLAFUR5_06756 CLAFUR5_11630 CLAFUR5_11995
CBET : CB0940_06831 CB0940_07069 CB0940_07733
CDEP : 91090272(L203_106064)
KMG : 30163174(I203_102164)
KNE : 92180036(IAR55_002778)
CCAC : CcaHIS019_0606210(CcaverHIS019_0606210)
PPL : POSPLDRAFT_103631 POSPLDRAFT_36293
ABP : AGABI1DRAFT43059(AGABI1DRAFT_43059)
ABV : AGABI2DRAFT79845(AGABI2DRAFT_79845)
SCM : SCHCO_02633256(SCHCODRAFT_02633256)
RIE : OCT59_003363 OCT59_006603
TET : TTHERM_00325590 TTHERM_00530510
PTM : GSPATT00020024001 GSPATT00037313001
PTI : PHATRDRAFT_28497(DEI1)
FCY : FRACYDRAFT_180456(ECH1)
» show all
Taxonomy
Reference
Authors
Filppula SA, Yagi AI, Kilpelainen SH, Novikov D, FitzPatrick DR, Vihinen M, Valle D, Hiltunen JK
Title
Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization.
Journal
Sequence
Reference
Authors
Modis Y, Filppula SA, Novikov DK, Norledge B, Hiltunen JK, Wierenga RK
Title
The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis.
Journal
Sequence
Reference
Authors
Geisbrecht BV, Schulz K, Nau K, Geraghty MT, Schulz H, Erdmann R, Gould SJ
Title
Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism.
Journal
Sequence
Reference
Authors
Gurvitz A, Mursula AM, Yagi AI, Hartig A, Ruis H, Rottensteiner H, Hiltunen JK
Title
Alternatives to the isomerase-dependent pathway for the beta-oxidation of oleic acid are dispensable in Saccharomyces cerevisiae. Identification of YOR180c/DCI1 encoding peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase.
Journal
Sequence
Reference
Authors
Zhang D, Liang X, He XY, Alipui OD, Yang SY, Schulz H
Title
Delta 3,5,delta 2,4-dienoyl-CoA isomerase is a multifunctional isomerase. A structural and mechanistic study.
Journal
Reference
Authors
Goepfert S, Vidoudez C, Rezzonico E, Hiltunen JK, Poirier Y
Title
Molecular identification and characterization of the Arabidopsis delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase, a peroxisomal enzyme participating in the beta-oxidation cycle of unsaturated fatty acids.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.21
ExPASy - ENZYME nomenclature database: 5.3.3.21