KEGG   ENZYME: 5.3.3.21
Entry
EC 5.3.3.21                 Enzyme                                 

Name
Delta3,5-Delta2,4-dienoyl-CoA isomerase;
3,5-tetradecadienoyl-CoA isomerase;
DCI1 (gene name)
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
Sysname
(3E,5Z)-alka-3,5-dienoyl-CoA Delta3,5-Delta2,4 isomerase
Reaction(IUBMB)
a (3E,5Z)-alka-3,5-dienoyl-CoA = a (2E,4E)-alka-2,4-dienoyl-CoA
Substrate
(3E,5Z)-alka-3,5-dienoyl-CoA
Product
(2E,4E)-alka-2,4-dienoyl-CoA
Comment
The enzyme participates in an alternative degradation route of fatty acids with cis-double bonds on odd-number carbons such as oleate and linoleate. The main physiological substrate is (3E,5Z)-tetradeca-3,5-dienoyl-CoA, but other (3E,5Z)-dienoyl-CoAs with varying carbon chain lengths are also substrates.
History
EC 5.3.3.21 created 2018
Orthology
K12663  Delta3,5-Delta2,4-dienoyl-CoA isomerase
K22587  Delta3,5-Delta2,4-dienoyl-CoA isomerase
Genes
HSA: 1891(ECH1)
PTR: 100608252 747511
PPS: 100980944(ECH1)
GGO: 101147000(ECH1)
PON: 100171488(ECH1) 100449591
NLE: 100591453
MCC: 694324(ECH1)
MCF: 102126859(ECH1)
CSAB: 103234640(ECH1)
RRO: 104676174 104676874
RBB: 108539017(ECH1)
CJC: 100393277(ECH1)
SBQ: 101054050(ECH1)
MMU: 51798(Ech1)
MCAL: 110297920(Ech1)
MPAH: 110330088(Ech1)
RNO: 64526(Ech1)
MUN: 110552539(Ech1)
CGE: 100768055(Ech1)
NGI: 103750721(Ech1)
HGL: 101712915(Ech1)
CCAN: 109695848(Ech1)
OCU: 100338389(ECH1)
TUP: 102495808(ECH1)
VVP: 112928412(ECH1)
AML: 100471547(ECH1)
UMR: 103661012(ECH1)
UAH: 113243607(ECH1)
ORO: 101363099(ECH1)
ELK: 111161466
FCA: 101093730(ECH1)
PTG: 102964312(ECH1)
PPAD: 109256640(ECH1)
AJU: 106988306(ECH1)
BTA: 507431(ECH1)
BOM: 102267373(ECH1)
BIU: 109572552(ECH1)
BBUB: 102408591(ECH1)
CHX: 102178387(ECH1)
OAS: 101112922(ECH1)
SSC: 733679(ECH1)
CFR: 102520180(ECH1)
CDK: 105103506(ECH1)
BACU: 103017534(ECH1)
LVE: 103074254(ECH1)
OOR: 101281084(ECH1)
DLE: 111180887(ECH1)
PCAD: 102993428(ECH1)
ECB: 100066427(ECH1)
EPZ: 103564553(ECH1)
EAI: 106836070(ECH1)
MYB: 102263606(ECH1)
MYD: 102770725(ECH1)
MNA: 107532203(ECH1)
HAI: 109395325(ECH1)
DRO: 112320171(ECH1)
PALE: 102883471(ECH1)
RAY: 107520964(ECH1)
MJV: 108405638(ECH1)
MDO: 100013539(ECH1)
PCW: 110202340(ECH1)
OAA: 100681370(ECH1)
GGA: 100858352(ECH1)
MGP: 100550981(ECH1) 104909213
NMEL: 110389128(ECH1)
LSR: 110478790(ECH1)
PHI: 106628908(ECH1)
CLV: 102088664(ECH1)
NNI: 104017283(ECH1)
AAM: 106487448(ECH1)
ASN: 102385413(ECH1)
AMJ: 102576964(ECH1)
PSS: 102451761(ECH1)
CMY: 102929410(ECH1)
CPIC: 101938914(ECH1)
ACS: 100566197(ech1)
PVT: 110075732(ECH1)
PBI: 103053242(ECH1)
PMUR: 107295479
PMUA: 114603227(ECH1)
GJA: 107106831(ECH1)
XLA: 444770(ech1.L)
XTR: 448218(ech1)
NPR: 108804971 108804972(ECH1)
DRE: 450048(ech1)
SRX: 107736640 107747316(ech1)
SANH: 107677099
CCAR: 109100078
IPU: 108280817(ech1)
PHYP: 113543394(ech1)
EEE: 113584659(ech1)
TRU: 101079675(ech1)
LCO: 104938714 109137402(ech1)
ONL: 100709616 100709888(ech1)
OLA: 101167137(ech1)
XMA: 102220767(ech1)
XCO: 114133531(ech1)
PRET: 103475228(ech1)
CVG: 107092492(ech1)
NFU: 107380139(ech1)
KMR: 108248553(ech1)
ALIM: 106522766(ech1)
AOCE: 111579387(ech1)
CSEM: 103377919(ech1)
POV: 109644907(ech1)
LCF: 108872695(ech1)
SDU: 111216972(ech1)
SLAL: 111657977(ech1)
HCQ: 109510770(ech1)
BPEC: 110172707(ech1)
MALB: 109973743(ech1)
SASA: 106580851(ech1)
OTW: 112265285(ech1)
SALP: 111949965
ELS: 105026806(ech1)
SFM: 108928784(ech1)
PKI: 111844058(ech1)
LCM: 102347846(ECH1)
RTP: 109921669(ech1)
BFO: 118425825
CIN: 100176710
DME: Dmel_CG9577(CG9577)
DER: 6550375
DSE: 6615093
DSI: Dsimw501_GD28939(Dsim_GD28939)
DAN: 6502948
DSR: 110184162
DPE: 6597335
DWI: 6648818
DAZ: 108618847
DNV: 108656263
DHE: 111593488
DVI: 6634409
MDE: 101893053
LCQ: 111685734
AAG: 5576287
AALB: 109425514
AME: 100578624
BIM: 100743223
BTER: 100648813
CCAL: 108623028
OBB: 114872777
SOC: 105206239
MPHA: 105839897
AEC: 105152340
ACEP: 105626407
PBAR: 105423804
VEM: 105563439
HST: 105191527
DQU: 106748811
CFO: 105248449
LHU: 105675542
PGC: 109854533
OBO: 105285690
PCF: 106793549
NVI: 100123403
CSOL: 105361973
DPA: 109541968
ATD: 109600413
NVL: 108557999
BMOR: 101739578
BMAN: 114248402
PMAC: 106720520
PRAP: 111000043
HAW: 110381190
TNL: 113505567
API: 100164087
DNX: 107167516
AGS: 114130672
RMD: 113556278
BTAB: 109040500
CLEC: 106667940
ZNE: 110834184
FCD: 110859233
PVM: 113813493
DPTE: 113793353
CSCU: 111631510
CEL: CELE_F58A6.1(F58A6.1) CELE_Y25C1A.13(Y25C1A.13)
BMY: Bm1_35505
TSP: Tsp_02522
PCAN: 112570588
CRG: 105321082
MYI: 110450322
OBI: 106873915
LAK: 106177778
NVE: 5509838
EPA: 110241905
ADF: 107327475
AMIL: 114956473
PDAM: 113677153
SPIS: 111345755
DGT: 114527126
HMG: 100199860
AQU: 100638551
ATH: AT5G43280(DCI1)
ALY: 9301509
CRB: 17875768
BRP: 103839250
BOE: 106313129
THJ: 104814199
CPAP: 110810833
CIT: 102611221
TCC: 18608898
GRA: 105783875
GAB: 108461856
DZI: 111282802
GMX: 100804855
GSJ: 114406573
VRA: 106771188
VAR: 108325212
VUN: 114189944
CCAJ: 109795029
CAM: 101506413
LJA: Lj0g3v0262349.1(Lj0g3v0262349.1)
LANG: 109354784
FVE: 101295299
RCN: 112200972
PPER: 18790909
PMUM: 103322119
PAVI: 110758785
MDM: 103452187
PXB: 103929034
CSV: 101216694
CMO: 103494575
MCHA: 111014684
CMAX: 111479454
CMOS: 111458038
CPEP: 111790185
RCU: 8274304
JCU: 105644864
HBR: 110659893
MESC: 110628656
PEU: 105133736
JRE: 109004779
VVI: 100249010
SLY: 101255297
SPEN: 107020723
SOT: 102601569
CANN: 107860535
NTA: 107783788
NSY: 104244791
NTO: 104113981
NAU: 109235472
INI: 109175866
SIND: 105156726
HAN: 110941153
LSV: 111889837
CCAV: 112523066
DCR: 108203109
BVG: 104897504
SOE: 110785744
PSOM: 113271549
OSA: 4327232
DOSA: Os01t0925200-01(Os01g0925200)
OBR: 102715171
BDI: 100829779
ATS: 109769988
SBI: 8059382
SITA: 101782993
PDA: 103707836
EGU: 105061424
MUS: 103992549
DCT: 110102333
PEQ: 110017978
ATR: 18434447
PPP: 112293757
SCE: YOR180C(DCI1)
NCS: NCAS_0F00380(NCAS0F00380)
NDI: NDAI_0D02720(NDAI0D02720)
TPF: TPHA_0F02640(TPHA0F02640)
TDL: TDEL_0G03960(TDEL0G03960)
KAF: KAFR_0G02430(KAFR0G02430)
CAL: CAALFM_C306730WA(CaO19.6830)
NCR: NCU06647
NTE: NEUTE1DRAFT144029(NEUTE1DRAFT_144029)
MGR: MGG_07309
SSCK: SPSK_05431
MAW: MAC_02599
CMT: CCM_01102
MBE: MBM_04576
ANI: AN2529.2
ANG: ANI_1_222084(An09g02050)
ABE: ARB_00718
TVE: TRV_00171
PTE: PTT_07376
CNE: CND02600
CNB: CNBD3740
TASA: A1Q1_02398
ABP: AGABI1DRAFT43059(AGABI1DRAFT_43059)
ABV: AGABI2DRAFT79845(AGABI2DRAFT_79845)
MGL: MGL_2518
MRT: MRET_4156
DDI: DDB_G0282261(ech1)
DFA: DFA_04510(ech1)
SMIN: v1.2.040401.t1(symbB.v1.2.040401.t1)
PTI: PHATRDRAFT_28497(DEI1)
FCY: FRACYDRAFT_180456(ECH1)
 » show all
Reference
1  [PMID:9417087]
  Authors
Filppula SA, Yagi AI, Kilpelainen SH, Novikov D, FitzPatrick DR, Vihinen M, Valle D, Hiltunen JK
  Title
Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization.
  Journal
J Biol Chem 273:349-55 (1998)
DOI:10.1074/jbc.273.1.349
  Sequence
[hsa:1891] [rno:64526]
Reference
2  [PMID:9739087]
  Authors
Modis Y, Filppula SA, Novikov DK, Norledge B, Hiltunen JK, Wierenga RK
  Title
The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis.
  Journal
Structure 6:957-70 (1998)
DOI:10.1016/S0969-2126(98)00098-7
  Sequence
[rno:64526]
Reference
3  [PMID:10381339]
  Authors
Geisbrecht BV, Schulz K, Nau K, Geraghty MT, Schulz H, Erdmann R, Gould SJ
  Title
Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism.
  Journal
Biochem Biophys Res Commun 260:28-34 (1999)
DOI:10.1006/bbrc.1999.0860
  Sequence
[sce:YOR180C]
Reference
4  [PMID:10455114]
  Authors
Gurvitz A, Mursula AM, Yagi AI, Hartig A, Ruis H, Rottensteiner H, Hiltunen JK
  Title
Alternatives to the isomerase-dependent pathway for the beta-oxidation of oleic acid are dispensable in Saccharomyces cerevisiae. Identification of YOR180c/DCI1  encoding peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase.
  Journal
J Biol Chem 274:24514-21 (1999)
DOI:10.1074/jbc.274.35.24514
  Sequence
[sce:YOR180C]
Reference
5  [PMID:11278886]
  Authors
Zhang D, Liang X, He XY, Alipui OD, Yang SY, Schulz H
  Title
Delta 3,5,delta 2,4-dienoyl-CoA isomerase is a multifunctional isomerase. A structural and mechanistic study.
  Journal
J Biol Chem 276:13622-7 (2001)
DOI:10.1074/jbc.M011315200
Reference
6  [PMID:16040662]
  Authors
Goepfert S, Vidoudez C, Rezzonico E, Hiltunen JK, Poirier Y
  Title
Molecular identification and characterization of the Arabidopsis delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase, a peroxisomal enzyme participating in the beta-oxidation cycle of unsaturated fatty acids.
  Journal
Plant Physiol 138:1947-56 (2005)
DOI:10.1104/pp.105.064311
  Sequence
[ath:AT5G43280]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.21
IUBMB Enzyme Nomenclature: 5.3.3.21
ExPASy - ENZYME nomenclature database: 5.3.3.21
BRENDA, the Enzyme Database: 5.3.3.21

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