KEGG   ENZYME: 5.3.3.21
Entry
EC 5.3.3.21                 Enzyme                                 
Name
Delta3,5-Delta2,4-dienoyl-CoA isomerase;
3,5-tetradecadienoyl-CoA isomerase;
DCI1 (gene name)
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
Sysname
(3E,5Z)-alka-3,5-dienoyl-CoA Delta3,5-Delta2,4 isomerase
Reaction(IUBMB)
a (3E,5Z)-alka-3,5-dienoyl-CoA = a (2E,4E)-alka-2,4-dienoyl-CoA
Substrate
(3E,5Z)-alka-3,5-dienoyl-CoA
Product
(2E,4E)-alka-2,4-dienoyl-CoA
Comment
The enzyme participates in an alternative degradation route of fatty acids with cis-double bonds on odd-number carbons such as oleate and linoleate. The main physiological substrate is (3E,5Z)-tetradeca-3,5-dienoyl-CoA, but other (3E,5Z)-dienoyl-CoAs with varying carbon chain lengths are also substrates.
History
EC 5.3.3.21 created 2018
Orthology
K12663  Delta3,5-Delta2,4-dienoyl-CoA isomerase
K22587  Delta3,5-Delta2,4-dienoyl-CoA isomerase
Genes
HSA1891(ECH1)
PTR100608252 747511
PPS100980944 117976943
GGO101147000(ECH1)
PON100171488(ECH1) 100449591
NLE100591453
MCC694324(ECH1)
MCF102126859(ECH1)
MTHB126942066
MNI105495395(ECH1)
CSAB103234640(ECH1)
CATY105594433(ECH1)
PANU100997211(ECH1)
TGE112612125(ECH1)
RRO104676174 104676874
RBB108539017(ECH1)
TFN117078242 117092488(ECH1)
PTEH111554038(ECH1)
CANG105519136
CJC100393277(ECH1)
SBQ101054050(ECH1)
CSYR103276948(ECH1)
MMUR105876816(ECH1)
LCAT123624363(ECH1)
PCOQ105820584(ECH1)
OGA100951737(ECH1)
MMU51798(Ech1)
MCAL110297920(Ech1)
MPAH110330088(Ech1)
RNO64526(Ech1)
MCOC116100432(Ech1)
MUN110552539(Ech1)
CGE100768055(Ech1)
MAUA101830747(Ech1)
PLEU114684700(Ech1)
MORG121449437(Ech1)
MFOT126486684
AAMP119821300(Ech1)
NGI103750721(Ech1)
HGL101712915(Ech1)
CPOC100729526(Ech1)
CCAN109695848(Ech1)
DORD105993166 105993180
DSP122097406 122097558
NCAR124967365
OCU100338389
OPI101522078(ECH1)
TUP102495808(ECH1)
GVR103591468(ECH1)
VVP112928412(ECH1)
VLG121485823(ECH1)
AML100471547(ECH1)
UMR103661012(ECH1)
UAH113243607(ECH1)
UAR123784510(ECH1)
ELK111161466
LLV125084075 125088500 125092368
MPUF101683258(ECH1)
NVS122899831 122911645(ECH1)
ORO101363099(ECH1)
EJU114198953(ECH1)
ZCA113927250 113936612(ECH1)
MLX118022692(ECH1)
NSU110590337(ECH1)
LWW102730875(ECH1)
FCA101093730(ECH1)
PYU121011492(ECH1)
PBG122494086(ECH1)
LRUF124511154
PTG102964312(ECH1)
PPAD109256640(ECH1)
AJU106988306(ECH1)
HHV120242041(ECH1)
BTA507431(ECH1)
BOM102267373(ECH1)
BIU109572552(ECH1)
BBUB102408591(ECH1)
BBIS104995321(ECH1)
CHX102178387(ECH1)
OAS101112922(ECH1)
ODA120872416(ECH1)
CCAD122421063(ECH1)
SSC733679(ECH1)
CFR102520180(ECH1)
CBAI105062821(ECH1)
CDK105103506(ECH1)
VPC102524986(ECH1)
BACU103017534(ECH1)
LVE103074254(ECH1)
OOR101281084(ECH1)
DLE111180887(ECH1)
PCAD102993428(ECH1)
PSIU116744211
ECB100066427(ECH1)
EPZ103564553(ECH1)
EAI106836070(ECH1)
MYB102263606(ECH1)
MYD102770725(ECH1)
MMYO118674805(ECH1)
MLF102442386(ECH1)
MNA107532203(ECH1)
PKL118702440(ECH1)
HAI109395325(ECH1)
DRO112320171(ECH1)
SHON118976326(ECH1)
AJM119040068(ECH1)
PDIC114510998(ECH1)
PHAS123823767(ECH1)
MMF118638992(ECH1)
RFQ117035537(ECH1)
PALE102883471(ECH1)
PGIG120596243(ECH1)
PVP105300183(ECH1)
RAY107520964(ECH1)
MJV108405638(ECH1)
TOD119249282(ECH1)
SARA101549312(ECH1)
LAV100655872 100656445 100656730
TMU101352322 101352581 101352835 101353098 111822758
ETF101645804(ECH1)
DNM101432906(ECH1) 101437967
MDO100013539(ECH1)
GAS123240047(ECH1)
PCW110202340(ECH1)
OAA100681370(ECH1)
GGA100858352(ECH1)
PCOC116237782(ECH1)
MGP100550981(ECH1) 104909213
NMEL110389128(ECH1)
LSR110478790(ECH1)
PMOA120507545
PHI106628908(ECH1)
CBRC103612501(ECH1)
CLV102088664(ECH1)
NNI104017283(ECH1)
ACHC115338167 115338172
HLE104831087(ECH1)
AGEN126035407
CUCA104068699(ECH1)
AAM106487448(ECH1)
AROW112961647(ECH1)
DNE112979309(ECH1)
ASN102385413(ECH1)
AMJ102576964(ECH1)
PSS102451761(ECH1)
CMY102929410(ECH1)
CPIC101938914(ECH1)
TST117888882(ECH1)
CABI116822400(ECH1)
MRV120388883(ECH1)
ACS100566197(ech1)
PVT110075732(ECH1)
SUND121915167(ECH1)
PBI103053242(ECH1)
PMUR107295479
CTIG120317167(ECH1)
PGUT117677726(ECH1)
VKO123025998(ECH1)
PMUA114603227(ECH1)
ZVI118086404(ECH1)
GJA107106831(ECH1)
STOW125434204(ECH1)
XLA444770(ech1.L)
XTR448218(ech1)
NPR108804971 108804972(ECH1)
RTEM120913415(ECH1)
BBUF121009241 121009242
BGAR122945973(ECH1)
DRE450048(ech1)
SRX107736640 107747316(ech1)
SANH107677099
SGH107567253 107598793 107598808
CCAR109100078
CAUA113098364(ech1)
PPRM120464709 120464722
MAMB125248470(ech1)
IPU108280817(ech1)
PHYP113543394(ech1)
SMEO124403439(ech1)
TFD113652844(ech1)
AMEX103039723(ech1) 103040042 103040349
EEE113584659(ech1)
TRU101079675(ech1)
TNGGSTEN00026821G001
LCO104938714 109137402(ech1)
CGOB115017420(ech1)
ELY117259459(ech1)
EFO125888785(ech1)
SLUC116053214(ech1)
ECRA117941635(ech1)
ESP116680559
PFLV114550159(ech1)
GAT120818026(ech1)
PPUG119213458(ech1)
MSAM119882016 119882249
CUD121515993(ech1)
ALAT119032331(ech1)
MZE101464128 101464407
ONL100709616 100709888(ech1)
OAU116327773(ech1)
OLA101167137(ech1)
OML112149526(ech1)
XMA102220767(ech1)
XCO114133531(ech1)
XHE116716569 116737536
PRET103475228(ech1)
PFOR103138334(ech1)
PLAI106951098(ech1)
PMEI106930376(ech1)
GAF122832849(ech1)
CVG107092492(ech1)
CTUL119783368(ech1)
GMU124883933(ech1)
NFU107380139(ech1)
KMR108248553(ech1)
ALIM106522766(ech1)
NWH119411391(ech1)
AOCE111579387(ech1)
MCEP125013450(ech1)
CSEM103377919(ech1)
POV109644907(ech1)
SSEN122773986(ech1)
HHIP117773318(ech1)
HSP118106187(ech1)
LCF108872695
SDU111216972(ech1)
SLAL111657977(ech1)
XGL120792047(ech1)
HCQ109510770(ech1)
BPEC110172707(ech1)
MALB109973743(ech1)
BSPL114867813(ech1)
SASA106580851(ech1)
STRU115163171(ech1)
OTW112265285
OMY110507582(ech1)
OGO123992936(ech1) 124005634
ONE115136942(ech1) 115141655
SALP111949965
SNH120018318(ech1)
CCLU121564011(ech1) 121567518
ELS105026806(ech1)
SFM108928784(ech1)
PKI111844058(ech1)
AANG118210234(ech1)
PSPA121304867 121304901(ech1)
ARUT117418839(ech1)
PSEX120540608(ech1)
LCM102347846(ECH1)
RTP109921669(ech1)
BFO118425825
BBEL109471003
CIN100176710
SCLV120345418 120345420
SPU115918238 578800
APLC110988065 110988088
AJC117123938
SKO100373151 102808591
DMEDmel_CG9577(Ech1)
DER6550375
DSE6615093
DSIDsimw501_GD28939(Dsim_GD28939)
DYADyak_GE15891
DAN6502948
DSR110184162
DPO4814580
DPE6597335
DMN108155039 117188180
DWI6648818
DGR6564868
DMODmoj_GI11030
DAZ108618847
DNV108656263
DHE111593488
DVI6634409
CCAT101457922
BOD106626708
RZE108366865 108375582 108376525
MDE101893053
SCAC106086397
LCQ111685734
LSQ119616496
HIS119657532
AGAAgaP_AGAP002661
ACOZ120947865
AARA120898620
ASTE118504976
AAG5576287
AALB109425514
CQUCpipJ_CPIJ002685
CPII120428284
CNS116342018
BCOO119067570
AME100578624
ACER107997538
ALAB122712743
BIM100743223
BBIF117210404
BVK117237801
BVAN117157981
BTER100648813
BPYO122577801
CCAL108623028
OBB114872777
MGEN117222844
NMEA116428631
CGIG122400379
SOC105206239
MPHA105839897
AEC105152340
ACEP105626407
PBAR105423804
VEM105563439
HST105191527
DQU106748811
CFO105248449
FEX115243170
LHU105675542
PGC109854533
OBO105285690
PCF106793549
PFUC122516470
VPS122632300
NVI100123403
CSOL105361973
TPRE106658785
MDL103574166 106693239
CGLO123274809
FAS105266356
DAM107048681
AGIF122857850
CINS118063894
LHT122500965
CCIN107274442
TCA656420 659277
DPA109541968
SOY115874827
ATD109600413
CSET123312407
AGB108908846
LDC111505037
NVL108557999
APLN108744673
PPYR116180445
OTU111423213 111423265
BMOR101739578
BMAN114248402
MSEX115452035
BANY112055444 112056984
NIQ126778543
PMAC106720520
PPOT106100264
PXU106125686
PRAP111000043
PBX123720015
PNAP125052656
ZCE119836108
CCRC123703738
HAW110381190
HZE124643072
TNL113505567
SLIU111358125
OFU114355335
PXY105389901 105397189
CFEL113389079 113389213
API100164087
DNX107167516
AGS114130672
RMD113556278
BTAB109040500
DCI103518652 103523550 108251806
CLEC106667940
HHAL106683642 106683647 112211865
NLU111046631
PHUPhum_PHUM163900
FOC113210193
TPAL117646873
ZNE110834184
CSEC111871702
SGRE126321830
FCD110859233
DPXDAPPUDRAFT_199888
DMK116921966 123475449
DPZ124328551 124340541
PVM113813493
PJA122251827
HAME121878268
PCLA123759469
PTRU123499558 123506764
HAZT108679550
EAF111698861
LSM121121200
PPOI119093172 119093174 119094558 119114574 119114575
ISCIscW_ISCW023956
DSV119463383
RSAN119401472
RMP119164114
VDE111248362
VJA111260071
TUT107360449 107362814
DPTE113793353
DFR124492231
CSCU111631510
PTEP107444488 107457486
SDM118188069 118201148
CELCELE_F58A6.1(F58A6.1) CELE_Y25C1A.13(Y25C1A.13)
CBRCBG_02334 CBG_19637 CBG_25649
BMYBM_BM8364(Bm8364)
LOALOAG_07056
NAINECAME_04904 NECAME_15165
TSPTsp_02522
HROHELRODRAFT_157486
LGILOTGIDRAFT_232526
PCAN112570588
BGT106057019
GAE121371953
HRF124120322 124120324
HRJ124255393 124255394
CRG105321082
MYI110450322
PMAX117324206 117324208
MMER123531935
OBI106873915
OSN115217161
LAK106177778
OVIT265_15446
NVE5509838
EPA110241905
ATEN116297115
ADF107327475
AMIL114956473
PDAM113677153
SPIS111345755
DGT114527126
XEN124435458
HMG100199860
TADTRIADDRAFT_19479 TRIADDRAFT_20308 TRIADDRAFT_34632
AQU100638551
ATHAT5G43280(DCI1)
ALY9301509
CRB17875768
CSAT104725139 104760625 104771473
EUSEUTSA_v10003257mg
BRP103839250
BNA106437370 106447057
BOE106313129
THJ104814199
CPAP110810833
CIT102611221
CICCICLE_v10032364mg
PVY116131268 116140760
MINC123212727
TCC18608898
GRA105783875
GHI107912942 107919096
GAB108461856
DZI111282802
EGR104417735 104425748
GMX100804855
GSJ114406573
PVUPHAVU_007G000700g
VRA106771188
VAR108325212
VUN114189944
CCAJ109795029
APRC113870865
MTR11418463
CAM101506413
PSAT127092494
LJALj0g3v0262349.1(Lj0g3v0262349.1)
ADU107458788 107461773 107467677 107474293
AIP107616276 107617815 107640222 107640470
AHF112701432 112705227 112712411 112722601 112747977 112748227 112775267
LANG109354784
FVE101295299
RCN112200972
PPER18790909
PMUM103322119
PAVI110758785
PDUL117638025
MDM103452187
PXB103929034
ZJU107417616 107435222
MNT21400486
CSV101216694
CMO103494575
BHJ120071400
MCHA111014684
CMAX111479454
CMOS111458038
CPEP111790185
RCU8274304
JCU105644864
HBR110659893
MESC110628656
POP7460573
PEU105133736
PALZ118043092
JRE109004779
CILL122311899 122313985
QSU111994488 112008098 112031203
QLO115979050
TWL120006922
VVI100249010
VRI117917521
SLY101255297
SPEN107020723
SOT102601569
SSTN125869083
CANN107860535
NTA107783788
NSY104244791
NTO104113981
NAU109235472
INI109175866
ITR116003129
SIND105156726
EGT105952610
SSPL121767521 121769806
APAN127250650
HAN110941153
ECAD122595794
LSV111889837
CCAV112523066
DCR108203109
CSIN114278791 114300552
BVG104897504
SOE110785744
CQI110690495 110711556
NNU104593912 104601029
MING122065534
TSS122638396
PSOM113271549
OSA4327232
DOSAOs01t0925200-01(Os01g0925200)
OBR102715171
BDI100829779
ATS109769988
TDC119270157 119270158 119278219
TAES123063160 123063162 123072066 123080349 123080350
TUA125545799 125545800
LPER127345442 127345443
SBI8059382
ZMA100192936 103655617
SITA101782993
SVS117857699
PVIR120709121 120709123
PHAI112894407
PDA103707836
EGU105061424
MUS103992549
ZOF122019037 122022822
DCT110102333
PEQ110017978
NCOL116258087
ATR18434447
SMOSELMODRAFT_106195 SELMODRAFT_430350
PPP112293757
VCNVOLCADRAFT_80880
CSLCOCSUDRAFT_14551
CVRCHLNCDRAFT_59779
OTAOT_ostta07g02020
BPGBathy02g03390
SCEYOR180C(DCI1)
SEUBDI49_5014
SPAOSPAR_O03070
VPOKpol_345p4
ZROZYRO0D14454g
NCSNCAS_0F00380(NCAS0F00380)
NDINDAI_0D02720(NDAI0D02720)
TPFTPHA_0F02640(TPHA0F02640)
TGBHG536_0H04060
TDLTDEL_0G03960(TDEL0G03960)
KAFKAFR_0G02430(KAFR0G02430)
KNGKNAG_0M00960(KNAG0M00960)
ZMKHG535_0G02410
PPAPAS_FragB_0022
DHADEHA2F04488g
PGUPGUG_01306
SPAASPAPADRAFT_62376
LELLELG_02996
CALCAALFM_C306730WA(CaO19.6830)
CTPCTRG_05691
COTCORT_0C00650
CDUCD36_86700
CTENCANTEDRAFT_113882
YLIYALI0A07733g
CLUCLUG_01292
CLUSA9F13_06g00957
CAURCJI97_002961 CJI97_002978
SLBAWJ20_4385
NCRNCU06647
NTENEUTE1DRAFT144029(NEUTE1DRAFT_144029)
SMPSMAC_06561
PANPODANSg7991
TTTTHITE_2106645
MTMMYCTH_2300510
CTHRCTHT_0052590
MGRMGG_07309
PPEIPpBr36_01955
TMNUCRPA7_938
SSCKSPSK_05431
FGRFGSG_09979
FPUFPSE_03878
FVRFVEG_02800
FOXFOXG_05330
NHENECHADRAFT_61301
TRETRIREDRAFT_5403
TRRM419DRAFT_88106
MAWMAC_02599
MAJMAA_03039 MAA_07373
CMTCCM_01102
VDAVDAG_00142
CFJCFIO01_08910
CLUPCLUP02_10806
CHIGCH63R_08927
SAPOSAPIO_CDS8667
ELAUCREL1_9968
PFYPFICI_07213
SSLSS1G_00908
BFUBCIN_14g02960
MBEMBM_04576
PSCOLY89DRAFT_706901
GLZGLAREA_03629
ANIAN2529.2
AFMAFUA_3G14520
ACTACLA_041980
NFINFIA_062740
AORAO090103000285 AO090701000555
ANGANI_1_222084(An09g02050)
AFVAFLA_005084 AFLA_013239
ALUCAKAW2_40165S
ACHEACHE_20041S
APUUAPUU_20756A APUU_30206S
PCSPc13g15840
PDPPDIP_24360
TMFPMAA_014580
TRGTRUGW13939_04670
CIMCIMG_07353
CPWCPC735_001430
UREUREG_07897
PBLPAAG_03407
PBNPADG_06425
ABEARB_00718
TVETRV_00171
AJEHCAG_08892
BGHBDBG_05192
PNOSNOG_06483
PTEPTT_07376
BZECOCCADRAFT_33897
BSCCOCSADRAFT_79464
BORCOCMIDRAFT_23179
AALTCC77DRAFT_1020267
ZTRMYCGRDRAFT_106870
PFJMYCFIDRAFT_47012 MYCFIDRAFT_47359
FFUCLAFUR5_06756 CLAFUR5_11630 CLAFUR5_11995
BCOMBAUCODRAFT_295553
NPAUCRNP2_3622
TMLGSTUM_00011881001
CNECND02600
CNBCNBD3740
CNGCNAG_01135
CGICGB_D5150W
TMSTREMEDRAFT_37467
TASAA1Q1_02398
PPLPOSPLDRAFT_103631 POSPLDRAFT_36293
TVSTRAVEDRAFT_42724
DSQDICSQDRAFT_110002
PCOPHACADRAFT_246170
HIRHETIRDRAFT_325829
PSQPUNSTDRAFT_94058
ADLAURDEDRAFT_143539
FMEFOMMEDRAFT_146473
GTRGLOTRDRAFT_102948
LBCLACBIDRAFT_300535
CCICC1G_05803
ABPAGABI1DRAFT43059(AGABI1DRAFT_43059)
ABVAGABI2DRAFT79845(AGABI2DRAFT_79845)
PCUBJR316_0011292
MRRMoror_5049
MOREE1B28_006048
SCMSCHCO_02633256(SCHCODRAFT_02633256)
CPUTCONPUDRAFT_111816
SLASERLADRAFT_388872
WSEWALSEDRAFT_60185
WICJ056_001173
UMAUMAG_10273
PFPPFL1_00078
MGLMGL_2518
MRTMRET_4156
PGRPGTG_01223
MLRMELLADRAFT_40335
DDIDDB_G0282261(ech1)
DFADFA_04510(ech1)
TGOTGME49_310830
TETTTHERM_00325590 TTHERM_00530510
PTMGSPATT00020024001 GSPATT00037313001
SMINv1.2.040401.t1(symbB.v1.2.040401.t1)
PTIPHATRDRAFT_28497(DEI1)
FCYFRACYDRAFT_180456(ECH1)
TPSTHAPSDRAFT_17312
 » show all
Reference
1  [PMID:9417087]
  Authors
Filppula SA, Yagi AI, Kilpelainen SH, Novikov D, FitzPatrick DR, Vihinen M, Valle D, Hiltunen JK
  Title
Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization.
  Journal
J Biol Chem 273:349-55 (1998)
DOI:10.1074/jbc.273.1.349
  Sequence
[hsa:1891] [rno:64526]
Reference
2  [PMID:9739087]
  Authors
Modis Y, Filppula SA, Novikov DK, Norledge B, Hiltunen JK, Wierenga RK
  Title
The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis.
  Journal
Structure 6:957-70 (1998)
DOI:10.1016/S0969-2126(98)00098-7
  Sequence
[rno:64526]
Reference
3  [PMID:10381339]
  Authors
Geisbrecht BV, Schulz K, Nau K, Geraghty MT, Schulz H, Erdmann R, Gould SJ
  Title
Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism.
  Journal
Biochem Biophys Res Commun 260:28-34 (1999)
DOI:10.1006/bbrc.1999.0860
  Sequence
[sce:YOR180C]
Reference
4  [PMID:10455114]
  Authors
Gurvitz A, Mursula AM, Yagi AI, Hartig A, Ruis H, Rottensteiner H, Hiltunen JK
  Title
Alternatives to the isomerase-dependent pathway for the beta-oxidation of oleic acid are dispensable in Saccharomyces cerevisiae. Identification of YOR180c/DCI1  encoding peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase.
  Journal
J Biol Chem 274:24514-21 (1999)
DOI:10.1074/jbc.274.35.24514
  Sequence
[sce:YOR180C]
Reference
5  [PMID:11278886]
  Authors
Zhang D, Liang X, He XY, Alipui OD, Yang SY, Schulz H
  Title
Delta 3,5,delta 2,4-dienoyl-CoA isomerase is a multifunctional isomerase. A structural and mechanistic study.
  Journal
J Biol Chem 276:13622-7 (2001)
DOI:10.1074/jbc.M011315200
Reference
6  [PMID:16040662]
  Authors
Goepfert S, Vidoudez C, Rezzonico E, Hiltunen JK, Poirier Y
  Title
Molecular identification and characterization of the Arabidopsis delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase, a peroxisomal enzyme participating in the beta-oxidation cycle of unsaturated fatty acids.
  Journal
Plant Physiol 138:1947-56 (2005)
DOI:10.1104/pp.105.064311
  Sequence
[ath:AT5G43280]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.21
IUBMB Enzyme Nomenclature: 5.3.3.21
ExPASy - ENZYME nomenclature database: 5.3.3.21
BRENDA, the Enzyme Database: 5.3.3.21

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