| Entry |
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| Name |
Delta3,5-Delta2,4-dienoyl-CoA isomerase;
3,5-tetradecadienoyl-CoA isomerase;
DCI1 (gene name)
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
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| Sysname |
(3E,5Z)-alka-3,5-dienoyl-CoA Delta3,5-Delta2,4 isomerase
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| Reaction(IUBMB) |
a (3E,5Z)-alka-3,5-dienoyl-CoA = a (2E,4E)-alka-2,4-dienoyl-CoA
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| Substrate |
(3E,5Z)-alka-3,5-dienoyl-CoA
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| Product |
(2E,4E)-alka-2,4-dienoyl-CoA
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| Comment |
The enzyme participates in an alternative degradation route of fatty acids with cis-double bonds on odd-number carbons such as oleate and linoleate. The main physiological substrate is (3E,5Z)-tetradeca-3,5-dienoyl-CoA, but other (3E,5Z)-dienoyl-CoAs with varying carbon chain lengths are also substrates.
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| History |
EC 5.3.3.21 created 2018
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| Orthology |
| K12663 | Delta3,5-Delta2,4-dienoyl-CoA isomerase |
| K22587 | Delta3,5-Delta2,4-dienoyl-CoA isomerase |
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| Genes |
» show all
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| Reference |
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| Authors |
Filppula SA, Yagi AI, Kilpelainen SH, Novikov D, FitzPatrick DR, Vihinen M, Valle D, Hiltunen JK |
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| Title |
Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Modis Y, Filppula SA, Novikov DK, Norledge B, Hiltunen JK, Wierenga RK |
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| Title |
The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Geisbrecht BV, Schulz K, Nau K, Geraghty MT, Schulz H, Erdmann R, Gould SJ |
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| Title |
Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Gurvitz A, Mursula AM, Yagi AI, Hartig A, Ruis H, Rottensteiner H, Hiltunen JK |
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| Title |
Alternatives to the isomerase-dependent pathway for the beta-oxidation of oleic acid are dispensable in Saccharomyces cerevisiae. Identification of YOR180c/DCI1 encoding peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Zhang D, Liang X, He XY, Alipui OD, Yang SY, Schulz H |
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| Title |
Delta 3,5,delta 2,4-dienoyl-CoA isomerase is a multifunctional isomerase. A structural and mechanistic study. |
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| Journal |
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| Reference |
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| Authors |
Goepfert S, Vidoudez C, Rezzonico E, Hiltunen JK, Poirier Y |
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| Title |
Molecular identification and characterization of the Arabidopsis delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase, a peroxisomal enzyme participating in the beta-oxidation cycle of unsaturated fatty acids. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.3.21 |
| ExPASy - ENZYME nomenclature database: | 5.3.3.21 |
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