KEGG ENZYME: 5.3.3.22

ENZYME: 5.3.3.22

Entry

EC 5.3.3.22 Enzyme

Name

lutein isomerase;
RPE65 (gene name);
meso-zeaxanthin isomerase

Class

Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds

Sysname

lutein Delta4-Delta5-isomerase

Reaction(IUBMB)

lutein = meso-zeaxanthin [RN:R12003]

Reaction(KEGG)

R12003

Substrate

lutein [CPD:C08601]

Product

meso-zeaxanthin [CPD:C21836]

Comment

The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase.

History

EC 5.3.3.22 created 2018

Orthology

K11158

retinoid isomerohydrolase / lutein isomerase

Genes

HSA:	6121(RPE65)

PTR:	744567(RPE65)

PPS:	100994777(RPE65)

GGO:	101152566(RPE65)

PON:	100453879(RPE65)

NLE:	100588685(RPE65)

MCC:	701764(RPE65)

MCF:	102122358(RPE65)

CSAB:

103224643(RPE65)

RRO:	104675297(RPE65)

RBB:	108532954(RPE65)

CJC:	100397525(RPE65)

SBQ:	101044000(RPE65)

MMU:	19892(Rpe65)

MCAL:

110291358(Rpe65)

MPAH:

110320423(Rpe65)

RNO:	89826(Rpe65)

MUN:	110542710(Rpe65)

CGE:	100767488(Rpe65)

NGI:	103746374(Rpe65)

HGL:	101716560(Rpe65)

CCAN:

109698727(Rpe65)

OCU:	100352270(RPE65)

TUP:	102499334(RPE65)

CFA:	403803(RPE65)

VVP:	112910518(RPE65)

AML:	100469948(RPE65)

UMR:	103663024(RPE65)

UAH:	113254543(RPE65)

ORO:	101373037(RPE65)

ELK:

111143374

FCA:	101090034(RPE65)

PTG:	102952948(RPE65)

PPAD:

109266700(RPE65)

AJU:	106982702(RPE65)

BTA:	282043(RPE65)

BOM:	102280727(RPE65)

BIU:	109557070(RPE65)

BBUB:

102402660(RPE65)

CHX:	102174353(RPE65)

OAS:	101116520(RPE65)

SSC:	100516743(RPE65)

CFR:	102504541(RPE65)

CDK:	105096629(RPE65)

BACU:

103007082(RPE65)

LVE:	103082229(RPE65)

OOR:	101280600(RPE65)

DLE:	111178432(RPE65)

PCAD:

102976541(RPE65)

ECB:	100068802(RPE65)

EPZ:	103556149(RPE65)

EAI:	106847823(RPE65)

MYB:	102264093(RPE65)

MYD:	102757349(RPE65)

MNA:	107540093(RPE65)

HAI:	109384924(RPE65)

DRO:	112309291(RPE65)

PALE:

102887612(RPE65)

RAY:	107520571(RPE65)

MJV:	108391176(RPE65)

LAV:	100664258(RPE65)

TMU:

101352162

MDO:	100030329(RPE65)

SHR:	100934519(RPE65)

PCW:	110212969(RPE65)

OAA:	100081441(RPE65)

GGA:	395700(RPE65)

MGP:	100539517(RPE65)

CJO:	107317795(RPE65)

NMEL:

110402639(RPE65)

APLA:

101801077(RPE65)

ACYG:

106043625(RPE65)

TGU:	100219959(RPE65)

LSR:	110473233(RPE65)

SCAN:

103815080(RPE65)

GFR:	102043093(RPE65)

FAB:	101808678(RPE65)

PHI:	102103362(RPE65)

PMAJ:

107208456(RPE65)

CCAE:

111932946(RPE65)

CCW:	104695122(RPE65)

FPG:	101918066(RPE65)

FCH:	102049984(RPE65)

CLV:	102085010(RPE65)

EGZ:	104123866(RPE65)

NNI:	104009234(RPE65)

ACUN:

113483067(RPE65)

PADL:

103913982(RPE65)

AAM:	106486524(RPE65)

ASN:	102369965(RPE65)

AMJ:	102560040(RPE65)

PSS:	102456788(RPE65)

CMY:	102935763(RPE65)

CPIC:

101936194(RPE65)

ACS:	100556137(rpe65)

PVT:	110079873(RPE65)

PBI:	103048404(RPE65)

PMUR:

107300213(RPE65)

TSR:	106544932(RPE65)

PMUA:

114598441(RPE65)

GJA:	107114347(RPE65)

XLA:	379961(rpe65.S) 447613(rpe65.L)

XTR:	100145692(rpe65)

NPR:	108795952(RPE65)

DRE:	100004076(rpe65c) 393724(rpe65a)

SRX:	107705134 107708597 107743896 107752442

SANH:

107657893 107693590 107700531

SGH:	107549757 107562849 107599830(rpe65) 107600304

CCAR:

109054720 109054721 109058080 109106900

IPU:	108267184(rpe65)

PHYP:

113526413(rpe65)

AMEX:

103023405(rpe65)

EEE:	113581111(rpe65) 113589215

TRU:	101062285 101065379(rpe65)

TNG:	GSTEN00016195G001 GSTEN00023173G001

LCO:	104935905(rpe65) 104936272

NCC:	104940880 104955976

MZE:	101479363 101485028

ONL:	100694376 100702412

OLA:	101163729 101172024(rpe65)

XMA:	102217285(rpe65) 102231785

XCO:	114146496 114150554

PRET:

103463130 103479670 103479672

CVG:	107090023(rpe65) 107101167

NFU:	107383888(rpe65) 107393007

KMR:	108241705(rpe65a) 108249795

ALIM:

106531270 106533754

AOCE:

111577418(rpe65) 111583702

CSEM:

103396306 103399738

POV:	109640235 109641398(rpe65)

LCF:	108879593 108883387(rpe65)

SDU:	111223483 111231109(rpe65)

SLAL:

111653254(rpe65) 111671744

HCQ:	109521243(rpe65) 109525455

BPEC:

110159583 110172291

MALB:

109952235 109957756

SASA:

106569137 106584339 106613887

OTW:	112244994 112247502 112250987 112260591

SALP:

111956276 111971359 111975570

ELS:	105011682(rpe65) 105019406

SFM:	108919070(rpe65) 108935006

PKI:	111847527(rpe65)

LCM:	102364001(RPE65)

CMK:	103189136(rpe65)

RTP:	109936090(rpe65)

PCAN:

ADF:

SPIS:

Reference

1 [PMID:28874556]

Authors

Shyam R, Gorusupudi A, Nelson K, Horvath MP, Bernstein PS

Title

RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye.

Journal

Proc Natl Acad Sci U S A 114:10882-10887 (2017)
DOI:10.1073/pnas.1706332114

Sequence

[hsa:6121] [gga:395700]

Other DBs

ExplorEnz - The Enzyme Database:

5.3.3.22

IUBMB Enzyme Nomenclature:

5.3.3.22

ExPASy - ENZYME nomenclature database:

5.3.3.22

BRENDA, the Enzyme Database:

5.3.3.22

All links

Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (387)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (195)   
   KEGG MGENES (191)   
Protein sequence (33)   
   UniProt (12)   
   SWISS-PROT (12)   
   RefSeq(pep) (9)   
DNA sequence (11)   
   RefSeq(nuc) (10)   
   GenBank (1)   
Protein domain (1)   
   InterPro (1)   
All databases (435)   

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