KEGG   ENZYME: 5.3.3.22
Entry
EC 5.3.3.22                 Enzyme                                 
Name
lutein isomerase;
RPE65 (gene name);
meso-zeaxanthin isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
Sysname
lutein Delta4-Delta5-isomerase
Reaction(IUBMB)
lutein = meso-zeaxanthin [RN:R12003]
Reaction(KEGG)
R12003
Substrate
lutein [CPD:C08601]
Product
meso-zeaxanthin [CPD:C21836]
Comment
The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase.
History
EC 5.3.3.22 created 2018
Orthology
K11158  retinoid isomerohydrolase / lutein isomerase
Genes
HSA6121(RPE65)
PTR744567(RPE65)
PPS100994777(RPE65)
GGO101152566(RPE65)
PON100453879(RPE65)
NLE100588685(RPE65)
MCC701764(RPE65)
MCF102122358(RPE65)
MTHB126962922
MNI105498352(RPE65)
CSAB103224643(RPE65)
CATY105595883(RPE65)
PANU101017887(RPE65)
TGE112635158(RPE65)
RRO104675297(RPE65)
RBB108532954(RPE65)
TFN117092079(RPE65)
PTEH111539710(RPE65)
CANG105508088(RPE65)
CJC100397525(RPE65)
SBQ101044000(RPE65)
CSYR103249819(RPE65)
MMUR105872873(RPE65)
LCAT123635529(RPE65)
PCOQ105817924(RPE65)
OGA100949307(RPE65)
MMU19892(Rpe65)
MCAL110291358(Rpe65)
MPAH110320423(Rpe65)
RNO89826(Rpe65)
MCOC116094428(Rpe65)
MUN110542710(Rpe65)
CGE100767488(Rpe65)
MAUA101841952(Rpe65)
PLEU114707607(Rpe65)
MORG121450683(Rpe65)
MFOT126506141
AAMP119801269(Rpe65)
NGI103746374(Rpe65)
HGL101716560(Rpe65)
CPOC100721944(Rpe65)
CCAN109698727(Rpe65)
DORD105988821(Rpe65)
DSP122109622(Rpe65)
NCAR124970939
OCU100352270
OPI101520754(RPE65)
TUP102499334(RPE65)
GVR103602215(RPE65)
CFA403803(RPE65)
CLUD112679190(RPE65)
VVP112910518(RPE65)
AML100469948(RPE65)
UMR103663024(RPE65)
UAH113254543(RPE65)
UAR123795323(RPE65)
ELK111143374
LLV125099325
MPUF101671454(RPE65)
NVS122900077(RPE65)
ORO101373037(RPE65)
EJU114208479(RPE65)
ZCA113916106(RPE65)
MLX118020203(RPE65)
NSU110570126(RPE65)
LWW102743168
FCA101090034(RPE65)
PYU121027297(RPE65)
PBG122480624(RPE65)
LRUF124516196
PTG102952948(RPE65)
PPAD109266700(RPE65)
AJU106982702(RPE65)
HHV120220328(RPE65)
BTA282043(RPE65)
BOM102280727(RPE65)
BIU109557070(RPE65)
BBUB102402660(RPE65)
BBIS104991595(RPE65)
CHX102174353(RPE65)
OAS101116520(RPE65)
ODA120857012(RPE65)
CCAD122436841(RPE65)
SSC100516743(RPE65)
CFR102504541(RPE65)
CBAI105075547(RPE65)
CDK105096629(RPE65)
VPC102528101(RPE65)
BACU103007082(RPE65)
LVE103082229(RPE65)
OOR101280600(RPE65)
DLE111178432(RPE65)
PCAD102976541(RPE65)
PSIU116754598(RPE65)
ECB100068802(RPE65)
EPZ103556149(RPE65)
EAI106847823(RPE65)
MYB102264093(RPE65)
MYD102757349(RPE65)
MMYO118677155(RPE65)
MLF102428728(RPE65)
MNA107540093(RPE65)
PKL118724360(RPE65)
HAI109384924(RPE65)
DRO112309291(RPE65)
SHON118984568(RPE65)
AJM119049324(RPE65)
PDIC114497616(RPE65)
PHAS123816555(RPE65)
MMF118627156(RPE65)
RFQ117027287(RPE65)
PALE102887612(RPE65)
PGIG120583212(RPE65)
PVP105295883(RPE65)
RAY107520571(RPE65)
MJV108391176(RPE65)
TOD119236157(RPE65)
SARA101539243(RPE65)
LAV100664258(RPE65)
TMU101352162
ETF101658533(RPE65)
DNM101422039(RPE65)
MDO100030329(RPE65)
GAS123244042(RPE65)
SHR100934519(RPE65)
PCW110212969(RPE65)
OAA100081441(RPE65)
GGA395700(RPE65)
PCOC116235820(RPE65)
MGP100539517(RPE65)
CJO107317795(RPE65)
NMEL110402639(RPE65)
APLA101801077(RPE65)
ACYG106043625(RPE65)
AFUL116492222(RPE65)
TGU100219959(RPE65)
LSR110473233(RPE65)
SCAN103815080(RPE65)
OTC121332659(RPE65)
PRUF121356107(RPE65)
GFR102043093(RPE65)
FAB101808678(RPE65)
PHI102103362(RPE65)
PMAJ107208456(RPE65)
CCAE111932946(RPE65)
CCW104695122(RPE65)
CBRC103621677(RPE65)
ZAB102063920(RPE65)
ACHL103811072(RPE65)
FPG101918066(RPE65)
FCH102049984(RPE65)
CLV102085010(RPE65)
EGZ104123866(RPE65)
NNI104009234(RPE65)
PLET104628784(RPE65)
PCRI104033042(RPE65)
PCAO104049861(RPE65)
ACUN113483067(RPE65)
TALA116965163(RPE65)
PADL103913982(RPE65)
AFOR103898460(RPE65)
ACHC115349146(RPE65)
HALD104314394(RPE65)
HLE104828068(RPE65)
AGEN126042036
GCL127019244
CCRI104158305(RPE65)
CMAC104485055(RPE65)
MUI104537000(RPE65)
FGA104076428(RPE65)
GSTE104261565(RPE65)
LDI104349794(RPE65)
MNB103769000(RPE65)
OHA104335051(RPE65)
NNT104408732(RPE65)
DPUB104307983(RPE65)
PGUU104470855(RPE65)
ACAR104518303(RPE65)
CPEA104386035(RPE65)
AVIT104276684(RPE65)
CVF104285495(RPE65)
CUCA104066573(RPE65)
TEO104376254(RPE65)
BRHI104497799(RPE65)
AAM106486524(RPE65)
AROW112970298(RPE65)
NPD112945545(RPE65)
TGT104567512(RPE65)
DNE112982252(RPE65)
SCAM104153244(RPE65)
ASN102369965(RPE65)
AMJ102560040(RPE65)
CPOO109307581(RPE65)
GGN109305417(RPE65)
PSS102456788(RPE65)
CMY102935763(RPE65)
CPIC101936194(RPE65)
TST117881743(RPE65)
CABI116819900(RPE65)
MRV120370338(RPE65)
ACS100556137(rpe65)
PVT110079873(RPE65)
SUND121928995(RPE65)
PBI103048404(RPE65)
PMUR107300213(RPE65)
CTIG120301632(RPE65)
TSR106544932(RPE65)
PGUT117674966(RPE65)
PMUA114598441(RPE65)
ZVI118088650(RPE65)
GJA107114347(RPE65)
STOW125433812(RPE65)
XLA379961(rpe65.S) 447613(rpe65.L)
XTR100145692(rpe65)
NPR108795952(RPE65)
RTEM120946038(RPE65)
BBUF120978890(RPE65)
BGAR122943687(RPE65)
DRE100004076(rpe65c) 393724(rpe65a)
SRX107705134 107708597 107743896 107752442
SANH107657893 107693590 107700531
SGH107549757 107562849 107599830(rpe65) 107600304
CCAR109054720 109054721 109058080 109106900
CAUA113046454 113069845 113107075
PPRM120461548(rpe65a) 120473993 120481924
MAMB125251988(rpe65a) 125279955
IPU108267184(rpe65a)
PHYP113526413(rpe65)
SMEO124387492(rpe65a)
TFD113658413(rpe65a)
AMEX103023405(rpe65)
EEE113581111(rpe65) 113589215
TRU101062285 101065379(rpe65)
TNGGSTEN00016195G001 GSTEN00023173G001
LCO104935905(rpe65) 104936272
NCC104940880 104955976
CGOB115006939 115022075(rpe65)
ELY117253333 117271695(rpe65a)
EFO125895624 125902002(rpe65a)
PLEP121937702 121951236(rpe65a)
SLUC116038155 116046008(rpe65a)
ECRA117950031 117954781(rpe65a)
ESP116696211
PFLV114561069 114564889(rpe65)
GAT120816104(rpe65a) 120823503
PPUG119206198(rpe65a) 119217183
MSAM119900319 119902021(rpe65a)
CUD121512430 121520043(rpe65a)
ALAT119011324(rpe65a) 119028714
MZE101479363 101485028
ONL100694376 100702412
OAU116315493 116318669(rpe65a)
OLA101163729 101172024(rpe65)
OML112147229(rpe65a) 112150125
XMA102217285(rpe65) 102231785
XCO114146496 114150554
XHE116722033 116726470 116730884
PRET103463130 103479670 103479672
PFOR103131468 103135788(rpe65)
PLAI106951621(rpe65) 106964853
PMEI106930879(rpe65) 106932818
GAF122839182 122841139(rpe65a)
CVG107090023(rpe65) 107101167
CTUL119789901 119795652(rpe65a)
GMU124870182(rpe65a) 124873461
NFU107383888(rpe65) 107393007
KMR108241705(rpe65a) 108249795
ALIM106531270 106533754
NWH119414550(rpe65a) 119430516
AOCE111577418(rpe65) 111583702
MCEP125009440 125010667(rpe65a)
CSEM103396306 103399738
POV109640235 109641398(rpe65)
SSEN122758609 122780954
HHIP117760857 117778748(rpe65a)
HSP118118098(rpe65a) 118121062
LCF108879593 108883387(rpe65a)
SDU111223483 111231109(rpe65)
SLAL111653254(rpe65) 111671744
XGL120790833 120798784(rpe65a)
HCQ109521243(rpe65) 109525455
BPEC110159583 110172291
MALB109952235 109957756
BSPL114844894(rpe65a) 114853594
SASA106569137 106584339 106613887
STRU115157162 115158369 115192515
OTW112244994 112250987 112260591
OMY110521549 110524415 110530459(rpe65a)
OGO123996963 124009989 124037071
ONE115108415 115114543 115145473
SALP111956276 111971359 111975570
SNH120051829 120055213 120055319
CCLU121532692 121534650 121539895
ELS105011682(rpe65) 105019406
SFM108919070(rpe65) 108935006
PKI111847527(rpe65)
AANG118225022 118228866
LOC102690422(rpe65)
PSPA121326874
ARUT117417355
PSEX120538348
LCM102364001(RPE65)
CMK103189136
RTP109936090(rpe65)
PCAN112555861
PMAX117344163
ADF107351382
SPIS111324579
 » show all
Reference
1  [PMID:28874556]
  Authors
Shyam R, Gorusupudi A, Nelson K, Horvath MP, Bernstein PS
  Title
RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye.
  Journal
Proc Natl Acad Sci U S A 114:10882-10887 (2017)
DOI:10.1073/pnas.1706332114
  Sequence
[hsa:6121] [gga:395700]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.22
IUBMB Enzyme Nomenclature: 5.3.3.22
ExPASy - ENZYME nomenclature database: 5.3.3.22
BRENDA, the Enzyme Database: 5.3.3.22

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