KEGG   ENZYME: 5.3.3.23
Entry
EC 5.3.3.23                 Enzyme                                 

Name
S-methyl-5-thioribulose 1-phosphate isomerase;
rlp (gene name);
5-methylthioribulose-1-phosphate isomerase (incorrect)
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
Sysname
S-methyl-5-thio-D-ribulose 1-phosphate 1,3-isomerase
Reaction(IUBMB)
(1) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate [RN:R12718];
(2) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-ribulose 5-phosphate [RN:R12719]
Reaction(KEGG)
R12718 R12719
Substrate
S-methyl-5-thio-D-ribulose 1-phosphate [CPD:C04582]
Product
S-methyl-1-thio-D-xylulose 5-phosphate [CPD:C22359];
S-methyl-1-thio-D-ribulose 5-phosphate [CPD:C22360]
Comment
The enzyme, characterized from the bacterium Rhodospirillum rubrum, participates in methionine salvage from S-methyl-5'-thioadenosine. It is a RubisCO-like protein (RLP) that is not capable of carbon fixation, and catalyses an isomerization reaction that converts S-methyl-5-thio-D-ribulose 1-phosphate to a 3:1 mixture of S-methyl-1-thioxylulose 5-phosphate and S-methyl-1-thioribulose 5-phosphate. The reaction is an overall 1,3-proton transfer, which likely consists of two 1,2-proton transfer events.
History
EC 5.3.3.23 created 2021
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K25035  S-methyl-5-thioribulose 1-phosphate isomerase
Genes
TIG: THII_1875
TVI: Thivi_3125
TMB: Thimo_2808
MPUR: MARPU_02945
TSY: THSYN_18660
THIP: N838_17160
AEH: Mlg_1168
HHA: Hhal_0467
HHK: HH1059_21120
WMA: WM2015_1506
URU: DSM104443_00902(rlp)
UPL: DSM104440_00833(rlp)
EAD: OV14_a1403(rbcL2)
SHZ: shn_03045
OAN: Oant_4835
OAH: DR92_3716
RPA: RPA2169(rlp1)
RPB: RPB_3227
RPC: RPC_2184
RPD: RPD_2233
RPE: RPE_3678
RPT: Rpal_2462
MSL: Msil_1244
MTUN: MTUNDRAET4_0551(rlp)
RVA: Rvan_0192
MMED: Mame_01572(mtnW)
RRU: Rru_A1998
RRF: F11_10265
CSQ: CSCA_0270
VPR: Vpar_1263
VRM: 44547418_01345(mtnW)
VDN: NCTC11831_00612(mtnW)
PUF: UFO1_2836
STED: SPTER_05100(mtnW)
CAP: CLDAP_27010(mtnW)
MRB: Mrub_0902
RMR: Rmar_1894
CPRV: CYPRO_1179
TLE: Tlet_1684
NDE: NIDE1881(rlp)
NMV: NITMOv2_0456(rlp)
NJA: NSJP_2757
 » show all
Reference
1  [PMID:18826254]
  Authors
Imker HJ, Singh J, Warlick BP, Tabita FR, Gerlt JA.
  Title
Mechanistic diversity in the RuBisCO superfamily: a novel isomerization reaction catalyzed by the RuBisCO-like protein from Rhodospirillum rubrum.
  Journal
Biochemistry 47:11171-3 (2008)
DOI:10.1021/bi801685f
Reference
2  [PMID:23042035]
  Authors
Erb TJ, Evans BS, Cho K, Warlick BP, Sriram J, Wood BM, Imker HJ, Sweedler JV, Tabita FR, Gerlt JA.
  Title
A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis.
  Journal
Nat Chem Biol 8:926-32 (2012)
DOI:10.1038/nchembio.1087
  Sequence
[rru:Rru_A1998]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.23
IUBMB Enzyme Nomenclature: 5.3.3.23
ExPASy - ENZYME nomenclature database: 5.3.3.23
BRENDA, the Enzyme Database: 5.3.3.23

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