S-methyl-5-thioribulose 1-phosphate isomerase;
rlp (gene name);
5-methylthioribulose-1-phosphate isomerase (incorrect)
Transposing C=C bonds
S-methyl-5-thio-D-ribulose 1-phosphate 1,3-isomerase
(1) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate [RN:
(2) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-ribulose 5-phosphate [RN:
S-methyl-5-thio-D-ribulose 1-phosphate [CPD:
S-methyl-1-thio-D-xylulose 5-phosphate [CPD:
S-methyl-1-thio-D-ribulose 5-phosphate [CPD:
The enzyme, characterized from the bacterium Rhodospirillum rubrum, participates in methionine salvage from S-methyl-5'-thioadenosine. It is a RuBisCO-like protein (RLP) that is not capable of carbon fixation, and catalyses an isomerization reaction that converts S-methyl-5-thio-D-ribulose 1-phosphate to a 3:1 mixture of S-methyl-1-thioxylulose 5-phosphate and S-methyl-1-thioribulose 5-phosphate. The reaction is an overall 1,3-proton transfer, which likely consists of two 1,2-proton transfer events.
EC 18.104.22.168 created 2021
ec00270 Cysteine and methionine metabolism
K25035 S-methyl-5-thioribulose 1-phosphate isomerase
VDN: NCTC11831_00612(mtnW) » show all
Imker HJ, Singh J, Warlick BP, Tabita FR, Gerlt JA.
Mechanistic diversity in the RuBisCO superfamily: a novel isomerization reaction catalyzed by the RuBisCO-like protein from Rhodospirillum rubrum.
Erb TJ, Evans BS, Cho K, Warlick BP, Sriram J, Wood BM, Imker HJ, Sweedler JV, Tabita FR, Gerlt JA.
A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis.
ExplorEnz - The Enzyme Database: 22.214.171.124
ExPASy - ENZYME nomenclature database: 126.96.36.199