Entry Name S-methyl-5-thioribulose 1-phosphate isomerase;
Class Isomerases;BRITE hierarchy
Sysname S-methyl-5-thio-D-ribulose 1-phosphate 1,3-isomerase
Reaction(IUBMB) (1) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate [RN:
R12718 ];
(2) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-ribulose 5-phosphate [RN:
R12719 ]
Reaction(KEGG) Substrate S-methyl-5-thio-D-ribulose 1-phosphate [CPD:
C04582 ]
Product S-methyl-1-thio-D-xylulose 5-phosphate [CPD:
C22359 ];
S-methyl-1-thio-D-ribulose 5-phosphate [CPD:
C22360 ]
Comment The enzyme, characterized from the bacterium Rhodospirillum rubrum, participates in methionine salvage from S-methyl-5'-thioadenosine. It is a RuBisCO-like protein (RLP) that is not capable of carbon fixation, and catalyses an isomerization reaction that converts S-methyl-5-thio-D-ribulose 1-phosphate to a 3:1 mixture of S-methyl-1-thioxylulose 5-phosphate and S-methyl-1-thioribulose 5-phosphate. The reaction is an overall 1,3-proton transfer, which likely consists of two 1,2-proton transfer events.
History EC 5.3.3.23 created 2021
Pathway ec00270 Cysteine and methionine metabolism
Orthology K25035 S-methyl-5-thioribulose 1-phosphate isomerase
Genes URU : DSM104443_00902(rlp)
UPL : DSM104440_00833(rlp)
MTUN : MTUNDRAET4_0551(rlp)
VRM : 44547418_01345(mtnW)
VDN : NCTC11831_00612(mtnW)
» show all Taxonomy Reference Authors Imker HJ, Singh J, Warlick BP, Tabita FR, Gerlt JA.
Title Mechanistic diversity in the RuBisCO superfamily: a novel isomerization reaction catalyzed by the RuBisCO-like protein from Rhodospirillum rubrum.
Journal Reference Authors Erb TJ, Evans BS, Cho K, Warlick BP, Sriram J, Wood BM, Imker HJ, Sweedler JV, Tabita FR, Gerlt JA.
Title A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 5.3.3.23
ExPASy - ENZYME nomenclature database: 5.3.3.23
