KEGG   ENZYME: 5.3.99.10
Entry
EC 5.3.99.10                Enzyme                                 
Name
thiazole tautomerase;
tenI (gene name)
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
Sysname
2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase
Reaction(IUBMB)
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate [RN:R09977]
Reaction(KEGG)
R09977
Substrate
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate [CPD:C20246]
Product
2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate [CPD:C20247]
Comment
The enzyme catalyses the irreversible aromatization of the thiazole moiety of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate.
History
EC 5.3.99.10 created 2012
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K10810  thiazole tautomerase (transcriptional regulator TenI)
Genes
IGNMMG00_09085
CRXCRECT_1046
APOCAPORC_0157
SDOSD1155_02250
BSUBSU11660(tenI)
BSRI33_1300
BSLA7A1_0983
BSHBSU6051_11660(tenI)
BSYI653_05925
BSUTBSUB_01268(tenI)
BSULBSUA_01268(tenI)
BSUSQ433_06590
BSOBSNT_07609(tenI)
BSNBSn5_17745
BSQB657_11660(tenI)
BSXC663_1194(tenI)
BSPU712_06000
BSSBSUW23_05895(tenI)
BSTGYO_1471
BLIBL01591(tenI)
BLDBLi01260(tenI)
BLHBaLi_c13950(tenI)
BAYRBAM_011670(tenI)
BAQBACAU_1128(tenI)
BYABANAU_1073(tenI)
BAMPB938_05675
BQYMUS_1211(tenI)
BAMLBAM5036_1067(tenI)
BAMARBAU_1129(tenI)
BAMNBASU_1106(tenI)
BAMBBAPNAU_2628(tenI)
BAMTAJ82_06560
BAMYV529_11150(tenI)
BMPNG74_01181(tenI)
BAOBAMF_1240(tenI)
BAZBAMTA208_11770(tenI)
BQLLL3_01247(tenI)
BXHBAXH7_02403(tenI)
BAMIKSO_014005
BAMCU471_11640
BAMFU722_05950
BSIACWD84_15905
BAEBATR1942_03475
BVMB9C48_05865
BSONS101395_03589(tenI)
BHTDIC78_03745
BMOJHC660_12240(tenI)
BTEQG4P54_06135(tenI)
BIQAN935_06055
BANBA_0729(tenI)
BARGBAA_0729(tenI)
BATBAS0695
BAHBAMEG_3830(tenI)
BAIBAA_0836(tenI)
BAXH9401_0698
BANTA16_08140
BANRA16R_08220
BANSBAPAT_0705
BANHHYU01_04015
BANVDJ46_5209(tenI)
BCEBC0746
BCABCE_0799(tenI)
BCZBCE33L0639(thiE)
BCRBCAH187_A0883(tenI)
BCBBCB4264_A0786(tenI)
BCUBCAH820_0806(tenI)
BCGBCG9842_B4545(tenI)
BCQBCQ_0820(tenI)
BCXBCA_0792(tenI)
BALBACI_c07600(thiE2)
BNCBCN_0707
BCFbcf_03845
BCERBCK_04490
BCEFBcrFT9_00678
BCYBcer98_0616
BTKBT9727_0639(thiE)
BTLBALH_0666
BTBBMB171_C0639(tenI)
BTTHD73_0864
BTHRYBT1520_04280
BTHIBTK_04255 BTK_04305
BTCCT43_CH0707(tenI)
BTFYBT020_03925
BTMMC28_0009
BTGBTB_c08220(tenI)
BTIBTG_17490
BTNBTF1_01360
BTHTH175_ch0713
BTHUYBT1518_04660
BTWBF38_1996(tenI)
BTHYAQ980_26570
BWEBcerKBAB4_0645
BWWbwei_4260(tenI)
BMYOBG05_5172(tenI)
BTYBtoyo_3427
BMYCDJ92_3340(tenI)
BBYCY96_02900
BWDCT694_04180
BTROFJR70_26055(tenI)
BMOBMLA2C4_03940
BNTGSN03_04070(tenI)
BPACLMD38_22290(tenI)
BPUBPUM_1095
BPUMBW16_06215
BPUSUP12_05815
BJSMY9_1271
BACIB1NLA3E_07765
BIFN288_03125
BMETBMMGA3_01095
GSTHW35_12450
BACWQR42_05650
BACPSB24_04035
BACBOY17_08535
BACOOXB_0158
BACYQF06_04780
BACLBS34A_12890(tenI)
BALMBsLM_1220
BSMBSM4216_0680
BGYBGLY_1279
BWHA9C19_14775
BXIBK049_02420
BALTCFN77_05815(tenI)
BACSAUL54_04795
BSAFBSL056_05755
BACQDOE78_13040
BFDNCTC4823_00320(tenI)
BSHILGQ02_16070(tenI)
BBADK7T73_07480(thiS)
BCABEFK13_06510(tenI)
BRYM0696_06425(tenI)
BCOBcell_0762
BHKB4U37_06145
BCOHBC6307_03695
BCIRC2I06_18805
BMQBMQ_0548
BMDBMD_0551
BMHBMWSH_4685(tenI)
BMEGBG04_2840(tenI)
BEOBEH_03335
PKSIE339_03110(tenI)
BGIBGM20_21135
BONA361_02660
CGOTJ1899_01395
CSUAIM538_04290(tenI)
GKAGK0622
GTEGTCCBUS3UF5_6900
GTKGT3570_02995
GTMGT3921_16485
GLIGLN3_13320
GTNGTNG_0535(tenI)
GWCGWCH70_0610
GYCGYMC61_1414
GYAGYMC52_0535
GCTGC56T3_2939
GMCGY4MC1_3187
GGHGHH_c05750(tenI)
GJFM493_03245
GEAGARCT_00596(tenI)
GELIB49_13385
GSEGT50_12625
GSRGS3922_12895
GEJA0V43_00485
GZAIC807_16665(tenI)
GTHGeoth_3207
PTLAOT13_06590
PTBDER53_07630(tenI)
PCALBV455_01136(tenI)
AFLAflv_2316(tenI)
AGNAFK25_02700
ANMGFC28_1935
AAMYGFC30_999
ANLGFC29_3499
ANDGRQ40_03575(tenI)
ACAIISX45_00430(tenI)
ASEDIRT44_15490
LGYT479_11215
LAGRFJQ98_02345
HHDHBHAL_3422
HMNHM131_18590
HLIHLI_03130
TAIDKS242_01650
VIRX953_15625
VHLBME96_15105
VIGBKP57_16350
VILCFK37_18020
VPNA21D_02454(tenI)
VIMGWK91_05245(tenI)
VPTKBP50_13600
LAOAOX59_02240
FPNABE65_019775
FARABE41_018785
SJEAAV35_010940
APAKAP3564_10210
BSJUP17_10595
BMURABE28_010665
PBUTDTO10_24110
PASABAOM_1979
PFRIL8956_11425(tenI)
AQTFN924_04405(tenI)
GRCGI584_17365
RUEDT065_09400
SALEEPH95_09395
SCIBHUG20_16625
SCIAHUG15_19545
POFGS400_16470(tenI)
NMKCHR53_16595
NTMBTDUT50_04330
MEKUHUW50_13730(tenI)
MSEMGMB29_05030
MDGK8L98_06020(tenI)
BLENNCTC4824_01712(tenI)
SEDDERJ70_03240(tenI)
BVQFHE72_12275
RMFD5E69_12095
BBEVBBEV_2245(thiE-2)
BSEBsel_2693
GAJMY490_18560
PSUAFLK61_23685
SERSERP2070
SEPSE_2057
SEPPSEB_02063
SEPSDP17_999
SHASH0565
SHHShL2_00460(tenI)
SSPSSPP136
SCASCA_2076
SLGSLGD_00498
SLNSLUG_04960
SSDSPSINT_0375
SDTSPSE_2079
SDPNCTC12225_02300(tenI)
SWAA284_01980
SPASSTP1_0997
SXYBE24_11340
SXLSXYLSMQ121_0150
SXOSXYL_00143
SHUSHYC_10375(thiE-2)
SCAPAYP1020_1664(tenI)
SSCHLH95_09890
SSCZRN70_10655
SAGQEP23_11770
SEQOSE1039_24290
SSIFAL483_11990
SCVA4G25_09835
SPETCEP67_07450
SLZB5P37_07770
SKLC7J89_03105
SFQC7J90_01385
SHOMEGX58_06370
SMUSC7J88_08780
SCARDWB96_02300
SCHRDWB92_10530
SARLSAP2_03630
SDBCNQ82_03155
SLLOISP08_01920
SAULI6G39_00700
SSCUCEP64_00955
SFFFOB90_09560
MLENH3V22_07355
MVTI6J10_09695
MCLMCCL_0120(thiE)
MCAKMCCS_02280(tenI)
MACRBHM04_09660
MBOEHT586_01270
MARYLAU42_00655
MBRUMGG13_00535
SHVAAT16_06160
SBACBVH56_01230
JEAJEM45_07405
ESIExig_1198
EANEab7_1154
EXMU719_06140
EXUESP131_08540
EACEKKI46_06335
BBEBBR47_32230(tenI)
BLRBRLA_c028190(tenI)
BFMBP422_11250
BAGRBA6348_14300
BRWGOP56_06640
BCOPJD108_10875
PPYPPE_02543
PPMPPSC2_13595(tenI)
PPOPPM_2608(tenI)
PPOLX809_30000
PPQPPSQR21_027030(thiE)
PPOYRE92_23140
PMSKNP414_01516
PMWB2K_09275
PTAHPL003_20225
PLVERIC2_c05510(tenI)
PSABPSAB_08630
PDUPDUR_09855
PBDPBOR_11700
PGMPGRAT_10845
PODPODO_09455
PAEAR70723_10620
PAEER70331_10290
PAEHH70357_11255
PIHUB51_13350
PRIPRIO_2351
PSONJI735_20515
PPEOABE82_14060
PNPIJ22_05520
PBVAR543_15205
PXLBS614_21245
PSWUSY83_08625
PDHB9T62_05595
PCXLPB68_19265
PKBB4V02_11455
PCHIPC41400_28395
PBACHUB98_03475
PSOPKP014_12355
PTRIKDC22_10045
PTJJRJ22_08915
ANXACH33_14270
ASOCCB4_03606(tenI)
ATHEK3F53_04640
AADTC41_2776
AFXJZ786_01830
BTSBtus_0498
KYRCVV65_03970(thiE)
TABCIG75_15150(thiE)
PANABBH88_04720
JEOJMA_36340
KURASO14_1578
SPSYAZE41_02025
SURESporoP32a_10790
SPOSDV702_14940
SPAEE2C16_14630
RSTATY39_11670
PANCE2636_03665(tenI)
NTRB0W44_17370
LFBC1X05_11810
TVUAB849_008970
KPULGXN76_10825
KEBGXN75_12165
PABSJIR001_21600(thiE_2)
CNONT01CX_1504
CBECbei_0648
CBZCbs_0648
CBEILF65_00721
CSRCspa_c48990(thiE2)
CPASClopa_4119
CPATCLPA_c33340(thiE2)
CPAECPAST_c33340(thiE2)
CSBCLSA_c25120
CLTCM240_2379
CACECACET_c37710(thiE2)
CBUTATN24_11570
CEUA7L45_01995
CDYF3K33_03670
RUJE5Z56_11415
CCTCC1_29720
ARFAR1Y2_1227
ACACEYQ97_11215
WCPH9Q76_00600
EACEAL2_c00370(tenI)
ELMELI_0854
EMTCPZ25_017210
ELIMB2M23_11970
VGUHYG85_03345
SAYTPY_3618
SAPSulac_1301
STHRBXT84_15515
MDVC5Q96_03425
LPILLIP_0284
ACITHPK19_14065
TROtrd_0401(thiE)
STISthe_1493
TAZTREAZ_2037
DDFDEFDS_2135
DAPDacet_2766
MEARMpt1_c00770(thiE1) Mpt1_c03060(thiE2)
 » show all
Reference
1  [PMID:21534620]
  Authors
Hazra AB, Han Y, Chatterjee A, Zhang Y, Lai RY, Ealick SE, Begley TP
  Title
A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase.
  Journal
J Am Chem Soc 133:9311-9 (2011)
DOI:10.1021/ja1110514
  Sequence
[bsu:BSU11660]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.10
IUBMB Enzyme Nomenclature: 5.3.99.10
ExPASy - ENZYME nomenclature database: 5.3.99.10
BRENDA, the Enzyme Database: 5.3.99.10

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