KEGG   ENZYME: 5.3.99.10
Entry
EC 5.3.99.10                Enzyme                                 

Name
thiazole tautomerase;
tenI (gene name)
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
Sysname
2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase
Reaction(IUBMB)
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate [RN:R09977]
Reaction(KEGG)
R09977
Substrate
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate [CPD:C20246]
Product
2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate [CPD:C20247]
Comment
The enzyme catalyses the irreversible aromatization of the thiazole moiety of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate.
History
EC 5.3.99.10 created 2012
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K10810  thiazole tautomerase (transcriptional regulator TenI)
Genes
CRX: CRECT_1046
APOC: APORC_0157
SDO: SD1155_02250
BSU: BSU11660(tenI)
BSR: I33_1300
BSL: A7A1_0983
BSH: BSU6051_11660(tenI)
BSY: I653_05925
BSUT: BSUB_01268(tenI)
BSUL: BSUA_01268(tenI)
BSUS: Q433_06590
BSS: BSUW23_05895(tenI)
BST: GYO_1471
BSO: BSNT_07609(tenI)
BSQ: B657_11660(tenI)
BSX: C663_1194(tenI)
BLI: BL01591(tenI)
BLD: BLi01260(tenI)
BLH: BaLi_c13950(tenI)
BAY: RBAM_011670(tenI)
BAQ: BACAU_1128(tenI)
BYA: BANAU_1073(tenI)
BAMP: B938_05675
BAML: BAM5036_1067(tenI)
BAMA: RBAU_1129(tenI)
BAMN: BASU_1106(tenI)
BAMB: BAPNAU_2628(tenI)
BAMT: AJ82_06560
BAMY: V529_11150(tenI)
BMP: NG74_01181(tenI)
BAO: BAMF_1240(tenI)
BAZ: BAMTA208_11770(tenI)
BQL: LL3_01247(tenI)
BXH: BAXH7_02403(tenI)
BQY: MUS_1211(tenI)
BAMI: KSO_014005
BAMC: U471_11640
BAMF: U722_05950
BSON: S101395_03589(tenI)
BAN: BA_0729(tenI)
BAR: GBAA_0729(tenI)
BAT: BAS0695
BAH: BAMEG_3830(tenI)
BAI: BAA_0836(tenI)
BANT: A16_08140
BANR: A16R_08220
BANS: BAPAT_0705
BANV: DJ46_5209(tenI)
BCE: BC0746
BCA: BCE_0799(tenI)
BCZ: BCE33L0639(thiE)
BCR: BCAH187_A0883(tenI)
BCB: BCB4264_A0786(tenI)
BCU: BCAH820_0806(tenI)
BCG: BCG9842_B4545(tenI)
BCQ: BCQ_0820(tenI)
BCX: BCA_0792(tenI)
BAL: BACI_c07600(thiE2)
BNC: BCN_0707
BCF: bcf_03845
BCER: BCK_04490
BTK: BT9727_0639(thiE)
BTL: BALH_0666
BTB: BMB171_C0639(tenI)
BTT: HD73_0864
BTC: CT43_CH0707(tenI)
BTM: MC28_0009
BTG: BTB_c08220(tenI)
BTI: BTG_17490
BTW: BF38_1996(tenI)
BWW: bwei_4260(tenI)
BMYO: BG05_5172(tenI)
BMYC: DJ92_3340(tenI)
BTRO: FJR70_26055(tenI)
BPU: BPUM_1095
BPUM: BW16_06215
BPUS: UP12_05815
BMQ: BMQ_0548
BMD: BMD_0551
BMH: BMWSH_4685(tenI)
BMEG: BG04_2840(tenI)
BJS: MY9_1271
BACW: QR42_05650
BACP: SB24_04035
BACB: OY17_08535
BACO: OXB_0158
BACY: QF06_04780
BACL: BS34A_12890(tenI)
BALM: BsLM_1220
BEO: BEH_03335
BGY: BGLY_1279
BBEV: BBEV_2245(thiE-2)
BALT: CFN77_05815(tenI)
BFD: NCTC4823_00320(tenI)
GKA: GK0622
GTN: GTNG_0535(tenI)
GGH: GHH_c05750(tenI)
GEA: GARCT_00596(tenI)
PTB: DER53_07630(tenI)
AFL: Aflv_2316(tenI)
AAMY: GFC30_999
AND: GRQ40_03575(tenI)
HLI: HLI_03130
VPN: A21D_02454(tenI)
VIM: GWK91_05245(tenI)
PASA: BAOM_1979
AQT: FN924_04405(tenI)
POF: GS400_16470(tenI)
MEKU: HUW50_13730(tenI)
BSE: Bsel_2693
SER: SERP2070
SEP: SE2057
SEPP: SEB_02063
SEPS: DP17_999
SHA: SH0565
SHH: ShL2_00460(tenI)
SSP: SSPP136
SCA: SCA_2076
SDT: SPSE_2079
SPAS: STP1_0997
SHU: SHYC_10375(thiE-2)
SCAP: AYP1020_1664(tenI)
SSCH: LH95_09890
SSCZ: RN70_10655
SAGQ: EP23_11770
SDP: NCTC12225_02300(tenI)
SARL: SAP2_03630
MCL: MCCL_0120(thiE)
MCAK: MCCS_02280(tenI)
ESI: Exig_1198
EAN: Eab7_1154
BBE: BBR47_32230(tenI)
BLR: BRLA_c028190(tenI)
PPY: PPE_02543
PPM: PPSC2_13595(tenI)
PPO: PPM_2608(tenI)
PPOL: X809_30000
PPQ: PPSQR21_027030(thiE)
PPOY: RE92_23140
PMW: B2K_09275
PLV: ERIC2_c05510(tenI)
PSAB: PSAB_08630
PRI: PRIO_2351
PSWU: SY83_08625
ASOC: CB4_03606(tenI)
AAD: TC41_2776
BTS: Btus_0498
KYR: CVV65_03970(thiE)
TAB: CIG75_15150(thiE)
JEO: JMA_36340
PANC: E2636_03665(tenI)
CBE: Cbei_0648
CBZ: Cbs_0648
CBEI: LF65_00721
CSR: Cspa_c48990(thiE2)
CPAS: Clopa_4119
CPAT: CLPA_c33340(thiE2)
CPAE: CPAST_c33340(thiE2)
CACE: CACET_c37710(thiE2)
CCT: CC1_29720
EAC: EAL2_c00370(tenI)
ELM: ELI_0854
SAY: TPY_3618
LPIL: LIP_0284
TRO: trd_0401(thiE)
STI: Sthe_1493
MEAR: Mpt1_c00770(thiE1) Mpt1_c03060(thiE2)
 » show all
Reference
1  [PMID:21534620]
  Authors
Hazra AB, Han Y, Chatterjee A, Zhang Y, Lai RY, Ealick SE, Begley TP
  Title
A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase.
  Journal
J Am Chem Soc 133:9311-9 (2011)
DOI:10.1021/ja1110514
  Sequence
[bsu:BSU11660]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.10
IUBMB Enzyme Nomenclature: 5.3.99.10
ExPASy - ENZYME nomenclature database: 5.3.99.10
BRENDA, the Enzyme Database: 5.3.99.10

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