KEGG   ENZYME: 5.3.99.11
Entry
EC 5.3.99.11                Enzyme                                 
Name
2-keto-myo-inositol isomerase;
IolI;
inosose isomerase;
2KMI isomerase.
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
Sysname
2,4,6/3,5-pentahydroxycyclohexanone 2-isomerase
Reaction(IUBMB)
2,4,6/3,5-pentahydroxycyclohexanone = 2D-2,3,5/4,6-pentahydroxycyclohexanone [RN:R09952]
Reaction(KEGG)
R09952
Substrate
2,4,6/3,5-pentahydroxycyclohexanone [CPD:C00691]
Product
2D-2,3,5/4,6-pentahydroxycyclohexanone [CPD:C20251]
Comment
Requires a divalent metal ion for activity. Mn2+, Fe2+ and Co2+ can be used. The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.
History
EC 5.3.99.11 created 2014
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K06606  2-keto-myo-inositol isomerase
Genes
ECQECED1_0306
STMSTM4427 STM4435
SEOSTM14_5319 STM14_5326
SEVSTMMW_43711 STMMW_43771
SEYSL1344_4359(iolI1) SL1344_4365(iolI2)
SEMSTMDT12_C45560 STMDT12_C45620
SEJSTMUK_4413 STMUK_4420
SEBSTM474_4624 STM474_4631
SEFUMN798_4794 UMN798_4802
SETUSTU288_22205 STU288_22240
SETCCFSAN001921_18240 CFSAN001921_18270
SENRSTMDT2_42741 STMDT2_42801
SENDDT104_44151 DT104_44211
SENICY43_23070 CY43_23105
SEENSE451236_05170 SE451236_05205
SPQSPAB_05574 SPAB_05584
SEASeAg_B4709 SeAg_B4717
SENSQ786_21815 Q786_21850
SEECCFSAN002050_05545 CFSAN002050_05580
SEEBSEEB0189_020200 SEEB0189_020235
SENBBN855_45020 BN855_45100
SENEIA1_21585 IA1_21620
SENCSEET0819_06010 SEET0819_06045
SALZEOS98_20060 EOS98_20090
CSKES15_3063(iolI)
CSZCSSP291_14195
CSJCSK29544_04268
CCONAFK62_04535
CDMAFK67_04495
CUIAFK65_04440
CMWAFK63_14150
CTUCTU_08910
KPNKPN_04669
KPUKP1_0551
KPMKPHS_05220
KPPA79E_4528
KPHKPNIH24_02680
KPZKPNIH27_02610
KPVKPNIH29_02770
KPWKPNIH30_02815
KPYKPNIH31_05275
KPGKPNIH32_02825
KPCKPNIH10_02665
KPQKPR0928_02670
KPTVK055_2789
KPOKPN2242_01435
KPRKPR_0646
KPJN559_4621
KPID364_23775
KPAKPNJ1_04944
KPSKPNJ2_04893
KPXPMK1_02137(iolI)
KPBFH42_19745
KPNEKU54_023920
KPNULI86_23760
KPNKBN49_4768
KVAKvar_4585
KPEKPK_4998
KPKA593_13395
KVDKR75_10850
KVQSP68_17435
KOXKOX_09355
KOEA225_0547
KOYJ415_00390
KOMHR38_08075
KOKKONIH1_03000
KOCAB185_33220
KQUAVR78_07240
EAEEAE_09790
EARCCG32079
KQVB8P98_24715
KLLBJF97_03750
KLWDA718_25700
KARLGL98_22320
KGRJJJ10_24815
RORRORB6_16190
RONTE10_04830
RPLNB1209_24195
RAODSD31_23000
RTGNCTC13098_06588(iolI)
REEelectrica_04540(iolI)
CIEAN232_01280 AN232_01310
IZHFEM41_17570
EBUCUC76_12705
YELLC20_00200
YEFFORC2_0164
YEEYE5303_38641
YALAT01_2636
YFRAW19_3419
YINCH53_1599
YKRCH54_2371
YROCH64_2445
YAKACZ76_08340
YMADA391_00600
YHID5F51_21310
YCAF0T03_20985
YMOHRD69_06290
SMARSM39_4134
SMACSMDB11_3909
SMWSMWW4_v1c46180(xylA)
SPESpro_4665
SRRSerAS9_4759
SRLSOD_c44630
SRYM621_24310
SPLYQ5A_024310
SRSSerAS12_4760
SRASerAS13_4760
SMAFD781_0083 D781_4377
SLQM495_23510
SERFL085_03355
SERSSERRSCBI_22385
SFWWN53_06480
SFGAV650_04450
SRZAXX16_0753
SERMCLM71_22520
SQUE4343_17425
SFJSAMEA4384070_4623
SOFNCTC11214_01429
SSURATE40_019705
SURIJ0X03_00945
SRHZFO014_11110
SENPKHA73_00420
SFOZ042_10570
RACEJHW33_16570
GQUAWC35_19255
RBADH2866_03120
BGJAWC36_04150
BIZHC231_14575
ETAETA_32950(iolI)
EBIEbC_42710
EGEEM595_0247
EPECI789_19830
ERWIGN242_01115
ERPLJN55_01415
PAMPANA_3268
PLFPANA5342_0800(iolI)
PAJPAJ_2487
PAQPAGR_g0815
PVAPvag_3029(iolI) Pvag_pPag30220(iolI)
PAGGAL522_02315 AL522_22285
PAOPat9b_3733
KLNLH22_03700
PANPPSNIH2_18535
PAGCBEE12_05590 BEE12_20040
PALHB1H58_06325
PANSFCN45_18110 FCN45_22890
PEYEE896_01460 EE896_20650
PDISD8B20_18395
PERLAC65_17010
PGZC2E15_01440
PCDC2E16_01505
MINTC7M51_03761(iolI)
MTHIC7M52_03265(iolI)
LRINCTC12151_03552(iolI_2)
VEJVEJY3_08685
PSTPSPTO_3496(iolI)
PSBPsyr_3270
PSYRN018_16410
PSPPSPPH_3190
PSAVPSA3335_12885
PAMGBKM19_019155
PCIPCH70_17480
PAVLBKM03_11755
PVDCFBP1590__3373
PCABJGS08_10550
PCOFPOR16_14905
PTREI9H09_10360
PSYIMME58_16765
PFLPFL_2589(iolL)
PPRCPFLCHA0_c26540(iolI)
PPROPPC_2636(iolL)
PFEPSF113_2376(iolI)
PFSPFLU_2578
PFCPflA506_3032(iolL)
PPZH045_10785
PFBVO64_5690
PMANOU5_0764
PTVAA957_02250
PCGAXG94_04355
PAZOAYR47_19720
POIBOP93_14400
PMEDE3Z27_16640
PFWPF1751_v1c22360(iolI)
PFFPFLUOLIPICF725530
PFXA7318_11610
PLULFOB45_08795
PBAPSEBR_a3352
PBCCD58_12350
PSKU771_19295
PCHEY04_11800
PCZPCL1606_36180
PCPJM49_18060
PSESPSCI_0434
PSEMTO66_12605
PSOSPOS17_2594
PFKPFAS1_22570
PANRA7J50_2469
PYMAK972_2363
PVKEPZ47_12240
PEZHWQ56_16480
PBZGN234_05915
PSEPC4K39_2605
PTRTHU722_0012850
PSAMHU731_003450
PASGKSS96_13030
PALVKSS97_12000
PZAHU749_018000
PTAENCTC10697_01802
AVNAvin_50090
AVLAvCA_50090
AVDAvCA6_50090
ACXAchr_2650 Achr_2660
AVZHWI77_18205
GAIIMCC3135_21485
HCHHCH_01162
HAHEENC22_24855
MARSA8C75_14450
GSNYC6258_05341
ZDFAN401_06635
ORBIPMB12_01890
AMAHDLM_0553 DLM_2149
AQSDKK66_02435 DKK66_18630
RSORSc1245(iolI)
RSCRCFBP_20192
RSLRPSI07_2131
RSNRSPO_c02128(iolI)
RSMCMR15_20451
RSEF504_1273
RSYRSUY_16690
RPUCDC45_06420
RSGJK151_10200
BURBcep18194_A6013
BCMBcenmc03_2714
BCHBcen2424_2685
BCJBCAL0918
BCENDM39_2775
BCEOI35_2750
BAMBamb_2738
BMJBMULJ_02648(iolI)
BMUBmul_0612
BMKDM80_2234
BMULNP80_2820
BCEDDM42_2386
BDLAK34_403
BPYRABD05_03455
BCONNL30_26520
BMECWJ16_13790
BSTLBBJ41_15335
BANNJFN94_13775
BURKDM992_06545
PACPFAZ97_27275
BOJCBF45_16085
KGYEHF36_16130
POLBpro_1854
POSDT070_20750
POOF7R28_09825
DACDaci_2926
DTSBI380_08655
DLAI6G47_02150 I6G47_09060
CBABSMCB_1923
SNNEWH46_19760
HSEHsero_3765
HSZACP92_18770
HRBHrubri_3723
HHFE2K99_19145
HFRG5S34_20490
CFUCFU_2085
CARELT85_1753
CPRACPter91_0712
MUMFCL38_02465
GLCJQN73_20785
LCHLcho_3284
RGUA4W93_11740
AONDEH84_10695
MLOmlr6178
MLNA9174_31105
MCIMesci_5854 Mesci_5870
MOPMesop_6428 Mesop_6444
MAMMesau_05901 Mesau_05917
MESWA9K65_031590 A9K65_031680
MESMEJ066_12015
MESPC1M53_10140
MHUAMCHK_13135 MCHK_8412
MJREB229_31730
MERDEB233_29595
HOEIMCC20628_04046
AAKAA2016_2139
AMIHCO731_02248
PHTBLM14_03330
PHYLHB779_19905
NKIKW403_18375
SMESM_b20711
SMKSinme_4317
SMQSinmeB_4810
SMXSM11_pD0201
SMIBN406_05281
SMEGC770_GR4pD0199
SMELSM2011_b20711
SMERDU99_26455
SMDSmed_4269
RHINGR_b20550 NGR_c25960
SFHSFHH103_02447(iolI) SFHH103_05176
SFDUSDA257_c15220 USDA257_c25740
SIXBSY16_215
SAMESAMCFNEI73_pC0588
SINOSS05631_b54180
EADOV14_a0856 OV14_b1383
EAHFA04_24380
ESJSJ05684_b44410
EAKEKH55_3681
EMXFKV68_27725
ATUAtu4555
ARAArad_9586
ATAAWN88_10430
AGRAGROH133_13936
ATFAch5_42510(iolI)
AROB0909_14750
AGTEYD00_14715
ALFCFBP5473_21830
RETRHE_PE00448
RECRHECIAT_PA0000371
RELREMIM1_PD00471
REPIE4803_PA00407
REIIE4771_PC00420
RLEpRL110624
RLTRleg2_6026
RLGRleg_7181
RLBRLEG3_05720
RLURLEG12_01495
RTRRTCIAT899_PC07030
RIRBN877_II0196 BN877_p0455
RPUSCFBP5875_14865
RHLLPU83_pLPU83d0180
RGARGR602_PC00464
RHNAMJ98_PD00457
RPHAAMC79_PB00380
RHXAMK02_PE00464
RHVBA939_26020
RHKKim5_PB00440
REZAMJ99_PC00458
RHRCKA34_26595
RGRFZ934_08355 FZ934_26665
RADCO657_32065
ROYG3A56_24610
RIIFFM53_030935
RHIDFFM81_030410
RBQJ2J99_29180
RLNJ0663_26720
RBANJ2J98_26025
RRGJ3P73_31235
RLSHB780_05020
RROSD4A92_23760
NGLRG1141_PA12110
NGGRG540_PA06870
RHTNT26_0567
SHZshn_13540
SOJK6301_10785
PDESFE840_019585
BQBJ4P68_0025620
BAPIBBC0122_003790
STARG3545_19980
LNEFZC33_31010
MNOMnod_7806
CHELAL346_12360
CDQBOQ54_05105
HDIHDIA_1418
AUAM673_18895
TSOIZ6_06850 IZ6_06880
PSFPSE_p0065
OATOAN307_c20150
OTMOSB_26350
CMARIMCC12053_2612
YANAYJ57_20180
AHTANTHELSMS3_01348
SAGUCDO87_03130
PDEPden_1677
PYEA6J80_02360
PZHCX676_09885
PAROCUV01_06175
PAAKFIU66_01025
PKDF8A10_19085
PLIAE4191_23510
DONBSK21_15055
GFUKM031_12935
SALOEF888_10330
RBZB9057_15550
ACRAcry_2319
AMVACMV_25510(iolI) ACMV_P1_01130(iolI)
BSUBSU39680(iolI)
BSRI33_4137
BSLA7A1_1974
BSHBSU6051_39680(iolI)
BSYI653_19500
BSUTBSUB_04210(iolI)
BSULBSUA_04210(iolI)
BSUSQ433_21905
BSOBSNT_10655(iolI)
BSNBSn5_10865
BSQB657_39680(iolI)
BSXC663_3887(iolI)
BSPU712_20070
BSSBSUW23_19800(iolI)
BSTGYO_4375
BLIBL00238(iolI)
BLDBLi04243(iolI)
BLHBaLi_c42340(iolI)
BAYRBAM_036700(iolI)
BAQBACAU_3684(iolI)
BYABANAU_3854(iolI)
BAMPB938_18820
BQYMUS_4359(iolI)
BAMLBAM5036_3590(iolI)
BAMARBAU_3797(iolI)
BAMNBASU_3579(iolI)
BAMBBAPNAU_3861(iolI)
BAMTAJ82_20705
BAMYV529_39370(iolI)
BMPNG74_03844(iolI)
BAOBAMF_3780(iolI)
BAZBAMTA208_19990(iolI)
BQLLL3_04103(iolI)
BXHBAXH7_04101(iolI)
BAMIKSO_000740
BAMCU471_38290
BAMFU722_19550
BSIACWD84_00845
BAEBATR1942_17850
BVMB9C48_18750
BSONS101395_04956(iolI)
BHTDIC78_11080
BMOJHC660_38870(iolI)
BIQAN935_20185
BGYBGLY_4628(iolI)
BITBIS30_09715
BSHILGQ02_18855
BCABEFK13_20370(iolI)
BRYM0696_20225(iolI)
BJSMY9_4099
BACPSB24_10410
BACBOY17_02025
BACYQF06_18305
BACLBS34A_42940(iolI)
BALMBsLM_4011
BACSAUL54_11430
BMQBMQ_3475(iolI)
BMDBMD_3469(iolI)
BEOBEH_02280
BHABH2315(iolI)
BGIBGM20_14110
GKAGK1892(iolI)
GTKGT3570_08995
GLIGLN3_02685
GMCGY4MC1_2175
GSEGT50_18765
GSRGS3922_07100
GEJA0V43_07015
PTBDER53_15260
TAPGZ22_16895
PPSRI6J18_08960(iolI)
PFRIL8956_04510(iolI)
GRCGI584_06580
POFGS400_06430
NDTL1999_25505
MEKUHUW50_10370(iolI) HUW50_23070
MLITKDJ21_025745(iolI)
BLENNCTC4824_04070(iolI_4)
LWIUE46_13185
BTHSCNY62_11325
PMQPM3016_2229
PTAHPL003_12830
PODPODO_18930
PAEFR50345_19300
PAEJH70737_19270
PXLBS614_26340
PKBB4V02_03380
PAIHASL14_05150
PALBEJC50_00225
PBKBack11_16420(lolI)
PRZGZH47_21090
PLYCGXP70_25420
COHNKCTCHS21_34000
AACOK1I37_13285(iolI)
NTRB0W44_10845
LRHLGG_00271(iolI)
LRGLRHM_0267
LRLLC705_00262(iolI)
LRALRHK_273
LROLOCK900_0255
LRCLOCK908_0271
LZEKG087_01180
LGNABM34_10280
CTYKCTK_C07490
CRSFQB35_05060
CPRFK7H06_11085
RUMCK1_18000
FPRFP2_24950
BYLA4V09_01410
BPROPMF13cell1_05203(iolI_1)
BLABEYS05_00790
BPRLCL2_16300
ARFAR1Y2_1058
ACACEYQ97_11955
VGUHYG85_18995
MFUNGXM21_00220
PUFUFO1_1236 UFO1_3158
PFTJBW_01424
MCOOMCOO_22950
NEXNE857_22305
MCRAID554_15155
RXYRxyl_1715
RUBGBA63_18080 GBA63_18090
CAPCLDAP_26120
CCZCCALI_02114
RBARB9367(lolI)
PSLPsta_2217
PIRVN12_01655(iolI)
RULUC8_32270(iolI_3)
RMLFF011L_35360(iolI_2)
MFFMFFC18_36660(iolI_2)
ROLCA51_44730(iolI_2)
AHELQ31a_31820(iolI)
LCREPla8534_39900(iolI_1) Pla8534_42280(iolI_2) Pla8534_43160(iolI_3)
AAGGETAA8_24790(iolI_1) ETAA8_31970(iolI_2)
BVOPan97_03890(iolI)
PLMPlim_3702
PEHSpb1_02020(iolI_1)
PBSPlabr_4063
PLHVT85_09750(iolI_1)
FMRFuma_04272(iolI_2)
GMRGmarT_45540(iolI_1) GmarT_57710(iolI_2)
GIMF1728_14800 F1728_22280
GPNPan110_43670(iolI_2) Pan110_60010(iolI_3)
MRIMal4_09140(iolI_1) Mal4_10340(iolI_2)
SDYNMal52_13050(iolI_1) Mal52_43710(iolI_3)
PLONPla110_21140(iolI)
GESVT84_20340(iolI_3)
GMSSOIL9_28570
TIMGMBLW1_35150 GMBLW1_36810
LRSPX52LOC_01491 PX52LOC_02919
FTJFTUN_7451 FTUN_8561
ULIETAA1_14240(iolI_1) ETAA1_35930(iolI_2)
TSPHKIH39_04985 KIH39_24290
IPAIsop_1865
SACISinac_2839 Sinac_5014
PBORBSF38_05397(iolI_4)
AGVOJF2_23210(iolI_1)
HBSIPV69_04355
TPITREPR_0400
SSMSpirs_0749 Spirs_1115
SBUSpiBuddy_0497
SASSMUG09_02705
TAZTREAZ_2566
SUSAcid_7006
PDIBDI_2741
PARCCI960_19945
PMERINE87_02912(iolI)
PGINFRZ67_13865
HHYHalhy_3562
PGSCPT03_00520
MGOTMgSA37_01693
MUHHYN43_014500
MGINFRZ54_03270
MRUBDEO27_014705
MGOSDIU38_014860
AGDFRZ59_06750
CMRCycma_0741 Cycma_1036
CAMUCA2015_0619
ALMAO498_05695
SLISlin_5789
SRDSD10_25250
SMONAWR27_18230
SPIRCWM47_15825
SPIKEXU85_01820
SPIBG8759_05315
STAEHNV11_01820
PSEZHME7025_02470(iolI)
RHOZGXP67_28790
DFEDfer_0291
RSIRunsl_4375
RUNDR864_02780
RUPDTQ70_08580
EOLEmtol_3339
FAEFAES_1171(lolI)
FIBA6C57_08825
ALSDJ013_07680
ADDHUW48_12805
ASWUHUW51_04280
FBTD770_18295
CHKD4L85_29185
RBIRB2501_12032
MARBCJ263_16550
EMARD1013_05615
TLETlet_1865
TTATheth_1106
PHYAJ81_01115
DTHDICTH_1667
DTUDtur_1777
 » show all
Reference
1  [PMID:12112707]
  Authors
Zhang RG, Dementieva I, Duke N, Collart F, Quaite-Randall E, Alkire R, Dieckman L, Maltsev N, Korolev O, Joachimiak A
  Title
Crystal structure of Bacillus subtilis ioli shows endonuclase IV fold with altered Zn binding.
  Journal
Proteins 48:423-6 (2002)
DOI:10.1002/prot.10159
  Sequence
[bsu:BSU39680]
Reference
2  [PMID:16461681]
  Authors
Yoshida K, Yamaguchi M, Morinaga T, Ikeuchi M, Kinehara M, Ashida H
  Title
Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome.
  Journal
Appl Environ Microbiol 72:1310-5 (2006)
DOI:10.1128/AEM.72.2.1310-1315.2006
  Sequence
[bsu:BSU39680]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.11
IUBMB Enzyme Nomenclature: 5.3.99.11
ExPASy - ENZYME nomenclature database: 5.3.99.11
BRENDA, the Enzyme Database: 5.3.99.11

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