| Entry |
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| Name |
prostaglandin-D synthase;
prostaglandin-H2 Delta-isomerase;
prostaglandin-R-prostaglandin D isomerase;
PGH-PGD isomerase(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase (incorrect);
(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase;
prostaglandin endoperoxide Delta-isomerase;
prostaglandin D synthetase
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
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| Sysname |
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
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| Reaction(IUBMB) |
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [RN: R02266]
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| Reaction(KEGG) |
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| Substrate |
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD: C00427]
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| Product |
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD: C00696]
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| Comment |
Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
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| History |
EC 5.3.99.2 created 1976, modified 1990
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| Pathway |
| ec00590 | Arachidonic acid metabolism |
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| Orthology |
| K01830 | prostaglandin-H2 D-isomerase |
| K04097 | prostaglandin-H2 D-isomerase / glutathione transferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Christ-Hazelhof E, Nugteren DH. |
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| Title |
Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzyme. |
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| Journal |
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| Reference |
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| Authors |
Shimizu T, Yamamoto S, Hayaishi O. |
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| Title |
Purification and properties of prostaglandin D synthetase from rat brain. |
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| Journal |
J Biol Chem 254:5222-8 (1979) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.99.2 |
| ExPASy - ENZYME nomenclature database: | 5.3.99.2 |
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