KEGG   ENZYME: 5.3.99.2
Entry
EC 5.3.99.2                 Enzyme                                 

Name
prostaglandin-D synthase;
prostaglandin-H2 Delta-isomerase;
prostaglandin-R-prostaglandin D isomerase;
PGH-PGD isomerase(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase (incorrect);
(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase;
prostaglandin endoperoxide Delta-isomerase;
prostaglandin D synthetase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
Sysname
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
Reaction(IUBMB)
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [RN:R02266]
Reaction(KEGG)
R02266
Substrate
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696]
Comment
Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
History
EC 5.3.99.2 created 1976, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K01830  prostaglandin-H2 D-isomerase
K04097  prostaglandin-H2 D-isomerase / glutathione transferase
Genes
HSA: 27306(HPGDS) 5730(PTGDS)
PTR: 100610452(PTGDS) 743219(HPGDS)
PPS: 100983768(PTGDS) 100990241(HPGDS)
GGO: 101123835(HPGDS) 101130674(PTGDS)
PON: 100442014(HPGDS) 100459419(PTGDS)
NLE: 100592404(PTGDS) 100598180(HPGDS)
MCC: 705227(HPGDS) 707990(PTGDS)
MCF: 101926100(PTGDS) 102131661(HPGDS)
CSAB: 103235987(HPGDS) 103239597(PTGDS)
RRO: 104669645(PTGDS) 104679857(HPGDS)
RBB: 108531868(HPGDS) 108542875(PTGDS)
CJC: 100394436(PTGDS) 100399167(HPGDS)
SBQ: 101033870(PTGDS) 101048967(HPGDS)
MMU: 19215(Ptgds) 54486(Hpgds)
MCAL: 110289823(Ptgds) 110295631(Hpgds)
MPAH: 110317199(Hpgds) 110319252(Ptgds)
RNO: 25526(Ptgds) 58962(Hpgds)
MUN: 110557021(Ptgds) 110564343(Hpgds)
CGE: 100762704(Ptgds) 100768035(Hpgds)
NGI: 103741183(Ptgds) 103743362(Hpgds)
HGL: 101699559(Ptgds) 101706734(Hpgds)
CCAN: 109700635(Ptgds)
OCU: 100009453 100353701(HPGDS)
TUP: 102482208(PTGDS) 102485301(HPGDS)
CFA: 403740(PTGDS) 478481(HPGDS)
VVP: 112906884(PTGDS) 112932672(HPGDS)
AML: 100466392(HPGDS) 100474593(PTGDS)
UMR: 103675299(PTGDS) 103677906(HPGDS)
ORO: 101372918(PTGDS) 101376365(HPGDS)
FCA: 101083337(HPGDS) 493852(PTGDS)
PTG: 102962017(PTGDS) 102970849(HPGDS)
PPAD: 109258819(PTGDS) 109275800(HPGDS)
AJU: 106988526(HPGDS) 106989498(PTGDS)
BTA: 100139892(HPGDS) 286858(PTGDS)
BOM: 102269024(HPGDS) 102274981(PTGDS)
BIU: 109559997(HPGDS) 109566622(PTGDS)
BBUB: 102399256(PTGDS) 102404824(HPGDS)
CHX: 102191223(HPGDS) 106502686(PTGDS)
OAS: 101116145(HPGDS) 443192(PTGDS)
SSC: 100623584(HPGDS) 397456(PTGDS)
CFR: 102512148(PTGDS) 102513633(HPGDS)
CDK: 105089526(HPGDS) 105106194(PTGDS)
BACU: 103013138(PTGDS) 103019771(HPGDS)
LVE: 103079273(HPGDS) 103088196(PTGDS)
OOR: 101280808(PTGDS) 101285619(HPGDS)
DLE: 111177005(PTGDS) 111179078(HPGDS)
PCAD: 102992900(HPGDS) 102995908(PTGDS)
ECB: 100053460(HPGDS) 100067921(PTGDS)
EPZ: 103552392(HPGDS) 103567817(PTGDS)
EAI: 106829529(HPGDS) 106845529(PTGDS)
MYB: 102238842(PTGDS) 102240667(HPGDS)
MYD: 102767586(HPGDS) 102773498(PTGDS)
MNA: 107532072(HPGDS) 107536157(PTGDS)
HAI: 109382064(PTGDS) 109385325(HPGDS)
DRO: 112306362(PTGDS) 112317839(HPGDS)
PALE: 102889838(PTGDS) 102895654(HPGDS)
RAY: 107503129(PTGDS) 107510631(HPGDS)
MJV: 108393953(HPGDS) 108406841(PTGDS)
LAV: 100666840(HPGDS) 100672974(PTGDS)
MDO: 100016454(HPGDS) 100022407(PTGDS)
SHR: 100913465(PTGDS) 100926080(HPGDS)
PCW: 110205092 110205307(PTGDS) 110223073(HPGDS)
OAA: 100078645(HPGDS) 100085740(PTGDS) 100681151
GGA: 374110(PTGDS) 395863(HPGDS)
CJO: 107313254(HPGDS) 107321660
NMEL: 110397718(HPGDS) 110406786
ACYG: 106037158(PTGDS) 106041241(HPGDS)
LSR: 110472190(PTGDS) 110472217 110481595(HPGDS)
SCAN: 103819086(PTGDS) 103826041(HPGDS)
GFR: 102038910 102044676(HPGDS)
PHI: 102102732(HPGDS) 102105998(PTGDS)
CCAE: 111928487(HPGDS) 111936898
CCW: 104688201(PTGDS) 104697200(HPGDS)
ETL: 114064151(PTGDS) 114067155(HPGDS)
FPG: 101912137 101913476(HPGDS)
FCH: 102054810(HPGDS) 102059754
CLV: 102092980 102094022(HPGDS)
EGZ: 104122621(HPGDS) 104123982(PTGDS)
NNI: 104018370(PTGDS) 104021198(HPGDS)
ACUN: 113479530(HPGDS) 113486363
PADL: 103921746(HPGDS)
AMJ: 102562368(PAEP) 102565053(PTGDS) 102574977(HPGDS)
PSS: 102450743(HPGDS) 102450917
CMY: 102940625 102944217(HPGDS)
CPIC: 101934059 101943956(HPGDS)
ACS: 100559774
PBI: 103067226
PMUR: 107302540
PMUA: 114598080
XLA: 100301961(obp.S) 108698139(cpl-1) 379417(hpgds.S) 397884(ptgds.S) 398969(hpgds.L) 444723(ptgds.L)
XTR: 448666(hpgds) 594897(obp) 779694(ptgds)
DRE: 336492(ptgdsb.1) 751701(ptgdsb.2) 767759(zgc:153704)
IPU: 100528611(gst28) 108276825(lcn2)
PHYP: 113544146(lcn2)
EEE: 113575964(lcn2) 113589053
NCC: 104941618(ptgds) 104965992 104968184(lcn15)
XMA: 102228717
CVG: 107104609
SASA: 100196042(hpgds) 106563592(CYTB) 106578378(LIPO) 106590529 106590538(LIPO) 106590877 106603057(LIPO)
SFM: 108923719
PKI: 111854155
LCM: 102352378(HPGDS) 102359406
CMK: 103184489(hpgds)
RTP: 109912194(hpgds)
DME: Dmel_CG8938(GstS1)
DER: 6548275
DSI: Dsimw501_GD25495(Dsim_GD25495)
DSR: 110182597
DPE: 6592395
DWI: 6646015
DAZ: 108616338
DNV: 108654342
DHE: 111595404
MDE: 101890455(GST)
LCQ: 111687996
AGA: AgaP_AGAP010404(GST_ANOGA)
AAG: 5575278
AALB: 109401280
AME: 411045(GstS4) 552283 552304(GstS1)
BMOR: 692543(GSTs2) 692631(GSTs1)
CSCU: 111638117
CEL: CELE_C02A12.1(gst-33) CELE_R11G1.3(gst-11) CELE_ZK546.11(gst-30)
CBR: CBG00918(Cbr-gst-13) CBG02264(Cbr-gst-6.1) CBG02265 CBG02278(Cbr-gst-30) CBG03411(Cbr-gst-3) CBG03451 CBG03453 CBG06381 CBG06384 CBG14247(Cbr-gst-11) CBG20632(Cbr-gst-5) CBG20649 CBG20668 CBG22411(Cbr-gst-33) CBG22850(Cbr-gst-38) CBG24808(Cbr-gst-6.2) CBG24809(Cbr-gst-7)
SHX: MS3_06482
EGL: EGR_04787
ANG: ANI_1_1838144(An16g06100)
SLA: SERLADRAFT_417671(glt1.1)
SMIN: v1.2.000995.t1(symbB.v1.2.000995.t1) v1.2.003070.t1(symbB.v1.2.003070.t1) v1.2.014814.t1(symbB.v1.2.014814.t1) v1.2.014815.t1(symbB.v1.2.014815.t1) v1.2.017551.t1(symbB.v1.2.017551.t1) v1.2.017577.t1(symbB.v1.2.017577.t1) v1.2.040628.t1(symbB.v1.2.040628.t1) v1.2.040628.t2(symbB.v1.2.040628.t2)
SAZ: Sama_0385
SAGA: M5M_17045
RFR: Rfer_3267
MCG: GL4_2957
 » show all
Reference
1  [PMID:32914]
  Authors
Christ-Hazelhof E, Nugteren DH.
  Title
Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzyme.
  Journal
Biochim Biophys Acta 572:43-51 (1979)
DOI:10.1016/0005-2760(79)90198-X
Reference
2  [PMID:109431]
  Authors
Shimizu T, Yamamoto S, Hayaishi O.
  Title
Purification and properties of prostaglandin D synthetase from rat brain.
  Journal
J Biol Chem 254:5222-8 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.2
IUBMB Enzyme Nomenclature: 5.3.99.2
ExPASy - ENZYME nomenclature database: 5.3.99.2
BRENDA, the Enzyme Database: 5.3.99.2
CAS: 65802-85-9

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