| Entry |
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| Name |
prostaglandin-I synthase;
prostacyclin synthase;
prostacycline synthetase;
prostagladin I2 synthetase;
PGI2 synthase;
PGI2 synthetase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
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| Sysname |
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
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| Reaction(IUBMB) |
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate [RN: R02267]
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| Reaction(KEGG) |
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| Substrate |
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD: C00427]
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| Product |
(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
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| Comment |
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into prostaglandin I2 (prostacyclin).
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| History |
EC 5.3.99.4 created 1984, modified 1990
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| Pathway |
| ec00590 | Arachidonic acid metabolism |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
DeWitt DL, Smith WL. |
|---|
| Title |
Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein. |
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| Journal |
J Biol Chem 258:3285-93 (1983) |
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| Reference |
|
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| Authors |
Ullrich V, Castle L, Weber P. |
|---|
| Title |
Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.99.4 |
| ExPASy - ENZYME nomenclature database: | 5.3.99.4 |
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