| Entry |
|
|---|
| Name |
prostaglandin-I synthase;
prostacyclin synthase;
prostacycline synthetase;
prostagladin I2 synthetase;
PGI2 synthase;
PGI2 synthetase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
|
|---|
| Class |
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
 |
|---|
| Sysname |
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
|
|---|
| Reaction(IUBMB) |
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate [RN: R02267]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD: C00427]
|
|---|
| Product |
(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
|
|---|
| Comment |
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into prostaglandin I2 (prostacyclin).
|
|---|
| History |
EC 5.3.99.4 created 1984, modified 1990
|
|---|
| Pathway |
| ec00590 | Arachidonic acid metabolism |
|
|---|
| Orthology |
|
|---|
| Genes |
» show all
 |
|---|
| Reference |
|
|---|
| Authors |
DeWitt DL, Smith WL. |
|---|
| Title |
Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein. |
|---|
| Journal |
J Biol Chem 258:3285-93 (1983) |
|---|
| Reference |
|
|---|
| Authors |
Ullrich V, Castle L, Weber P. |
|---|
| Title |
Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase. |
|---|
| Journal |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.99.4 |
| ExPASy - ENZYME nomenclature database: | 5.3.99.4 |
|
|---|
