KEGG ENZYME: 5.3.99.4

ENZYME: 5.3.99.4

Entry

EC 5.3.99.4                 Enzyme

Name

prostaglandin-I synthase;
prostacyclin synthase;
prostacycline synthetase;
prostagladin I2 synthetase;
PGI2 synthase;
PGI2 synthetase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase

Class

Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases

Sysname

(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase

Reaction(IUBMB)

(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate [RN:R02267]

Reaction(KEGG)

R02267

Substrate

(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]

Product

(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate

Comment

A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into prostaglandin I2 (prostacyclin).

History

EC 5.3.99.4 created 1984, modified 1990

Pathway

ec00590

Arachidonic acid metabolism

ec01100

Metabolic pathways

Orthology

K01831

prostacyclin synthase

Genes

HSA:	5740(PTGIS)

PTR:	458323(PTGIS)

PPS:	100987973(PTGIS)

GGO:	101132214(PTGIS)

PON:	100440673(PTGIS)

NLE:	100592236(PTGIS)

MCC:	703407(PTGIS)

MCF:	102123511(PTGIS)

MTHB:

126964381

CSAB:

103244560(PTGIS)

CATY:

105585406(PTGIS)

PANU:

101015498(PTGIS)

TGE:	112633809(PTGIS)

RRO:	104678532(PTGIS)

RBB:	108539469(PTGIS)

TFN:	117068897(PTGIS)

PTEH:

111521024(PTGIS)

CANG:

105502580(PTGIS)

CJC:	100403062(PTGIS)

SBQ:	101034236(PTGIS)

CSYR:

103264305(PTGIS)

MMUR:

105866470(PTGIS)

LCAT:

123622705(PTGIS)

PCOQ:

105818619(PTGIS)

OGA:	100950088(PTGIS)

MMU:	19223(Ptgis)

MCAL:

110289735(Ptgis)

MPAH:

110318865(Ptgis)

RNO:	25527(Ptgis)

MCOC:

116091420(Ptgis)

MUN:	110549006(Ptgis)

CGE:	100757024(Ptgis)

MAUA:

101832459(Ptgis)

PLEU:

114692661(Ptgis)

MORG:

121460257(Ptgis)

MFOT:

126495663

AAMP:

119814555(Ptgis)

NGI:	103735556(Ptgis)

HGL:	101700601(Ptgis)

CPOC:

100734621(Ptgis)

CCAN:

109690523(Ptgis)

DORD:

105991642(Ptgis)

DSP:	122127890(Ptgis)

NCAR:

124975994

OCU:

103346149

OPI:	101516658(PTGIS)

TUP:	102496170(PTGIS)

GVR:	103608250(PTGIS)

CFA:	100856661(PTGIS)

CLUD:

112674100(PTGIS)

VVP:	112931895(PTGIS)

VLG:	121478064(PTGIS)

AML:	100466540(PTGIS)

UMR:	103669841(PTGIS)

UAH:	113258701(PTGIS)

UAR:	123775935(PTGIS)

ELK:

111141584

LLV:

125109103

MPUF:

101671387(PTGIS)

ORO:	101382580(PTGIS)

EJU:	114225538(PTGIS)

ZCA:	113938092(PTGIS)

MLX:	118023956(PTGIS)

NSU:	110576722(PTGIS)

LWW:	102726976(PTGIS)

FCA:	101082050(PTGIS)

PYU:	121020122(PTGIS)

PBG:	122467288(PTGIS)

LRUF:

124504362

PTG:	102952139(PTGIS)

PPAD:

109272209(PTGIS)

AJU:	106986024(PTGIS)

HHV:	120230439(PTGIS)

BTA:	282021(PTGIS)

BOM:	102279286(PTGIS)

BIU:

109567538

BBUB:

102391623(PTGIS)

BBIS:

104985111(PTGIS)

CHX:	100860894(PTGIS)

OAS:	101116418(PTGIS)

ODA:	120869080(PTGIS)

CCAD:

122448178(PTGIS)

SSC:	100126284(PTGIS)

CFR:	102521764(PTGIS)

CBAI:

105071862(PTGIS)

CDK:	105087868(PTGIS)

VPC:	102541985(PTGIS)

BACU:

103018962(PTGIS)

LVE:	103069768(PTGIS)

OOR:	101285307(PTGIS)

DLE:	111186649(PTGIS) 111187839

PCAD:

102985868 114483838(PTGIS)

PSIU:

116739916(PTGIS) 116761081

ECB:	100071412(PTGIS)

EPZ:	103541173(PTGIS)

EAI:	106825769(PTGIS)

MYB:	102249227(PTGIS)

MYD:	102772939(PTGIS)

MMYO:

118663392(PTGIS)

MLF:	102427459(PTGIS)

MNA:	107540608(PTGIS)

PKL:	118707885(PTGIS)

HAI:	109381877(PTGIS)

DRO:	112303771(PTGIS)

SHON:

118996479(PTGIS)

AJM:	119065200(PTGIS)

PDIC:

114506671(PTGIS)

PHAS:

123815195(PTGIS)

MMF:	118618421(PTGIS)

RFQ:	117015885(PTGIS)

PALE:

102885283(PTGIS)

PGIG:

120603782(PTGIS)

PVP:	105296058(PTGIS)

RAY:	107510328(PTGIS)

MJV:	108391976(PTGIS)

TOD:	119236360(PTGIS)

SARA:

101552132(PTGIS)

LAV:	100669854(PTGIS)

TMU:

101360898

ETF:	101663459(PTGIS)

DNM:	101431527(PTGIS)

MDO:	100029131(PTGIS)

GAS:	123233545(PTGIS)

SHR:	100924178(PTGIS)

PCW:	110206638(PTGIS)

OAA:	100076102(PTGIS)

ASN:	102380148(PTGIS)

AMJ:	102570396(PTGIS)

CPOO:

109313135(PTGIS)

GGN:	109292458(PTGIS)

PSS:	102459815(PTGIS)

CMY:	102929462(PTGIS)

CPIC:

101948711(PTGIS)

TST:	117885954(PTGIS)

CABI:

116815882(PTGIS)

MRV:	120380169(PTGIS)

ACS:	100565699(ptgis)

PVT:	110071794(PTGIS)

SUND:

121929525(PTGIS)

PBI:	103056719(PTGIS)

PMUR:

107290825(PTGIS)

CTIG:

120311576(PTGIS)

TSR:	106539549(PTGIS)

PGUT:

117663569(PTGIS)

VKO:	123028456(PTGIS)

PMUA:

114599622(PTGIS)

ZVI:	118089309(PTGIS)

GJA:

107122715

STOW:

125433394(PTGIS)

XLA:	108700877(ptgis.L)

XTR:	100492372(ptgis)

NPR:

108803621

RTEM:

120918948(PTGIS)

BBUF:

121004288(PTGIS)

BGAR:

122940309(PTGIS)

DRE:	559148(ptgis)

SRX:	107708106 107713538

SANH:

107667039 107680687

SGH:	107555969 107561003(ptgis)

CCAR:

109052726 109056482

CAUA:

113050312 113097085

PPRM:

120459861(ptgis)

MAMB:

125273493(ptgis)

IPU:	108271893 108272147(ptgis)

PHYP:

113533815 113536922

SMEO:

124382830(ptgis) 124385911

TFD:	113642707(ptgis) 113643075

AMEX:

103027408 103041888

EEE:	113569647 113578002

TRU:	101069230 101079540

TNG:	GSTEN00012489G001 GSTEN00027310G001 GSTEN00027470G001

LCO:	104920521 104928129(ptgis)

NCC:	104950923 104965629

CGOB:

115008341 115008599

ELY:	117257285(ptgis) 117257379

EFO:	125887345 125895416(ptgis)

PLEP:

121956234 121958442(ptgis)

SLUC:

116041731 116051588(ptgis)

ECRA:

117943749(ptgis) 117943957

ESP:	116687286 116688089

PFLV:

114554500 114554558

GAT:	120834951(ptgis) 120835857

PPUG:

119229980 119230097(ptgis)

MSAM:

119885948(ptgis) 119886340

CUD:	121507016(ptgis) 121507099

ALAT:

119020588 119021399(ptgis)

MZE:	101476415 101482090

ONL:	100693506 100703351

OAU:	116333908 116334268(ptgis)

OLA:	101170919(ptgis)

OML:	112144503 112144760

XMA:	102218429 102224227

XCO:	114135636 114136163

XHE:	116710528 116711125

PRET:

103464557 103465211

PFOR:

103137429 103150691

PLAI:

106950329(ptgis) 106959003

PMEI:

106923751 106931052(ptgis)

GAF:	122833576(ptgis) 122834642

CVG:	107093334 107096113(ptgis)

CTUL:

119772186(ptgis) 119779959

GMU:	124857072 124857121(ptgis)

NFU:	107385183 107385744

KMR:	108231375(ptgis) 108235780

ALIM:

106516065 106517980(ptgis)

NWH:	119412756(ptgis) 119412831

AOCE:

111575285 111575521

MCEP:

125006184(ptgis) 125006984

CSEM:

103385737 103385896(ptgis)

POV:	109629045(ptgis) 109638533

SSEN:

122768072(ptgis) 122768404

HHIP:

117761812 117761956(ptgis)

HSP:	118104431 118104899(ptgis)

LCF:	108889866 127143127

SDU:	111222105(ptgis) 111222893

SLAL:

111657863 111660836(ptgis)

XGL:	120782896 120806916(ptgis)

HCQ:	109522667 109531485

BPEC:

110168753 110168791(ptgis)

MALB:

109964506(ptgis)

BSPL:

114856271 114856369(ptgis)

SASA:

106565340 106565585 106583179 106583533

STRU:

115150334 115150522 115207896 115208094

OTW:	112214994(ptgis) 112217010 112254650 112254827

OMY:	110494089(ptgis) 110494258 110528167 110529007

OGO:	124002969 124003982 124019180 124019605

ONE:	115140159 115142963 115143122 115146132

SALP:

111963902 111966323 111969616 111970136

SNH:	120025390 120025923(ptgis) 120064563 120064608

CCLU:

121575874(ptgis) 121575916 121577574 121578164

ELS:	105017022(ptgis) 105026471

SFM:	108923412 108939002(ptgis)

PKI:	111833099 111840521(ptgis)

AANG:

118207232(ptgis) 118211429

LOC:	102688932(ptgis)

PSPA:

121297677 121319212

ARUT:

117416641 117428392

PSEX:

120514787(ptgis)

LCM:	102358660(PTGIS)

CMK:	103190529(ptgis)

RTP:

109914197

» show all

Reference

1 [PMID:6338016]

Authors

DeWitt DL, Smith WL.

Title

Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein.

Journal

J Biol Chem 258:3285-93 (1983)

Reference

2 [PMID:7023490]

Authors

Ullrich V, Castle L, Weber P.

Title

Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase.

Journal

Biochem Pharmacol 30:2033-6 (1981)
DOI:10.1016/0006-2952(81)90218-5

Other DBs

ExplorEnz - The Enzyme Database:

5.3.99.4

IUBMB Enzyme Nomenclature:

5.3.99.4

ExPASy - ENZYME nomenclature database:

5.3.99.4

BRENDA, the Enzyme Database:

5.3.99.4

CAS:	65802-86-0

DBGET integrated database retrieval system