KEGG   ENZYME: 5.3.99.5
Entry
EC 5.3.99.5                 Enzyme                                 
Name
thromboxane-A synthase;
thromboxane synthase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
Sysname
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [RN:R02268]
Reaction(KEGG)
R02268
Substrate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [CPD:C02198]
Comment
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2.
History
EC 5.3.99.5 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K01832  thromboxane-A synthase
Genes
HSA6916(TBXAS1)
PTR463774(TBXAS1)
PPS100974860(TBXAS1)
GGO101143018(TBXAS1)
PON100173366(TBXAS1)
NLE100580072(TBXAS1)
MCC711748(TBXAS1)
MCF102128548(TBXAS1)
CSAB103227005(TBXAS1)
CATY105589661(TBXAS1)
PANU101020071(TBXAS1)
TGE112621111(TBXAS1)
RRO104656601(TBXAS1)
RBB108534817(TBXAS1)
TFN117072824(TBXAS1)
PTEH111521449(TBXAS1)
CJC100405880(TBXAS1)
SBQ101049596(TBXAS1)
CSYR103250556
MMUR105873228(TBXAS1)
OGA100956288(TBXAS1)
MMU21391(Tbxas1)
MCAL110296424(Tbxas1)
MPAH110317008(Tbxas1)
RNO24886(Tbxas1)
MCOC116098761(Tbxas1)
MUN110545795(Tbxas1)
CGE100772642(Tbxas1)
MAUA101825106(Tbxas1)
PLEU114706813(Tbxas1)
MORG121435528 121463429(Tbxas1)
NGI103726097(Tbxas1)
HGL101697368(Tbxas1)
CPOC100719442(Tbxas1)
CCAN109687422(Tbxas1)
DORD105989534(Tbxas1)
DSP122105987(Tbxas1)
NCAR124990543
OCU100339354(TBXAS1)
OPI101534820(TBXAS1)
TUP102482189(TBXAS1)
CFA482771(TBXAS1)
VVP112907016(TBXAS1)
VLG121489949(TBXAS1)
AML100481563(TBXAS1)
UMR103669108(TBXAS1)
UAH113264996(TBXAS1)
UAR123788885(TBXAS1)
ELK111151949
LLV125081062
MPUF101678513(TBXAS1)
ORO101374074(TBXAS1)
EJU114211672(TBXAS1)
ZCA113911732(TBXAS1)
MLX118021152(TBXAS1)
FCA101091097(TBXAS1)
PYU121028253(TBXAS1)
PBG122488393(TBXAS1)
PTG102970130(TBXAS1)
PPAD109269096(TBXAS1)
AJU106970434(TBXAS1)
HHV120233009(TBXAS1)
BTA509326(TBXAS1)
BOM102269002(TBXAS1)
BIU109557691(TBXAS1)
BBUB102396566(TBXAS1)
CHX102178240(TBXAS1)
OAS101111361(TBXAS1)
ODA120877649(TBXAS1)
CCAD122438714(TBXAS1)
SSC397112(TBXAS1)
CFR102522566(TBXAS1)
CBAI105063030(TBXAS1)
CDK105091642(TBXAS1)
VPC102526977(TBXAS1)
BACU103014081(TBXAS1)
LVE103076764(TBXAS1)
OOR101279392(TBXAS1)
DLE111177728(TBXAS1)
PCAD102990697(TBXAS1)
PSIU116759004(TBXAS1)
ECB100066198(TBXAS1)
EPZ103556299(TBXAS1)
EAI106842627(TBXAS1)
MYB102246253(TBXAS1)
MYD102752445(TBXAS1)
MMYO118666352(TBXAS1)
MLF102442505(TBXAS1)
MNA107531092(TBXAS1)
PKL118713702(TBXAS1)
HAI109388522(TBXAS1)
DRO112299898(TBXAS1)
SHON118989084(TBXAS1)
AJM119044402(TBXAS1)
PDIC114507760(TBXAS1)
PHAS123829832(TBXAS1)
MMF118619832(TBXAS1)
RFQ117017967(TBXAS1)
PALE102880503(TBXAS1)
PGIG120601147(TBXAS1)
PVP105291613(TBXAS1)
RAY107519333(TBXAS1)
MJV108405198(TBXAS1)
TOD119250844
SARA101550945(TBXAS1)
LAV100666117(TBXAS1)
DNM101446347(TBXAS1)
MDO100023523(TBXAS1)
GAS123249553(TBXAS1)
SHR100933239(TBXAS1)
PCW110216137(TBXAS1)
OAA100087744(TBXAS1)
GGA418101(TBXAS1)
PCOC116226795(TBXAS1)
MGP100547506
CJO107316123(TBXAS1)
NMEL110394089(TBXAS1)
APLA101799380(TBXAS1)
ACYG106031025(TBXAS1)
AFUL116502115(TBXAS1)
TGU100220562(TBXAS1)
LSR110473708(TBXAS1)
SCAN103819643(TBXAS1)
PMOA120501721(TBXAS1)
OTC121332941(TBXAS1)
PRUF121363583(TBXAS1)
GFR102033663(TBXAS1)
FAB101821781(TBXAS1)
PHI102099408(TBXAS1)
PMAJ107204806(TBXAS1)
CCAE111931337(TBXAS1)
CCW104696219(TBXAS1)
ETL114056159(TBXAS1)
ZAB102066064(TBXAS1)
FPG101921622(TBXAS1)
FCH102058879(TBXAS1)
CLV102090566(TBXAS1)
EGZ104135574(TBXAS1)
NNI104013364(TBXAS1)
ACUN113475880(TBXAS1)
TALA104360509(TBXAS1)
PADL103924418(TBXAS1)
ACHC115352671(TBXAS1)
AAM106488440(TBXAS1)
AROW112974654(TBXAS1)
NPD112946626(TBXAS1)
DNE112995066(TBXAS1)
ASN102382949(TBXAS1)
AMJ102558059(TBXAS1)
CPOO109316546(TBXAS1)
GGN109296140(TBXAS1)
PSS102461458(TBXAS1)
CMY102935048(TBXAS1)
CPIC101953436(TBXAS1)
TST117881553(TBXAS1)
CABI116825732(TBXAS1)
MRV120372623(TBXAS1)
ACS100561371(tbxas1)
PVT110082702(TBXAS1)
SUND121930907
PBI103066404(TBXAS1)
PMUR107289397(TBXAS1)
TSR106543013(TBXAS1)
PGUT117655849(TBXAS1)
VKO123028954(TBXAS1)
PMUA114605650(TBXAS1)
ZVI118091364(TBXAS1)
GJA107119575
STOW125435763(TBXAS1)
XLA379702(MGC68990) 779365(tbxas1.L)
XTR100327243(tbxas1)
NPR108797764(TBXAS1)
RTEM120932743(TBXAS1)
BBUF121004866(TBXAS1)
BGAR122928471(TBXAS1)
DRE792041(tbxas1)
SRX107722474 107738402
SANH107684653
SGH107559817 107587020
CCAR109109645
CAUA113061548 113070573 113118226
PPRM120462043(tbxas1)
MAMB125253843(tbxas1)
IPU108264404 124625925
PHYP113534482(tbxas1)
SMEO124395680(tbxas1)
TFD113652445(tbxas1)
AMEX103045961(tbxas1)
EEE113570867(tbxas1)
TRU101064915(tbxas1)
TNGGSTEN00015938G001
LCO104923716(tbxas1)
NCC104950691(tbxas1)
CGOB115009477(tbxas1)
ELY117254019(tbxas1)
PLEP121949921(tbxas1)
SLUC116038348(tbxas1)
ECRA117948627(tbxas1)
PFLV114560458(tbxas1)
GAT120809243
PPUG119196247(tbxas1)
MSAM119894445(tbxas1)
CUD121514442(tbxas1)
ALAT119023795(tbxas1)
MZE101479408 101479900 101486083
ONL100695304 100695569 102078896
OAU116312564 116312566
OLA101158441(tbxas1)
OML112152712(tbxas1)
XMA102224720(tbxas1)
XCO114161908(tbxas1)
XHE116707702(tbxas1)
PRET103481207(tbxas1)
PFOR103138851(tbxas1)
PLAI106958802(tbxas1)
PMEI106928646(tbxas1)
GAF122835737(tbxas1)
CVG107100264(tbxas1)
CTUL119787246(tbxas1)
GMU124855610(tbxas1)
NFU107389081 107395858
KMR108237448(tbxas1) 108237512 108237513 108237514 108237515
ALIM106523183(tbxas1)
NWH119415611 119416022 119416191 119416234 119416235 119416236
AOCE111575925(tbxas1)
CSEM103380419(tbxas1)
POV109641916(tbxas1) 109642234
SSEN122776062(tbxas1)
HHIP117763564(tbxas1) 117763565
HSP118110021(tbxas1) 118110278
LCF108875270 108875456 108879784
SDU111228551(tbxas1)
SLAL111661817(tbxas1)
XGL120792974(tbxas1)
HCQ109530412(tbxas1)
BPEC110175058
MALB109961809(tbxas1)
BSPL114857464(tbxas1)
SASA100306773(thas) 106561393
OTW112218751(tbxas1) 112252557
OMY110497983(tbxas1) 110532319
OGO124034733(tbxas1)
ONE115134080
SALP111952359 112068905
SNH120054089(tbxas1)
ELS105018137(tbxas1)
SFM108935974(tbxas1)
PKI111839790
AANG118232036(tbxas1)
LOC102684731(tbxas1)
PSPA121318097(tbxas1)
ARUT117419838(tbxas1)
LCM102350410(TBXAS1)
CMK103181850(tbxas1)
BBEL109481435 109485038
DMK116929938
PJA122256756 122257284 122265553
PCHN125031830 125042480
HAME121868234
PCLA123770692
PTRU123498795
HAZT108679136
PPOI119091729 119108617
DSV119440153 119444283 119450491 119453378 119454116 119455651 119455669 119461578 119462279 119462280 119462281
RSAN119373477 119381585 119383537 119383538 119385508 119391232 119393204 119395915 119395916 119397372 119399657 119399662 119399831
RMP119161224 119169215 119169220 119170586 119171699 119173732 119173746 119174259 119178335 119179240 119187401
VJA111269250 111269254 111270518
DFR124494583 124497057
SDM118188144 118194578 118196836 118197729 118198670 118200841
BGT106051040 106067639 106078831
HRJ124264467
PMAX117329029
MMER123531218 123531219
OBI106880759
OSN115216235 115224815 115224863 115228175 115230612 115230908 115231081
ATEN116289350 116290469
 » show all
Reference
1  [PMID:3745158]
  Authors
Shen RF, Tai HH.
  Title
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung.
  Journal
J Biol Chem 261:11592-9 (1986)
Reference
2  [PMID:6221511]
  Authors
Ullrich V, Haurand M.
  Title
Thromboxane synthase as a cytochrome P450 enzyme.
  Journal
Adv Prostaglandin Thromboxane Leukot Res 11:105-10 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.5
IUBMB Enzyme Nomenclature: 5.3.99.5
ExPASy - ENZYME nomenclature database: 5.3.99.5
BRENDA, the Enzyme Database: 5.3.99.5
CAS: 61276-89-9

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