Entry |
|
Name |
thromboxane-A synthase;
thromboxane synthase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase
|
Class |
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
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Sysname |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase
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Reaction(IUBMB) |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [RN: R02268]
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Reaction(KEGG) |
|
Substrate |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD: C00427]
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Product |
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [CPD: C02198]
|
Comment |
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2.
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History |
EC 5.3.99.5 created 1984, modified 1990
|
Pathway |
ec00590 | Arachidonic acid metabolism |
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Orthology |
|
Genes |
MORG: | 121435528 121463429(Tbxas1) |
XLA: | 379702(MGC68990) 779365(tbxas1.L) |
CAUA: | 113061548 113070573 113118226 |
CGIB: | 127934180 127976933 |
MASI: | 127417285 127455786 |
ASTR: | 137593758(tbxas1) 137594584 |
MZE: | 101479408 101479900 101486083 |
ONL: | 100695304 100695569 102078896 |
KMR: | 108237448(tbxas1) 108237512 108237513 108237514 108237515 |
NWH: | 119415611 119416022 119416191 119416234 119416235 119416236 |
POV: | 109641916(tbxas1) 109642234 |
HHIP: | 117763564(tbxas1) 117763565 |
HSP: | 118110021(tbxas1) 118110278 |
PPLT: | 128445161 128445162(tbxas1) |
SASA: | 100306773(thas) 106561393 |
STRU: | 115152206 115197407 |
OTW: | 112218751(tbxas1) 112252557 |
OMY: | 110497983(tbxas1) 110532319 |
SALP: | 111952359 112068905 |
CCLU: | 121532280 121576974 |
BBEL: | 109481435 109485038 |
LPIC: | 129265218 129266442 129266901 |
PFLL: | 139133876 139133885 139135398 139140422 |
PJA: | 122256756 122257284 122265553 |
PCHN: | 125031830 125042480 |
PCLA: | 123770692 138353084 |
ESN: | 127002872 127002877 127002965 127002974 |
MNZ: | 135199800 135205277 135207825 135212749 135217180 135217757 |
MRJ: | 136827964 136827965 136827966 136829407 136830899 136832807 136835303 136855895 |
PPOI: | 119091729 119108617 |
DSV: | 119444283 119450491 119453378 119454116 119455651 119455669 119461578 119462279 119462280 119462281 |
RSAN: | 119373477 119381585 119383537 119383538 119385508 119393204 119395915 119395916 119397372 119399657 119399662 119399831 |
RMP: | 119161224 119169215 119169220 119170586 119171699 119173732 119174259 119178335 119179240 119187401 |
VJA: | 111269250 111269254 111270518 |
CVS: | 136973720 136973722 136977979 136979967 136979992 136980961 136981019 136986327 136989604 |
ABRU: | 129957010 129957012 129957013 129957015 129957154 129961890 129963550 129963646 129964235 129969389 129981492 129981554 |
UDV: | 129218298 129218437 129218592 129219084 129219320 129219321 129223382 129231868 129231879 129234181 |
SDM: | 118188144 118194578 118196836 118197729 118198670 118200841 |
LPOL: | 106462769 106464168 106465504 106468050 106469604 106472169 |
LSAX: | 138946177 138949719 138955646 138975415 138980376 |
AIRR: | 138314302 138328387 138328388 |
MMER: | 123531218 123531219 |
RPHI: | 132715831 132733708 |
OSN: | 115216235 115224815 115224863 115228175 115230612 115230908 115231081 |
ATEN: | 116289350 116290469 |
MCAZ: | 138041512 138041535 138056361 |
MFOO: | 137967631 138007795 138010326 138010928 |
RES: | 135683303 135683304 135684283 135684287 |
» show all
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Reference |
|
Authors |
Shen RF, Tai HH. |
Title |
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung. |
Journal |
J Biol Chem 261:11592-9 (1986) |
Reference |
|
Authors |
Ullrich V, Haurand M. |
Title |
Thromboxane synthase as a cytochrome P450 enzyme. |
Journal |
Adv Prostaglandin Thromboxane Leukot Res 11:105-10 (1983) |
Other DBs |
ExplorEnz - The Enzyme Database: | 5.3.99.5 |
ExPASy - ENZYME nomenclature database: | 5.3.99.5 |
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