KEGG   ENZYME: 5.4.1.4
Entry
EC 5.4.1.4                  Enzyme                                 

Name
D-galactarolactone isomerase;
GLI
Class
Isomerases;
Intramolecular transferases;
Transferring acyl groups
Sysname
D-galactaro-1,5-lactone isomerase (D-galactaro-1,4-lactone-forming)
Reaction(IUBMB)
D-galactaro-1,5-lactone = D-galactaro-1,4-lactone [RN:R10846]
Reaction(KEGG)
R10846
Substrate
D-galactaro-1,5-lactone [CPD:C20889]
Product
D-galactaro-1,4-lactone [CPD:C20896]
Comment
The enzyme, characterized from the bacterium Agrobacterium fabrum strain C58, belongs to the amidohydrolase superfamily. It participates in the degradation of D-galacturonate.
History
EC 5.4.1.4 created 2015
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Orthology
K18982  D-galactarolactone isomerase
Genes
LEH: C3F35_03335
LAZ: A8A57_10890
SRZ: AXX16_3563
RBAD: H2866_21825
PPUD: DW66_2032
POR: APT59_07800
PCH: EY04_12420
PSW: LK03_17540
PPSL: BJP27_22685
CSA: Csal_2475
HEL: HELO_3406
HAM: HALO3642
SALN: SALB1_0469
CGD: CR3_4200
BTQ: BTQ_4276
BTJ: BTJ_5314
BTZ: BTL_3776
BTV: BTHA_4107
BTHE: BTN_3882
BTHM: BTRA_3773
BTHA: DR62_3924
BTHL: BG87_3732
BCN: Bcen_3836
BCJ: BCAM1714
BMUL: NP80_4821
BCT: GEM_3925
BLAT: WK25_27295
BTEI: WS51_01410
BPSL: WS57_05430
BPH: Bphy_6996
CABA: SBC2_07840(pmdD)
BPT: Bpet3816
BHM: D558_2746
ODI: ODI_R3125
POL: Bpro_4571
CTES: O987_17595
MES: Meso_1945
ATU: Atu3138
ATF: Ach5_29930(gli)
NEN: NCHU2750_21880(gli)
XAU: Xaut_3369
MNO: Mnod_8626
PHL: KKY_3039
ALB: AEB_P0145
SHUM: STHU_34000
 » show all
Reference
1  [PMID:24450804]
  Authors
Bouvier JT, Groninger-Poe FP, Vetting M, Almo SC, Gerlt JA
  Title
Galactaro delta-lactone isomerase: lactone isomerization by a member of the amidohydrolase superfamily.
  Journal
Biochemistry 53:614-6 (2014)
DOI:10.1021/bi5000492
  Sequence
[atu:Atu3138]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.1.4
IUBMB Enzyme Nomenclature: 5.4.1.4
ExPASy - ENZYME nomenclature database: 5.4.1.4
BRENDA, the Enzyme Database: 5.4.1.4

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