| Entry |
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| Name |
phosphoglucosamine mutase
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| Class |
Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)
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| Sysname |
alpha-D-glucosamine 1,6-phosphomutase
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| Reaction(IUBMB) |
alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate [RN: R02060]
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| Reaction(KEGG) |
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| Substrate |
alpha-D-glucosamine 1-phosphate [CPD: C06156]
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| Product |
D-glucosamine 6-phosphate [CPD: C00352]
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| Comment |
The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6-bisphosphate, which is an intermediate in the reaction, alpha-D-glucose 1,6-bisphosphate or ATP. It can also catalyse the interconversion of alpha-D-glucose 1-phosphate and glucose 6-phosphate, although at a much lower rate.
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| History |
EC 5.4.2.10 created 2001
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
| ec01130 | Biosynthesis of antibiotics |
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| Orthology |
| K03431 | phosphoglucosamine mutase |
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| Genes |
» show all
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| Reference |
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| Authors |
Mengin-Lecreulx D, van Heijenoort J. |
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| Title |
Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
De Reuse H, Labigne A, Mengin-Lecreulx D. |
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| Title |
The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Jolly L, Wu S, van Heijenoort J, de Lencastre H, Mengin-Lecreulx D, Tomasz A. |
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| Title |
The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphoglucosamine mutase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Jolly L, Ferrari P, Blanot D, Van Heijenoort J, Fassy F, Mengin-Lecreulx D. |
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| Title |
Reaction mechanism of phosphoglucosamine mutase from Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Jolly L, Pompeo F, van Heijenoort J, Fassy F, Mengin-Lecreulx D. |
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| Title |
Autophosphorylation of phosphoglucosamine mutase from Escherichia coli. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.4.2.10 |
| ExPASy - ENZYME nomenclature database: | 5.4.2.10 |
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