KEGG   ENZYME: 5.4.2.4
Entry
EC 5.4.2.4                  Enzyme                                 
Name
bisphosphoglycerate mutase;
diphosphoglycerate mutase;
glycerate phosphomutase;
bisphosphoglycerate synthase;
bisphosphoglyceromutase;
biphosphoglycerate synthase;
diphosphoglyceric mutase;
2,3-diphosphoglycerate mutase;
phosphoglyceromutase;
2,3-diphosphoglycerate synthase;
DPGM;
2,3-bisphosphoglycerate mutase;
BPGM;
diphosphoglyceromutase;
2,3-diphosphoglyceromutase
Class
Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)
Sysname
3-phospho-D-glycerate 1,2-phosphomutase
Reaction(IUBMB)
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate [RN:R01662]
Reaction(KEGG)
R01662
Substrate
3-phospho-D-glyceroyl phosphate [CPD:C00236]
Product
2,3-bisphospho-D-glycerate [CPD:C01159]
Comment
In the direction shown, this enzyme is phosphorylated by 3-phosphoglyceroyl phosphate, to give phosphoenzyme and 3-phosphoglycerate. The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. This enzyme also catalyses, slowly, the reaction of EC 5.4.2.11 [phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)] and EC 5.4.2.12 [phosphoglycerate mutase (2,3-diphosphoglycerate-independent)].
History
EC 5.4.2.4 created 1961 as EC 2.7.5.4, transferred 1984 to EC 5.4.2.4
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
Orthology
K01837  bisphosphoglycerate/phosphoglycerate mutase
Genes
HSA669(BPGM)
PTR463746(BPGM)
PPS100967755(BPGM)
GGO101148078(BPGM)
PON100445966(BPGM)
NLE100586238(BPGM)
MCC706741(BPGM)
MCF101925598(BPGM)
MTHB126949690
CSAB103226934(BPGM)
CATY105589610(BPGM)
PANU101022185(BPGM)
TGE112620672(BPGM)
RRO104655279(BPGM) 104657786
RBB108522539(BPGM)
TFN117073599(BPGM)
PTEH111524783(BPGM)
CJC100386672(BPGM)
SBQ101031409(BPGM)
CSYR103275724(BPGM)
MMUR105860194(BPGM)
LCAT123647165(BPGM)
OGA100956918(BPGM)
MMU12183(Bpgm)
MCAL110296243(Bpgm)
MPAH110316482(Bpgm)
RNO296973(Bpgm)
MCOC116098708(Bpgm)
MUN110561663(Bpgm)
CGE100757548(Bpgm)
MAUA101840847(Bpgm)
PLEU114691032(Bpgm)
MORG121463368(Bpgm)
MFOT126505296
AAMP119807579(Bpgm)
NGI103726061(Bpgm)
HGL101706859(Bpgm)
CPOC100722842(Bpgm)
CCAN109688796
DORD105989600(Bpgm)
DSP122099556(Bpgm) 122125320
NCAR124986309 124990814
OCU100009096(BPGM)
OPI101521357(BPGM)
TUP102496494(BPGM)
GVR103601037 103604804
CFA482704(BPGM)
CLUD112670467(BPGM)
VVP112908884(BPGM)
VLG121489532(BPGM)
AML100479620(BPGM)
UMR103678255(BPGM)
UAH113264369(BPGM)
UAR123788931(BPGM)
ELK111151975
LLV125081060
MPUF101674272(BPGM)
ORO101365932(BPGM)
EJU114211742(BPGM)
ZCA113911925(BPGM)
MLX118021113(BPGM)
NSU110582871(BPGM)
LWW102729597(BPGM)
FCA101095644(BPGM)
PYU121028302(BPGM) 121031877
PBG122488305(BPGM)
LRUF124524429
PTG102952979(BPGM)
PPAD109269034(BPGM)
AJU106975708(BPGM)
HHV120238873(BPGM)
BTA112447087 533785(BPGM)
BOM102270409 102275256 102275503 102285424
BIU109557654(BPGM)
BBUB102402470(BPGM)
BBIS104982297(BPGM)
CHX102187916(BPGM)
OAS101121089(BPGM)
ODA120878223(BPGM)
CCAD122438665(BPGM)
SSC106506774(BPGM)
CFR102514048(BPGM)
CBAI105063063(BPGM)
CDK105085404(BPGM)
VPC102540862(BPGM)
BACU103009787(BPGM) 103015640
LVE103089210(BPGM)
OOR101286738 101287641(BPGM)
DLE111178164(BPGM) 111178314
PCAD102985972(BPGM)
PSIU116759523(BPGM) 116764955
ECB100065115(BPGM)
EPZ103551316(BPGM)
EAI106830008(BPGM)
MYB102254057(BPGM)
MYD102772643(BPGM)
MMYO118666381(BPGM) 118676662
MLF102437274(BPGM)
MNA107544342(BPGM)
PKL118713079(BPGM)
HAI109389371(BPGM)
DRO112299894(BPGM)
SHON118989129(BPGM)
AJM119064246(BPGM)
PDIC114507744(BPGM)
PHAS123829765(BPGM)
MMF118619861(BPGM)
RFQ117018353(BPGM)
PALE102886645(BPGM)
PGIG120600999(BPGM)
PVP105291639(BPGM)
RAY107510540(BPGM)
MJV108396501(BPGM)
TOD119247218(BPGM)
SARA101557521(BPGM)
LAV100673907(BPGM)
TMU101360256
ETF101648579(BPGM)
DNM101418854(BPGM)
MDO100021814(BPGM)
GAS123249258(BPGM)
SHR100920227(BPGM)
PCW110219158(BPGM)
OAA100075920(BPGM)
GGA418172(BPGM)
PCOC116226884(BPGM)
MGP100546129(BPGM)
CJO107314945(BPGM)
NMEL110395716(BPGM)
APLA101803151(BPGM)
ACYG106030917(BPGM)
AFUL116501828(BPGM)
TGU100221163(BPGM)
LSR110482586(BPGM)
SCAN103820477(BPGM)
PMOA120501586(BPGM)
OTC121332759(BPGM)
PRUF121362704(BPGM)
GFR102033451(BPGM)
FAB101817641(BPGM)
PHI102108959(BPGM)
PMAJ107204390(BPGM)
CCAE111928156(BPGM)
CCW104692259(BPGM)
CBRC103624705(BPGM)
ETL114066474(BPGM)
ZAB102069397(BPGM)
ACHL103809151(BPGM)
FPG101915204(BPGM)
FCH102046661(BPGM)
CLV102089457(BPGM)
EGZ104134376(BPGM)
NNI104017943(BPGM)
PLET104624741(BPGM)
PCRI104026196(BPGM)
PCAO104045004(BPGM)
ACUN113491488(BPGM)
TALA104361469(BPGM)
PADL103924352(BPGM)
AFOR103898662(BPGM)
ACHC115352328(BPGM)
HALD104314996(BPGM)
HLE104830915(BPGM)
AGEN126048074
GCL127029695
CCRI104162724(BPGM)
CSTI104551983(BPGM)
EHS104516903(BPGM)
CMAC104480596(BPGM)
MUI104535330(BPGM)
FGA104072180(BPGM)
GSTE104252617(BPGM)
LDI104341706(BPGM)
MNB103768831(BPGM)
OHA104337122(BPGM)
NNT104404033(BPGM)
DPUB104304682(BPGM)
PGUU104469551(BPGM)
ACAR104529043(BPGM)
CPEA104384749 104393436(BPGM)
AVIT104272414(BPGM)
CVF104281617(BPGM)
CUCA104064597(BPGM)
TEO104371170(BPGM)
BRHI104489910(BPGM)
AAM106488955(BPGM)
AROW112968285(BPGM)
NPD112945515(BPGM)
TGT104573508(BPGM)
DNE112993366(BPGM)
SCAM104147258(BPGM)
ASN102373803(BPGM)
AMJ102568684(BPGM)
CPOO109316438(BPGM)
GGN109296253(BPGM)
PSS102447629(BPGM)
CMY102946921(BPGM)
CPIC101941911(BPGM)
TST117882902(BPGM)
CABI116835612(BPGM)
MRV120380589(BPGM)
ACS100564984(bpgm)
PVT110088825(BPGM)
SUND121930490(BPGM)
PBI103062795(BPGM)
PMUR107294354(BPGM)
CTIG120319426(BPGM)
TSR106545025(BPGM)
PGUT117655757(BPGM)
VKO123036382(BPGM)
PMUA114605263(BPGM)
ZVI118091307(BPGM)
GJA107125358(BPGM)
STOW125435616(BPGM)
XLA444102(bpgm.L) 444279(bpgm.S)
XTR549353(bpgm)
NPR108792024(BPGM)
RTEM120932636(BPGM)
BBUF121007153(BPGM)
BGAR122928322(BPGM)
DRE436903(bpgm)
SRX107716700 107753699
SANH107661509
SGH107576414 107590805
CAUA113043324 113066900
PPRM120469137(bpgm)
MAMB125247216(bpgm)
IPU108269072(bpgm)
PHYP113529410(bpgm)
SMEO124386517(bpgm)
TFD113635654(bpgm)
AMEX103029505(bpgm)
EEE113579716(bpgm)
TRU101074347(bpgm)
TNGGSTEN00029715G001
LCO104940663(bpgm)
NCC104946798(bpgm)
CGOB115010217(bpgm)
ELY117261671(bpgm)
EFO125887994(bpgm)
PLEP121950612(bpgm)
SLUC116038699(bpgm)
ECRA117949451(bpgm)
ESP116693930(bpgm)
PFLV114560377(bpgm)
GAT120809117(bpgm)
PPUG119196237(bpgm)
MSAM119893483(bpgm)
CUD121515662(bpgm)
ALAT119023925(bpgm)
MZE101473870(bpgm)
ONL100708072(bpgm)
OAU116332722(bpgm)
OLA101172407(bpgm)
OML112152318(bpgm)
XMA102233730(bpgm)
XCO114133815(bpgm)
XHE116708874(bpgm)
PRET103465823(bpgm)
PFOR103134420(bpgm)
PLAI106945301(bpgm)
PMEI106929157(bpgm)
GAF122835778(bpgm)
CVG107095033(bpgm)
CTUL119799137(bpgm)
GMU124879263(bpgm)
NFU107388481(bpgm)
KMR108229885(bpgm)
ALIM106525486(bpgm)
NWH119416394(bpgm)
AOCE111567052(bpgm)
MCEP125015235(bpgm)
CSEM103380563(bpgm)
POV109623942(bpgm)
SSEN122775377(bpgm)
HHIP117763052(bpgm)
HSP118110035(bpgm)
LCF108888560
SDU111229658(bpgm)
SLAL111651502(bpgm)
XGL120793177(bpgm)
HCQ109530859(bpgm)
BPEC110169450(bpgm)
MALB109951197(bpgm)
BSPL114857824(bpgm)
SASA100196266(pmge) 106561646
STRU115152372 115197620
OTW112218898 112252694
OMY110500043 110524766
OGO124004499 124032856(bpgm)
ONE115109699(bpgm) 115115104
SALP111952995 111962766
SNH120053540 120066779
CCLU121531280 121577059
ELS105021856(bpgm)
SFM108920769 108931367
PKI111843107 111854613
AANG118219313 118232037(bpgm)
LOC102690514(bpgm)
PSPA121318552 121319494
ARUT117415332 117419669
PSEX120539400(bpgm)
LCM102350982(BPGM)
CMK103185559(bpgm)
RTP109927982(bpgm)
 » show all
Reference
1
  Authors
Ray, W.J., Jr. and Peck, E.J., Jr.
  Title
Phosphomutases.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.
Reference
2  [PMID:5687724]
  Authors
Rose ZB.
  Title
The purification and properties of diphosphoglycerate mutase from human erythrocytes.
  Journal
J Biol Chem 243:4810-20 (1968)
Reference
3  [PMID:6255773]
  Authors
Rose ZB.
  Title
The enzymology of 2,3-bisphosphoglycerate.
  Journal
Adv Enzymol Relat Areas Mol Biol 51:211-53 (1980)
DOI:10.1002/9780470122969.ch5
Other DBs
ExplorEnz - The Enzyme Database: 5.4.2.4
IUBMB Enzyme Nomenclature: 5.4.2.4
ExPASy - ENZYME nomenclature database: 5.4.2.4
BRENDA, the Enzyme Database: 5.4.2.4
CAS: 37211-69-1

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