KEGG   ENZYME: 5.4.2.9
Entry
EC 5.4.2.9                  Enzyme                                 
Name
phosphoenolpyruvate mutase;
phosphoenolpyruvate-phosphonopyruvate phosphomutase;
PEP phosphomutase;
phosphoenolpyruvate phosphomutase;
PEPPM;
PEP phosphomutase
Class
Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)
Sysname
phosphoenolpyruvate 2,3-phosphonomutase
Reaction(IUBMB)
phosphoenolpyruvate = 3-phosphonopyruvate [RN:R00661]
Reaction(KEGG)
R00661
Substrate
phosphoenolpyruvate [CPD:C00074]
Product
3-phosphonopyruvate [CPD:C02798]
Comment
Involved in the biosynthesis of the C-P bond, although the equilibrium greatly favours phosphoenolpyruvate.
History
EC 5.4.2.9 created 1990
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K01841  phosphoenolpyruvate phosphomutase
K23999  phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase
Genes
ZNE110838650
CSEC111872613
SGRE126354574
IEL124163496
FCD110846421
PPOI119098639
LGILOTGIDRAFT_228330
PVUL126825161
PCAN112561240
BGT106079080
GAE121367841
CRG105327128 117692442
CVN111099182
CANU128188098
OED125656041
MYI110459395
PMAX117333732
MCAF127712173
MMER123533891
RPHI132747811
DPOL127852662
MAEA128230325
OBI106868978
OSN115222540
LJP135476734
LAK106181605
NVE5508858
EPA110252232
ATEN116289673
ADF107334552
AMIL114960205
PDAM113681042
SPIS111330077
DGT114532990
XEN124434290
HMG100204901
HSY130623412
TMNUCRPA7_8548
FPOAFPOAC1_006409
FFCNCS54_01075000
FKRNCS57_01069000
FMUJ7337_007851
PSCOLY89DRAFT_26512
TETTTHERM_00022810
PTMGSPATT00017928001 GSPATT00022184001
TCR508851.189 511589.140
HDEHDEF_0203
BSELRHD99_08490(aepX)
SRLSOD_c30090(bcpB)
FSMCCS41_00895(aepX)
ECAECA0487(fom1)
PATREV46_02520
PATOGZ59_05030(fom1)
PCTPC1_0476
PCCPCC21_005010
PWAPecwa_0572
PPARA8F97_15530
PECW5S_0590
PWSA7983_10780
PPOABJK05_19415
PPUJE2566_02925(aepX)
PARII2D83_19365(aepX)
PPAVLOZ86_04705(aepX)
PCACOI450_03795(aepX)
PRODPCO85_08040
LBQCKQ53_06560(aepX)
LPOPI6N93_15650(aepX)
SODSant_3984(pepM)
EPECI789_05510(aepX)
PAMPANA_3291(pepM)
PLFPANA5342_0777(pepM) PANA5342_2583
PAQPAGR_g0790 PAGR_g3818
MHANK6958_19855(aepX)
PLUplu1865
PLUMA4R40_09345
XBVXBW1_2042
XDOXDD1_1002(PEPM)
EICNT01EI_2703
XVAC7V42_03530(aepX)
XHYFZ025_12110(aepX)
XDYNYR95_03920(aepX)
VFIVF_1249
PMOSO165_002420
PSYRN018_11280
PTREI9H09_23690(aepX)
PASTN015_19680(aepX)
PFLPFL_2141(aepX)
PPRCPFLCHA0_c21830(pphA)
PPROPPC_2159(aepX)
PFCPflA506_4617(aepX)
PPZH045_01960
PTOLI7845_10730
PENPSEEN3956
PSOSPOS17_2086(aepX)
PVWHU752_022625(aepX)
PANHHU763_013985(aepX)
PNBNK667_06950(aepX)
SDNSden_1161
PMAWMACH26_33050
OSGBST96_06905
NOCNoc_1317
NHLNhal_1306
NWANwat_1199
NWRE3U44_16825(aepX)
NTGNSCAC_0558
ZPLZBT109_1640
MPRFJ8N69_05410(aepX)
CHICN8I74_01985
RPJN234_04640
RMERmet_1808(pepM)
CBWRR42_s0339
CCUPBKK81_29240
CUPBKK80_27115
CUUBKK79_33035
CPAUEHF44_14440(aepX)
COXE0W60_18815(aepX)
CCAMM5D45_07525(aepX)
BMABMAA1768(pepM)
BMVBMASAVP1_0758(pepM)
BMLBMA10229_1051(pepM)
BMNBMA10247_A2026(pepM)
BMALDM55_4014(aepX)
BMAQDM76_4710(aepX)
BMAIDM57_07165
BMAFDM51_3461(aepX)
BMAZBM44_3974(aepX)
BMABBM45_4751(aepX)
BPSBPSS0509 BPSS0610
BPMBURPS1710b_A2065(pepM)
BPLBURPS1106A_A0691(pepM) BURPS1106A_A0818
BPDBURPS668_A0780 BURPS668_A0910
BPSEBDL_3735(aepX) BDL_3837(aepX)
BPSMBBQ_5585(aepX) BBQ_5687(aepX)
BPSUBBN_3909(aepX) BBN_4009(aepX)
BPSDBBX_5572(aepX) BBX_5674(aepX)
BPZBP1026B_II0564 BP1026B_II0674
BPQBPC006_II0735 BPC006_II0866
BPKBBK_3881(aepX) BBK_5714(aepX)
BPSHDR55_4742(aepX) DR55_4843(aepX)
BPSABBU_5436(aepX) BBU_5538(aepX)
BPSOX996_3790(aepX) X996_4593(aepX)
BUTX994_4009(aepX) X994_4111(aepX)
BTEBTH_II1908
BTQBTQ_5190(aepX)
BTJBTJ_3820(aepX)
BTZBTL_4576(aepX) BTL_4676(aepX)
BTDBTI_5338(aepX) BTI_5422
BTVBTHA_5553(aepX)
BTHEBTN_4315(aepX)
BTHMBTRA_4580(aepX)
BTHADR62_4261 DR62_4364
BTHLBG87_4647(aepX)
BOKDM82_2520(aepX) DM82_4611(aepX) DM82_4705(aepX) DM82_5468(aepX)
BOCBG90_2213(aepX) BG90_5140(aepX) BG90_5888(aepX) BG90_5980(aepX)
BUUWS70_20055 WS70_24280
BSAVWS86_03985 WS86_21240 WS86_21655
BHGI6G56_25495(aepX)
BUDAQ610_28100
BVIBcep1808_4687
BVEAK36_4232(aepX)
BURBcep18194_B1914
BCMBcenmc03_3398
BCHBcen2424_4121
BCJBCAM1245
BCENDM39_3753(aepX)
BCEWDM40_4163(aepX)
BCEOI35_5094
BAMBamb_3535
BACBamMC406_4016
BMJBMULJ_04039
BMUBmul_4471
BMKDM80_3632(aepX)
BMULNP80_4148(aepX)
BCTGEM_4495
BCEDDM42_3846(aepX)
BCEPAPZ15_18450
BDLAK34_4230(aepX)
BPYRABD05_29915
BCONNL30_06370
BUBBW23_4919(aepX)
BDFWI26_19325
BLATWK25_23150
BTEIWS51_03920
BSEMWJ12_26085
BPSLWS57_07790
BMECWJ16_24710
BSTGWT74_17330 WT74_25015
BANNJFN94_23430(aepX)
BARINLX30_32410(aepX)
BAENL3V59_19235(aepX)
BGLbglu_2g13460
BGUKS03_4595(aepX)
BUGBC1001_5203
BGFBC1003_4280
BGDbgla_2g13360
BGOBM43_5003(aepX)
BYIBYI23_A006810
BUKMYA_4542
BUEBRPE67_ACDS06750
BULBW21_5018(aepX)
BUQAC233_24010
BGPBGL_2c11770
BPLAbpln_2g12610
BUMAXG89_10160
BUIAX768_03885
BURKDM992_19615(aepX)
BXEBxe_B2235
BXBDR64_4566(aepX)
BPHBphy_3822
BGEBC1002_3393
BPXBUPH_05878
BPYBphyt_5999
BUZAYM40_23410
BFNOI25_4536(aepX)
BCAIK788_0000151
PSPWBJG93_18660(aepX)
PARABTO02_27435
PARBCJU94_32420(aepX)
PHSC2L64_30760(aepX)
PTERC2L65_27420(aepX)
PGPCUJ91_19555(aepX)
PCJCUJ87_30240(aepX)
PTSCUJ90_26940(aepX)
PCAFDSC91_002024
PMEGFNZ07_08530(aepX)
PTROG5S35_19400(aepX)
PGISI6I06_19275(aepX)
PACPFAZ97_15190(aepX)
PACSFAZ98_20205(aepX)
PEWKZJ38_30035(aepX)
PDIOPDMSB3_0865.1
PBRYNDK50_32650(aepX)
PSAAQEN71_14455(aepX)
PKFRW095_12000(aepX)
PBONQS306_15245(aepX)
PPAIE1956_23915(aepX)
BRHRBRH_02824
PPKU875_16965
PPNODA70_09035
PPNMLV28_21770
PRBX636_17455
PPULRO07_15785 RO07_16160
PSPUNA29_20990
PAPISG18_00140
PVEUC34_07420
POXMB84_11760
PFGAB870_18110
PNRAT302_26645
PANDDRB87_06680(aepX)
PFIBPI93_020425(aepX)
PCOMNTU39_08430(aepX)
CABASBC2_10680(prpB_1)
BUOBRPE64_ACDS07730
CABKNK8_07530(aepX)
TCARU0034_22530(aepX)
BPARBN117_3742(pepM)
BBHBN112_2401(pepM)
BBRBB1046(pepM)
BBMBN115_0996(pepM)
BBXBBS798_1016(pepM)
BHOD560_3796
BHMD558_3769
BHZACR54_02067(pphA_1)
BBROBAU06_01990
BPDZBBN53_11400
AXYAXYL_04811
AXONH44784_064211
AXNAX27061_4661
AXXERS451415_04691(pphA_2)
ADTAPT56_21465
AISBUW96_13040
ACHRC2U31_15990
ACHBDVB37_20080
APESFOC84_21880
AAEGRA224_08265
AFAUZ73_10460
AFQAFA_00195
AAQUD3M96_00180
AAMMFE795_00160
PHNPAEH1_00300
PARKLSG25_17940
AAVAave_3887
AAAAcav_2122
RDPRD2015_687
TCTPX653_18275(aepX)
ETBN7L95_23020(aepX)
MEUACJ67_08960
AZOazo2698(pepM)
AOAdqs_2833
MLOmlr5882 mlr9115
MLNA9174_32585
MESPC1M53_20905 C1M53_20975(aepX)
MJREB229_33300(aepX)
MERDEB233_30950(aepX)
MOHIHQ72_34585(aepX)
AMISAmn_10680
PHTBLM14_26360
PHYLHB779_09245
SMKSinme_5760 Sinme_6918
EAKEKH55_5861
EMXFKV68_24015(aepX)
ENUPYH37_006200(aepX)
EGIPZN02_005971(aepX)
STEGQA637_30210(aepX)
AVIAvi_3412
REPIE4803_PB00125
RTRRTCIAT899_PB01485
RJGCCGE525_35255(aepX)
AOLS58_09510
BRCBCCGELA001_29045
BICLMTR13_25005 LMTR13_25105
BGQX265_36095(aepX)
BGZXH91_35300(aepX)
BARHWN72_10290(aepX) WN72_10315
BVZBRAD3257_7243(bcpB)
BAUTQA635_32650(aepX)
BBRAQA636_34260(aepX)
BXNI3J27_33275(aepX)
BROSQUH67_10075(aepX)
BRAZLRP30_31375(aepX) LRP30_31545(aepX)
RPCRPC_3871
SIWGH266_09715(aepX)
THAACFI11_00245(aepX)
RGIRGI145_09790
ROSCTJ15_07640(aepX)
RMUCFOB66_09665(aepX)
RMTIAI58_18640(aepX)
LCKHN018_01540(aepX)
SHUMSTHU_42930(pepM)
SVCSTVA_42000(pepM)
STELSTAQ_05370(pepM)
AZZDEW08_28020(aepX)
MAGXXM1_0907(pepM)
TMOTMO_b0348
ECOGFIV45_08000(aepX)
SNEANBZ79_03295(aepX)
HCPHCN_1062
HCBHCBAA847_0912
HWIA0Z60_07480(aepX)
CJUC8J_1331
CHYOCHH_1593
CHWA2J15_004815(aepX)
CINFCINF_1344
AFCAFAEC_0069 AFAEC_0075
ANTArnit_2943
NSANitsa_1412
PCAPcar_0628
PACEA6070_12585
PPDPpro_2167
DLMDPPLL_12490
DAKDaAHT2_1860
DALDalk_1323
DAODesac_2268
SCLsce7305(pepM)
SCUSCE1572_42550
MRMA7982_08317
LLUAKJ09_10387
BSTOC0V70_16040(aepX)
BSSBSUW23_01000(rhiH)
BITBIS30_11520
BYABANAU_0589(pepM)
BQYMUS_0647
BAMBBAPNAU_0598(pepM)
BMPNG74_00659(pphA)
BCABEFK13_01325(aepX)
BRYM0696_19605(aepX)
BACIB1NLA3E_03305
BACBOY17_06005
BMQBMQ_0784(aepX)
BMDBMD_0785(aepX)
BMHBMWSH_4464
BMEGBG04_3078(aepX)
PARHI5S86_23670(aepX)
PTBDER53_11735(aepX)
PCALBV455_03446(pphA)
VPTKBP50_14610
MEKUHUW50_16405(aepX)
BOUI5818_22340(aepX)
SLMSMM221_05175(aepX)
BLRBRLA_c034010
BRWGOP56_09095(aepX)
PPYPPE_04396 PPE_04791
PPOLX809_41430
PTAHPL003_06765
PLVERIC2_c18340(bcpB) ERIC2_c19750(pphA)
PIHUB51_20100 UB51_20630
PPEOABE82_25180
PKBB4V02_00175 B4V02_16725
PAIHASL14_12565
PLUTEI981_13655(aepX)
PCHIPC41400_18315(aepX)
PTHINDS46_01335(aepX)
PKAPQ456_19760(aepX)
PNKAASFL403_21920
ADAUNZD86_21650(aepX)
TUMCBW65_17945
TABCIG75_00855(aepX) CIG75_11125(aepX)
EFFskT53_29670
SURLBI350_13790
STHOQNH10_07760(aepX)
KEBGXN75_05285(aepX)
PABSJIR001_16510
CTCCTC_01698
CTETBN906_01840
CBJH04402_02796
CBECbei_4338
CBZCbs_4338
CBEILF65_04862
CSRCspa_c46190(ppm)
CSBCLSA_c08730(ppm)
CBUTATN24_05940
CARGRSJ17_12820
CDYF3K33_22185(aepX)
CCAAKQH81_02885(aepX)
CNNCNEO_1087(ppm)
CGELpsyc5s11_47370
HHJNQ487_01265(aepX) NQ487_01315(aepX)
RALRumal_1340
RCHRUM_11420
ALACJYE50_12220(aepX) JYE50_12300(aepX)
AHCJYE49_12525(aepX)
BPENNQ488_09095(aepX)
CBAFJS518_12300(aepX) JS518_12380(aepX)
RIXRO1_19910
RRKH8S51_002390(aepX)
CLEClole_3577
HASHalsa_0038
SSGSelsp_0338
SELEADJ74_04700
SELOAXE86_05255
SELTBCS37_10905
SDIAQU667_11285(aepX)
STIMH1B31_02600(aepX)
LCGL3BBH23_02720
OLSOlsu_0594
NBRO3I_021395
NTPCRH09_19455
NOZDMB37_07995
NAHF5544_23990
SDVBN159_4099(pphA)
SALSSLNWT_1191
SCIB446_27570
STRTA8713_00495
SGSAVL59_02540 AVL59_12480 AVL59_31615
SALWCP975_03135
SVUB1H20_34190
SALFSMD44_04407(pepM)
SGDELQ87_04600(aepX)
SSPODDQ41_14920
SRIMCP984_37460(aepX)
SPHVF9278_14905
STSUB7R87_30300
SATAC5746_04685
SCHFIPT68_10945
SDWK7C20_15030
SCALI6J39_33920
SPEUCGZ69_10215
SROIIAG44_40255
SDDD9753_30290
SCIRSTRCI_003017
SCHGNRO40_23745
STTNBSL84_13975
SINNABB07_09595
KBUQ4V64_24610
KSKKSE_22660
KABB7C62_03680
STRIC7M71_015100
LSEF1C12_11070
RTXTI83_02260
RTCAPU90_04215
ARHAHiyo8_pI68760
CELHGXP71_14045
TESBW730_00185
SAIUJ4H86_04280(aepX)
FRAFrancci3_1533
FALFRAAL6377
AMYCCU254_05890
AMYYYIM_29505(pphA)
APRTMUY14_07205
APRECNX65_16920
SSYIEKG83_20790
KALKALB_5539
KUTJJ691_31290
ACTAC1701_23200(aepX)
SAQSare_1956
MPRNQ3V37_07920
ACTLL3i22_084340
ASICQ0Z83_111400
AOUACTOB_005081(aepX)
DAURDaura_24720
NHYJQS43_02325(aepX)
CCAZCOUCH_33540
SNASnas_5665
NAVJQS30_13655(aepX)
ARDAXF14_02085
AYMYM304_30130
ARPNIES39_A00310
MPROBJP34_15505
NEDHUN01_29215(aepX)
MDPNIES3275_60670
TOQHCG51_21875(aepX)
SCYTSAMD_46620
NCNBZZ01_05235
LMAJGKN94_04170(aepX)
OBGVerru16b_03222(pphA)
ELUTCKA38_13745(aepX)
TDETDE_1413
TBETrebr_0279
TPITREPR_2364
TPKJO40_09715
TPHGFUT81_06855(aepX)
TRIDYE50_04590(aepX)
TPAVHRQ91_06190(aepX)
TSKHRI97_05665(aepX)
BPAAK7I13_01580(aepX)
SSMSpirs_4230
STASTHERM_c15610
HPRIP0082_09550(aepX)
SBUSpiBuddy_0272
SGPSpiGrapes_1560
TAZTREAZ_2217
SCDSpica_1331
BHCJFL75_01540(aepX)
TPXTurpa_2340
FSUFisuc_0993
FSCFSU_1439
BTHBT_1720
BTHOBtheta7330_01295(pphA)
BFRBF1832 BF2578
BFSBF9343_1814(aepX)
BFGBF638R_1867
BUNBun01g_29040
BEGINE88_02862
BSTEK6V31_00385(aepX)
BDOEL88_10435
PCOILK433_14490(aepX)
DRCG0Q07_19260(aepX)
PGJQG516_04645
FUVJR347_10760(aepX)
RCGN7E81_15220(aepX)
FAXFUAX_43910
NDENIDE2903
NMVNITMOv2_0598(pepM)
NIONITINOP_0319
NJANSJP_1710
NKFNkreftii_001262
NIFW02_05720(pepM)
NTIDNFV4_01001
NALLPP769_10810(aepX)
NNEOPQG83_01550(aepX)
NLIG3M70_12635(aepX)
NVAG3M78_13645(aepX)
METBAW729_03845
TARTALC_00083
NMRNmar_0160
NZTNZOSNM25_001929
NCTNMSP_0156
NIUDSQ19_09555
LOBNEF87_004219
PSYTDSAG12_01622(ribL_1)
ARGQT11_C0001G0509
 » show all
Reference
1
  Authors
Bowman, E., McQueney, M., Barry, R.J. and Dunaway-Mariano, D.
  Title
Catalysis and thermodynamics of the phosphoenolpyruvate phosphonopyruvate rearrangement - entry into the phosphonate class of naturally-occurring organo-phosphorus compounds.
  Journal
J Am Chem Soc 110:5575-5576 (1988)
Reference
2  [PMID:2160937]
  Authors
Hidaka T, Imai S, Hara O, Anzai H, Murakami T, Nagaoka K, Seto H
  Title
Carboxyphosphonoenolpyruvate phosphonomutase, a novel enzyme catalyzing C-P bond formation.
  Journal
J Bacteriol 172:3066-72 (1990)
DOI:10.1128/JB.172.6.3066-3072.1990
Reference
3  [PMID:3138545]
  Authors
Seidel HM, Freeman S, Seto H, Knowles JR
  Title
Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon-phosphorus bond.
  Journal
Nature 335:457-8 (1988)
DOI:10.1038/335457a0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.4.2.9
IUBMB Enzyme Nomenclature: 5.4.2.9
ExPASy - ENZYME nomenclature database: 5.4.2.9
BRENDA, the Enzyme Database: 5.4.2.9
CAS: 115756-49-5

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