KEGG ENZYME: 5.4.3.9

ENZYME: 5.4.3.9

Entry

EC 5.4.3.9                  Enzyme

Name

glutamate 2,3-aminomutase

Class

Isomerases;
Intramolecular transferases;
Transferring amino groups

Sysname

L-glutamate 2,3-aminomutase

Reaction(IUBMB)

L-glutamate = 3-aminopentanedioate [RN:R10153]

Reaction(KEGG)

R10153

Substrate

L-glutamate [CPD:C00025]

Product

3-aminopentanedioate [CPD:C05574]

Comment

This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster, which is coordinated by 3 cysteines and binds an exchangeable S-adenosyl-L-methionine molecule. During the reaction cycle, the AdoMet forms a 5'-deoxyadenosyl radical, which is regenerated at the end of the reaction.

History

EC 5.4.3.9 created 2012

Orthology

K19814

glutamate 2,3-aminomutase

Genes

DFL:	DFE_1413(kamA)

PNW:

SYK_01640

DESU:

NLA06_00180

DLM:	DPPLL_04560

CCB:	Clocel_2678

CACE:

CACET_c07510(kamA1)

CFM:	BJL90_09905

CSEP:

CP523_02425(eam)

OCW:	OW730_21130(eam)

PROQ:

P6M73_07410

HSC:	HVS_09740(eam)

CSS:	Cst_c09560(kamA1)

CSD:

Clst_0916

SWO:

Swol_1121

SLP:

Slip_1437

SALQ:

SYNTR_0636

DSY:

DSY4027

DHD:

Dhaf_1337

DDH:	Desde_0983 Desde_1272

DDL:	Desdi_1057

DMT:	DESME_03065 DESME_04100

SGY:

Sgly_2707

DOR:	Desor_0517

DAI:	Desaci_0733

DMI:	Desmer_0614

DED:	DHBDCA_p1654

DEC:	DCF50_p1663

DRS:	DEHRE_12100

DCA:	Desca_1530

PTH:	PTH_0616(KamA)

DRM:

Dred_2148

DRU:	Desru_1637

DFG:	B0537_10675

DAE:	Dtox_0599 Dtox_2931

DKU:	Desku_1193

DAU:

Daud_1068

TJR:	TherJR_1812

DGI:	Desgi_3039

ALKA:

J0B03_02685

ACAE:

HYG86_17310(eam)

CTHM:

CFE_1096 CFE_1097

CSH:	Closa_2267

AMT:

Amet_2738

PBIF:

KXZ80_10945(eam)

PSOR:

RSJ16_12680

CDF:	CD630_22520(kamA)

PDC:	CDIF630_02487(eam)

CDC:	CD196_2109(kamA)

CDL:	CDR20291_2152(kamA)

PDF:	CD630DERM_22520(kamA)

ROC:	HF520_03610(eam)

TEB:	T8CH_0897(eam)

THYR:

P4S50_12610(eam)

TTE:	TTE1204(KamA2)

CHY:

CHY_2479

ADG:

Adeg_1408

TPZ:	Tph_c22230(kamA)

GEK:	kuro4_08900 kuro4_08940

MTA:

Moth_0457

MTHO:

MOTHE_c03930(eam)

MTHZ:

MOTHA_c04820(eam)

NTH:	Nther_1768

NCD:	ACONDI_00898(eam_2)

CSC:

Csac_0232

ATE:

Athe_2274

COB:	COB47_2039

CHD:	Calhy_0483

COW:	Calow_1972

CKI:	Calkr_2290

CLC:	Calla_0160

CKN:	Calkro_0356

CCHA:

ELD05_01180(eam)

CDIA:

CaldiYA01_03110(eam)

CNAG:

OTJ99_002263(eam)

CMOR:

OTK00_000190(eam)

CDAN:

SOJ16_002405(eam)

MHAP:

JFY71_03305

CAD:	Curi_c04320(kamA)

CAZO:

G3A45_02895(eam)

CALK:

HUE98_06730(eam)

XCL:	G4Z02_00090

MMIL:

sm9_1912

MEYE:

TL18_07795

MEZ:

Mtc_0931

» show all

Reference

1 [PMID:17222594]

Authors

Ruzicka FJ, Frey PA

Title

Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes.

Journal

Biochim Biophys Acta 1774:286-96 (2007)
DOI:10.1016/j.bbapap.2006.11.008

Sequence

[cdf:CD630_22520]

Other DBs

ExplorEnz - The Enzyme Database:

5.4.3.9

IUBMB Enzyme Nomenclature:

5.4.3.9

ExPASy - ENZYME nomenclature database:

5.4.3.9

BRENDA, the Enzyme Database:

5.4.3.9

DBGET integrated database retrieval system