KEGG   ENZYME: 5.4.4.4Help
Entry
EC 5.4.4.4                  Enzyme                                 

Name
geraniol isomerase
Class
Isomerases;
Intramolecular transferases;
Transferring hydroxy groups
BRITE hierarchy
Sysname
geraniol hydroxymutase
Reaction(IUBMB)
geraniol = (3S)-linalool [RN:R09708]
Reaction(KEGG)
Substrate
geraniol [CPD:C01500]
Product
(3S)-linalool [CPD:C11389]
Comment
In absence of oxygen the bifunctional linalool dehydratase-isomerase can catalyse in vitro two reactions, the isomerization of (3S)-linalool to geraniol and the hydration of myrcene to (3S)-linalool, the latter activity being classified as EC 4.2.1.127, linalool dehydratase.
History
EC 5.4.4.4 created 2011, modified 2012
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20614  linalool dehydratase / geraniol isomerase
Genes
CDN: BN940_14136
Taxonomy
Reference
1  [PMID:20663876]
  Authors
Brodkorb D, Gottschall M, Marmulla R, Luddeke F, Harder J
  Title
Linalool dehydratase-isomerase, a bifunctional enzyme in the anaerobic degradation of monoterpenes.
  Journal
J Biol Chem 285:30436-42 (2010)
DOI:10.1074/jbc.M109.084244
  Sequence
Reference
2  [PMID:21950166]
  Authors
Luddeke F, Harder J
  Title
Enantiospecific (S)-(+)-linalool formation from beta-myrcene by linalool dehydratase-isomerase.
  Journal
Z Naturforsch C 66:409-12 (2011)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.4.4.4
IUBMB Enzyme Nomenclature: 5.4.4.4
ExPASy - ENZYME nomenclature database: 5.4.4.4
BRENDA, the Enzyme Database: 5.4.4.4

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