KEGG   ENZYME: 5.4.99.13
Entry
EC 5.4.99.13                Enzyme                                 
Name
isobutyryl-CoA mutase;
isobutyryl coenzyme A mutase;
butyryl-CoA:isobutyryl-CoA mutase;
icmA (gene name);
icmB (gene name);
icmF (gene name)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
2-methylpropanoyl-CoA CoA-carbonylmutase
Reaction(IUBMB)
2-methylpropanoyl-CoA = butanoyl-CoA [RN:R01181]
Reaction(KEGG)
R01181
Substrate
2-methylpropanoyl-CoA [CPD:C00630]
Product
butanoyl-CoA [CPD:C00136]
Comment
This bacterial enzyme utilizes 5'-deoxyadenosylcobalamin as a cofactor. Following substrate binding, the enzyme catalyses the homolytic cleavage of the cobalt-carbon bond of AdoCbl, yielding cob(II)alamin and a 5'-deoxyadenosyl radical, which initiates the the carbon skeleton rearrangement reaction by hydrogen atom abstraction from the substrate. At the end of each catalytic cycle the 5'-deoxyadenosyl radical and cob(II)alamin recombine, regenerating the resting form of the cofactor. The enzyme is prone to inactivation resulting from occassional loss of the 5'-deoxyadenosyl molecule. Inactivated enzymes are repaired by the action of EC 2.5.1.17, cob(I)yrinic acid a,c-diamide adenosyltransferase, and a G-protein chaperone, which restore cob(II)alamin (which is first reduced to cob(I)alamin by an unidentified reductase) to 5'-deoxyadenosylcobalamin and load it back on the mutase. Some mutases are fused with their G-protein chaperone. These enzyme can also catalyse the interconversion of isovaleryl-CoA with pivalyl-CoA.
History
EC 5.4.99.13 created 1992, revised 2017
Orthology
K11942  isobutyryl-CoA mutase
K25820  isobutyryl-CoA mutase large subunit
K25821  isobutyryl-CoA mutase small subunit
Genes
XSASB85_06415
XTNFD63_05995
XHYFZ025_21135
SACZAOT14_13180
STEKAXG53_11455
PSUPsesu_1629
PSUWWQ53_15300
PMEXH4W19_02735
PJPLAG73_09255
PDDMNQ95_13880
LABLA76x_3173
LAQGLA29479_11
LCPLC55x_3186
LGULG3211_2045
LEZGLE_1980(mutA)
LEMLEN_3025(mcmA)
LMBC9I47_1876
LYTDWG18_07850
LUEDCD74_05100
LYJFKV23_09940
LSOLGOY17_11865
LSXH8B22_13715
LAREHIV01_006775
LHXLYSHEL_00670(icmF)
LCASLYSCAS_00670(icmF)
LCICINQ41_05610
LAVIINQ42_05400
LUMCNR27_08725
LUSE5843_06665
LUGFPZ22_12140
THESFHQ07_02235
THEHG7079_08935
TCNH9L16_14330
TBVH9L17_15425
RHDR2APBS1_2554
RGLCS053_06510
RTHLRK53_13330
DJICH75_13680
DJAHY57_09880
DTXATSB10_15140
DYEEO087_07010
DCSISN74_05190
DTLH8F01_16425
DKOI596_1202
LRZBJI69_01070
LPYFIV34_14745
XBAC7S18_04395
RBDALSL_1829
COZA3Q34_16635
COLWA3Q33_00100
COLADBO93_10845
COVEKO29_12680
CBERB5D82_06105
MVSMVIS_1782
MYAMORIYA_0502(icmF)
MMAAFR932_08340
CYQQ91_1545
CZACYCME_0915
CYYCPC19_05135
BLEPAL038_14760
NOCNoc_1893
NHLNhal_2497
NWRE3U44_09670
WMAWM2015_1236
WOCBA177_11785
BMARHF888_09960
SDFACG33_02015
SOKD0B54_09445
FCEJN531_006670
GBIPG2T_03725
SEDSAAY24_02515
PSPIPS2015_869
VFFVITFI_CDS1175
RSORSc0237
RSCRCFBP_21252
RSLRPSI07_3174
RSNRSPO_c03163(sbm)
RSMCMR15_30709
RSEF504_254
RSYRSUY_30420(mutB)
RPIRpic_0089
RPFRpic12D_0095
RPJN234_01265
RMNTK49_04195
RINACS15_0133
RPUCDC45_01225
RSGJK151_04180
REHH16_A0280(sbm1)
CNCCNE_1c02900(sbm)
CUHBJN34_01660
REUReut_A0253
RMERmet_0210(sbm)
CTIRALTA_A0218
CBWRR42_m0324
CGDCR3_0214
CCUPBKK81_03850
CUPBKK80_03195
CUUBKK79_09070
CPAUEHF44_04400
COXE0W60_11980
BUGBC1001_0155
BGFBC1003_0181
BUQAC233_01045
BXEBxe_A4277
BXBDR64_1955
BPHBphy_0156
BGEBC1002_0175
BPXBUPH_04066
BPYBphyt_0431
BUZAYM40_00880
BCAIK788_0004168
PSPWBJG93_11705
PARABTO02_01910
PARBCJU94_04365
PHSC2L64_01040
PTERC2L65_00870
PGPCUJ91_01165
PCJCUJ87_00925
PTSCUJ90_01055
PCAFDSC91_005603
PGISI6I06_10475
PEWKZJ38_00155
PDIOPDMSB3_0259(icmF)
PTXABW99_15045
LIMNHKT17_01135
RFRRfer_3612
RSBRS694_18240
RACRA876_03190
RHFEUB48_19080
RHGEXZ61_19695
POLBpro_4054
PNAPnap_3524
POSDT070_04005
POOF7R28_05435
PVACHC248_00378(icmF)
RTARta_10110
OTDJ1M35_18930
LIML103DPR2_00610(scpA_1)
LIHL63ED372_00087(scpA_1)
HYRBSY239_284
HYBQ5W_17245
HYLLPB072_03595
HYCE5678_19890
HPSEHPF_03360(scpA1)
HYNF9K07_05325 F9K07_08230
HTNKI616_23700
CBAASRAA_1743
CBABSMCB_1714
STHMIS481_03015
PBHAAW51_4725
KIAG8A07_24290
MPTMpe_A0903
METPC1M51_13715
MNRACZ75_17840
MASWAM586_01865
MASSCR152_03100
MASZC9I28_27585
MTIMDIR46_13005
MASYDPH57_21750
MALIEYF70_27655
MUMFCL38_21860
MFLAGO485_17190
MANCIV454_09185
DUGHH213_12195
UPVEJN92_07170
UPIEJG51_010500
NOKFAY22_20230
LCHLcho_3844
TINTint_2187
THITHI_2523
RGERGE_43760
RBNRBXJA2T_01760
RDPRD2015_4407
PKTAT984_15960
SNNEWH46_01685
TTWLCC91_10505
IDCLRM40_17950
SHDSUTH_00621
DOEDENOEST_3246(icmF)
DSUDsui_1105
ARESIWH25_05840
AIQAzoinq_05475
RBUPG1C_12670
OTROTERR_03370
NIVJY500_00175
EBAebA3766
ABREpbN1_23010(icmF)
APETToN1_20110(icmF)
RBHB4966_02060
DARDaro_0243
DEYHYN24_01260
QAUKI612_01150
FLEKI610_01330
AZOazo0696
AOAdqs_0766
AZAAZKH_4043
AZIAzCIB_4080
ACOMCEW83_12770
AZDCDA09_19790
AZRCJ010_04365
TMZTmz1t_3371
THUAC731_011785
TCLTchl_1708
THKCCZ27_14770
TAKTharo_2771
AZQG3580_16950
ZPAC3497_01680
APPCAP2UW1_0492
DDZDSYM_26920
GMEGmet_1722
GEMGM21_1375
GEBGM18_1282
GPIGPICK_16260
GAOA2G06_13105
GURGura_1342
GBMGbem_2838
GBNGEOBRER4_13850(mcm)
GSBGSUB_09605
GERKP004_12970
GSUBKP001_01515
GNTKP003_12470
GPLM1B72_06780
DESDSOUD_0302
DEUDBW_0031
DVEDESUT3_20060(mcm_2)
DPRDespr_1143
DBKDGMP_12130(mcm)
DOLDole_2188
DMLDmul_11530(mcmL)
DALDalk_2754
DATHRM2_10030(mcmL)
DTOTOL2_C06760(mcmL)
DOVDSCO28_15810(mcm_1) DSCO28_44070(mcm_2)
DWDDSCW_05270(mcm_1) DSCW_49480(mcm_2)
DALKDSCA_33630(mcm)
DLIdnl_39840(icmF)
DMMdnm_092420(icmF)
DEKDSLASN_19550(mcm)
AFWAnae109_3169
MXAMXAN_2261
MSDMYSTI_03848
MYMA176_004788
MFBMFUL124B02_20665
CCXCOCOR_06686(sbm)
MFULILAB_19015
MMASMYMAC_002233
SURSTAUR_6825
AGEAA314_05368
MBDMEBOL_007315
CFUSCYFUS_005122
CCROCMC5_053660
SAMYDB32_004793
LLUAKJ09_03309
MRMA7982_01430
DTIDesti_2572
DBRDeba_0776
BSEDDN745_13930
PCAYFRD00_29140
BBAEFRD01_02670
DEXHWD60_12315
DVNHQ394_12070
BBABd1853
BBATBdt_1825
BBWBDW_08170
BBACEP01_05350
BDQCIK05_09160
BDCDOE51_08800
BDZDOM22_11180
BEXA11Q_1097
BMXBMS_3379
HAXBALOs_2980
BSTOC0V70_18475
SBFJCM31447_21710
HTLHPTL_0224
BACIB1NLA3E_21640
BIFN288_23925
BMETBMMGA3_16155(mutB2)
GSTHW35_09260
BACOOXB_1405
BWHA9C19_00480
BACQDOE78_23850
BFDNCTC4823_00418(scpA_1)
BDAFSZ17_22125
BSHILGQ02_20115
BBADK7T73_18895
BCOBcell_4112
BHKB4U37_20550
BCOHBC6307_22170
BMQBMQ_5180
BMDBMD_5166
BMHBMWSH_0101
BMEGBG04_2174
BEOBEH_23560
BFXBC359_01810
PKSIE339_22895
BCKBCO26_2830
BAGBcoa_1424
BHABH3796
BKWBkAM31D_24640(scpA_3)
BPFBpOF4_07035
BONA361_26135
BKOCKF48_12120
CSUAIM538_22750
OCNCUC15_17660
GKAGK3391
GTEGTCCBUS3UF5_38090
GTKGT3570_16655
GTMGT3921_02005
GLIGLN3_09675
GTNGTNG_3336
GWCGWCH70_3339
GYCGYMC61_3448
GYAGYMC52_3480
GCTGC56T3_3376
GMCGY4MC1_3734
GGHGHH_c34870(mutB2)
GJFM493_17740
GEAGARCT_03375(scpA_3)
GELIB49_09510
GSEGT50_08705
GSRGS3922_16315
GEJA0V43_14635
GZAIC807_12990
GTHGeoth_3839
PTLAOT13_03610
PTBDER53_04210
PCALBV455_01904(scpA_1)
AFLAflv_2734
AGNAFK25_13995
ANMGFC28_2788
AAMYGFC30_336
ANLGFC29_2646
ANDGRQ40_17760
ACAIISX45_15070
ASEDIRT44_04310
LSPBsph_0976
LGYT479_02665
LFUHR49_21140
LYSLBYS11_02705
LYBC3943_03380
LYZDCE79_02250
LYGC1N55_04150
LPAKGDS87_02770
LAGRFJQ98_03455
LMACI6G82_15725
HHDHBHAL_4636(mcm1)
HMNHM131_03995
HLIHLI_14310
VIRX953_17450
VHLBME96_16945
VILCFK37_07735
VNECFK40_03000
VIMGWK91_11760
LAOAOX59_15575
FPNABE65_020265
FARABE41_019405
SJEAAV35_002175
BSJUP17_24310
BMURABE28_022995
PBUTDTO10_10895
PASABAOM_4896
PPSRI6J18_15465
PFRIL8956_25775
BTHVCQJ30_18260
PSYHD0S48_09080
PSYOPB01_03275
PRDF7984_18170
POFGS400_18315
NMKCHR53_27200
NTMBTDUT50_02315
MEKUHUW50_08085
MSEMGMB29_25755
MDGK8L98_23945
AIAAWH56_006450
BLENNCTC4824_03902(scpA_2)
SEDDERJ70_17300
BVQFHE72_22540
RMFD5E69_21130
BVJI5776_20100
BOUI5818_24630
CTHUHUR95_01895
BBEVBBEV_0155(mutB)
BSEBsel_3186
MCUIG8O30_12635
GAJMY490_21375
BBEBBR47_54940
BLRBRLA_c044670
BFMBP422_23145
BAGRBA6348_04795
BRWGOP56_14905
BCHSJNE38_28980
BCOPJD108_20890
PJDPjdr2_2590
PALBEJC50_28755
PRZGZH47_31130
PLYCGXP70_16515
PCELHUB94_17015
ANXACH33_01310
ASOCCB4_00559(scpA_1)
ATHEK3F53_17700
AFXJZ786_09515
ACURJZ785_11070
BTSBtus_1053
KYRCVV65_10875
TUMCBW65_12405
TABCIG75_16080
EFFskT53_15690(mcm)
SIVSSIL_3403
SSILSOLI23_01420
SOBCSE16_02320
PLNPlano_2422
PKUAUO94_03510
PRTAUC31_14005
PANABBH88_06815
PDGBCM40_03085
PHCBBI08_09355
PMARB0X71_15140
PPLABBI15_08320
PFAEAJGP001_14040
PLXCW734_14370
PMATBBI11_13935
PDECH1Q58_13245
JEOJMA_30540
KURASO14_2559
KZONCTC404_00483(scpA_1)
SPSYAZE41_19600
SPORSporoP33_11390
SPOPSporoP37_11780
SURESporoP32a_12045
SPOSDV702_16115
SPAEE2C16_11650
SPOOJ3U78_18580
RSTATY39_16730
PAEKD3873_02550
PANCE2636_13595
PLAYDNR44_007570
VIJJNUCC6_17475
NTRB0W44_17170
LFBC1X05_16340
TVUAB849_005205
KPULGXN76_15690
KEBGXN75_17025
PABSJIR001_30790(mcm)
HMOHM1_0899(mutB)
NFANFA_10360
NFRERS450000_03079(scpA_2)
NBRO3I_006065
NNONONO_c12080
NSRNS506_07235
NTPCRH09_06790
NOZDMB37_26960
NODFOH10_25190
NAHF5544_07145
NADNCTC11293_01917(scpA_1)
NWLNWFMUON74_60030(mcm)
NIEKV110_06610
NHUH0264_07410
NYALTV02_25540
NGPLTT66_06275
SPINKV203_00170
SCOSCO4800(icmB) SCO5415(icmA)
SALBXNR_1417 XNR_3858
SMASAVERM_2832(icmA) SAVERM_3460(icmB)
SGRSGR_2120 SGR_2730
SGBWQO_21915 WQO_24905
SCBSCAB_28301(icmA) SCAB_35881(icmB) SCAB_6731
SSXSACTE_4066 SACTE_4606
SVLStrvi_1715 Strvi_6281 Strvi_8659
SHYSHJG_5902 SHJG_6493
SHOSHJGH_5664 SHJGH_6253
SRCM271_16885 M271_28390 M271_48335
SMALSMALA_3350 SMALA_5360
SSOII1A49_20535 I1A49_30460
SCTSCAT_3693 SCAT_4229
SCYSCATT_36840 SCATT_42170
SFASfla_1914 Sfla_2428
SBHSBI_00608 SBI_03740 SBI_04768(icmB)
SVESVEN_4477 SVEN_5069
SDVBN159_2993(mmcm-1) BN159_3615
SALSSLNWT_1872 SLNWT_4702 SLNWT_6927
STRPF750_4368 F750_4912
SFISFUL_4604 SFUL_5214
SCIB446_22535 B446_25380
SALUDC74_4961 DC74_5545
SALLSAZ_26525 SAZ_29295
SLVSLIV_11430 SLIV_14360
SGUSGLAU_20635 SGLAU_23270
SVTSVTN_23315 SVTN_26100
STREGZL_03337 GZL_03909
SCWTU94_19950 TU94_22760
SLDT261_2656 T261_3275
SLCSL103_28870 SL103_31715
SXISXIM_33820 SXIM_42240
STRMM444_21170 M444_23730
STRCAA958_21670 AA958_25065
SAMBSAM23877_4616 SAM23877_5161(icmA)
SPRISPRI_2477 SPRI_3090
SCZABE83_10475 ABE83_13350
SCXAS200_16405 AS200_19765
SRWTUE45_05319(scpA_2) TUE45_05890(scpA_4)
STRFASR50_21950 ASR50_24525
SLEsle_22410(sle_22410) sle_28760(sle_28760)
SRNA4G23_03471(scpA_2) A4G23_03998(scpA_4)
SPAVSpa2297_20260 Spa2297_22890
STRTA8713_19185 A8713_21835
SCLFBB341_07230 BB341_10065
SGSAVL59_04755 AVL59_07710
STSIA4E84_24835 A4E84_27630
SKYD0C37_08655 D0C37_20965
SALWCP975_21465 CP975_24760
SGMGCM10017557_25010 GCM10017557_31070 GCM10017557_69740(mcm)
SCADDN051_13150 DN051_16385
SLSSLINC_1346 SLINC_5168 SLINC_5808
SNRSNOUR_14580 SNOUR_17335
SPLULK06_020230 LK06_023425
STRDNI25_12170 NI25_14925
SNWBBN63_09765 BBN63_12430
SAUOBV401_20230 BV401_30620
SSIAA7J05_11770 A7J05_14580
SVUB1H20_22285 B1H20_25450
SPUNBFF78_07200 BFF78_14065 BFF78_17000
SGVB1H19_25100 B1H19_27700
SLAUSLA_4663 SLA_5297
SALFSMD44_05320 SMD44_05966
SALJSMD11_2167 SMD11_2706
SLXSLAV_12725(scpA1) SLAV_15435(scpA3)
STROSTRMOE7_23690 STRMOE7_26525
SFKKY5_4891 KY5_5538
SNZDC008_21335 DC008_24260
SGEDWG14_02729(mutB_2) DWG14_03332(scpA_3) DWG14_07607(icmF)
SRJSRO_2425 SRO_2948 SRO_7022
SLKSLUN_24400 SLUN_27305
SDXC4B68_12240 C4B68_15625
SGDELQ87_12575 ELQ87_15440
SQZFQU76_21180 FQU76_24010
SCYAEJ357_28315 EJ357_31855
SASTCD934_10050 CD934_12695
SNQCP978_20560 CP978_23260 CP978_27985
STIRDDW44_18455 DDW44_21240
SKACP970_13410 CP970_16805
SGZC0216_03350 C0216_05865
SVNCP980_10435 CP980_13375
SNKCP967_09830 CP967_12920
SHAWCEB94_25195 CEB94_28250
SRKFGW37_19990 FGW37_22795
SFICEIZ62_09455 EIZ62_12530
SGALCP966_22380 CP966_25120
SSPODDQ41_20105 DDQ41_21230
SVRCP971_11740 CP971_20070
SPADDVK44_21460 DVK44_24745
SFYGFH48_13900 GFH48_16960
SAQUEJC51_29770 EJC51_33120 EJC51_40335
SGFHEP81_02635 HEP81_03157 HEP81_07354(mcm)
SCAVCVT27_21260 CVT27_24195
SSEOD0Z67_17695 D0Z67_20200
SBYH7H31_08960 H7H31_20960
SRIMCP984_12275 CP984_15410
SSUBCP968_10705 CP968_13525
SPHVF9278_31205 F9278_34105 F9278_44585
SCINCP977_21075 CP977_23880
SFUGCNQ36_21640 CNQ36_24675
SPACB1H29_11500 B1H29_14460
STSUB7R87_20855 B7R87_23765
SCHACP983_13630 CP983_16870
SGXH4W23_24700 H4W23_27680
SCOECP976_03950 CP976_26625 CP976_29765
SBATG4Z16_08860 G4Z16_11670
SSPBCP982_25685 CP982_28740
SNFJYK04_05197(scpA_2) JYK04_05796(scpA_4)
SPLACP981_23800 CP981_26835
SBROGQF42_26585 GQF42_29615
STUIGCM10017668_43530 GCM10017668_49240
SATAC5746_25335 C5746_28650
SCHFIPT68_21990 IPT68_25665
SHUNDWB77_02509(scpA_2) DWB77_03113
SHARHUT13_17225 HUT13_20935
SCYGS1361_23960(scpA2) S1361_26745(scpA4)
SFEUIM697_36260 IM697_40090
SLIAHA039_10110 HA039_12830
SDWK7C20_22645 K7C20_25540
SVDCP969_04255 CP969_23680 CP969_26215
SCALI6J39_22025 I6J39_25130
SAUHSU9_020735 SU9_024220
SFBCP974_18825 CP974_21620
SMOBJ7W19_19675 J7W19_22435
SPRACP972_21910 CP972_24610
SPEUCGZ69_21550 CGZ69_24900
SROIIAG44_09540 IAG44_15405
SXNIAG42_10815 IAG42_13735
SGJIAG43_19190 IAG43_22115
SHKJ2N69_22495 J2N69_25695
SANUK7396_11325 K7396_14290
STRYEQG64_22100 EQG64_25235
SDDD9753_10945 D9753_13885
SACTDMT42_23825 DMT42_26855
SMAOCAG99_05615 CAG99_08950
SGOBtest1122_16760 test1122_19530
SINEKI385_27730 KI385_30695
SLFJEQ17_15465 JEQ17_18750 JEQ17_40420 JEQ17_46405
SDECL3078_01290 L3078_05720 L3078_28675 L3078_31490
KSKKSE_30840(icmB) KSE_50550(icmA)
KABB7C62_22635 B7C62_26010
KAUB6264_06805 B6264_14720
KITCFP65_2877 CFP65_5012
STRIC7M71_011455 C7M71_020920
YIALO772_13790
ACITHPK19_17130
DNIHX89_10850
DAYFV141_04340 FV141_10055
LMOIVV02_09755 VV02_19330
YIMJ5M86_13840
ALXLVQ62_08785 LVQ62_16980
ICAIntca_1058 Intca_2805
ARSADJ73_00005 ADJ73_15610
JTEASJ30_13735
JLIEXU32_01030
JMEEEW87_001810
TEHGKE56_00020 GKE56_01355
PHWG7075_00840
PEIH9L10_10195
SERJSGUI_0766
SERWFY030_05685 FY030_10835
ORNDV701_04950 DV701_17690
ORZFNH13_02595
AUSIPK37_01570 IPK37_02535
GYUFE374_01055
HALTIM660_10825
MPHMLP_12500(icmB) MLP_29880(icmA)
MIKFOE78_06630 FOE78_14790
MICGGJV80_22610
RAINRai3103_01225 Rai3103_01475
NCANoca_1802 Noca_3591 Noca_4143
NDKI601_1647(scpA_1)
NOYEXE57_04930 EXE57_07330
NOIFCL41_02530
NOOFE634_03025
NSNEXE58_05685
NBEBack2_29080(mcm)
NANOG5V58_19395
NMESH9L09_13020 H9L09_16000
NAROCFH99_21895
NPIG7071_10645
NAQUENKNEFLB_00504(icmF)
NROK8W59_15360
NOQLN652_15565
NCQK6T13_04100 K6T13_05995
NPCKUV85_11665
PSIMKR76_24415
AERAERYTH_01270
AEZC3E78_16385
AEBC6I20_00270
AEFGEV26_16350
MGGMPLG2_0425(icmF)
MUZH4N58_03305
KFLKfla_1266 Kfla_4977
KQIF1D05_07230 F1D05_26090
TFUTfu_2811
THAONI17_017595
TALXFOF52_15045
NDANdas_0059 Ndas_0363
NALB005_2846 B005_3234
NGVCDO52_23005 CDO52_24720
STRREKD16_03005(scpA1) EKD16_05400(scpA2)
SAIUJ4H86_11250 J4H86_20125
TCUTcur_1029
AGRAAGRA3207_000544
SROSros_1242 Sros_1703 Sros_3556
NOABKM31_36860
NOWGBF35_08250
NCXNocox_07615(scpA1)
NGNLCN96_08575
TBITbis_1618
FRAFrancci3_3652
FREFranean1_1077
FRIFraEuI1c_0995
FALFRAAL5865(mcm)
FSYFsymDg_3783 FsymDg_3895
ACEAcel_0674
NMLNamu_3099
GOBGobs_2225
BSDBLASA_3889(yliK) BLASA_4220
MMARMODMU_5259
SVISvir_24570
SACCEYD13_13690(scpA1)
AMDAMED_2498(mcm)
AMNRAM_12700
AMMAMES_2471(mcm)
AMZB737_2472(mcm)
AOIAORI_2461
AJAAJAP_26520
AMQAMETH_4866(mcm)
AMYCCU254_10285
AMYBBKN51_04905
AABA4R43_16160
AMYYYIM_14340(scpA2)
AORISD37_13360
AACDLWP59_29320
PDXPsed_4409
PSEAWY02_26050
PSEEFRP1_16895
PSEHXF36_16385
PSEQAD006_24345
PECQAD017_03935
PHHAFB00_02390
PAUTPdca_45940(mcm)
PBROHOP40_33530
APRECNX65_11590
AMIAmir_2277
SESPBN6_32830
SSYIEKG83_33575
KALKALB_3062
KPHYAOZ06_35580
LEDBBK82_28495
AHMTL08_07500 TL08_24600
ACTIUA75_07225 UA75_28225
ACADUA74_07230 UA74_27685
AHGAHOG_06950(scpA1) AHOG_25540(scpA4)
ACTAC1701_13770 C1701_17880
ALOCRK57417
PMADBAY61_10865
STPStrop_3608 Strop_3814
SAQSare_3989 Sare_4204
MAUMicau_5073 Micau_5399
MILML5_0492 ML5_3238
MICBMicB006_4092 MicB006_4407
MTUACSH63_30490 CSH63_32465
MICHFJK98_26750 FJK98_28275
MTEMGCE86_20095 GCE86_21555
MCABHXZ27_25695 HXZ27_27005
MSAGGCM10017556_13510 GCM10017556_16530
VMAVAB18032_00570 VAB18032_29406
ASEACPL_7414(icmA) ACPL_892(icmB)
AMSAMIS_7150 AMIS_71640
ACTNL083_1046(icmB) L083_7030(sbm5)
AFSAFR_05085 AFR_37170
ACTSACWT_0775 ACWT_7284
AIHAiant_32540 Aiant_50550
PLKCIK06_04695 CIK06_23000
PLABC6361_21005 C6361_33160
PLATC6W10_22755 C6W10_23985
PFLAPflav_041560 Pflav_041570
PSUUPsuf_041740 Psuf_047080
VERHUT12_26580 HUT12_27830
ATLAthai_20880 Athai_52450
ASERAsera_22390 Asera_53830
PRYPrubr_14870 Prubr_38300
CATICS0771_06030 CS0771_22070
DVCDvina_07650 Dvina_49365
NHYJQS43_04490 JQS43_06190
CCAZCOUCH_07340 COUCH_34690
CAICaci_1274 Caci_7994
SNASnas_1393 Snas_6220
NAVJQS30_10810
GLYK3N28_03060 K3N28_10770
EKEEK0264_14905 EK0264_16545
JTLM6D93_07195
BSOLFSW04_19575
CWOCwoe_2289
AQZKSP35_11240
IAMHC251_02540
ERZER308_03030
EUZDVS28_a4941
DPTDeipr_1108
DRDLMT64_05080
WCHwcw_0462(mcm)
UAMUABAM_01500
LILLA_2956
LIELIF_A2404
LICLIC_11105(mcm1)
LISLIL_12525(sbm)
LBJLBJ_2060
LBILEPBI_I3196
LBFLBF_3084
LSTLSS_01872
LAJA0128_12330
LMAYDPV73_10990
LKMEFP84_04210
LWLFHG68_05830
LKBLPTSP3_g33400(icmF)
TPXTurpa_2076
THYDTTHT_0671
SCORJ3U87_18200
GAUGAU_2108
BLQL21SP5_02883(scpA_2)
MBASALGA_3861
SRUSRU_1689
SRMSRM_01894(bhbA)
RMRRmar_0923
RMGRhom172_1943
RBARAWN76_001840
CPICpin_1068
CBAECOR50_03265
CHITFW415_02415
CHIHGWR21_20920
COYHF329_23710
CFILMYF79_05350
NKONiako_6707
NSONIASO_12420
FLASY85_19860
FGGFSB75_16820
FLNFLA_5249
PSEGD3H65_25090
PGINFRZ67_09810
PGOFSB84_04965
FLSGLV81_10580
LACSH4075_01700
FEIK9M53_01545
FLCKJS93_19905
FLVKJS94_16260
HHYHalhy_2347
SGNSGRA_1904
PHEPhep_1164
PEPAQ505_21930
PCMAY601_3310
PSTYBFS30_04435
PGSCPT03_00240
PEJFYC62_09140
PEKFFJ24_014970
PEXIZT61_20035
SCNSolca_3923
MUPA0256_02725
MUCMuYL_4032
MGOTMgSA37_04235(scpA_2)
MGINFRZ54_09365
AGDFRZ59_17955
SBXCA265_14780
BBDBelba_3560
EVIEchvi_2441
ESTDN752_18190
ECHIFKX85_11630
ALMAO498_12895
MDAIPZ59_12885
SLISlin_2256
SRDSD10_12955
SPIRCWM47_13765
SPIKEXU85_14930
SPIBG8759_31710
STAEHNV11_07035
RHOZGXP67_14570
RSIRunsl_3876
RUNDR864_00770
RUPDTQ70_16085
FAEFAES_2675
FIBA6C57_03295
FLIFleli_1246
HSWHsw_2041
HYMN008_18685
HYDPK28_09665
HYEAM218_06720
HYGAUC43_13930
HYPA0257_01170
HYZAXW84_10260
HNVDDQ68_05595
HYHD3Y59_04880
HYJFHG12_19195
HQIH9L05_18180
HRSHER32_20050
HBNGUY19_03905
HTSHMJ29_17080
HMTMTP16_15870
PKOPKOR_17560
PACTCA264_07155
RTIDC20_17110
RUDTH61_15630
NIBGU926_03300
ADDHUW48_15580
ASWUHUW51_23265
MTTFtrac_0827
FPFDCC35_07870
FLMMY04_0175
FLLEI427_12170
FYAKMW28_15425
FKAKM029_17305
FBTD770_06735
CHKD4L85_01835
FUVJR347_10200
GFOGFO_0483
GRLLPB144_06975
GFLGRFL_2313
GRSC7S20_10685
FPSFP1940
FPCFPSM_00858
FPYFPG101_04155
FPOFPG3_08345
FPQIB65_09710
FPVIA03_09485
FPWIA04_09425
FPKIA06_09430
FPSZAMR72_15825
FJOFjoh_2332
FJGBB050_00315(scpA_1)
FBRFBFL15_2050
FCOFCOL_05930
FINKQS_06400
FGLEM308_08940
FCMBIW12_02295
FATDVK85_12465
FKIFK004_10225
FPALHYN49_10255
FMGHYN48_09855
FALBHYN59_16695
FCRHYN56_12770
FSEDI487_11235
FSNGS03_01878(icmF)
FNKE1750_15320
FAKFUA48_11535
FFLHYN86_10860
FENJ0383_03665
FCVAWN65_04430
FSDLXD69_11370
RBIRB2501_11102
ZPRZPR_3143
CATCA2559_06870
MAREEJ994_09645
CAOCelal_0391
CLYCelly_0353
CLHIX49_01460
CBALM667_19390
CBATM666_19330
KDIKrodi_0132
DOKMED134_03589(bhbA)
DDOI597_2470(scpA_2)
DODDCS32_11585
LANLacal_0276
LVNBWR22_04790
LACICW733_08765
MRSMurru_0397
MLTVC82_506
MUTGVT53_11780
MAQILDL77_03835
SPONHME9304_00468
ASLAeqsu_0394
AEVEI546_04240
AICJK629_00995
PTQP700755_002645
NDODDD_2639
NOMAAT17_00970
NSDBST91_04935
NOBCW736_09705
NOJEJ995_10295
POMMED152_05935
PRNBW723_08210
POLABXQ17_13630
POACW731_08315
PHALH9I45_06740
PLITK8354_10945
PPECH9W90_00855
PBATJL193_15250
PCEAJ3359_05775
MYRMYRA21_2708
MPWMPR_1529
MODAS202_13310
MYZBK054_12860
WINWPG_0356
WIJBWZ20_12830
SZEAW14_14450
SYISB49_07425
TDIAUW17_09750
TENLPB136_07020
TJETJEJU_3087
TMARMARIT_2504
TMPF9Y86_11325
LUTLupro_11715
FOPFNB79_00140
SALTAO058_09015
SMISLDL76_10045
SEONBWZ22_02255
AALGAREALGSMS7_04828(icmF)
OLLCW732_17425
OAQDZC78_06285
FEKC1H87_20695
TAJC1A40_16405
AUEC5O00_09325
KOSKORDIASMS9_04464(icmF)
KANIMCC3317_15900(icmF)
MARFCJ739_2784
AQBD1818_21220
AQAD1815_10705
AQDD1816_23865
MUREQY75_09295
PSYNE9099_11665
ANPFK178_08915
OCIFEZ18_10650
MGELG5B37_13540
MESQC7H62_1786
GAAHX109_02040
ALTIALE3EI_0195
MARXINR76_00615
LPALLDL79_04390
SINHLS482_17640
FLGLV716_12655
SABUMBM09_12650
ZSPMQE36_09705
BIAGMA17_01595
FBEFF125_17225
FBAFIC_02231
FBUUJ101_00960
WVIWeevi_2029
EAOBD94_0244
EMNM876_00175
EENBBD30_05450
ELBVO54_02353(scpA_2)
EMGBBD33_02120
EGOBBD34_10585
EGMAYC65_15975
ELZFCS00_09490
ELTFGE20_06220
CHZCHSO_4564
CGNOK18_05720
CIHATE47_13845
CHHA0O34_11320
CIOCEQ15_16190
CHRYCEY12_12385
CPIPCJF12_16385
CHRSEAG08_13450
CHRZCO230_09970
CARHEGY05_19615
CSHAEG350_01935
CNKEG343_11960
CJTEG359_12655
CILEG358_19325
CCAUEG346_08725
CBENEG339_03590
CGLENCTC11432_02887(scpA_1)
CTAINCTC12078_02746(scpA_2)
CLACEG342_03085
CTAK4412677_01335(scpA)
CSALNBC122_01262(icmF)
CBPEB354_21890
CNPM0D58_09430
CJGNCTC13459_01560(scpA)
CCASEIB73_08280
CANTNCTC13489_02598(scpA)
KDAEIB71_06570
KBEJ4771_11200
EVAEIB75_02615
EZEKI430_10740
CNREB819_00105
EBVF0358_11860
EFALFH779_10375
ESTEHNV03_06630
FBOJ9309_09375
FTEFluta_2690
FLUCHH17_04735
CRMK6119_00035
OHOOweho_1455
CHYDH4K34_02895
SHYRLA303_04295
BBAUAEM51_10775
CPRVCYPRO_1836
 » show all
Reference
1
  Authors
Brendelberger, G., Retey, J., Ashworth, D.M., Reynolds, K., Willenbrock, F. and Robinson, J.A.
  Title
The enzymic interconversion of isobutyryl and N-butyrylcarba(dethia)-coenzyme-A - a coenzyme-B12-dependent carbon skeleton rearrangement.
  Journal
Angew Chem Int Ed Engl 27:1089-1091 (1988)
Reference
2  [PMID:10531377]
  Authors
Ratnatilleke A, Vrijbloed JW, Robinson JA.
  Title
Cloning and sequencing of the coenzyme B(12)-binding domain of isobutyryl-CoA mutase from Streptomyces cinnamonensis, reconstitution of mutase activity, and characterization of the recombinant enzyme produced in Escherichia coli.
  Journal
J Biol Chem 274:31679-85 (1999)
DOI:10.1074/jbc.274.44.31679
  Sequence
Reference
3  [PMID:19864421]
  Authors
Cracan V, Padovani D, Banerjee R
  Title
IcmF is a fusion between the radical B12 enzyme isobutyryl-CoA mutase and its G-protein chaperone.
  Journal
J Biol Chem 285:655-66 (2010)
DOI:10.1074/jbc.M109.062182
  Sequence
[gka:GK3391] [nfa:NFA_10360] [bxe:Bxe_A4277]
Reference
4  [PMID:22167181]
  Authors
Cracan V, Banerjee R
  Title
Novel coenzyme B12-dependent interconversion of isovaleryl-CoA and pivalyl-CoA.
  Journal
J Biol Chem 287:3723-32 (2012)
DOI:10.1074/jbc.M111.320051
  Sequence
[rme:Rmet_0210] [gka:GK3391]
Reference
5  [PMID:26318610]
  Authors
Jost M, Born DA, Cracan V, Banerjee R, Drennan CL
  Title
Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases.
  Journal
J Biol Chem 290:26882-98 (2015)
DOI:10.1074/jbc.M115.676890
  Sequence
[rme:Rmet_0210]
Reference
6  [PMID:28130442]
  Authors
Li Z, Kitanishi K, Twahir UT, Cracan V, Chapman D, Warncke K, Banerjee R
  Title
Cofactor Editing by the G-protein Metallochaperone Domain Regulates the Radical B12 Enzyme IcmF.
  Journal
J Biol Chem 292:3977-3987 (2017)
DOI:10.1074/jbc.M117.775957
  Sequence
[rme:Rmet_0210]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.13
IUBMB Enzyme Nomenclature: 5.4.99.13
ExPASy - ENZYME nomenclature database: 5.4.99.13
BRENDA, the Enzyme Database: 5.4.99.13
CAS: 116405-23-3

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