| Entry |
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| Name |
protostadienol synthase;
PdsA;
(S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]
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| Class |
Isomerases;
Intramolecular transferases;
Transferring other groups
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| Sysname |
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]
|
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| Reaction(IUBMB) |
(3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3beta-ol [RN: R09689]
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| Reaction(KEGG) |
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| Substrate |
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD: C01054]
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| Product |
(17Z)-protosta-17(20),24-dien-3beta-ol [CPD: C19820]
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| Comment |
(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.
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| History |
EC 5.4.99.32 created 2011
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| Pathway |
| ec00909 | Sesquiterpenoid and triterpenoid biosynthesis |
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| Orthology |
| K15811 | protostadienol synthase |
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| Genes |
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| Reference |
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| Authors |
Lodeiro S, Xiong Q, Wilson WK, Ivanova Y, Smith ML, May GS, Matsuda SP |
|---|
| Title |
Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 5.4.99.32 |
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