KEGG   ENZYME: 5.4.99.38
Entry
EC 5.4.99.38                Enzyme                                 
Name
camelliol C synthase;
CAMS1;
LUP3 (gene name)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C [RN:R09713]
Reaction(KEGG)
R09713
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
camelliol C [CPD:C19835]
Comment
The product is 97% camelliol, 2% achilleol A and 0.2% beta-amyrin. Achilleol is an isomer of camelliol C with a 4-methylenecyclohexanol ring system. This enzyme probably evolved from EC 5.4.99.39, beta-amyrin synthase.
History
EC 5.4.99.38 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15822  camelliol C synthase
Genes
ATH: AT1G78955(CAMS1)
ALY: 9325285
CRB: 17895192
CSAT: 104752321
EUS: EUTSA_v10018165mg
BRP: 103832372
BNA: 106354659 106378247
BOE: 106298763
RSZ: 108827358
THJ: 104808106 104812339
Reference
1  [PMID:17985917]
  Authors
Kolesnikova MD, Wilson WK, Lynch DA, Obermeyer AC, Matsuda SP
  Title
Arabidopsis camelliol C synthase evolved from enzymes that make pentacycles.
  Journal
Org Lett 9:5223-6 (2007)
DOI:10.1021/ol702399g
  Sequence
[ath:AT1G78955]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.38
IUBMB Enzyme Nomenclature: 5.4.99.38
ExPASy - ENZYME nomenclature database: 5.4.99.38
BRENDA, the Enzyme Database: 5.4.99.38

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (12)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (25)   

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