KEGG   ENZYME: 5.4.99.39
Entry
EC 5.4.99.39                Enzyme                                 
Name
beta-amyrin synthase;
2,3-oxidosqualene beta-amyrin cyclase;
AsbAS1;
BPY;
EtAS;
GgbAS1;
LjAMY1;
MtAMY1;
PNY;
BgbAS
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-amyrin-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin [RN:R06469]
Reaction(KEGG)
R06469
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
beta-amyrin [CPD:C08616]
Comment
Some organism possess a monofunctional beta-amyrin synthase [3,4,6-11], other have a multifunctional enzyme that also catalyses the synthesis of alpha-amyrin (EC 5.4.99.40) [5] or lupeol (EC 5.4.99.41) [6].
History
EC 5.4.99.39 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15813  beta-amyrin synthase
K15815  lupeol synthase 2
K20658  alpha/beta-amyrin synthase
K21928  delta/alpha/beta-amyrin synthase
Genes
ATHAT1G78950(BAS) AT1G78960(LUP2)
CRB17894179 17894180
CSAT104714177
EUSEUTSA_v10018166mg EUTSA_v10022563mg
BRP103830506 103832374
BNA106354658
CIT102618743 102626251
CICCICLE_v10027855mg
PVY116105746 116112829 116124705 116124714 116130196
MINC123194150 123204911 123209396 123212922 123213322 123213323 123214663 123214831 123214833 123214843 123214871 123214903 123217891 123217892
TCC18595542
GRA105770710
GHI107906373 107958478
GAB108450227
DZI111280380 111280462
EGR104418125 104418208 104441322 104450707 104450711 104450715 104450716 104452267
GMX100778398 100781065 100809670 100810544 547702(AMS1)
GSJ114386344 114406586 114406588 114417867 114424383
PVUPHAVU_010G165100g
VRA106779110
VAR108320601
VUN114167020
CCAJ109808037
APRC113857274
MTRMTR_0013s0230 MTR_3g436160 MTR_4g005190 MTR_4g005270 MTR_7g034535
CAM101507549 101509140 101514948
LJALj3g3v1983420.1(Lj3g3v1983420.1) Lj3g3v1983420.2(Lj3g3v1983420.2) Lj3g3v1983420.3(Lj3g3v1983420.3) Lj3g3v1983430.1(Lj3g3v1983430.1) Lj3g3v2027430.1(Lj3g3v2027430.1) Lj3g3v2027430.2(Lj3g3v2027430.2)
ADU107482523
AIP107638387
AHF112740785 112795505
LANG109339602 109356963
FVE101300752 101305573 101311150
RCN112186812 112187619 112188240 112188242 112188482 112197596
PPER18781703 18784434
PMUM103327460
PAVI110761677
PDUL117620888 117620929 117621182 117622046 117622047 117622048 117624085
MDM103417397 103426165 103426167 103429285 103429325 103432258 103443360(OSC1) 103443364
PXB103927760 103935918 103935920 103936042 103939378 103958474 103967646 103967650 103967653
ZJU107425952 107428101
MNT112094630 112094634 112094688 112094692 21394597 21395405 21397009 21397010 21397013
CSV101216643 101216873 101217112
BHJ120069943 120075890 120079834 120080055
MCHA111022720
CMAX111496120
CMOS111454504
CPEP111798890
RCU8259939 8259940
JCU105646125 105646244
HBR110634117 110634126 110654191 110657399 110665723
MESC110600327 110618086
POP112323268 112324065 18104702 18104704 7465577
PEU105130436 105130437
PALZ118037554 118037653 118050536 118050539 118056627 118059114
JRE108989601 109004270
QSU111984348 111984351 111984352 111984353 111984354 111988686 111993359 111999310 112000640 112028926 112029397 112029583 112029584 112029585
QLO115957665 115988421 115988911 115989778 115989779 115989780 115989781 115989786 115991553 115992905 115993033 115993103
TWL119986645 119991856 119996392 119998230 120005806 120007835 120010185 120010891 120014597 120016340
VVI100246387 100249623 100251248 100251443 100252187 100254746 100256581 100259856 100265044
VRI117909133 117909134 117909135 117921480 117922024 117922025 117922026 117922027 117922028 117922033 117922888 117923539 117923540
SLY100529100(TTS2) 100529102(lTTS1) 101262591
SPEN107005696 107005698
SOT102591877 102592553 102593367 102593690 102600538
SSTN125850184 125852109 125852112 125862054 125863368
CANN107841181 107841772 107841773 107841775 107841776 107841780 107856119
NTA107762202 107762781 107770515 107804056
NSY104229110 104229111
NTO104088725 104106203
NAU109226501 109226503 109239410
INI109156437 109183903 109183911
ITR115998581 116002437
SIND105167784 105173656
OEU111377143 111409925 111411935
EGT105956335
SSPL121750224 121792459
HAN110899433 110930222 110930250
ECAD122599088
LSV111918115 111918119 111918120 111918121
CCAV112527373 112527442 112528193
DCR108192236 108218800 108223283
CSIN114265759 114265761 114265762 114300891
BVG104908690
SOE110779736
CQI110687932 110687933 110726758 110726782 110726783 110726784 110731879
NNU104589211
MING122070630
TSS122661972
PSOM113353971 113358745
 » show all
Reference
1
  Authors
Abe, I, Ebizuka, Y., Seo, S. and Sankawa, U.
  Title
Purification of squalene-2,3-epoxide cyclases from cell suspension cultures of Rabdosia japonica Hara.
  Journal
FEBS Lett 249:100-104 (1989)
Reference
2
  Authors
Abe, I., Sankawa, U. and Ebizuka, Y.
  Title
Purification of 2,3-oxdosqualene:beta-amyrin cyclase from pea seedlings.
  Journal
Chem Pharm Bull 37:536 (1989)
Reference
3  [PMID:9746369]
  Authors
Kushiro T, Shibuya M, Ebizuka Y
  Title
Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants.
  Journal
Eur J Biochem 256:238-44 (1998)
DOI:10.1046/j.1432-1327.1998.2560238.x
  Sequence
Reference
4  [PMID:11510484]
  Authors
Hayashi H, Huang P, Kirakosyan A, Inoue K, Hiraoka N, Ikeshiro Y, Kushiro T, Shibuya M, Ebizuka Y
  Title
Cloning and characterization of a cDNA encoding beta-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice.
  Journal
Biol Pharm Bull 24:912-6 (2001)
DOI:10.1248/bpb.24.912
  Sequence
Reference
5  [PMID:11247608]
  Authors
Husselstein-Muller T, Schaller H, Benveniste P
  Title
Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana.
  Journal
Plant Mol Biol 45:75-92 (2001)
DOI:10.1023/A:1006476123930
  Sequence
Reference
6  [PMID:12683345]
  Authors
Iturbe-Ormaetxe I, Haralampidis K, Papadopoulou K, Osbourn AE
  Title
Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus.
  Journal
Plant Mol Biol 51:731-43 (2003)
DOI:10.1023/a:1022519709298
Reference
7  [PMID:12736505]
  Authors
Zhang H, Shibuya M, Yokota S, Ebizuka Y
  Title
Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants.
  Journal
Biol Pharm Bull 26:642-50 (2003)
DOI:10.1248/bpb.26.642
  Sequence
Reference
8  [PMID:15256745]
  Authors
Hayashi H, Huang P, Takada S, Obinata M, Inoue K, Shibuya M, Ebizuka Y
  Title
Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra.
  Journal
Biol Pharm Bull 27:1086-92 (2004)
DOI:10.1248/bpb.27.1086
  Sequence
Reference
9  [PMID:16005035]
  Authors
Kajikawa M, Yamato KT, Fukuzawa H, Sakai Y, Uchida H, Ohyama K
  Title
Cloning and characterization of a cDNA encoding beta-amyrin synthase from petroleum plant Euphorbia tirucalli L.
  Journal
Phytochemistry 66:1759-66 (2005)
DOI:10.1016/j.phytochem.2005.05.021
Reference
10 [PMID:17803686]
  Authors
Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K
  Title
Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae.
  Journal
FEBS J 274:5028-42 (2007)
DOI:10.1111/j.1742-4658.2007.06025.x
  Sequence
Reference
11 [PMID:19420748]
  Authors
Liu Y, Cai Y, Zhao Z, Wang J, Li J, Xin W, Xia G, Xiang F
  Title
Cloning and Functional Analysis of a beta-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM.
  Journal
Biol Pharm Bull 32:818-24 (2009)
DOI:10.1248/bpb.32.818
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.39
IUBMB Enzyme Nomenclature: 5.4.99.39
ExPASy - ENZYME nomenclature database: 5.4.99.39
BRENDA, the Enzyme Database: 5.4.99.39

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