KEGG   ENZYME: 5.4.99.48
Entry
EC 5.4.99.48                Enzyme                                 
Name
achilleol B synthase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, achilleol-B-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = achilleol B [RN:R09908]
Reaction(KEGG)
R09908
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
achilleol B [CPD:C20187]
Comment
Achilleol B is probably formed by cleavage of the 8-14 and 9-10 bonds of (3S)-2,3-epoxy-2,3-dihydrosqualene as part of the cyclization reaction, after formation of the oleanane skeleton.
History
EC 5.4.99.48 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K19011  achilleol B synthase
Genes
OSA4350288 4350291 4350295 4350734
DOSAOs11t0285000-01(Os11g0285000) Os11t0286800-01(Os11g0286800) Os11t0562100-01(Os11g0562100)
OBR102701306 102701586 102703694
BDI100827654 100843778
ATS109734192 109736669 109739339 109743284 109770264 109777463
TDC119284479 119288449 119290044 119293087 119315173 119323019 119323648 119333936 119340556 119361867
TAES123043239 123083663 123084663 123088665 123089814 123089815 123095544 123132191 123136222 123141178 123142911 123150783 123154489 123159283 123166066 123170385
TUA125516081 125516140 125520744 125522489 125523582 125523738 125524235 125524236 125524237
SBI110434442 110436943 8062668 8063842 8064550 8067848 8069958 8072983 8073228
ZMA100193317 100285643 103626416 103653555 103654534
SITA101752607 101756143 101761176 101767046 101769509 101784323 101786482
SVS117843020 117851924 117852781 117853708 117855859 117856263 117864379 117864418 117864489
PVIR120644241 120644823 120646058 120654626 120669159 120669934 120702021
PHAI112874083 112885223 112891129 112899190 112902491
 » show all
Reference
1  [PMID:21526825]
  Authors
Ito R, Mori K, Hashimoto I, Nakano C, Sato T, Hoshino T
  Title
Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases.
  Journal
Org Lett 13:2678-81 (2011)
DOI:10.1021/ol200777d
  Sequence
[osa:4350288]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.48
IUBMB Enzyme Nomenclature: 5.4.99.48
ExPASy - ENZYME nomenclature database: 5.4.99.48
BRENDA, the Enzyme Database: 5.4.99.48

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