KEGG   ENZYME: 5.4.99.57
Entry
EC 5.4.99.57                Enzyme                                 
Name
baruol synthase;
BARS1
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, baruol-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = baruol [RN:R09917]
Reaction(KEGG)
R09917
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
baruol [CPD:C20200]
Comment
The enzyme from Arabidopsis thaliana also produces traces of 22 other triterpenoids.
History
EC 5.4.99.57 created 2012
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K16206  baruol synthase
Genes
ATH: AT4G15370(BARS1)
CSAT: 104718873 104732114
EUS: EUTSA_v10027177mg
Reference
1  [PMID:17705488]
  Authors
Lodeiro S, Xiong Q, Wilson WK, Kolesnikova MD, Onak CS, Matsuda SP
  Title
An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis.
  Journal
J Am Chem Soc 129:11213-22 (2007)
DOI:10.1021/ja073133u
  Sequence
[ath:AT4G15370]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.57
IUBMB Enzyme Nomenclature: 5.4.99.57
ExPASy - ENZYME nomenclature database: 5.4.99.57
BRENDA, the Enzyme Database: 5.4.99.57

  All links  
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
All databases (2)   

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