KEGG ENZYME: 5.4.99.58

ENZYME: 5.4.99.58

Entry

EC 5.4.99.58                Enzyme

Name

methylornithine synthase;
PylB

Class

Isomerases;
Intramolecular transferases;
Transferring other groups

Sysname

L-lysine carboxy-aminomethylmutase

Reaction(IUBMB)

L-lysine = (3R)-3-methyl-D-ornithine [RN:R10010]

Reaction(KEGG)

R10010

Substrate

L-lysine [CPD:C00047]

Product

(3R)-3-methyl-D-ornithine [CPD:C20277]

Comment

The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases.

History

EC 5.4.99.58 created 2012

Pathway

ec00300

Lysine biosynthesis

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K16180

methylornithine synthase

Genes

DAT:	HRM2_15240(bioB2)

DOV:	DSCO28_05090

DSY:

DSY4958

DHD:

Dhaf_4857

DDH:	Desde_0574

DOR:	Desor_1148 Desor_1623 Desor_3055

DMI:	Desmer_1592 Desmer_2996

DAE:

Dtox_0028

FWA:	DCMF_07900 DCMF_16375 DCMF_28145 DCMF_28345

AACX:

DEACI_4244

TJR:	TherJR_0023

DGI:	Desgi_3925

ELIM:

B2M23_05175

WHJ:	H9Q79_07365(pylB)

AMIJ:

EQM06_09285(pylB)

AMIC:

Ami3637_11535(pylB)

ABUT:

Ami103574_12095(pylB)

ETM:	CE91St48_13120

EMJ:	V1225_13070(pylB)

TPZ:	Tph_c27770

AAR:	Acear_0357

MANA:

MAMMFC1_01955(bioB_2)

SSPH:

SPSPH_029840(pylB) SPSPH_029990(pylB)

SOVA:

SOV_01670(pylB)

SSID:

SPSIL_001490

SACV:

SPACI_001430 SPACI_039560(bioB_3) SPACI_044140(bioB_4)

MBA:	Mbar_A0838

MBY:	MSBRM_0156

MBW:	MSBRW_0163

MBAR:

MSBR2_2225

MBAK:

MSBR3_2276

MAC:	MA_0154(bioB)

MMA:

MM_1444

MMAZ:

MmTuc01_1502

MMJ:	MSMAS_3220

MMAC:

MSMAC_3242

MVC:	MSVAZ_3360

MEK:	MSKOL_3319

MLS:	MSLAZ_3210

METM:

MSMTP_3120

MEF:	MSWH1_3069

MEQ:	MSWHS_3280

MSJ:	MSSAC_0136

MSZ:	MSSIH_0123

MSW:	MSSIT_0127

MTHR:

MSTHT_1933

MTHE:

MSTHC_1350

MHOR:

MSHOH_3966

MFZ:	AOB57_008965(pylB)

MBU:	Mbur_2085(pylB)

MMET:

MCMEM_0284

MELO:

J7W08_11515(pylB)

MMH:

Mmah_0282

MHAZ:

BHR79_02110

MPOT:

BKM01_06295

MEV:	Metev_0937

MZH:	Mzhil_1026

MPY:	Mpsy_1722(bioB)

MZI:	HWN40_00970(pylB)

MMAV:

RE476_10045(pylB)

MSEB:

RE474_06590(pylB)

MHZ:	Metho_0021

MEHF:

MmiHf6_12410

MEES:

MmiEs2_14440

MEAM:

MU439_04805(pylB)

MEAE:

QEN48_05365(pylB)

TAR:	TALC_00497

MAX:	MMALV_04280

MER:	MMINT_08920

MEAR:

Mpt1_c05690(pylB2)

MEUZ:

KRP56_05620(pylB)

MARC:

AR505_1324

» show all

Reference

1 [PMID:21455182]

Authors

Gaston MA, Zhang L, Green-Church KB, Krzycki JA

Title

The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine.

Journal

Nature 471:647-50 (2011)
DOI:10.1038/nature09918

Sequence

[mac:MA_0154]

Reference

2 [PMID:22095926]

Authors

Quitterer F, List A, Eisenreich W, Bacher A, Groll M

Title

Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis.

Journal

Angew Chem Int Ed Engl 51:1339-42 (2012)
DOI:10.1002/anie.201106765

Sequence

[mba:Mbar_A0838]

Other DBs

ExplorEnz - The Enzyme Database:

5.4.99.58

IUBMB Enzyme Nomenclature:

5.4.99.58

ExPASy - ENZYME nomenclature database:

5.4.99.58

BRENDA, the Enzyme Database:

5.4.99.58

DBGET integrated database retrieval system