KEGG   ENZYME: 5.4.99.67
Entry
EC 5.4.99.67                Enzyme                                 

Name
4-amino-4-deoxychorismate mutase;
cmlD (gene name);
papB (gene name)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
4-amino-4-deoxychorismate pyruvatemutase
Reaction(IUBMB)
4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate [RN:R12491]
Reaction(KEGG)
R12491
Substrate
4-amino-4-deoxychorismate [CPD:C11355]
Product
4-amino-4-deoxyprephenate [CPD:C22210]
Comment
The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC 5.4.99.5, chorismate mutase.
History
EC 5.4.99.67 created 2019
Orthology
K23874  4-amino-4-deoxychorismate mutase
Genes
LBQ: CKQ53_12640
PLU: plu3564
PLUM: A4R40_17725
PAY: PAU_01183(papB)
PTT: VY86_14280
PAKH: B0X70_18040
PFS: PFLU_1772
POI: BOP93_20460
PRH: LT40_00235
PUM: HGP31_16695
HOH: Hoch_1371
MAI: MICA_333
MAN: A11S_316
AAC: Aaci_2346
AAD: TC41_2630
RER: RER_18490
REY: O5Y_08880
ROP: ROP_61640
REQ: REQ_23860
RHB: NY08_973
RRT: 4535765_02687(tyrA_2)
RCR: NCTC10994_00407(tyrA_1)
GOR: KTR9_2682
SVE: SVEN_0918
DOU: BMF77_00659(tyrA_1)
 » show all
Reference
1  [PMID:9044253]
  Authors
Blanc V, Gil P, Bamas-Jacques N, Lorenzon S, Zagorec M, Schleuniger J, Bisch D, Blanche F, Debussche L, Crouzet J, Thibaut D
  Title
Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-phenylalanine precursor of pristinamycin I.
  Journal
Mol Microbiol 23:191-202 (1997)
DOI:10.1046/j.1365-2958.1997.2031574.x
  Sequence
Reference
2  [PMID:11577160]
  Authors
He J, Magarvey N, Piraee M, Vining LC
  Title
The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene.
  Journal
Microbiology 147:2817-29 (2001)
DOI:10.1099/00221287-147-10-2817
  Sequence
[sve:SVEN_0918]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.67
IUBMB Enzyme Nomenclature: 5.4.99.67
ExPASy - ENZYME nomenclature database: 5.4.99.67
BRENDA, the Enzyme Database: 5.4.99.67

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