KEGG   ENZYME: 5.4.99.7Help
Entry
EC 5.4.99.7                 Enzyme                                 

Name
lanosterol synthase;
2,3-epoxysqualene lanosterol cyclase;
squalene-2,3-oxide-lanosterol cyclase;
lanosterol 2,3-oxidosqualene cyclase;
squalene 2,3-epoxide:lanosterol cyclase;
2,3-oxidosqualene sterol cyclase;
oxidosqualene cyclase;
2,3-oxidosqualene cyclase;
2,3-oxidosqualene-lanosterol cyclase;
oxidosqualene-lanosterol cyclase;
squalene epoxidase-cyclase;
(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lanosterol-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol [RN:R03199]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
lanosterol [CPD:C01724]
History
EC 5.4.99.7 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 5.4.99.7 rest to EC 1.14.99.7
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K01852  lanosterol synthase
Genes
HSA: 4047(LSS)
PTR: 474058(LSS)
PON: 100432375(LSS)
MCC: 709227(LSS)
MMU: 16987(Lss)
RNO: 81681(Lss)
CFA: 491611(LSS)
AML: 100482594(LSS)
BTA: 615906(LSS)
SSC: 100625138(LSS)
ECB: 100055292(LSS)
MDO: 100026255(LSS)
SHR: 100933933(LSS)
OAA: 100083602(LSS)
GGA: 424037(LSS)
MGP: 100544500(LSS)
TGU: 100223318(LSS)
FPG: 101912237(LSS)
ACS: 100558321(lss)
XLA: 108703025(lss.S)
XTR: 733925(lss)
DRE: 795400(lss)
SPU: 576764
ATH: AT3G45130(LAS1)
THJ: 104799632
SCE: YHR072W(ERG7)
PIC: PICST_77382(ERG7)
CAL: CAALFM_C202460WA(ERG7)
CDU: CD36_17130(ERG7)
NCR: NCU01119
MGR: MGG_11702
ANG: ANI_1_1064084(An09g01330) ANI_1_846084(An09g06490)
ABE: ARB_06777
TVE: TRV_05691
SPO: SPAC13G7.01c(erg7)
CNE: CND02520
MGL: MGL_1532
DDI: DDB_G0269226(cas1)
 » show all
Taxonomy
Reference
1  [PMID:6027261]
  Authors
Dean PD, Ortiz de Montellano PR, Bloch K, Corey EJ.
  Title
A soluble 2,3-oxidosqualene sterol cyclase.
  Journal
J Biol Chem 242:3014-5 (1967)
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.7
IUBMB Enzyme Nomenclature: 5.4.99.7
ExPASy - ENZYME nomenclature database: 5.4.99.7
BRENDA, the Enzyme Database: 5.4.99.7
CAS: 9032-71-7

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