KEGG   ENZYME: 5.5.1.13
Entry
EC 5.5.1.13                 Enzyme                                 

Name
ent-copalyl diphosphate synthase;
ent-kaurene synthase A;
ent-kaurene synthetase A;
ent-CDP synthase;
ent-copalyl-diphosphate lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
ent-copalyl-diphosphate lyase (ring-opening)
Reaction(IUBMB)
geranylgeranyl diphosphate = ent-copalyl diphosphate [RN:R02068]
Reaction(KEGG)
R02068
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
ent-copalyl diphosphate [CPD:C06089]
Comment
Part of a bifunctional enzyme involved in the biosynthesis of kaurene. See also EC 4.2.3.19 (ent-kaurene synthase)
History
EC 5.5.1.13 created 2002
Pathway
ec00904  Diterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04120  ent-copalyl diphosphate synthase
K20657  ent-copalyl diphosphate/ent-kaurene synthase
Genes
ATH: AT4G02780(GA1)
ALY: 9310964
CRB: 17883900
CSAT: 104707805 104714573 104737446
EUS: EUTSA_v10029352mg
BRP: 103836713 103860100
BNA: 106392263 106426697 106443785
BOE: 106313827
RSZ: 108826010 108831603
THJ: 104801236
CPAP: 110814715
TCC: 18613340
EGR: 104456994
GMX: 100784193(TPS22) 100807519(TPS1) 100808585(TPS2)
LJA: Lj0g3v0251619.1(Lj0g3v0251619.1) Lj1g3v0682850.3(Lj1g3v0682850.3) Lj1g3v0682850.4(Lj1g3v0682850.4) Lj1g3v4434270.1(Lj1g3v4434270.1) Lj1g3v4434270.3(Lj1g3v4434270.3)
PPER: 18767747
PMUM: 103334237
PAVI: 110749801
MDM: 103448353 103448995(CPS)
CSV: 101214392
CMO: 103491661
MCHA: 111025355
RCU: 8272032
JCU: 105649988
QSU: 112000653
SLY: 544303(CPS)
SPEN: 107021672
CANN: 107874554
INI: 109158259(CPS1)
LSV: 111886441
BVG: 104898566
SOE: 110797142
DOSA: Os02t0278700-01(Os02g0278700) Os02t0571100-01(Os02g0571100)
OBR: 102712336(CPS1)
BDI: 100825198
SBI: 8064919
ZMA: 542165(an2) 542253(an1)
EGU: 105042778
DCT: 110096881
PEQ: 110024537
AOF: 109832398
ATR: 18428889
MGR: MGG_01949
 » show all
Reference
1  [PMID:4331199]
  Authors
Fall RR, West CA.
  Title
Purification and properties of kaurene synthetase from Fusarium moniliforme.
  Journal
J Biol Chem 246:6913-28 (1971)
Reference
2  [PMID:7994182]
  Authors
Sun TP, Kamiya Y
  Title
The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis.
  Journal
Plant Cell 6:1509-18 (1994)
DOI:10.1105/tpc.6.10.1509
  Sequence
[ath:AT4G02780]
Reference
3  [PMID:9268298]
  Authors
Kawaide H, Imai R, Sassa T, Kamiya Y
  Title
Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis.
  Journal
J Biol Chem 272:21706-12 (1997)
DOI:10.1074/jbc.272.35.21706
  Sequence
Reference
4  [PMID:10803977]
  Authors
Toyomasu T, Kawaide H, Ishizaki A, Shinoda S, Otsuka M, Mitsuhashi W, Sassa T
  Title
Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase.
  Journal
Biosci Biotechnol Biochem 64:660-4 (2000)
DOI:10.1271/bbb.64.660
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.13
IUBMB Enzyme Nomenclature: 5.5.1.13
ExPASy - ENZYME nomenclature database: 5.5.1.13
BRENDA, the Enzyme Database: 5.5.1.13
CAS: 9055-64-5

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