KEGG   ENZYME: 5.5.1.19
Entry
EC 5.5.1.19                 Enzyme                                 

Name
lycopene beta-cyclase;
CrtL;
CrtL-b;
CrtY;
LCYb;
carotenoid beta-end group lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
carotenoid beta-end group lyase (ring-opening)
Reaction(IUBMB)
carotenoid psi-end group = carotenoid beta-end group
Reaction(KEGG)
Substrate
carotenoid psi-end group
Product
carotenoid beta-end group [CPD:C21915]
Comment
The enzyme is a non-redox flavoprotein, containing FADH2 that is used for stabilization of a transition state. Lycopene has a psi-end group at both ends. When acting on one end, the enzyme forms gamma-carotene. When acting on both ends it forms beta-carotene. It also acts on neurosporene to give beta-zeacarotene.
History
EC 5.5.1.19 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K06443  lycopene beta-cyclase
K14605  lycopene cyclase CruA
K14606  lycopene cyclase CruP
K17841  15-cis-phytoene synthase / lycopene beta-cyclase
K22502  lycopene beta-cyclase
Genes
API: 100159332 100161104 100571777 100574964 103308018
DNX: 107165434 107165441 107165442 107165443 107165458
AGS: 114125976 114125977 114125978 114125983
RMD: 113548061 113548676 113549964 113549966 113549967
TUT: 107364280 107365901
ATH: AT3G10230(LYC)
ALY: 9318724
CRB: 17891714
CSAT: 104745202 104760303 104764729
EUS: EUTSA_v10020573mg
BRP: 103870482
BOE: 106295141
RSZ: 108862408
CPAP: 110822614
CIT: 102578042
TCC: 18598805
GRA: 105783300
GAB: 108461128
DZI: 111297247
EGR: 104444307
VRA: 106752577
VAR: 108329637
VUN: 114191752
CCAJ: 109815644
CAM: 101508316
LJA: Lj0g3v0231639.1(Lj0g3v0231639.1)
ADU: 107492682
AIP: 107645549
LANG: 109358646
FVE: 101295928
RCN: 112189564
PPER: 18771811
PMUM: 103339232
PAVI: 110770275
MDM: 103454566
PXB: 103933980
CSV: 101207778
CMO: 103497264(LBCY)
MCHA: 111021308
RCU: 8286646
JCU: 105645080
HBR: 110664739
MESC: 110623049
JRE: 108988394
VVI: 100252133(LBCY2)
SLY: 101267662 544104(LCY1)
CANN: 107843894 107869983(LCY1)
NTA: 107763207(CrtL-1) 107809095
NSY: 104240314
NTO: 104108950
NAU: 109233173
INI: 109162118
SIND: 105159883
OEU: 111370424
HAN: 110878757
LSV: 111904093
CCAV: 112512462
DCR: 108193045
BVG: 104889451
SOE: 110797905
NNU: 104608835
OSA: 4328572
DOSA: Os02t0190600-00(Os02g0190600)
BDI: 104583450
ATS: 109754598
SBI: 8077659
ZMA: 100383002
SITA: 101763950
PDA: 103722475
EGU: 105060532
MUS: 103998368
DCT: 110095206
PEQ: 110030862
AOF: 109824674
ATR: 18429822
MNG: MNEG_8175
CVR: CHLNCDRAFT_30425(LCYB)
APRO: F751_1786
NCR: NCU00585(al-2)
NTE: NEUTE1DRAFT53791(NEUTE1DRAFT_53791)
SMP: SMAC_01277(putative al2)
BFU: BCIN_01g04560(Bcphs1)
MBE: MBM_00659
TVE: TRV_03236
PTE: PTT_09938
ESA: ESA_00344
CSK: ES15_0619(crtY)
CTU: CTU_35420(crtY)
KOT: EH164_13630(crtY)
LEI: C2U54_12115(crtY)
LEH: C3F35_04360(crtY)
LEE: DVA44_16450(crtY)
LER: GNG29_07320(crtY)
LEA: GNG26_06945(crtY)
AHN: NCTC12129_03058(crtL)
PSTS: E05_04210
EGE: EM595_0219(crtY)
PAM: PANA_4160(crtY)
PLF: PANA5342_p10301(crtY)
PAJ: PAJ_p0124(crtY)
PAQ: PAGR_p227
PVA: Pvag_pPag30173(crtY)
PAGG: AL522_02520(crtY)
PSTW: DSJ_25970
PANS: FCN45_21425(crtY)
PEY: EE896_20455(crtY)
PDIS: D8B20_19310(crtY)
PGZ: C2E15_03085(crtY)
PCD: C2E16_03190(crtY)
PLU: plu4341(crtY)
LUM: CNR27_10985(crtY)
PVD: CFBP1590__2675(crtY)
PSA: PST_3874
PSTT: CH92_19215
PLUL: FOB45_11895(crtY)
PSED: DM292_21275(crtY)
ACX: Achr_15290(crtY)
GNI: GNIT_0398(lcyB)
GPS: C427_1921(lcyB)
HMI: soil367_17425(crtY)
LHA: LHA_1129
THIP: N838_26825(crtY)
PLE: B186_261(crtY)
PLY: C530_251
PLR: PAQ_256(crtY)
PLO: C548_251
PLD: PalTV_231(crtY)
PLB: PTV_231(crtY)
PLC: PAD_239(crtY)
PLI: PLF_238(crtY)
PALY: O3E_01515
PAUR: FGL86_00510(crtY)
SALN: SALB1_1270
RTA: Rta_07720
MELM: C7H73_12395(crtY)
MASZ: C9I28_27260(crtY)
MTIM: DIR46_08610(crtY)
MASY: DPH57_22000(crtY)
MALI: EYF70_25695(crtY)
MUM: FCL38_23645(crtY)
MFLA: GO485_19155(crtY)
SSDC: SSDC_01989(crtY)
MXA: MXAN_0900
SCL: sce0582
HOH: Hoch_2209
NEO: CYG48_12275(crtY)
BRA: BRADO6508(crtY)
XAU: Xaut_3576
RVA: Rvan_0149
AALA: IGS74_06945(crtY)
CAK: Caul_1713
CMB: CSW64_08145(crtY)
CFH: C1707_14420(crtY)
BVC: CEP68_00755(crtY)
BRF: E4M01_08555(crtY)
BREV: E7T10_10700(crtY)
PYE: A6J80_22070(crtY)
PARR: EOJ32_07415(crtY)
PLIA: E4191_05650(crtY)
NAR: Saro_1817
NOV: TQ38_003990(crtY)
NOT: C7W88_11885(crtY)
NOR: FA702_16870(crtY)
NGF: FRF71_04730(crtY)
NOG: GKE62_02565(crtY)
SAL: Sala_3135
SPHP: LH20_01370
SMAZ: LH19_18595
SPHX: E5675_18395(crtY)
SPHU: SPPYR_3142(crtY)
SWI: Swit_3200
SPHD: HY78_09555
SPHM: G432_07835
STAX: MC45_14765
SPHI: TS85_20450
SSAN: NX02_00965
SPKC: KC8_11305
SPHC: CVN68_16205(crtY)
SPHF: DM480_06130(crtY)
SPHA: D3Y57_11045(crtY)
SPAU: DRN02_014720(crtY)
SLUT: H9L13_06665(crtY)
SRHI: H9L12_01850(crtY)
SLAN: GV829_03335(crtY)
SPAP: H3Z74_21135(crtY)
SXA: FMM02_01305(crtY)
SJP: SJA_C1-01610(crtY)
SSY: SLG_31720(crtY)
SPMI: K663_01395
SPHB: EP837_01645(lcyB)
SPHR: BSY17_1788(crtY)
SINB: SIDU_17130
SPHT: K426_20400
SHYD: CJD35_07280(crtY)
SYA: A6768_23665(crtY)
SUFL: FIL70_16710(crtY)
SBAR: H5V43_12660(crtY)
SPHY: CHN51_13375(crtY)
BLAS: BSY18_2317(crtY)
RDI: CMV14_00555(crtY)
SPZR: G5C33_01980(crtY)
PALG: HFP57_12485(crtY)
PARJ: J4G78_04010(crtY)
SMIC: SmB9_24680
SPHS: ETR14_09430(crtY)
SAND: H3309_11770(crtY)
AAY: WYH_03020
ALB: AEB_P3490
ALH: G6N82_05700(crtY)
EFV: CHH26_13515(crtY)
ELI: ELI_09880
ERK: CD351_14880(crtY)
ERR: DVR09_04945(crtY)
EMV: HQR01_12375(crtY)
PHZ: CHX26_05585(crtY)
POT: E2E27_17090(crtY)
PUB: SAR11_0122(crtY)
BBA: Bd1730
AAC: Aaci_2822
AAD: TC41_3168
MVA: Mvan_5914
MGI: Mflv_0950
MVQ: MYVA_5869(crtL)
MDU: MDUV_44340(lcyB)
MAUU: NCTC10437_05672(crtL)
MAIC: MAIC_57100
MALV: MALV_52190(lcyE)
MARZ: MARA_40230(lcyB)
MGAD: MGAD_43040(lcyB)
MHEV: MHEL_22810
MANY: MANY_40170(lcyB)
MPOF: MPOR_04760
ASD: AS9A_1909(crtL)
CEF: CE1680
CJK: jk0978
CUR: cu1013
CRD: CRES_1060(crtL)
CVA: CVAR_1461
CTER: A606_05690
COA: DR71_19
CAQU: CAQU_06595
CCHO: CCHOA_06055(crtL)
CPRE: Csp1_14000(crtL)
NFA: NFA_34900(crtL2) NFA_7290(crtL1)
NFR: ERS450000_00558(crtL_1) ERS450000_03396(crtL_2)
NAD: NCTC11293_01538(crtL_1) NCTC11293_04877(crtL_2)
RER: RER_30640(crtL)
REY: O5Y_14040
ROP: ROP_69910(crtL)
REQ: REQ_22360
RHB: NY08_1078
RFA: A3L23_04326(crtL)
RHS: A3Q41_03941(crtL)
RHU: A3Q40_01667(crtL)
RRT: 4535765_02241(crtL)
GBR: Gbro_2394
GOR: KTR9_2309
GRU: GCWB2_13335(crtL)
GOM: D7316_00915(crtL)
TPR: Tpau_2495
SCO: SCO0191(crtY)
SALB: XNR_5692
SMA: SAVERM_1021(crtY)
SGR: SGR_54t(crtY2) SGR_6824(crtY) SGR_7085t(crtY3)
SCB: SCAB_5491(crtY)
SHY: SHJG_1676
SCT: SCAT_p0246(crtY)
SFA: Sfla_0350
SALS: SLNWT_1106
STRP: F750_6661
SFI: SFUL_37
STRM: M444_00680
SPRI: SPRI_1989
SLE: sle_65910(sle_65910)
SLAU: SLA_5752
SRJ: SRO_7454
CMS: CMS2605
IDO: I598_1140(crtL)
SERJ: SGUI_1797
BLIN: BLSMQ_3109
DCO: SAMEA4475696_0723(crtL)
TLA: TLA_TLA_01578(crtL)
TFU: Tfu_3088
NDA: Ndas_3568
NAL: B005_0704
KRA: Krad_0091
SEN: SACE_2184
AOI: AORI_2833(lcyB)
AMYY: YIM_18245(crtL)
AORI: SD37_15200
PSEA: WY02_03220
PSEE: FRP1_09575
PSEH: XF36_11050
PAUT: Pdca_32160
AMI: Amir_5144
SESP: BN6_56360(crtY) BN6_62220(crtL)
KAL: KALB_3743
ACTI: UA75_12655
ACAD: UA74_12575
AHG: AHOG_11845(crtL)
ALO: CRK56378
SAQ: Sare_2557
MIL: ML5_5108
AYM: YM304_23780(crtL)
SYY: SYNGTS_1984(sll0147) SYNGTS_2802(sll0659)
SYT: SYNGTI_1983(sll0147) SYNGTI_2801(sll0659)
SYS: SYNPCCN_1982(sll0147) SYNPCCN_2800(sll0659)
SYQ: SYNPCCP_1982(sll0147) SYNPCCP_2800(sll0659)
SYC: syc0876_d syc2031_d(crtL)
SYW: SYNW0728(crtL)
SYG: sync_0974
SYR: SynRCC307_0743(crtL)
SYX: SynWH7803_1588(crtL)
SYNR: KR49_04885
SYND: KR52_06575
SYH: Syncc8109_2036(crtL)
SYNW: SynWH8103_00830(crtL-b)
TEL: tlr1139
THN: NK55_02970(cruA)
PMA: Pro_1136(lcyB)
PMM: PMM1064(crtL1)
PMT: PMT_1123
PRC: EW14_1203
PRM: EW15_1582
AMR: AM1_2386(cruP) AM1_2622(cruP) AM1_5425(cruA) AM1_6075(crtL)
MPK: VL20_6410
CYL: AA637_01080(cruA) AA637_11195(cruP)
ARP: NIES39_A06350(cruA) NIES39_K00660(cruP)
PAGH: NIES204_19440(cruP) NIES204_36730(cruA)
GLJ: GKIL_3349(cruP) GKIL_3517(cruA)
NSP: BMF81_02823(cruA)
CEO: ETSB_0653
CAU: Caur_1819
CAG: Cagg_1563
HAU: Haur_3909
ATM: ANT_14930
CAP: CLDAP_21410(crtL)
DGO: DGo_CA2369(crtL) DGo_CA2876(cruF)
DFC: DFI_00345
TTH: TT_P0060
TTJ: TTHB104
TAQ: TO73_1252
IPA: Isop_3503
SRU: SRU_1501(crtY)
SRM: SRM_01699
RMR: Rmar_1608
CPI: Cpin_4955
SLI: Slin_0447
FAE: FAES_4443(crtY)
PSEZ: HME7025_01013(lcyB)
HSW: Hsw_0139
GFO: GFO_2502(crtY)
GFL: GRFL_0485
FPS: FP1447(crtY)
FJO: Fjoh_0926
FBR: FBFL15_2138(crtY)
FIN: KQS_13045(crtY)
ZPR: ZPR_0873
MARM: YQ22_09455
CBAL: M667_06290
CBAT: M666_06235
DOK: MED134_08681(crtY)
DDO: I597_0502
ZGA: ZOBELLIA_1952(crtY)
MLT: VC82_1583
NDO: DDD_2392(crtY)
POM: MED152_02660(crtY)
WIN: WPG_0049
SPON: HME9304_01749(lcyB)
MESQ: C7H62_2005
CTE: CT0456
CPC: Cpar_0452
CCH: Cag_0265
CLI: Clim_2017
PVI: Cvib_1484
PLT: Plut_1700
PAA: Paes_0426
CTS: Ctha_0083
HAL: VNG_2137G(ggt)
HSL: OE_3983R(crtY)
HHB: Hhub_3439(crtY)
HMA: rrnAC2067(crtY)
HHI: HAH_2562(crtY)
NPH: NP_0652A(crtY)
NMO: Nmlp_1293(crtY)
HUT: Huta_0316
HTI: HTIA_0509
HMU: Hmuk_1284
HALL: LC1Hm_0498
HWA: HQ_1018A(crtY)
HWC: Hqrw_1020(crtY)
HLA: Hlac_2731
NAT: NJ7G_2815
 » show all
Reference
1  [PMID:8344419]
  Authors
Cunningham FX Jr, Chamovitz D, Misawa N, Gantt E, Hirschberg J
  Title
Cloning and functional expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme that catalyzes the biosynthesis of beta-carotene.
  Journal
FEBS Lett 328:130-8 (1993)
DOI:10.1016/0014-5793(93)80980-9
Reference
2  [PMID:7919981]
  Authors
Cunningham FX Jr, Sun Z, Chamovitz D, Hirschberg J, Gantt E.
  Title
Molecular structure and enzymatic function of lycopene cyclase from the cyanobacterium Synechococcus sp strain PCC7942.
  Journal
Plant Cell 6:1107-21 (1994)
DOI:10.1105/tpc.6.8.1107
  Sequence
Reference
3  [PMID:7550379]
  Authors
Hugueney P, Badillo A, Chen HC, Klein A, Hirschberg J, Camara B, Kuntz M
  Title
Metabolism of cyclic carotenoids: a model for the alteration of this biosynthetic pathway in Capsicum annuum chromoplasts.
  Journal
Plant J 8:417-24 (1995)
DOI:10.1046/j.1365-313X.1995.08030417.x
  Sequence
Reference
4  [PMID:8624411]
  Authors
Pecker I, Gabbay R, Cunningham FX Jr, Hirschberg J
  Title
Cloning and characterization of the cDNA for lycopene beta-cyclase from tomato reveals decrease in its expression during fruit ripening.
  Journal
Plant Mol Biol 30:807-19 (1996)
DOI:10.1007/BF00019013
  Sequence
[sly:544104] [ag:CAA57386]
Reference
5  [PMID:11943208]
  Authors
Hornero-Mendez D, Britton G
  Title
Involvement of NADPH in the cyclization reaction of carotenoid biosynthesis.
  Journal
FEBS Lett 515:133-6 (2002)
DOI:10.1016/S0014-5793(02)02453-5
Reference
6  [PMID:17606904]
  Authors
Maresca JA, Graham JE, Wu M, Eisen JA, Bryant DA
  Title
Identification of a fourth family of lycopene cyclases in photosynthetic bacteria.
  Journal
Proc Natl Acad Sci U S A 104:11784-9 (2007)
DOI:10.1073/pnas.0702984104
  Sequence
Reference
7  [PMID:20178989]
  Authors
Yu Q, Schaub P, Ghisla S, Al-Babili S, Krieger-Liszkay A, Beyer P
  Title
The lycopene cyclase CrtY from Pantoea ananatis (formerly Erwinia uredovora) catalyzes an FADred-dependent non-redox reaction.
  Journal
J Biol Chem 285:12109-20 (2010)
DOI:10.1074/jbc.M109.091843
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.19
IUBMB Enzyme Nomenclature: 5.5.1.19
ExPASy - ENZYME nomenclature database: 5.5.1.19
BRENDA, the Enzyme Database: 5.5.1.19
CAS: 220801-82-1

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