Entry
Name
lycopene beta-cyclase;
CrtL;
CrtL-b;
CrtY;
LCYb;
carotenoid beta-end group lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
carotenoid beta-end group lyase (ring-opening)
Reaction(IUBMB)
carotenoid psi-end group = carotenoid beta-end group
Reaction(KEGG)
Substrate
carotenoid psi-end group
Product
carotenoid beta-end group [CPD:
C21915 ]
Comment
The enzyme is a non-redox flavoprotein, containing FADH2 that is used for stabilization of a transition state. Lycopene has a psi-end group at both ends. When acting on one end, the enzyme forms gamma-carotene. When acting on both ends it forms beta-carotene. It also acts on neurosporene to give beta-zeacarotene.
History
EC 5.5.1.19 created 2011
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K17841 15-cis-phytoene synthase / lycopene beta-cyclase
Genes
API : 100159332 100161104 100571777 100574964 103308018
DNX : 107165434 107165441 107165442 107165443 107165458
AGS : 114125976 114125977 114125978 114125983
RMD : 113548061 113548676 113549964 113549966 113549967
CSAT : 104745202 104760303 104764729
LJA : Lj0g3v0231639.1(Lj0g3v0231639.1)
CMAX : 111465974 111477982
CMOS : 111432483 111439634
CPEP : 111781078 111804889
PALZ : 118031929 118053044
QSU : 111993761 112019038 112021618
SLY : 101267662 544104(LCY1)
SPEN : 107002371 107017654
SSTN : 125856701 125865518
CANN : 107843894 107869983
NTA : 107763207(CrtL-1) 107809095
SSPL : 121747074 121750645
MING : 122059933 122061986 122065812 122067830
PSOM : 113274665 113304188
DOSA : Os02t0190600-00(Os02g0190600)
TAES : 101290666 123127204 123136803
PVIR : 120648385 120654925
ZOF : 121970914 121976708 121976710
SMO : SELMODRAFT_147622 SELMODRAFT_266613
CVR : CHLNCDRAFT_30425(LCYB)
CCP : CHC_T00002318001 CHC_T00003979001
NTE : NEUTE1DRAFT53791(NEUTE1DRAFT_53791)
SMP : SMAC_01277(putative al2)
BFU : BCIN_01g04560(Bcphs1)
ALUC : AKAW2_10489A AKAW2_12055A
FCY : FRACYDRAFT_183412(LCYB2) FRACYDRAFT_190208(LCYB1)
EHX : EMIHUDRAFT_42521 EMIHUDRAFT_448849
GTT : GUITHDRAFT_100338 GUITHDRAFT_111949
AHN : NCTC12129_03058(crtL)
PLF : PANA5342_p10301(crtY)
PVA : Pvag_pPag30173(crtY)
PVD : CFBP1590__2675(crtY)
LANT : TUM19329_07890(crtY)
AGE : AA314_01167 AA314_01872
AVM : JQX13_22195 JQX13_39890
CFUS : CYFUS_001186 CYFUS_002284
MAUU : NCTC10437_05672(crtL)
NFA : NFA_34900(crtL2) NFA_7290(crtL1)
NFR : ERS450000_00558(crtL_1) ERS450000_03396(crtL_2)
NCY : NOCYR_0762 NOCYR_2341
NBR : O3I_004140 O3I_027635
NNO : NONO_c08340 NONO_c41560
NSL : BOX37_03650 BOX37_18840
NSR : NS506_04292(lcyB) NS506_07641
NTP : CRH09_05015 CRH09_21710
NOZ : DMB37_06625 DMB37_25065
NOD : FOH10_16225 FOH10_27095
NAH : F5544_04805 F5544_27405
NAD : NCTC11293_01538(crtL_1) NCTC11293_04877(crtL_2)
NWL : NWFMUON74_08220 NWFMUON74_35940(lcyB)
NIE : KV110_04375 KV110_26920
NHU : H0264_05540 H0264_26675
NYA : LTV02_07950 LTV02_27420
NGP : LTT66_07975 LTT66_26170
RAV : AAT18_11055 AAT18_13340
RRZ : CS378_00805 CS378_03110
RCR : NCTC10994_00143 NCTC10994_00580(crtL)
SPIN : KV203_03840 KV203_10250
SGR : SGR_54t(crtY2) SGR_6824(crtY) SGR_7085t(crtY3)
SLE : sle_65910(sle_65910)
STRD : NI25_03610 NI25_35270
SGF : HEP81_07767 HEP81_07983
DCO : SAMEA4475696_0723(crtL)
SESP : BN6_56360(crtY) BN6_62220(crtL)
RUB : GBA63_13010 GBA63_19305 GBA63_20120
RMAR : GBA65_04420 GBA65_07865
SYZ : MYO_120030 MYO_128280
SYY : SYNGTS_1984(sll0147) SYNGTS_2802(sll0659)
SYT : SYNGTI_1983(sll0147) SYNGTI_2801(sll0659)
SYS : SYNPCCN_1982(sll0147) SYNPCCN_2800(sll0659)
SYQ : SYNPCCP_1982(sll0147) SYNPCCP_2800(sll0659)
SYJ : D082_03870 D082_26830
SYO : C7I86_10350 C7I86_14640
SYC : syc0876_d syc2031_d(crtL)
SYU : M744_06080 M744_13550
SYF : Synpcc7942_0652 Synpcc7942_2062
SYR : SynRCC307_0743(crtL)
SYX : SynWH7803_1588(crtL)
SYP : SYNPCC7002_A0043(cruP) SYNPCC7002_A2153(cruA)
SYNE : Syn6312_0718 Syn6312_2405
SYNP : Syn7502_00573 Syn7502_01962
SYH : Syncc8109_2036(crtL)
SYNW : SynWH8103_00830(crtL-b)
SYV : AWQ23_00225 AWQ23_10770
SYL : AWQ21_00205 AWQ21_10920
DSL : Dacsa_0807 Dacsa_3625
PMA : Pro_0790(lcyE) Pro_1136(lcyB)
PMM : PMM0633(crtL2) PMM1064(crtL1)
PMN : PMN2A_0073 PMN2A_0688
PMI : PMT9312_0633 PMT9312_1075
PMB : A9601_06891 A9601_11691
PMC : P9515_06991 P9515_11541
PMF : P9303_09161 P9303_23511
PMG : P9301_06601 P9301_11701
PMH : P9215_07161 P9215_11991
PMJ : P9211_07411 P9211_11261
PME : NATL1_06951 NATL1_15221
CMP : Cha6605_0728 Cha6605_4748
AMR : AM1_2386(cruP) AM1_2622(cruP) AM1_5425(cruA) AM1_6075(crtL)
WNA : KA717_21700 KA717_24950
LEP : Lepto7376_0727 Lepto7376_1690
LEN : LEP3755_10910 LEP3755_45660
LET : O77CONTIG1_01742 O77CONTIG1_03048
LSC : KIK02_02880 KIK02_03810
LSK : J5X98_11670 J5X98_13820
HHG : XM38_003580 XM38_024980(crtL) XM38_038090
PSEU : Pse7367_0611 Pse7367_2280
PSER : ABRG53_1642 ABRG53_2843(cruA)
GLP : Glo7428_2174 Glo7428_2231 Glo7428_3267
GEE : GM3708_2909 GM3708_798
CHON : NIES4102_01530 NIES4102_14080
MIQ : B5D77_19235 B5D77_21845
MVZ : myaer102_26940 myaer102_42250
CAN : Cyan10605_1231 Cyan10605_2641
CSN : Cyast_1408 Cyast_2478
CYL : AA637_01080(cruA) AA637_11195(cruP)
HAO : PCC7418_2321 PCC7418_3475
ENN : FRE64_01525 FRE64_14935
CWA : CwatDRAFT_1341 CwatDRAFT_6211
CYP : PCC8801_0550 PCC8801_1030
CYH : Cyan8802_0567 Cyan8802_1059
CYC : PCC7424_2895 PCC7424_3550
CYJ : Cyan7822_0735 Cyan7822_3124
CYN : Cyan7425_1722 Cyan7425_1974
ARP : NIES39_A06350(cruA) NIES39_K00660(cruP)
PAGH : NIES204_19440(cruP) NIES204_36730(cruA)
PPSU : NO713_01930 NO713_03561
OXY : HCG48_03180 HCG48_17175
MVAG : D0A34_08875 D0A34_25125
LFS : HFV01_04095 HFV01_30415
MIC : Mic7113_0588 Mic7113_5704
OAC : Oscil6304_3038 Oscil6304_3788
ONI : Osc7112_1242 Osc7112_5721
PHOR : JWS08_08855 JWS08_12390
PYH : NEA10_03055 NEA10_19750
CEP : Cri9333_1398 Cri9333_3151
GLJ : GKIL_3349(cruP) GKIL_3517(cruA)
GML : ISF26_01885 ISF26_02605
NPU : Npun_R4002 Npun_R4207
NOS : Nos7107_1316 Nos7107_4873
NOP : Nos7524_2134 Nos7524_4384
NON : NOS3756_04720 NOS3756_10060
NFL : COO91_00204 COO91_04358
NOE : CLI64_02720 CLI64_02995
NED : HUN01_12475 HUN01_13455
ANB : ANA_C10732 ANA_C11482
ACY : Anacy_0335 Anacy_2266
AWA : AA650_07590 AA650_15095
ANN : EH233_13890 EH233_26980
CSG : Cylst_0957 Cylst_4610
RSIN : B6N60_01989 B6N60_02588
CALO : Cal7507_0656 Cal7507_2436
CALT : Cal6303_1474 Cal6303_5438
CALH : IJ00_17960 IJ00_24240
CALN : NIES2098_03940 NIES2098_65770
RIV : Riv7116_2354 Riv7116_3742
FIS : FIS3754_00560 FIS3754_20730
NSPH : BDGGKGIB_00938 BDGGKGIB_01396
DOU : BMF77_01587 BMF77_02567
DFS : HGD76_04650 HGD76_09950
DHT : NG743_18895 NG743_22930
CCUR : IAR63_01045 IAR63_15750
CRK : L3I90_02430 L3I90_09315
TOQ : HCG51_14135 HCG51_26105
NCN : BZZ01_14015 BZZ01_16780
CTHE : Chro_0094 Chro_5277
PLP : Ple7327_0794 Ple7327_3427
SCS : Sta7437_3925 Sta7437_4296
STAN : STA3757_14890 STA3757_37230
DMR : Deima_1579 Deima_3262
DGO : DGo_CA2369(crtL) DGo_CA2876(cruF)
DCH : SY84_07010 SY84_15400
DPU : SU48_01090 SU48_09440
DEIN : DAAJ005_11865 DAAJ005_15620
DGA : DEGR_13250 DEGR_27990
DRD : LMT64_00280 LMT64_06350
DAH : DAETH_07620 DAETH_30470
DAQU : M8445_03635 M8445_14530
MTAI : Mtai_v1c24760 Mtai_v1c24770
MSV : Mesil_1488 Mesil_1489
MDA : IPZ59_03660 IPZ59_15075
PSEZ : HME7025_01013(lcyB)
RSI : Runsl_0235 Runsl_4034
RUN : DR864_01520 DR864_24195
SPON : HME9304_01749(lcyB)
PTQ : P700755_000617 P700755_001416
CLZ : BIU88_09110 BIU88_11000
CPH : Cpha266_0192 Cpha266_0474
CPB : Cphamn1_0272 Cphamn1_0462
PROC : Ptc2401_00218 Ptc2401_00444
CPRV : CYPRO_0402 CYPRO_2828
SAIM : K0C01_01975 K0C01_09435
HRA : EI982_09595 EI982_11170
HRM : K6T25_06250 K6T25_11975
HACB : Hbl1158_01775 Hbl1158_11750
NPL : FGF80_05460 FGF80_08435
NGE : Natgr_0245 Natgr_3013
NBG : DV706_04830 DV706_12800
» show all
Taxonomy
Reference
Authors
Cunningham FX Jr, Chamovitz D, Misawa N, Gantt E, Hirschberg J
Title
Cloning and functional expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme that catalyzes the biosynthesis of beta-carotene.
Journal
Reference
Authors
Cunningham FX Jr, Sun Z, Chamovitz D, Hirschberg J, Gantt E.
Title
Molecular structure and enzymatic function of lycopene cyclase from the cyanobacterium Synechococcus sp strain PCC7942.
Journal
Sequence
Reference
Authors
Hugueney P, Badillo A, Chen HC, Klein A, Hirschberg J, Camara B, Kuntz M
Title
Metabolism of cyclic carotenoids: a model for the alteration of this biosynthetic pathway in Capsicum annuum chromoplasts.
Journal
Sequence
Reference
Authors
Pecker I, Gabbay R, Cunningham FX Jr, Hirschberg J
Title
Cloning and characterization of the cDNA for lycopene beta-cyclase from tomato reveals decrease in its expression during fruit ripening.
Journal
Sequence
Reference
Authors
Hornero-Mendez D, Britton G
Title
Involvement of NADPH in the cyclization reaction of carotenoid biosynthesis.
Journal
Reference
Authors
Maresca JA, Graham JE, Wu M, Eisen JA, Bryant DA
Title
Identification of a fourth family of lycopene cyclases in photosynthetic bacteria.
Journal
Sequence
Reference
Authors
Yu Q, Schaub P, Ghisla S, Al-Babili S, Krieger-Liszkay A, Beyer P
Title
The lycopene cyclase CrtY from Pantoea ananatis (formerly Erwinia uredovora) catalyzes an FADred-dependent non-redox reaction.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.19
ExPASy - ENZYME nomenclature database: 5.5.1.19