KEGG   ENZYME: 5.5.1.26
Entry
EC 5.5.1.26                 Enzyme                                 

Name
nogalonic acid methyl ester cyclase;
methyl nogalonate cyclase;
SnoaL (gene name);
methyl nogalonate lyase (cyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
nogalaviketone lyase (ring-opening)
Reaction(IUBMB)
nogalaviketone = methyl nogalonate [RN:R09328]
Reaction(KEGG)
R09328
Substrate
nogalaviketone [CPD:C18630]
Product
methyl nogalonate [CPD:C12415]
Comment
The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin.
History
EC 5.5.1.26 created 2015
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15943  nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase
Genes
STIR: DDW44_27900
SKA: CP970_39840
MAU: Micau_3999
MIL: ML5_4422
Reference
1  [PMID:15071504]
  Authors
Sultana A, Kallio P, Jansson A, Wang JS, Niemi J, Mantsala P, Schneider G
  Title
Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.
  Journal
EMBO J 23:1911-21 (2004)
DOI:10.1038/sj.emboj.7600201
Reference
2  [PMID:15159574]
  Authors
Sultana A, Kallio P, Jansson A, Niemi J, Mantsala P, Schneider G
  Title
Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis.
  Journal
Acta Crystallogr D Biol Crystallogr 60:1118-20 (2004)
DOI:10.1107/S090744490400705X
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.26
IUBMB Enzyme Nomenclature: 5.5.1.26
ExPASy - ENZYME nomenclature database: 5.5.1.26
BRENDA, the Enzyme Database: 5.5.1.26

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