KEGG   ENZYME: 5.5.1.28
Entry
EC 5.5.1.28                 Enzyme                                 
Name
(-)-kolavenyl diphosphate synthase;
SdKPS;
TwTPS14;
TwTPS10/KPS;
SdCPS2;
clerodienyl diphosphate synthase;
CLPP
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
(-)-kolavenyl diphosphate lyase (ring-opening)
Reaction(IUBMB)
geranylgeranyl diphosphate = (-)-kolavenyl diphosphate [RN:R11869]
Reaction(KEGG)
R11869
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
(-)-kolavenyl diphosphate [CPD:C21735]
Comment
Isolated from the hallucinogenic plant Salvia divinorum (seer's sage) and the medicinal plant Tripterygium wilfordii (thunder god vine).
History
EC 5.5.1.28 created 2017
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22948  (-)-kolavenyl diphosphate synthase
Genes
SSPL121742662
Reference
1  [PMID:27801964]
  Authors
Hansen NL, Heskes AM, Hamberger B, Olsen CE, Hallstrom BM, Andersen-Ranberg J, Hamberger B
  Title
The terpene synthase gene family in Tripterygium wilfordii harbors a labdane-type diterpene synthase among the monoterpene synthase TPS-b subfamily.
  Journal
Plant J 89:429-441 (2017)
DOI:10.1111/tpj.13410
  Sequence
Reference
2  [PMID:28204567]
  Authors
Chen X, Berim A, Dayan FE, Gang DR
  Title
A (-)-kolavenyl diphosphate synthase catalyzes the first step of salvinorin A biosynthesis in Salvia divinorum.
  Journal
J Exp Bot 68:1109-1122 (2017)
DOI:10.1093/jxb/erw493
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.28
IUBMB Enzyme Nomenclature: 5.5.1.28
ExPASy - ENZYME nomenclature database: 5.5.1.28
BRENDA, the Enzyme Database: 5.5.1.28

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