KEGG   ENZYME: 5.5.1.31
Entry
EC 5.5.1.31                 Enzyme                                 

Name
hapalindole H synthase;
famC2 (gene name);
famC3 (gene name)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (hapalindole H-forming)
Reaction(IUBMB)
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H [RN:R12004]
Reaction(KEGG)
R12004
Substrate
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21837]
Product
hapalindole H [CPD:C21838]
Comment
The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the hapalindole family of alkaloids. The enzyme is a heterodimeric complex.
History
EC 5.5.1.31 created 2018
Orthology
K22971  hapalindole H/12-epi-hapalindole U/12-epi-fischerindole U synthase
Reference
1  [PMID:28288107]
  Authors
Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH
  Title
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.
  Journal
Nat Chem Biol 13:467-469 (2017)
DOI:10.1038/nchembio.2327
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.31
IUBMB Enzyme Nomenclature: 5.5.1.31
ExPASy - ENZYME nomenclature database: 5.5.1.31
BRENDA, the Enzyme Database: 5.5.1.31

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