Entry
Name
hapalindole H synthase;
famC2 (gene name);
famC3 (gene name)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (hapalindole H-forming)
Reaction(IUBMB)
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H [RN:
R12004 ]
Reaction(KEGG)
Substrate
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:
C21837 ]
Product
Comment
The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the hapalindole family of alkaloids. The enzyme is a heterodimeric complex.
History
EC 5.5.1.31 created 2018
Orthology
K22971 hapalindole H/12-epi-hapalindole U/12-epi-fischerindole U/hapalindole U synthase
Reference
Authors
Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH
Title
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.31
ExPASy - ENZYME nomenclature database: 5.5.1.31