KEGG   ENZYME: 5.5.1.32
Entry
EC 5.5.1.32                 Enzyme                                 

Name
12-epi-hapalindole U synthase;
famC1 (gene name);
HpiC1 (gene name)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (12-epi-hapalindole U-forming)
Reaction(IUBMB)
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-hapalindole U [RN:R12005]
Reaction(KEGG)
R12005
Substrate
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21837]
Product
12-epi-hapalindole U [CPD:C21839]
Comment
The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the 12-epi-hapalindole family of alkaloids.
History
EC 5.5.1.32 created 2018
Orthology
K22971  hapalindole H/12-epi-hapalindole U/12-epi-fischerindole U synthase
Reference
1  [PMID:26629885]
  Authors
Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH
  Title
Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.
  Journal
J Am Chem Soc 137:15366-9 (2015)
DOI:10.1021/jacs.5b10136
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.32
IUBMB Enzyme Nomenclature: 5.5.1.32
ExPASy - ENZYME nomenclature database: 5.5.1.32
BRENDA, the Enzyme Database: 5.5.1.32

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