KEGG   ENZYME: 5.5.1.33
Entry
EC 5.5.1.33                 Enzyme                                 

Name
12-epi-fischerindole U synthase;
fisC (gene name);
fimC5 (gene name)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (12-epi-fischerindole U-forming)
Reaction(IUBMB)
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-fischerindole U [RN:R12006]
Reaction(KEGG)
R12006
Substrate
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21837]
Product
12-epi-fischerindole U [CPD:C21840]
Comment
The enzyme, characterized from multiple species of the cyanobacterial genus Fischerella, participates in the biosynthesis of the terpenoid indole alkaloids 12-epi-fischerindoles.
History
EC 5.5.1.33 created 2018
Orthology
K22971  hapalindole H/12-epi-hapalindole U/12-epi-fischerindole U synthase
Reference
1  [PMID:28288107]
  Authors
Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH
  Title
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.
  Journal
Nat Chem Biol 13:467-469 (2017)
DOI:10.1038/nchembio.2327
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.33
IUBMB Enzyme Nomenclature: 5.5.1.33
ExPASy - ENZYME nomenclature database: 5.5.1.33
BRENDA, the Enzyme Database: 5.5.1.33

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