Entry
Name
(+)-cis,trans-nepetalactol synthase;
NEPS1 (gene name);
NEPS2 (gene name)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(S)-8-oxocitronellyl enol cyclase [(+)-cis,trans-nepetalactol-forming]
Reaction(IUBMB)
(S)-8-oxocitronellyl enol = (+)-cis,trans-nepetalactol [RN:
R12520 ]
Reaction(KEGG)
Substrate
(S)-8-oxocitronellyl enol [CPD:
C22225 ]
Product
(+)-cis,trans-nepetalactol [CPD:
C09804 ]
Comment
The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. The product is a precursor of (+)-cis,trans-nepetalactone, the primary ingredient responsible for the psychoactive effects catnip has on cats.
History
EC 5.5.1.34 created 2019
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K23862 (+)-cis,trans-nepetalactol synthase
K23990 nepetalactol dehydrogenase / (+)-cis,trans-nepetalactol synthase
Reference
Authors
Lichman BR, Kamileen MO, Titchiner GR, Saalbach G, Stevenson CEM, Lawson DM, O'Connor SE
Title
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.
Journal
Sequence
Reference
Authors
Lichman BR, O'Connor SE, Kries H
Title
Biocatalytic Strategies towards [4+2] Cycloadditions.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.34
ExPASy - ENZYME nomenclature database: 5.5.1.34