KEGG   ENZYME: 5.5.1.35
Entry
EC 5.5.1.35                 Enzyme                                 

Name
(+)-cis,cis-nepetalactol synthase;
NEPS3 (gene name)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
(S)-8-oxocitronellyl enol cyclase [(+)-cis,cis-nepetalactol-forming]
Reaction(IUBMB)
(S)-8-oxocitronellyl enol = (+)-cis,cis-nepetalactol [RN:R12521]
Reaction(KEGG)
R12521
Substrate
(S)-8-oxocitronellyl enol [CPD:C22225]
Product
(+)-cis,cis-nepetalactol [CPD:C22200]
Comment
The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. The product is a precursor of (+)-cis,cis-nepetalactone, one of the stereoisomers responsible for the psychoactive effects catnip has on cats.
History
EC 5.5.1.35 created 2019
Orthology
K01861  (+)-cis,cis-nepetalactol synthase
Reference
1  [PMID:30531909]
  Authors
Lichman BR, Kamileen MO, Titchiner GR, Saalbach G, Stevenson CEM, Lawson DM, O'Connor SE
  Title
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.
  Journal
Nat Chem Biol 15:71-79 (2019)
DOI:10.1038/s41589-018-0185-2
  Sequence
Reference
2  [PMID:30664302]
  Authors
Lichman BR, O'Connor SE, Kries H
  Title
Biocatalytic Strategies towards [4+2] Cycloadditions.
  Journal
Chemistry 25:6864-6877 (2019)
DOI:10.1002/chem.201805412
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.35
IUBMB Enzyme Nomenclature: 5.5.1.35
ExPASy - ENZYME nomenclature database: 5.5.1.35
BRENDA, the Enzyme Database: 5.5.1.35

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