KEGG   ENZYME: 5.6.1.2
Entry
EC 5.6.1.2                  Enzyme                                 

Name
dynein ATPase;
dynein adenosine 5'-triphosphatase
Class
Isomerases;
Isomerases altering macromolecular conformation;
Enzymes altering polypeptide conformation or assembly
Sysname
ATP phosphohydrolase (tubulin-translocating)
Reaction(IUBMB)
ATP + H2O + a dynein associated with a microtubule at position n = ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
dynein associated with a microtubule at position n
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
dynein associated with a microtubule at position n-1 (toward the minus end)
Comment
A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa).
History
EC 5.6.1.2 created 1984 as EC 3.6.1.33, transferred 2000 to EC 3.6.4.2, transferred 2018 to EC 5.6.1.2
Reference
1  [PMID:5289252]
  Authors
Summers KE, Gibbons IR.
  Title
Adenosine triphosphate-induced sliding of tubules in trypsin-treated flagella of sea-urchin sperm.
  Journal
Proc Natl Acad Sci U S A 68:3092-6 (1971)
DOI:10.1073/pnas.68.12.3092
Reference
2  [PMID:2972702]
  Authors
Gibbons IR.
  Title
Dynein ATPases as microtubule motors.
  Journal
J Biol Chem 263:15837-40 (1988)
Reference
3  [PMID:9760728]
  Authors
Gee M, Vallee R.
  Title
The role of the dynein stalk in cytoplasmic and flagellar motility.
  Journal
Eur Biophys J 27:466-73 (1998)
DOI:10.1007/s002490050157
Other DBs
ExplorEnz - The Enzyme Database: 5.6.1.2
IUBMB Enzyme Nomenclature: 5.6.1.2
ExPASy - ENZYME nomenclature database: 5.6.1.2
BRENDA, the Enzyme Database: 5.6.1.2

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