KEGG   ENZYME: 5.6.1.4Help
Entry
EC 5.6.1.4                  Enzyme                                 

Name
minus-end-directed kinesin ATPase;
non-claret disjunctional;
ncd (gene name)
Class
Isomerases;
Isomerases altering macromolecular conformation;
Enzymes altering polypeptide conformation or assembly
BRITE hierarchy
Sysname
kinesin ATP phosphohydrolase (minus-end-directed)
Reaction(IUBMB)
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
kinesin associated with a microtubule at position n
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
kinesin associated with a microtubule at position n-1 (toward the minus end)
Comment
Kinesins are a family of motor proteins that move unidirectionally along microtubules as they hydrolyse ATP and are involved in organelle movement. This enzyme is similar to EC 5.6.1.3, plus-end-directed kinesin ATPase, but the organization of the different domains differs, resulting in movement in the opposite direction along the microtubules.
History
EC 5.6.1.4 created 2000, as 3.6.4.5, transferred 2018 to EC 5.6.1.4
Reference
1  [PMID:2261638]
  Authors
McDonald HB, Stewart RJ, Goldstein LS
  Title
The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor.
  Journal
Cell 63:1159-65 (1990)
DOI:10.1016/0092-8674(90)90412-8
  Sequence
Reference
2  [PMID:8473343]
  Authors
Chandra R, Salmon ED, Erickson HP, Lockhart A, Endow SA
  Title
Structural and functional domains of the Drosophila ncd microtubule motor protein.
  Journal
J Biol Chem 268:9005-13 (1993)
  Sequence
Reference
3  [PMID:8112290]
  Authors
Lockhart A, Cross RA
  Title
Origins of reversed directionality in the ncd molecular motor.
  Journal
EMBO J 13:751-7 (1994)
DOI:10.1002/j.1460-2075.1994.tb06317.x
  Sequence
Reference
4  [PMID:9288974]
  Authors
Henningsen U, Schliwa M.
  Title
Reversal in the direction of movement of a molecular motor.
  Journal
Nature 389:93-6 (1997)
DOI:10.1038/38022
Reference
5  [PMID:9796817]
  Authors
Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ.
  Title
Direction determination in the minus-end-directed kinesin motor ncd.
  Journal
Nature 395:813-6 (1998)
DOI:10.1038/27463
Other DBs
ExplorEnz - The Enzyme Database: 5.6.1.4
IUBMB Enzyme Nomenclature: 5.6.1.4
ExPASy - ENZYME nomenclature database: 5.6.1.4
BRENDA, the Enzyme Database: 5.6.1.4

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