Entry
Name
minus-end-directed kinesin ATPase;
non-claret disjunctional;
ncd (gene name)
Class
Isomerases;
Isomerases altering macromolecular conformation;
Enzymes altering polypeptide conformation or assembly
BRITE hierarchy
Sysname
kinesin ATP phosphohydrolase (minus-end-directed)
Reaction(IUBMB)
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
Substrate
ATP [CPD:
C00002 ];
H2O [CPD:
C00001 ];
kinesin associated with a microtubule at position n
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
kinesin associated with a microtubule at position n-1 (toward the minus end)
Comment
Kinesins are a family of motor proteins that move unidirectionally along microtubules as they hydrolyse ATP and are involved in organelle movement. This enzyme is similar to EC
5.6.1.3 , plus-end-directed kinesin ATPase, but the organization of the different domains differs, resulting in movement in the opposite direction along the microtubules.
History
EC 5.6.1.4 created 2000 as 3.6.4.5, transferred 2018 to EC 5.6.1.4
Orthology
K10405 kinesin family member C1 (minus-end-directed kinesin ATPase)
Genes
MMU : 100502766(Kifc1) 16580(Kifc5b)
MCAL : 110283992(Kifc1) 110284026
PBRV : 138150064(KIFC1) 138161315
GGA : 101748559(KIFC1L) 417037(KIFC1)
NMEL : 110391555 110406672
CBOY : 140644777(KIFC1) 140662664
SANH : 107665178 107666336
CCAR : 109062119 122143852
CAUA : 113062592 113119796 113119851
CGIB : 127935731 127979715
PTET : 122335288(kifc1) 122342454
MASI : 127421088 127425039
SLUC : 116038256 116047069(kifc1)
GAF : 122843547 122844031(kifc1)
NFU : 107374624 107394862(kifc1)
KMR : 108242628(kifc1) 108246444
SSCO : 133996398 133996443
SASA : 106569966 106588407(KIFC1)
CCLU : 121571571 121586452
OEP : 134031726 134040850(kifc1)
SFM : 108930378(kifc1) 114910514 114910515
ARUT : 117434181 117964927
LERI : 129693927 129701766 129715253
LPIC : 129268146 129268147
DSI : Dsimw501_GD17657(Dsim_GD17657)
AALB : 109402835 109422590
CCAL : 108625082 108625122
CGIG : 122399816 122402850
TLN : 139809814 139811685 139820613
PMEC : 138932363 138932550
PPYR : 116167867 116168628
MCIX : 123653505 123668703
CCRN : 123292462 123305515
DPX : DAPPUDRAFT_237863 DAPPUDRAFT_299597 DAPPUDRAFT_95626
HAZT : 108666634 108672222
LSM : 121127591(ncd) 121127915
PPOI : 119108462 119108522
PCAN : 112554994 112559509
CANU : 128172348 128184905
EPA : 110236066 110236067 110242638
XEN : 124455035 124459294 124459308
TAD : TRIADDRAFT_28174 TRIADDRAFT_28367
VPO : Kpol_1050p103 Kpol_505p39
NCS : NCAS_0F03470(NCAS0F03470)
NDI : NDAI_0B05770(NDAI0B05770)
TPF : TPHA_0D03200(TPHA0D03200) TPHA_0D04190(TPHA0D04190)
TBL : TBLA_0C03940(TBLA0C03940) TBLA_0C05310(TBLA0C05310)
TDL : TDEL_0F03640(TDEL0F03640)
KAF : KAFR_0B06590(KAFR0B06590)
KNG : KNAG_0A07880(KNAG0A07880)
LBG : 92208963(LODBEIA_P37670)
CAL : CAALFM_C209370CA(KAR3)
ASAU : 88173350(PUMCH_002285)
YLI : 2909516(YALI2_B00539g)
NTE : NEUTE1DRAFT77317(NEUTE1DRAFT_77317)
SMP : 10809941(SMAC4_02750)
RTHE : 98124360(VTJ83DRAFT_3348)
TATV : 25783055(TrAtP1_010859)
TASP : 90967029(TrAFT101_009232)
PLJ : 28891301(PLICBS_010615)
CDET : 87951335(CDEST_14835)
ELA : UCREL1_10246 UCREL1_5360
PFY : PFICI_00640 PFICI_05435 PFICI_10786 PFICI_13959
BFU : BCIN_09g02690 BCIN_16g01520(Bckar3)
PTRR : 6347883(PtrM4_128580)
ADAC : 96085413(ACET3X_005091)
SPO : 2542655(pkl1) 2543360(klp2)
SOM : SOMG_00390(klp2) SOMG_03353(pkl1)
CDEC : 89990726(IAS62_003954)
CTEG : 91990637(I308_103781)
CBAS : 91983946(I312_103901)
CDEP : 91087341(L203_103130)
KMG : 30160749(I203_105112)
KNE : 92184234(IAR55_006976)
KDJ : 28972417(I303_106639)
KBI : 30209079(I302_101306)
KPIN : 30173758(I206_107067)
KSH : 87958162(IL334_006032) 87958164(IL334_006034)
KER : 91103636(V865_004835)
CCAC : CcaHIS019_0506200(KAR3)
ABP : AGABI1DRAFT77659(AGABI1DRAFT_77659)
ABV : AGABI2DRAFT229385(AGABI2DRAFT_229385)
SRE : PTSG_05270 PTSG_05273
EHI : EHI_119530(163.t00013)
EDI : EDI_023470 EDI_313830
EIV : EIN_345750 EIN_469650
TET : TTHERM_000522699 TTHERM_00115410 TTHERM_00564430 TTHERM_00681890
PTM : GSPATT00031428001 GSPATT00034472001
PTI : PHATRDRAFT_15440(Pt-KIF10)
TPS : THAPSDRAFT_bd1214 THAPS_35310
AAF : AURANDRAFT_12514 AURANDRAFT_1821 AURANDRAFT_18774 AURANDRAFT_59386 AURANDRAFT_59470
PIF : PITG_03872 PITG_10514
PSOJ : PHYSODRAFT_314320 PHYSODRAFT_346145 PHYSODRAFT_386492 PHYSODRAFT_469853 PHYSODRAFT_525208
SPAR : SPRG_04772 SPRG_10304 SPRG_10585 SPRG_16910
NGR : NAEGRDRAFT_65526 NAEGRDRAFT_73429
SSAO : 94294367(SS50377_20344)
EHX : EMIHUDRAFT_470226 EMIHUDRAFT_52859
GTT : GUITHDRAFT_158802 GUITHDRAFT_58112 GUITHDRAFT_63542 GUITHDRAFT_76865 GUITHDRAFT_78073 GUITHDRAFT_89903 GUITHDRAFT_92940
» show all
Taxonomy
Reference
Authors
McDonald HB, Stewart RJ, Goldstein LS
Title
The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor.
Journal
Sequence
Reference
Authors
Chandra R, Salmon ED, Erickson HP, Lockhart A, Endow SA
Title
Structural and functional domains of the Drosophila ncd microtubule motor protein.
Journal
J Biol Chem 268:9005-13 (1993)
Sequence
Reference
Authors
Lockhart A, Cross RA
Title
Origins of reversed directionality in the ncd molecular motor.
Journal
Sequence
Reference
Authors
Henningsen U, Schliwa M.
Title
Reversal in the direction of movement of a molecular motor.
Journal
Reference
Authors
Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ.
Title
Direction determination in the minus-end-directed kinesin motor ncd.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.6.1.4
ExPASy - ENZYME nomenclature database: 5.6.1.4
BRENDA, the Enzyme Database: 5.6.1.4