KEGG   ENZYME: 5.6.1.5
Entry
EC 5.6.1.5                  Enzyme                                 

Name
proteasome ATPase
Class
Isomerases;
Isomerases altering macromolecular conformation;
Enzymes altering polypeptide conformation or assembly
Sysname
ATP phosphohydrolase (polypeptide-degrading)
Reaction(IUBMB)
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
polypeptide [CPD:C00403]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
unfolded polypeptide
Comment
Belongs to the AAA-type superfamily and, like EC 5.6.1.4 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.
History
EC 5.6.1.5 created 2000 as 3.6.4.8, transferred 2018 to EC 5.6.1.5
Reference
1  [PMID:9228289]
  Authors
Rivett AJ, Mason GG, Murray RZ, Reidlinger J.
  Title
Regulation of proteasome structure and function.
  Journal
Mol Biol Rep 24:99-102 (1997)
DOI:10.1023/a:1006814306401
Reference
2  [PMID:9688553]
  Authors
Mason GG, Murray RZ, Pappin D, Rivett AJ.
  Title
Phosphorylation of ATPase subunits of the 26S proteasome.
  Journal
FEBS Lett 430:269-74 (1998)
DOI:10.1016/S0014-5793(98)00676-0
Other DBs
ExplorEnz - The Enzyme Database: 5.6.1.5
IUBMB Enzyme Nomenclature: 5.6.1.5
ExPASy - ENZYME nomenclature database: 5.6.1.5
BRENDA, the Enzyme Database: 5.6.1.5

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