KEGG   ENZYME: 6.2.1.12
Entry
EC 6.2.1.12                 Enzyme                                 

Name
4-coumarate---CoA ligase;
4-coumaroyl-CoA synthetase;
p-coumaroyl CoA ligase;
p-coumaryl coenzyme A synthetase;
p-coumaryl-CoA synthetase;
p-coumaryl-CoA ligase;
feruloyl CoA ligase;
hydroxycinnamoyl CoA synthetase;
4-coumarate:coenzyme A ligase;
caffeolyl coenzyme A synthetase;
p-hydroxycinnamoyl coenzyme A synthetase;
feruloyl coenzyme A synthetase;
sinapoyl coenzyme A synthetase;
4-coumaryl-CoA synthetase;
hydroxycinnamate:CoA ligase;
p-coumaryl-CoA ligase;
p-hydroxycinnamic acid:CoA ligase;
4CL
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
4-coumarate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-coumarate [CPD:C00811];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-coumaroyl-CoA [CPD:C00223]
History
EC 6.2.1.12 created 1976
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec00940  Phenylpropanoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01904  4-coumarate--CoA ligase
Genes
BFO: BRAFLDRAFT_216949 BRAFLDRAFT_279625 BRAFLDRAFT_280542 BRAFLDRAFT_285011 BRAFLDRAFT_88901
CIN: 100175890 100175931 100178317 100178942 100179929 100180897 100181730 100182943 100187395 113473993
SPU: 581946
APLC: 110978158
SKO: 100373806 100374282 100377026 100377139 100377142 102807583
DER: 6546805 6550610 6555023
DSI: Dsimw501_GD15826(Dsim_GD15826) Dsimw501_GD21070(Dsim_GD21070) Dsimw501_GD25844(Dsim_GD25844) Dsimw501_GD25845(Dsim_GD25845)
DYA: Dyak_GE13452 Dyak_GE13453 Dyak_GE16079 Dyak_GE23452
DSR: 110178304 110178309 110186309 110187130 110188585 110188741 110190932 110190959
DPO: Dpse_GA10983 Dpse_GA19414 Dpse_GA21474 Dpse_GA27413 Dpse_GA27415
CEL: CELE_ZK1127.2(acs-6)
OBI: 106877149
HMG: 101239080
AQU: 100635352
LJA: Lj0g3v0306889.1(Lj0g3v0306889.1) Lj1g3v0129860.1(Lj1g3v0129860.1) Lj2g3v1536270.1(Lj2g3v1536270.1) Lj2g3v2125730.1(Lj2g3v2125730.1) Lj3g3v1113010.1(Lj3g3v1113010.1) Lj3g3v2040010.1(Lj3g3v2040010.1) Lj3g3v3056700.1(Lj3g3v3056700.1) Lj4g3v2093610.2(Lj4g3v2093610.2) Lj6g3v0750030.1(Lj6g3v0750030.1)
DOSA: Os01t0901600-01(Os01g0901600) Os02t0177600-01(Os02g0177600) Os02t0697400-01(Os02g0697400) Os03t0152400-01(Os03g0152400) Os06t0656500-01(Os06g0656500) Os08t0143300-00(Os08g0143300) Os08t0245200-01(Os08g0245200) Os08t0448000-01(Os08g0448000) Os10t0578950-00(Os10g0578950)
ATS: 109738097(LOC109738097) 109739271(LOC109739271) 109741493(LOC109741493) 109754527(LOC109754527) 109754969(LOC109754969) 109783113(LOC109783113) 109784645(LOC109784645)
SLB: AWJ20_3904(PCS60)
NCR: NCU10546
NTE: NEUTE1DRAFT97785(NEUTE1DRAFT_97785)
ANG: ANI_1_2258184(An04g09730) ANI_1_686144(An16g04830)
PBL: PAAG_05989 PAAG_08670 PAAG_12136(PAAG_06016)
PBN: PADG_06008 PADG_07276 PADG_12016(PADG_05984)
ABP: AGABI1DRAFT119847(AGABI1DRAFT_119847) AGABI1DRAFT131074(AGABI1DRAFT_131074) AGABI1DRAFT40522(AGABI1DRAFT_40522) AGABI1DRAFT97118(AGABI1DRAFT_97118)
ABV: AGABI2DRAFT212169(AGABI2DRAFT_212169) AGABI2DRAFT239433(AGABI2DRAFT_239433) AGABI2DRAFT239435(AGABI2DRAFT_239435) AGABI2DRAFT72962(AGABI2DRAFT_72962)
MRT: MRET_0077
DDI: DDB_G0284743(4cl3) DDB_G0284745(4cl2) DDB_G0284831(4cl1)
DFA: DFA_09884(4cl1)
SPAR: SPRG_06390
 » show all
Reference
1  [PMID:4364250]
  Authors
Gross GG, Zenk MH.
  Title
Isolation and properties of hydroxycinnamate: CoA ligase from lignifying tissue of Forsythia.
  Journal
Eur J Biochem 42:453-9 (1974)
DOI:10.1111/j.1432-1033.1974.tb03359.x
Reference
2  [PMID:4699252]
  Authors
Lindl T, Kreuzaler F, Hahlbrock K.
  Title
Synthesis of p-coumaroyl coenzyme a with a partially purified p-coumarate:CoA ligase from cell suspension cultures of soybean (Glycine max).
  Journal
Biochim Biophys Acta 302:457-64 (1973)
DOI:10.1016/0005-2744(73)90174-5
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.12
IUBMB Enzyme Nomenclature: 6.2.1.12
ExPASy - ENZYME nomenclature database: 6.2.1.12
BRENDA, the Enzyme Database: 6.2.1.12
CAS: 37332-51-7

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