KEGG   ENZYME: 6.2.1.14
Entry
EC 6.2.1.14                 Enzyme                                 
Name
6-carboxyhexanoate---CoA ligase;
6-carboxyhexanoyl-CoA synthetase;
pimelyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
6-carboxyhexanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA [RN:R03209]
Reaction(KEGG)
R03209
Substrate
ATP [CPD:C00002];
6-carboxyhexanoate [CPD:C02656];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
6-carboxyhexanoyl-CoA [CPD:C01063]
History
EC 6.2.1.14 created 1983
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01906  6-carboxyhexanoate--CoA ligase
Genes
PCAPcar_1666(bioW)
PACEA6070_06910
PEFA7E78_02755
DESDSOUD_1422
DEUDBW_2418(bioW)
DVEDESUT3_28120(bioW)
DDSDdes_0424
DFIAXF13_07405
MALUKU6B_03740
BSUBSU30240(bioW)
BSRI33_3078(bioW)
BSLA7A1_1652
BSHBSU6051_30240(bioW)
BSYI653_14475
BSUTBSUB_03213(bioW)
BSULBSUA_03213(bioW)
BSUSQ433_16400
BSOBSNT_09444
BSNBSn5_05960
BSQB657_30240(bioW)
BSXC663_2869(bioW)
BSPU712_15010
BSSBSUW23_14650(bioW)
BSTGYO_3272(bioW)
BLIBL02411(bioW)
BLDBLi00766(bioW)
BLHBaLi_c08640(bioW)
BAYRBAM_018290
BYABANAU_1954(bioW)
BAMPB938_09460
BQYMUS_2183(bioW)
BAMLBAM5036_1766(bioW)
BAMARBAU_1804(bioW)
BAMNBASU_1784(bioW)
BAMBBAPNAU_1915(bioW)
BAMTAJ82_10390
BAMYV529_17990(bioW)
BMPNG74_01905(bioW)
BAOBAMF_1924(bioW)
BAZBAMTA208_07885(bioW)
BQLLL3_02014(bioW)
BXHBAXH7_01606(bioW)
BAMIKSO_010220
BAMCU471_18840
BAMFU722_09675
BSIACWD84_11850
BAEBATR1942_12910
BVMB9C48_09335
BSONS101395_00961(bioW)
BHTDIC78_16480(bioW)
BMOJHC660_28880(bioW)
BIQAN935_15135
BGYBGLY_0780
BITBIS30_04490
BCABEFK13_15365(bioW)
BRYM0696_15075(bioW)
BJSMY9_3024
BACPSB24_00510
BACBOY17_12280
BACOOXB_3347
BACYQF06_13310
BACLBS34A_32880(bioW)
BALMBsLM_3008
BACSAUL54_01440
BACQDOE78_13830(bioW)
BEOBEH_11230
BFXBC359_10250
BKWBkAM31D_02740(bioW)
BGIBGM20_09070
BPFBpOF4_16065(bioW)
LGYT479_02545
VPNA21D_01033(bioW)
APAKAP3564_14135
PASABAOM_1991
MSEMGMB29_11985(bioW)
SAUSA2211
SAVSAV2423
SAWSAHV_2407
SAHSaurJH1_2497
SAJSaurJH9_2449
SAMMW2346
SASSAS2314
SARSAR2513
SACSACOL2424(bioW)
SAXUSA300HOU_2407(bioW)
SAASAUSA300_2369
SAOSAOUHSC_02712
SAENWMN_2322(bioW)
SADSAAV_2489(bioW)
SUUM013TW_2385
SUVSAVC_10990
SUESAOV_2472c
SUJSAA6159_02324
SUCECTR2_2282
SUTSAT0131_02618
SUQHMPREF0772_10764
SUZMS7_2438
SUDST398NM01_2476
SUXSAEMRSA15_23220
SUWSATW20_25530
SUGSAPIG2476
SUFSARLGA251_22050
SAUASAAG_00250
SAUERSAU_002262(bioW)
SAUNSAKOR_02404
SAUSSA40_2173
SAUUSA957_2257
SAUGSA268_2330
SAUZSAZ172_2528
SAUTSAI1T1_2017980(bioW)
SAUJSAI2T2_1017990(bioW)
SAUKSAI3T3_1017980(bioW)
SAUQSAI4T8_1017990(bioW)
SAUVSAI7S6_1017980(bioW)
SAUWSAI5S5_1017920(bioW)
SAUXSAI6T6_1017920(bioW)
SAUYSAI8T7_1017960(bioW)
SAUFX998_2409
SABSAB2304c
SUYSA2981_2360
SAUBC248_2471
SAUMBN843_24650
SAUCCA347_2503
SAURSABB_02993(bioW)
SAUIAZ30_12740
SAUDCH52_06865
SAMSNI36_12020
SUHSAMSHR1132_22520
SERSERP2393(bioW)
SEPSE_0182
SEPPSEB_00113
SEPSDP17_1279
SSDSPSINT_2336
SDTSPSE_0126(bioW)
SDPNCTC12225_00148(bioW)
SHUSHYC_01065(bioW)
SSCHLH95_00995
SSCZRN70_01215
SAGQEP23_09060
SPETCEP67_07590
SLZB5P37_05420
SFQC7J90_03530
SCHRDWB92_00920
SSHNCTC13712_02374(bioW)
SSACI6I31_04040
SRAILN051_00710
SFFFOB90_06765
ANXACH33_05725
ASOCCB4_02730(bioW)
ATHEK3F53_13175
TUMCBW65_01040
SPAEE2C16_15325(bioW)
SURLBI350_03175
FPENKIW23_04250
CACECACET_c13450(bioW)
CFMBJL90_12075
PBIFKXZ80_10540
RTORTO_04560
PSORRSJ16_12320
DORDesor_2670
DKUDesku_2247
TFRBR63_04280
CTHMCFE_1510
TKITKV_c07350(bioW)
HALSD7D81_09505
IFNGM661_06630
PHARNCTC13077_01223(bioW)
CADCuri_c25540(bioW)
VPRVpar_1006
VATB7L28_04875
VRM44547418_01018(bioW)
VDNNCTC11831_00891(bioW)
VNKVEIT17_08280(bioW)
VRGOKW85_04430
DHODia5BBH33_18170(bioW)
SSGSelsp_0126
SRISELR_03060(bioWF)
MHGMHY_24740
MFUNGXM21_08830
PUFUFO1_4053
PFTJBW_00789 JBW_04119
STEDSPTER_12670(bioW)
PFACPFJ30894_02090(bioW)
CDIDIP1381
CDPCD241_1323
CDHCDB402_1292
CDTCDHC01_1323
CDECDHC02_1282
CDRCDHC03_1302
CDACDHC04_1303
CDZCD31A_1398
CDBCDBH8_1375
CDSCDC7B_1385
CDDCDCE8392_1298
CDWCDPW8_1371
CDVCDVA01_1266
CDIPERS451417_01397(bioW)
CKPckrop_1506(bioWF)
CPUCPFRC_05945
CPLCp3995_1206(bioW)
CPGCP316_06095
CPPCpP54B96_1201(bioW)
CPKCP1002_07200
CPQCPC231_05950
CPXCPI19_05570
CPZCpPAT10_1177(bioW)
CORCp267_1234(bioW)
COPCP31_06325
CODCp106_1161(bioW)
COSCp4202_1171(bioW)
COICPCIP5297_06110
COECP258_06110
COUCP162_05185
CPSECPTA_01755
CPSUCPTB_02008
CPSFCPTC_01746
CULCULC22_01291(bioW)
CUCCULC809_01277(bioW)
CUECULC0102_1406(bioW)
CUNCul210932_1345(bioW)
CUSCulFRC11_1258(bioW)
CUQCul210931_1242(bioW)
CUZCul05146_1318(bioW)
CUJCUL131002_1273(bioW)
CVTB843_06145
CIICIMIT_09415
CUVCUREI_07155
COADR71_1458(bioF)
CEICEPID_09085
CLWCLAC_02085
CSPWM42_2495
CPHOCPHO_10675
CSTRCBE89_06150
CSPHCSPHI_02660
CMINNCTC10288_01030(bioW)
CPEGCPELA_04945(bioW)
CGKCGERO_06225(bioW)
CRFFRC0190_01412
CPSOCPPEL_05150(bioW)
CKFI6I12_05810
CPRPI6I69_10265
CAMCI6I65_09405
CGLUI6J20_04705
CSILCBE74_06945
CKWCKALI_03420(bioW)
CORYFQV43_04060
CMFGWO64_003750
CWKIA203_07480
CACCCACC_08710(bioW)
PACPPA1866
PAKHMPREF0675_4919
PAVTIA2EST22_09135
PAXTIA2EST36_09115
PAZTIA2EST2_09075
PAWPAZ_c19410(bioF)
PADTIIST44_02135
PCNTIB1ST10_09540
PACCPAC1_09540
PACHPAGK_1785
PACNTIA1EST1_09165
CACNRN83_09625
PRAPALO_01675
PRLBCB70_09080
CGRN4412665_00276(bioW)
AAGGETAA8_58000
TPITREPR_3053(bioW)
TRIDYE50_09460
FSUFisuc_2956
FSCFSU_0221(bioW)
AAEaq_1659(bioW)
HYAHY04AAS1_0813
HHOHydHO_0808
HYSHydSN_0825
HTHHTH_1774(bioW)
HTEHydth_1756
TALThal_1538
TRDTHERU_03735
SULSYO3AOP1_1703
SAFSULAZ_1395(bioW)
PMXPERMA_1854(bioW)
TAMTheam_0831
DTEDester_0730
TYETHEYE_A0810(bioW)
DTPJZK55_14060(bioW)
LFCLFE_0971
LFILFML04_1509(bioW)
LFPY981_07525
LEGABH19_05580
MJAMJ_1297
MVUMetvu_0266
MFSMFS40622_0356
MIFMetin_0084
MJHJH146_0329
MESGMLAUSG7_1138(bioW)
MESAMLASG1_0637(bioW)
MIGMetig_1269
MMPMMP1575(bioW)
MMQMmarC5_0001
MMXMmarC6_1095
MMZMmarC7_0822
MMDGYY_08730
MMAKMMKA1_18050(bioW)
MMAOMMOS7_16870(bioW)
MMADMMJJ_12610(bioW)
MAEMaeo_1420
MVNMevan_0887
MVOMvol_1143
MOKMetok_1553
METFCFE53_06525
MRUmru_2041(bioW)
MOLYLM1_1481
 » show all
Reference
1  [PMID:4623286]
  Authors
Izumi Y, Morita H, Sato K, Tani Y, Ogata K.
  Title
Synthesis of biotin-vitamers from pimelic acid and coenzyme A by cell-free extracts of various bacteria.
  Journal
Biochim Biophys Acta 264:210-3 (1972)
DOI:10.1016/0304-4165(72)90133-X
Reference
2
  Authors
Izumi, Y., Morita, H., Tani, Y. and Ogata, K.
  Title
The pimelyl-CoA synthetase responsible for the first step in biotin biosynthesis by microorganisms.
  Journal
Agric Biol Chem 38:2257-2262 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.14
IUBMB Enzyme Nomenclature: 6.2.1.14
ExPASy - ENZYME nomenclature database: 6.2.1.14
BRENDA, the Enzyme Database: 6.2.1.14
CAS: 55467-50-0

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