KEGG   ENZYME: 6.2.1.18
Entry
EC 6.2.1.18                 Enzyme                                 
Name
citrate---CoA ligase;
citryl-CoA synthetase;
citrate:CoA ligase;
citrate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
citrate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA [RN:R01322]
Reaction(KEGG)
R01322
Substrate
ATP [CPD:C00002];
citrate [CPD:C00158];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
(3S)-citryl-CoA [CPD:C00566]
Comment
The enzyme is a component of EC 2.3.3.8 ATP citrate synthase.
History
EC 6.2.1.18 created 1986
Pathway
ec00720  Other carbon fixation pathways
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15232  citryl-CoA synthetase large subunit
Genes
CTM: Cabther_A1178
CVL: J8C06_05140
CHLO: J8C02_05720
AAE: aq_1306(sucC1)
HYA: HY04AAS1_1267
HHO: HydHO_1257
HYS: HydSN_1287
HTH: HTH_1737(ccsA)
HTE: Hydth_1719
TAL: Thal_0201
TRD: THERU_06630
PDIZ: IAE16_08385
PFLO: G3M65_04780
DKU: Desku_1349
CWO: Cwoe_4214
NCON: LC1Nh_1032(sucC)
NOCC: SVXNc_0939(sucC)
 » show all
Reference
1  [PMID:6749502]
  Authors
Lill U, Schreil A, Eggerer H.
  Title
Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase.
  Journal
Eur J Biochem 125:645-50 (1982)
DOI:10.1111/j.1432-1033.1982.tb06731.x
Reference
2  [PMID:15101981]
  Authors
Aoshima M, Ishii M, Igarashi Y.
  Title
A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  Journal
Mol Microbiol 52:751-61 (2004)
DOI:10.1111/j.1365-2958.2004.04009.x
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.18
IUBMB Enzyme Nomenclature: 6.2.1.18
ExPASy - ENZYME nomenclature database: 6.2.1.18
BRENDA, the Enzyme Database: 6.2.1.18
CAS: 856428-87-0

  All links  
Protein sequence (3)   
   UniProt (3)   
DNA sequence (5)   
   GenBank (2)   
   EMBL (3)   
All databases (8)   

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