KEGG   ENZYME: 6.2.1.18
Entry
EC 6.2.1.18                 Enzyme                                 

Name
citrate---CoA ligase;
citryl-CoA synthetase;
citrate:CoA ligase;
citrate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
citrate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA [RN:R01322]
Reaction(KEGG)
R01322
Substrate
ATP [CPD:C00002];
citrate [CPD:C00158];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
(3S)-citryl-CoA [CPD:C00566]
Comment
The enzyme is a component of EC 2.3.3.8 ATP citrate synthase.
History
EC 6.2.1.18 created 1986
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15232  citryl-CoA synthetase large subunit
Genes
DKU: Desku_1349
CWO: Cwoe_4214
CTM: Cabther_A1178
CVL: J8C06_05140
CHLO: J8C02_05720
AAE: aq_1306(sucC1)
HYA: HY04AAS1_1267
HHO: HydHO_1257
HYS: HydSN_1287
HTH: HTH_1737(ccsA)
TAL: Thal_0201
NCON: LC1Nh_1032(sucC)
 » show all
Reference
1  [PMID:6749502]
  Authors
Lill U, Schreil A, Eggerer H.
  Title
Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase.
  Journal
Eur J Biochem 125:645-50 (1982)
DOI:10.1111/j.1432-1033.1982.tb06731.x
Reference
2  [PMID:15101981]
  Authors
Aoshima M, Ishii M, Igarashi Y.
  Title
A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  Journal
Mol Microbiol 52:751-61 (2004)
DOI:10.1111/j.1365-2958.2004.04009.x
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.18
IUBMB Enzyme Nomenclature: 6.2.1.18
ExPASy - ENZYME nomenclature database: 6.2.1.18
BRENDA, the Enzyme Database: 6.2.1.18
CAS: 856428-87-0

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