KEGG   ENZYME: 6.2.1.22Help
Entry
EC 6.2.1.22                 Enzyme                                 

Name
[citrate (pro-3S)-lyase] ligase;
citrate lyase ligase;
citrate lyase synthetase;
acetate: SH-[acyl-carrier-protein] enzyme ligase (AMP);
acetate:HS-citrate lyase ligase;
acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming);
acetate:[citrate-(pro-3S)-lyase](thiol-form) ligase (AMP-forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
acetate:holo-[citrate-(pro-3S)-lyase] ligase (AMP-forming)
Reaction(IUBMB)
ATP + acetate + holo-[citrate (pro-3S)-lyase] = AMP + diphosphate + acetyl-[citrate (pro-3S)-lyase] [RN:R04449]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
acetate [CPD:C00033];
holo-[citrate (pro-3S)-lyase] [CPD:C04298]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
acetyl-[citrate (pro-3S)-lyase] [CPD:C04334]
Comment
Both this enzyme and EC 2.3.1.49,deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase, acetylate and activate EC 4.1.3.6, citrate (pro-3S)-lyase.
History
EC 6.2.1.22 created 1989
Orthology
K01910  [citrate (pro-3S)-lyase] ligase
Genes
ECO: b0618(citC)
ECJ: JW0610(citC)
ECD: ECDH10B_0578(citC) ECDH10B_0686(citC)
EBW: BWG_0491(citC)
ECOK: ECMDS42_0479(citC)
ECE: Z0762(citC)
ECS: ECs0657
ECF: ECH74115_0706(citC)
ETW: ECSP_0672(citC)
ELX: CDCO157_0644
EOJ: ECO26_0693(citC)
EOI: ECO111_0649(citC)
EOH: ECO103_0626(citC)
ECOO: ECRM13514_0642(citC)
ECOH: ECRM13516_0587(citC)
ECG: E2348C_0519(citC)
EOK: G2583_0782(citC)
ESO: O3O_06795
ESM: O3M_18480
ESL: O3K_18500
ELH: ETEC_0647
EUN: UMNK88_654(citC)
ECC: c0709(citC)
ECP: ECP_0649
ECI: UTI89_C0622(citC)
ECV: APECO1_1434(citC)
ECX: EcHS_A0669(citC)
ECM: EcSMS35_0637(citC)
ECY: ECSE_0686
ECR: ECIAI1_0602(citC)
ECQ: ECED1_0615(citC)
ECK: EC55989_0610(citC)
ECT: ECIAI39_0594(citC)
EOC: CE10_0617(citC)
EUM: ECUMN_0711(citC)
ECZ: ECS88_0659(citC)
ELO: EC042_0654(citC)
ESE: ECSF_0558
EBR: ECB_00586(citC)
EBD: ECBD_3034
EKF: KO11_20575(citC)
EAB: ECABU_c06700(citC)
EDJ: ECDH1ME8569_0588(citC)
EIH: ECOK1_0629(citC)
ENA: ECNA114_0560(citC)
ELW: ECW_m0673(citC)
ELL: WFL_03345(citC)
ELC: i14_0677(citC)
ELD: i02_0677(citC)
ELP: P12B_c0602(citC)
EBL: ECD_00586(citC)
EBE: B21_00575(citC)
ELF: LF82_0307(citC)
ECOI: ECOPMV1_00637(citC)
ECOJ: P423_03035
ECOS: EC958_0737(citC)
EFE: EFER_0032(citC)
EAL: EAKF1_ch0843(citC)
EMA: C1192_09620(citC)
STY: STY0067(citC2) STY0673(citC)
STT: t0060(citC) t2243(citC)
STM: STM0058(citC2) STM0624(citC)
SEO: STM14_0069(citC2) STM14_0725(citC)
SEY: SL1344_0059(citC2) SL1344_0612(citC)
SEJ: STMUK_0059(citC2) STMUK_0629(citC)
SEB: STM474_0061(citC2) STM474_0645(citC)
SEF: UMN798_0066(citC2) UMN798_0674(citC)
SENR: STMDT2_00591(citC2) STMDT2_06151(citC)
SEND: DT104_00581(citC2) DT104_06531(citC)
SPT: SPA0059(citC) SPA2110(citC)
SEI: SPC_0062(citC2) SPC_0637(citC)
SEC: SCH_0052(citC2) SCH_0653(citC)
SEH: SeHA_C0062(citC) SeHA_C0737(citC)
SEE: SNSL254_A0063(citC) SNSL254_A0678(citC)
SEW: SeSA_A0064(citC) SeSA_A0783(citC)
SEA: SeAg_B0065(citC) SeAg_B0664(citC)
SED: SeD_A0063(citC) SeD_A0724(citC)
SEG: SG0062(citC2) SG0628(citC)
SEL: SPUL_0062(citC2) SPUL_2340(citC)
SEGA: SPUCDC_0062(citC2) SPUCDC_2326(citC)
SET: SEN0059(citC2) SEN0593(citC)
SEEP: I137_10670
SENB: BN855_590 BN855_6170(citC)
SENE: IA1_03270
SBG: SBG_0532(citC)
SBZ: A464_598
SFL: SF0535(citC)
SFX: S0542(citC)
SFE: SFxv_0591(citC)
SFN: SFy_0705
SFS: SFyv_0748
SFT: NCTC1_00563(citC)
SBO: SBO_0483(citC)
SBC: SbBS512_E0532(citC)
ENC: ECL_04298
ECLO: ENC_32200
EEC: EcWSU1_03769(citC)
ECLX: LI66_18855
ECLY: LI62_20315
ESA: ESA_00320
CSK: ES15_0597(citC)
CTU: CTU_35660(citC)
KPN: KPN_00034(citC2)
KPT: VK055_2541(citC)
KPE: KPK_4715(citC)
KPJ: N559_4398
KPNU: LI86_22600
KPNK: BN49_4306(citC) BN49_4524(citC2)
KVA: Kvar_4355
KOE: A225_2159
EAR: CCG31799
KQV: B8P98_02620(citC) B8P98_23625(citC)
CKO: CKO_02541
CRO: ROD_06331(citC)
CBRA: A6J81_09975(citC)
CWE: CO701_15680(citC)
CAMA: F384_02740
CAF: AL524_19550(citC)
CIF: AL515_07750(citC)
CFAR: CI104_07450(citC) CI104_19410(citC)
CIR: C2U53_16655(citC)
EBT: EBL_c06510(citC)
LNI: CWR52_00490(citC) CWR52_16380(citC)
LEW: DAI21_08620(citC)
EBF: D782_0731
EBC: C2U52_13380(citC)
YEN: YE2653(citC)
YEY: Y11_15371
YEL: LC20_02069(citC)
YEW: CH47_1997(citC)
YEE: YE5303_24181(citC)
YAL: AT01_22(citC)
YFR: AW19_799(citC)
YIN: CH53_3446(citC)
YKR: CH54_863(citC)
YRO: CH64_165(citC)
YRU: BD65_742(citC)
YMA: DA391_08440(citC)
SPE: Spro_3171
SRL: SOD_c30560(citC)
SMAF: D781_2923
SMW: SMWW4_v1c32190(citC)
SMAR: SM39_2662(citC)
SMAC: SMDB11_2460(citC)
SERF: L085_12485
SERA: Ser39006_011295(citC) Ser39006_015650(citC)
SERM: CLM71_15350(citC)
RAA: Q7S_07745
ECA: ECA2574(citC)
PATR: EV46_12435
PATO: GZ59_19890(citC)
PCT: PC1_1752
PEC: W5S_1971
DDD: Dda3937_04525(citC_2) Dda3937_04561(citC_1)
DDQ: DDI_1739
DFN: CVE23_10170(citC)
PSX: DR96_2647(citC)
PRG: RB151_015740(citC)
PALA: CO695_16375(citC)
ETR: ETAE_0227(citC)
ETD: ETAF_0197
ETE: ETEE_1985(citC)
HIN: HI0025(citC)
HIT: NTHI0032(citC)
HIU: HIB_00250
HIE: R2846_0622(citC)
HIZ: R2866_0680(citC)
HIK: HifGL_001523(citC)
HIA: H733_0711(citC)
HIW: NTHI477_01053(citC)
HIC: NTHIC486_01018(citC)
HIX: NTHI723_01692(citC)
HDU: HD_1240(citC)
ASU: Asuc_0305
APOR: DDU33_03670(citC)
AAT: D11S_0861
AAN: D7S_01555
AACN: AANUM_0932
BTO: WQG_12910
BTRE: F542_9130
BTRH: F543_10470
BTRA: F544_13250
VCH: VC0796
VCS: MS6_0606
VCE: Vch1786_I0302(citC)
VCI: O3Y_03705
VCO: VC0395_A0323(citC)
VCR: VC395_0813(citC)
VCM: VCM66_0754(citC)
VCX: VAA049_2903(citC)
VCZ: VAB027_1448(citC)
VHR: AL538_01530(citC)
VAN: VAA_02016
VAU: VANGNB10_cI1183(citC)
VMI: AL543_13260(citC)
VTA: B0182(citC)
PPR: PBPRA2295(STM0624)
RFR: Rfer_2410
RGE: RGE_23130(citC)
SMUL: SMUL_2349(citC)
SHAL: SHALO_2095
SULJ: SJPD1_2122
GBM: Gbem_3862(citC)
GEM: GM21_3947
GEB: GM18_4293
PPD: Ppro_1088
RPE: RPE_3427
ASZ: ASN_2630(citC)
AZL: AZL_a08510(citC)
PPY: PPE_03595
LLA: L0038(citC)
LPK: LACPI_1076(citC)
SPY: SPy_1192(citC)
SPZ: M5005_Spy0910(citC)
SPYM: M1GAS476_0966(citC)
SPYA: A20_0947c(citC)
SPM: spyM18_1143(citC)
SPG: SpyM3_0837(citC)
SPS: SPs1037
SPH: MGAS10270_Spy1024(citC)
SPI: MGAS10750_Spy1060(citC)
SPJ: MGAS2096_Spy0969(citC)
SPK: MGAS9429_Spy1012(citC)
SPF: SpyM50887(citC)
SPB: M28_Spy0883(citC)
STG: MGAS15252_0908(citC)
STX: MGAS1882_0903(citC)
SOZ: Spy49_0940c(citC)
STZ: SPYALAB49_000901(citC)
SPYH: L897_04505
SMU: SMU_1010(citC)
SMC: SmuNN2025_1012(citC)
SMJ: SMULJ23_1021(citC)
SMUA: SMUFR_0881(citC)
SEZ: Sez_0983(citC)
SEQ: SZO_09850
SEZO: SeseC_01284(citC)
SEQU: Q426_04275
SEU: SEQ_1211
SDS: SDEG_0981(citC)
SDA: GGS_0961(citC)
SDC: SDSE_1010(citC)
STK: STP_0105
SIK: K710_0366
LPL: lp_1106(citC)
LPJ: JDM1_0912(citC)
LPT: zj316_1137(citC)
LPS: LPST_C0886(citC)
LPZ: Lp16_0889
LAC: LBA0914(citC)
LAD: LA14_0935
LAF: SD55_0935(citC)
LSA: LCA_1227(citC)
LCA: LSEI_1860
LPAP: LBPC_1819
LCB: LCABL_20840(citC)
LCS: LCBD_2053
LCE: LC2W_2035
LCW: BN194_20340(citC)
LRU: HMPREF0538_20651(citC)
LRT: LRI_0440
LHE: lhv_0987
LHL: LBHH_1199
LHV: lhe_0917
LHH: LBH_0813
LHD: HUO_07170
LRH: LGG_01917(citC)
LRG: LRHM_1840
LRL: LC705_01905(citC)
LRA: LRHK_1904
LCR: LCRIS_00968(citC)
LAM: LA2_04770
LKE: WANG_0748(citC)
LSN: LSA_13010(citC)
LAE: LBAT_0821
PCE: PECL_253(citC)
EFA: EF3322(citC)
EFL: EF62_0381(citC)
EFI: OG1RF_12567(citC)
EFS: EFS1_2722(citC)
EFN: DENG_03214(citC)
EFQ: DR75_2039(citC)
EFAU: EFAU085_p1080(citC_1) EFAU085_p1081(citC_2)
EFM: M7W_160
ECAS: ECBG_03042
EMU: EMQU_1786(citC)
EGA: AL523_04180(citC)
MPS: MPTP_1976
MPX: MPD5_1776
THL: TEH_07960(citC)
OOE: OEOE_0420
LCI: LCK_00107(citC)
LKI: LKI_04100
LGS: LEGAS_0213(citC)
CPE: CPE1146
CPR: CPR_1162(citC)
CTC: CTC_02557(citC)
CTET: BN906_02808(citC)
CLJ: CLJU_c25350(citC1) CLJU_c40550(citC2)
CSR: Cspa_c37420(citC1) Cspa_c44210(citC2)
CSB: CLSA_c34880(citC)
CSQ: CSCA_4334
CACE: CACET_c34350(citC)
AMT: Amet_2958
FPR: FP2_21230
BHAN: CGC63_11355(citC)
CSO: CLS_27190
CBOL: CGC65_03180(citC)
EAC: EAL2_808p05970(citC)
BPRM: CL3_00770
BPRS: CK3_12430
PFT: JBW_01521
AIN: Acin_0343(citC)
ERH: ERH_0750(citC)
EML: EMELA_v1c00440(citC)
SCQ: SCULI_v1c01720(citC)
SERI: SERIO_v1c06580(citC)
SHJ: SHELI_v1c10420(citC)
SCOU: SCORR_v1c05650(citC)
MBJ: KQ51_00883(citC)
TDE: TDE1522(citC)
TPED: TPE_2042(citC)
FNU: FN0319
FPD: CTM68_10590(citC)
FVA: FV113G1_07080(citC)
FUL: C4N20_02765(citC)
FMO: C4N19_05595(citC)
TAI: Taci_1673
TLI: Tlie_0826
SBR: SY1_03230
BOA: Bovatus_04895(citC)
BLQ: L21SP5_03883(citC)
MBAS: ALGA_3103
 » show all
Taxonomy
Reference
1  [PMID:7128585]
  Authors
Antranikian G, Gottschalk G.
  Title
Copurification of citrate lyase and citrate lyase ligase from Rhodopseudomonas gelatinosa and subsequent separation of the two enzymes.
  Journal
Eur J Biochem 126:43-7 (1982)
DOI:10.1111/j.1432-1033.1982.tb06743.x
Reference
2  [PMID:3935436]
  Authors
Antranikian G, Herzberg C, Gottschalk G.
  Title
Covalent modification of citrate lyase ligase from Clostridium sphenoides by phosphorylation/dephosphorylation.
  Journal
Eur J Biochem 153:413-20 (1985)
DOI:10.1111/j.1432-1033.1985.tb09318.x
Reference
3  [PMID:3994485]
  Authors
Quentmeier A, Antranikian G.
  Title
Characterization of citrate lyase from Clostridium sporosphaeroides.
  Journal
Arch Microbiol 141:85-90 (1985)
Reference
4  [PMID:4365579]
  Authors
Schmellenkamp H, Eggerer H.
  Title
Mechanism of enzymic acetylation of des-acetyl citrate lyase.
  Journal
Proc Natl Acad Sci U S A 71:1987-91 (1974)
DOI:10.1073/pnas.71.5.1987
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.22
IUBMB Enzyme Nomenclature: 6.2.1.22
ExPASy - ENZYME nomenclature database: 6.2.1.22
BRENDA, the Enzyme Database: 6.2.1.22
CAS: 52660-22-7

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