KEGG   ENZYME: 6.2.1.23
Entry
EC 6.2.1.23                 Enzyme                                 
Name
dicarboxylate---CoA ligase;
carboxylyl-CoA synthetase;
dicarboxylyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
omega-dicarboxylate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + an alpha,omega-dicarboxylate + CoA = AMP + diphosphate + an omega-carboxyacyl-CoA [RN:R04157]
Reaction(KEGG)
R04157
Substrate
ATP [CPD:C00002];
alpha,omega-dicarboxylate;
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
omega-carboxyacyl-CoA [CPD:C03188]
Comment
Acts on dicarboxylic acids of chain length C5 to C16; the best substrate is dodecanedioic acid.
History
EC 6.2.1.23 created 1989, modified 2011
Reference
1  [PMID:4062873]
  Authors
Vamecq J, de Hoffmann E, Van Hoof F.
  Title
The microsomal dicarboxylyl-CoA synthetase.
  Journal
Biochem J 230:683-93 (1985)
DOI:10.1042/bj2300683
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.23
IUBMB Enzyme Nomenclature: 6.2.1.23
ExPASy - ENZYME nomenclature database: 6.2.1.23
BRENDA, the Enzyme Database: 6.2.1.23
CAS: 99332-77-1

  All links  
Protein sequence (811)   
   UniProt (1)   
   RefSeq(pep) (810)   
DNA sequence (2057)   
   RefSeq(nuc) (1564)   
   GenBank (247)   
   EMBL (246)   
All databases (2868)   

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