Entry |
|
Name |
dicarboxylate---CoA ligase;
carboxylyl-CoA synthetase;
dicarboxylyl-CoA synthetase
|
Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
|
Sysname |
omega-dicarboxylate:CoA ligase (AMP-forming)
|
Reaction(IUBMB) |
ATP + an alpha,omega-dicarboxylate + CoA = AMP + diphosphate + an omega-carboxyacyl-CoA [RN: R04157]
|
Reaction(KEGG) |
|
Substrate |
ATP [CPD: C00002];
alpha,omega-dicarboxylate;
CoA [CPD: C00010]
|
Product |
|
Comment |
Acts on dicarboxylic acids of chain length C5 to C16; the best substrate is dodecanedioic acid.
|
History |
EC 6.2.1.23 created 1989, modified 2011
|
Reference |
|
Authors |
Vamecq J, de Hoffmann E, Van Hoof F. |
Title |
The microsomal dicarboxylyl-CoA synthetase. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 6.2.1.23 |
ExPASy - ENZYME nomenclature database: | 6.2.1.23 |
|