KEGG   ENZYME: 6.2.1.25Help
Entry
EC 6.2.1.25                 Enzyme                                 

Name
benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
benzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]
Comment
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
History
EC 6.2.1.25 created 1989
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04105  4-hydroxybenzoate-CoA ligase
K04110  benzoate-CoA ligase
K23108  benzoate---CoA ligase
Genes
ATH: AT1G65880(BZO1)
MTHD: A3224_01560
MII: BTJ40_01805
ADI: B5T_02169
CRZ: D1345_21875
RPJ: N234_07060 N234_31305
REH: H16_A1412(h16_A1412) H16_B1918(h16_B1918)
CNC: CNE_1c14400(bclA) CNE_2c18780(bclA)
CUH: BJN34_07200
REU: Reut_A1327
RME: Rmet_1224(bzdA)
CGD: CR3_1586(badA)
BXB: DR64_3582(bclA) DR64_7554(bclA)
BPH: Bphy_1543
BFN: OI25_2711
BPT: Bpet3574
BHZ: ACR54_04089(bclA_1)
AXX: ERS451415_04891(bclA_4)
RFR: Rfer_0216
PNA: Pnap_2948
DAC: Daci_0076
CTES: O987_00467
RTA: Rta_22340
LCH: Lcho_3655
PBH: AAW51_0206(badA)
EBA: ebA2757(bclA) ebA5301(bclA)
AZO: azo3052(bzdA)
AZA: AZKH_2151(bclA) AZKH_4514(bclA)
AOA: dqs_3186
GME: Gmet_2143(bamY)
BJA: blr1077
BRA: BRADO6791
BBT: BBta_0747
BRS: S23_67390
AOL: S58_06690
RPA: RPA0661(badA) RPA0669(hbaA)
RPB: RPB_4656
VGO: GJW-30_1_01037(hbaA)
RBM: TEF_07985
SIL: SPO3697(badA-1)
JAN: Jann_0669
LABT: FIU93_06225(bclA1)
SPSE: SULPSESMR1_02749(hbaA)
RID: RIdsm_00622(hbaA_1)
AHT: ANTHELSMS3_04347(prpE)
MALU: KU6B_38090
SWI: Swit_0829
SPHD: HY78_22550
MAG: amb2869
MAGX: XM1_2792(bclA)
MAGN: WV31_19615
MFJ: MFLOJ_46020(badA)
AMD: AMED_8609(badA)
AMN: RAM_44185
AMM: AMES_8478(badA)
AMZ: B737_8479(badA)
 » show all
Taxonomy
Reference
1
  Authors
Hutber, G.N. and Ribbons, D.W.
  Title
Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
  Journal
J Gen Microbiol 129:2413-2420 (1983)
Reference
2  [PMID:2857161]
  Authors
Schennen U, Braun K, Knackmuss HJ.
  Title
Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
  Journal
J Bacteriol 161:321-5 (1985)
DOI:10.1128/JB.161.1.321-325.1985
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.25
IUBMB Enzyme Nomenclature: 6.2.1.25
ExPASy - ENZYME nomenclature database: 6.2.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
BRENDA, the Enzyme Database: 6.2.1.25
CAS: 95329-17-2

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