KEGG   ENZYME: 6.2.1.25
Entry
EC 6.2.1.25                 Enzyme                                 

Name
benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
benzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
Reaction(KEGG)
R01422
Substrate
ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]
Comment
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
History
EC 6.2.1.25 created 1989
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04105  4-hydroxybenzoate-CoA ligase
K04110  benzoate-CoA ligase
K23108  benzoate---CoA ligase
Genes
ATH: AT1G65880(BZO1)
MTHD: A3224_01560
MII: BTJ40_01805
THIS: HZT40_02665
ADI: B5T_02169
VFF: VITFI_CDS1599
CRZ: D1345_21875
CHAE: CH06BL_45340
RPJ: N234_07060 N234_31305
REH: H16_A1412(h16_A1412) H16_B1918(h16_B1918)
CNC: CNE_1c14400(bclA) CNE_2c18780(bclA)
RME: Rmet_1224(bzdA)
CGD: CR3_1586(badA) CR3_3376(badA)
BXB: DR64_3582(bclA) DR64_7554(bclA)
BPH: Bphy_1543
BFN: OI25_2711
PPNO: DA70_23835
PPNM: LV28_06875
PPUL: RO07_00960
PSPU: NA29_10705
PAPI: SG18_01135
BPT: Bpet3574
BHO: D560_2016(bclA)
BHM: D558_2001(bclA)
BHZ: ACR54_04089(bclA_1)
AXX: ERS451415_04891(bclA_4)
AMIM: MIM_c27210
RFR: Rfer_0216
PNA: Pnap_2948
VEI: Veis_0730
DAC: Daci_0076
CTES: O987_00467
RTA: Rta_22340
LIM: L103DPR2_00827(bclA_2)
LIH: L63ED372_02250(bclA_2)
HYB: Q5W_16405
CBAA: SRAA_0581
LCH: Lcho_3655
THI: THI_0472(badA)
PBH: AAW51_0206(badA)
EBA: ebA2757(bclA) ebA5301(bclA)
ABRE: pbN1_03820(hcl2) pbN1_04230(bclA1) pbN1_17360(bclA2)
APET: ToN1_26720(bclA1) ToN1_39210(hcl2) ToN1_48960(bclA2)
AZO: azo3052(bzdA)
AOA: dqs_3186
AZA: AZKH_2151(bclA) AZKH_4514(bclA)
BJA: blr1077(blr1077)
BRA: BRADO6791
BBT: BBta_0747 BBta_6637(badA)
BRS: S23_67390
AOL: S58_06690
BARH: WN72_46160
RPA: RPA0661(badA) RPA0669(hbaA)
RPB: RPB_4656
VGO: GJW-30_1_01037(hbaA)
RBM: TEF_07985
LABT: FIU93_06225(bclA1)
SIL: SPO3697(badA-1)
JAN: Jann_0669
SPSE: SULPSESMR1_02749(hbaA)
RID: RIdsm_00622(hbaA_1)
AHT: ANTHELSMS3_04347(prpE)
MALU: KU6B_38090
SWI: Swit_0829
SPHD: HY78_22550
SPHI: TS85_01660
MAG: amb2869
MAGX: XM1_2792(bclA)
MAGN: WV31_19615
 » show all
Reference
1
  Authors
Hutber, G.N. and Ribbons, D.W.
  Title
Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
  Journal
J Gen Microbiol 129:2413-2420 (1983)
Reference
2  [PMID:2857161]
  Authors
Schennen U, Braun K, Knackmuss HJ.
  Title
Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
  Journal
J Bacteriol 161:321-5 (1985)
DOI:10.1128/JB.161.1.321-325.1985
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.25
IUBMB Enzyme Nomenclature: 6.2.1.25
ExPASy - ENZYME nomenclature database: 6.2.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
BRENDA, the Enzyme Database: 6.2.1.25
CAS: 95329-17-2

DBGET integrated database retrieval system