KEGG ENZYME: 6.2.1.25

ENZYME: 6.2.1.25

Entry

EC 6.2.1.25                 Enzyme

Name

benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)

Class

Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases

Sysname

benzoate:CoA ligase (AMP-forming)

Reaction(IUBMB)

ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]

Reaction(KEGG)

R01422

Substrate

ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]

Comment

Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.

History

EC 6.2.1.25 created 1989

Pathway

ec00362

Benzoate degradation

ec00627

Aminobenzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K04105

4-hydroxybenzoate-CoA ligase

K04110

benzoate-CoA ligase

K23108

benzoate---CoA ligase

Genes

ATH:	AT1G65880(BZO1)

MTHD:

A3224_01560

MII:	BTJ40_01805

THIS:

HZT40_02665

ADI:

B5T_02169

MARL:

HH196_07215

VFF:	VITFI_CDS1599

CRZ:	D1345_21875

CHAE:

CH06BL_45340

RPJ:	N234_07060 N234_31305

REH:	H16_A1412(h16_A1412) H16_B1918(h16_B1918)

CNC:	CNE_1c14400(bclA) CNE_2c18780(bclA)

CUH:	BJN34_07200 BJN34_32120

REU:	Reut_A1327

RME:	Rmet_1224(bzdA)

CTI:	RALTA_A1325 RALTA_B1617

CBW:	RR42_m1521 RR42_s3017

CGD:	CR3_1586(badA) CR3_3376(badA)

CCUP:

BKK81_12740 BKK81_26760

CUP:	BKK80_12955 BKK80_29555

CUU:	BKK79_19345 BKK79_35510

CPAU:

EHF44_15385

COX:	E0W60_03195 E0W60_17010

CCAM:

M5D45_06170

CCAX:

KZ686_10295 KZ686_17600

CUK:	KB879_07280 KB879_14645

CNAN:

A2G96_10140 A2G96_24400

CUPR:

IC580_08285 IC580_17490

CUPE:

KLP38_06620

CUPP:

CTP10_R12280 CTP10_R54450

BUG:	BC1001_2395

BGF:	BC1003_1063

BUQ:	AC233_12265

BXE:	Bxe_A1419 Bxe_C0896

BXB:	DR64_3582(bclA) DR64_7554(bclA)

BPH:

Bphy_1543

BGE:	BC1002_1980

BPX:	BUPH_02971

BPY:	Bphyt_2700

BUZ:	AYM40_13865

BFN:

OI25_2711

BCAI:

K788_0006461

PSPW:

BJG93_02470

PARB:

CJU94_11375

PHS:	C2L64_05420

PTER:

C2L65_05205

PGP:	CUJ91_12165

PCJ:	CUJ87_05105

PTS:	CUJ90_12230

PCAF:

DSC91_004077

PMEG:

FNZ07_26495

PTRO:

G5S35_23215

PGIS:

I6I06_01075

PACP:

FAZ97_21035

PACS:

FAZ98_17245

PDIO:

PDMSB3_3016(bclA)

PBRY:

NDK50_13990

PSAA:

QEN71_05350

PKF:	RW095_24725

PPAI:

E1956_16965

PLAD:

PPGU16_10570

PAZZ:

PBP221_10560

BRH:	RBRH_00494

PPK:	U875_06765

PPNO:

DA70_23835

PPNM:

LV28_06875

PRB:	X636_02815

PPUL:

RO07_00960

PSPU:

NA29_10705

PAPI:

SG18_01135

PVE:	UC34_17215

POX:	MB84_21990

PTX:	ABW99_07645

PFG:	AB870_04255

PNR:	AT302_14885

PAND:

DRB87_15915

PFIB:

PI93_010770

PCOM:

NTU39_18915

PANN:

PanNE5_27820

PANX:

OYT13_17420

TVL:	FAZ95_11620

BPT:

Bpet3574

BHO:	D560_2016(bclA)

BHM:	D558_2001(bclA)

BHZ:	ACR54_04089(bclA_1)

BBRO:

BAU06_05165

BFZ:	BAU07_21260

BPDZ:

BBN53_02645

BGM:	CAL15_08690

BGV:	CAL12_05275

AXY:	AXYL_05035

AXO:	NH44784_035101

AXN:	AX27061_4854

AXX:	ERS451415_04891(bclA_4)

ADT:	APT56_22200

AIS:	BUW96_14000

ASW:	CVS48_13515

ACHB:

DVB37_21295

ADY:	HLG70_28640

ACHO:

H4P35_20175

AMUI:

PE062_16830

APES:

FOC84_20810

AAEG:

RA224_07430

ASEL:

RAS12_29140

ACHM:

V6V88_20725

ACHA:

KYT87_22525

ACHH:

ABFG95_08660

ACHJ:

LN047_21610

PUS:	CKA81_01040

POLL:

OEG81_13645

AKA:	TKWG_07570

AMIM:

MIM_c27210

CDN:	BN940_14776

PARK:

LSG25_10610

NARM:

N7E01_12325

PUD:	G9Q38_06750

RFR:

Rfer_0216

RHF:	EUB48_04930

RLH:	MIZ03_2348

POL:	Bpro_1624 Bpro_2983

PNA:

Pnap_2948

POS:	DT070_17695

POO:	F7R28_12890

PVAC:

HC248_01620(bclA)

ACK:	C380_20140

ACIV:

EXV95_12215

AFAC:

ACN9MJ_21160

VEI:

Veis_0730

DAC:

Daci_0076

DEL:	DelCs14_0077

DTS:	BI380_22110

DHK:	BO996_02615

DLA:	I6G47_22060

VAP:	Vapar_0089

VPE:	Varpa_0102

VPD:	VAPA_1c00910

VBO:	CKY39_00520

VAM:	C4F17_18580

VAZ:	H7F35_12400

VAV:	IG196_31290

VAE:	RZE79_00550

VAX:	H7F36_05970

VAW:	SFB74_00635

CTT:	CtCNB1_0097

CTES:

O987_00467

CRJ:	QMY55_00450

RTA:

Rta_22340

OTD:	J1M35_05270

LIM:	L103DPR2_00827(bclA_2)

LIH:	L63ED372_02250(bclA_2)

LIMM:

LMORI2_07770

HYR:	BSY239_631

HYB:

Q5W_16405

HYL:	LPB072_05870

HTN:	KI616_07605

HCZ:	G9Q37_21430

HYY:	JNX00_17220

HYDR:

SOM08_17440

HYDA:

ABSY19_08135

DIH:	G7047_17790

DAER:

H9K75_07735

DRG:	H9K76_04160

CBAA:

SRAA_0581

PBH:	AAW51_0206(badA)

SAQA:

OMP39_14365

SNN:	EWH46_00425

SMIO:

CATMQ487_11100

ATER:

MW290_08080

LCH:

Lcho_3655

THI:	THI_0472(badA)

SHD:	SUTH_01659

EBA:	ebA2757(bclA) ebA5301(bclA)

ABRE:

pbN1_03820(hcl2) pbN1_04230(bclA1) pbN1_17360(bclA2)

APET:

ToN1_26720(bclA1) ToN1_39210(hcl2) ToN1_48960(bclA2)

AZO:	azo3052(bzdA)

AOA:

dqs_3186

AZA:	AZKH_2151(bclA) AZKH_4514(bclA)

AZI:	AzCIB_1616 AzCIB_4632

AZD:	CDA09_12090 CDA09_22715

AZR:	CJ010_18885

TMZ:	Tmz1t_3136

TCL:	Tchl_1101 Tchl_1107

TAK:	Tharo_1132 Tharo_1138

DDZ:	DSYM_19340

NIY:	FQ775_02940

MESO:

BSQ44_18050

RPOD:

E0E05_11160

OST:	ABWH87_10290

KMN:	HW532_10710

ABAW:

D5400_06445

BJA:	blr1077(blr1077)

BJU:	BJ6T_11070

BJP:	RN69_05405

BRA:

BRADO6791

BBT:	BBta_0747 BBta_6637(badA)

BRS:

S23_67390

AOL:

S58_06690

BRC:	BCCGELA001_34230

BIC:	LMTR13_36370

BRO:	BRAD285_6939

BRK:	CWS35_10155

BOT:	CIT37_08890

BRQ:	CIT40_30030

BGQ:	X265_34650

BGZ:	XH91_33040

BSYM:

CIT39_29155

BBET:

F8237_13035

BARH:

WN72_46160

BVZ:	BRAD3257_8649(hbaA)

BEL:	BE61_90320

BDG:	LPJ38_02130

BSEP:

HAP48_0011945

BQB:	J4P68_0015785

BSEI:

KMZ68_03440

BBAN:

J4G43_003765

BCAN:

BcanWSM471_35440

BAUT:

QA635_04845

BBRA:

QA636_04320

BGK:	IC762_32500

BCOU:

IC761_15165 IC761_34625

BPAH:

QA639_04265

BXN:	I3J27_37575

BROS:

QUH67_33660

BRAZ:

LRP30_42145

BOY:	LQG66_27065

BRAY:

ML401_32640

BRAI:

FJV43_14675

BRAA:

NL528_04145

BLUP:

AB3L03_15530

BGEA:

ACP2YP_38190

BGEP:

ACP2YO_04620

BRAN:

RX330_34540

BRAB:

RX331_03155

RPA:	TX73_003425 TX73_003465(hbaA)

RPB:

RPB_4656

RPC:	RPC_1016 RPC_1025

RPD:	RPD_0878 RPD_1526 RPD_1534

RPE:	RPE_0592 RPE_0604

RPT:	Rpal_0728 Rpal_0736

RPX:	Rpdx1_4117 Rpdx1_4125

RBK:	E0H22_11680

RHOL:

RBJ75_18385

RHOE:

LRC39_03405 LRC39_03445

VGO:	GJW-30_1_01037(hbaA)

TRB:	HB776_18425

TARD:

RSO67_12295

RHZ:	RHPLAN_60910

PTAW:

DW352_20895

RLAC:

QMO75_01870

RBM:

TEF_07985

LAP:	ACP90_01135

LABR:

CHH27_19245

LABT:

FIU93_06225(bclA1)

LAGG:

B0E33_12635

CAUL:

KCG34_06235

SIL:	SPO3697(badA-1)

JAN:

Jann_0669

RPON:

G3256_16625

RFU:	ROLI_036890(hbaA)

SUAM:

BOO69_15590

SULZ:

C1J03_02525

SMED:

JNX03_11420

SPSE:

SULPSESMR1_02749(hbaA)

TOM:	BWR18_14125

TATE:

ACMHLQ_15070

TATY:

ACERHN_06910

RID:	RIdsm_00622(hbaA_1)

AHT:	ANTHELSMS3_04347(prpE)

SAGU:

CDO87_17715

SSTL:

ABFK29_08835

SAGZ:

QNI11_13885

THAA:

CFI11_22025

OCD:	FHY55_19220

MALU:

KU6B_38090

TGL:	HFZ77_06810

TRY:	QF118_10475

ASCA:

QEZ52_02780

MATG:

ACMVPR_08995

PTP:	RCA23_c19110

MALC:

QQG91_02020

SEDI:

EBB79_19940

PPSO:

QPJ95_08515

GCE:	KYE46_09665

GYJ:	AADW23_12615

SPHI:

TS85_01660

SPAP:

H3Z74_17260

SPSO:

G4G27_15780

SWI:

Swit_0829

SPHD:

HY78_22550

MAGX:

XM1_2792(bclA)

MAGN:

WV31_19615

AALU:

ABWI00_00625

MAG:

amb2869

NACI:

NUH88_06790

SNEA:

NBZ79_15040

MINW:

ACMVY4_20270

DVR:	Dvar_25510 Dvar_33710

SUR:	STAUR_3224

PBRU:

LZC95_17620

PRUE:

LVJ94_17980 LVJ94_37830

PALJ:

LZC94_24585

SORG:

NQZ70_02468(bclA)

CCRO:

CMC5_025720

PAUU:

E8A73_045010

NANN:

O0S08_10320

STYI:

C9F11_00345 C9F11_42335

SLUA:

AB8735_06240 AB8735_30785

STCZ:

JHY03_59110(menE)

STHU:

M1P56_11865

ACAU:

ACOJVX_18335

AMAS:

QU670_04535

PARQ:

DSM112329_04279(bclA)

VAB:

WPS_02300

» show all

Reference

Authors

Hutber GN, Ribbons DW.

Title

Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.

Journal

J Gen Microbiol 129:2413-2420 (1983)

Reference

2 [PMID:2857161]

Authors

Schennen U, Braun K, Knackmuss HJ.

Title

Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.

Journal

J Bacteriol 161:321-5 (1985)
DOI:10.1128/JB.161.1.321-325.1985

Other DBs

ExplorEnz - The Enzyme Database:

6.2.1.25

IUBMB Enzyme Nomenclature:

6.2.1.25

ExPASy - ENZYME nomenclature database:

6.2.1.25

UM-BBD (Biocatalysis/Biodegradation Database):

6.2.1.25

BRENDA, the Enzyme Database:

6.2.1.25

CAS:	95329-17-2

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Protein sequence (585)   
   UniProt (546)   
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DNA sequence (745)   
   RefSeq(nuc) (31)   
   GenBank (360)   
   EMBL (354)   
3D Structure (2)   
   PDB (2)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (3571)   

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