KEGG ENZYME: 6.2.1.25

ENZYME: 6.2.1.25

Entry

EC 6.2.1.25 Enzyme

Name

benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)

Class

Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases

Sysname

benzoate:CoA ligase (AMP-forming)

Reaction(IUBMB)

ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]

Reaction(KEGG)

R01422

Substrate

ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]

Comment

Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.

History

EC 6.2.1.25 created 1989

Pathway

ec00362

Benzoate degradation

ec00627

Aminobenzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K04105

4-hydroxybenzoate-CoA ligase

K04110

benzoate-CoA ligase

K23108

benzoate---CoA ligase

Genes

ATH:	AT1G65880(BZO1)

MTHD:

A3224_01560

MII:	BTJ40_01805

THIS:

HZT40_02665

ADI:

B5T_02169

VFF:	VITFI_CDS1599

CRZ:	D1345_21875

CHAE:

CH06BL_45340

RPJ:	N234_07060 N234_31305

REH:	H16_A1412(h16_A1412) H16_B1918(h16_B1918)

CNC:	CNE_1c14400(bclA) CNE_2c18780(bclA)

CUH:	BJN34_07200 BJN34_32120

REU:	Reut_A1327

RME:	Rmet_1224(bzdA)

CTI:	RALTA_A1325 RALTA_B1617

CBW:	RR42_m1521 RR42_s3017

CGD:	CR3_1586(badA) CR3_3376(badA)

CCUP:

BKK81_12740 BKK81_26760

CUP:	BKK80_12955 BKK80_29555

CUU:	BKK79_19345 BKK79_35510

CPAU:

EHF44_15385

COX:	E0W60_03195 E0W60_17010

BUG:	BC1001_2395

BGF:	BC1003_1063

BUQ:	AC233_12265

BXE:	Bxe_A1419 Bxe_C0896

BXB:	DR64_3582(bclA) DR64_7554(bclA)

BPH:

Bphy_1543

BGE:	BC1002_1980

BPX:	BUPH_02971

BPY:	Bphyt_2700

BUZ:	AYM40_13865

BFN:

BCAI:

PSPW:

PARB:

PHS:	C2L64_05420

PTER:

C2L65_05205

PGP:	CUJ91_12165

PCJ:	CUJ87_05105

PTS:	CUJ90_12230

PCAF:

PMEG:

PTRO:

PGIS:

PACP:

BRH:	RBRH_00494

PPK:	U875_06765

PPNO:

DA70_23835

PPNM:

LV28_06875

PRB:	X636_02815

PPUL:

RO07_00960

PSPU:

NA29_10705

PAPI:

SG18_01135

PVE:	UC34_17215

POX:	MB84_21990

PTX:	ABW99_07645

PFG:	AB870_04255

PNR:	AT302_14885

PAND:

DRB87_15915

PFIB:

PI93_010770

BPT:

Bpet3574

BHO:	D560_2016(bclA)

BHM:	D558_2001(bclA)

BHZ:	ACR54_04089(bclA_1)

BBRO:

BAU06_05165

BFZ:	BAU07_21260

BPDZ:

BBN53_02645

BGM:	CAL15_08690

AXY:	AXYL_05035

AXO:	NH44784_035101

AXN:	AX27061_4854

AXX:	ERS451415_04891(bclA_4)

ADT:	APT56_22200

AIS:	BUW96_14000

ASW:	CVS48_13515

ACHB:

DVB37_21295

PUD:	G9Q38_06750

AKA:	TKWG_07570

AMIM:

MIM_c27210

CDN:	BN940_14776

RFR:

Rfer_0216

RHF:	EUB48_04930

POL:	Bpro_1624 Bpro_2983

PNA:

Pnap_2948

POS:	DT070_17695

POO:	F7R28_12890

ACK:	C380_20140

VEI:

Veis_0730

DAC:

Daci_0076

DEL:	DelCs14_0077

DTS:	BI380_22110

DHK:	BO996_02615

DLA:	I6G47_22060

VAP:	Vapar_0089

VPE:	Varpa_0102

VPD:	VAPA_1c00910

VBO:	CKY39_00520

VAM:	C4F17_18580

CTT:	CtCNB1_0097

CTES:

O987_00467

RTA:

Rta_22340

LIM:	L103DPR2_00827(bclA_2)

LIH:	L63ED372_02250(bclA_2)

HYR:	BSY239_631

HYB:

Q5W_16405

HYL:	LPB072_05870

DIH:	G7047_17790

DAER:

H9K75_07735

DRG:	H9K76_04160

CBAA:

SRAA_0581

LCH:

Lcho_3655

THI:	THI_0472(badA)

SNN:	EWH46_00425

PBH:	AAW51_0206(badA)

SHD:	SUTH_01659

EBA:	ebA2757(bclA) ebA5301(bclA)

ABRE:

pbN1_03820(hcl2) pbN1_04230(bclA1) pbN1_17360(bclA2)

APET:

ToN1_26720(bclA1) ToN1_39210(hcl2) ToN1_48960(bclA2)

AZO:	azo3052(bzdA)

AOA:

dqs_3186

AZA:	AZKH_2151(bclA) AZKH_4514(bclA)

AZI:	AzCIB_1616 AzCIB_4632

AZD:	CDA09_12090 CDA09_22715

AZR:	CJ010_18885

TMZ:	Tmz1t_3136

TCL:	Tchl_1101 Tchl_1107

TAK:	Tharo_1132 Tharo_1138

DDZ:	DSYM_19340

SUR:	STAUR_3224

CCRO:

CMC5_025720

MESO:

BSQ44_18050

RPOD:

E0E05_11160

NIY:	FQ775_02940

KMN:	HW532_10710

ABAW:

D5400_06445

BJA:	blr1077(blr1077)

BJU:	BJ6T_11070

BJP:	RN69_05405

BRA:

BRADO6791

BBT:	BBta_0747 BBta_6637(badA)

BRS:

S23_67390

AOL:

S58_06690

BRC:	BCCGELA001_34230

BIC:	LMTR13_36370

BRO:	BRAD285_6939

BRK:	CWS35_10155

BOT:	CIT37_08890

BRQ:	CIT40_30030

BGQ:	X265_34650

BGZ:	XH91_33040

BSYM:

CIT39_29155

BBET:

F8237_13035

BARH:

WN72_46160

BVZ:	BRAD3257_7383 BRAD3257_8649(hbaA)

RPA:	RPA0661(badA) RPA0669(hbaA)

RPB:

RPB_4656

RPC:	RPC_1016 RPC_1025

RPD:	RPD_0878 RPD_1526 RPD_1534

RPE:	RPE_0592 RPE_0604

RPT:	Rpal_0728 Rpal_0736

RPX:	Rpdx1_4117 Rpdx1_4125

VGO:	GJW-30_1_01037(hbaA)

TRB:	HB776_18425

RHZ:	RHPLAN_60910

RBM:

TEF_07985

LAP:	ACP90_01135

LAGG:

B0E33_12635

LABR:

CHH27_19245

LABT:

FIU93_06225(bclA1)

SIL:	SPO3697(badA-1)

JAN:

Jann_0669

RPON:

G3256_16625

SUAM:

BOO69_15590

SPSE:

SULPSESMR1_02749(hbaA)

SULZ:

C1J03_02525

TOM:	BWR18_14125

RID:	RIdsm_00622(hbaA_1)

AHT:	ANTHELSMS3_04347(prpE)

SAGU:

CDO87_17715

THAA:

CFI11_22025

OCD:	FHY55_19220

MALU:

KU6B_38090

TGL:	HFZ77_06810

PTP:	RCA23_c19110

SEDI:

SWI:

SPHD:

SPHI:

SPAP:

MAG:

MAGX:

XM1_2792(bclA)

MAGN:

WV31_19615

» show all

Reference

Authors

Hutber, G.N. and Ribbons, D.W.

Title

Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.

Journal

J Gen Microbiol 129:2413-2420 (1983)

Reference

2 [PMID:2857161]

Authors

Schennen U, Braun K, Knackmuss HJ.

Title

Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.

Journal

J Bacteriol 161:321-5 (1985)
DOI:10.1128/JB.161.1.321-325.1985

Other DBs

ExplorEnz - The Enzyme Database:

6.2.1.25

IUBMB Enzyme Nomenclature:

6.2.1.25

ExPASy - ENZYME nomenclature database:

6.2.1.25

UM-BBD (Biocatalysis/Biodegradation Database):

6.2.1.25

BRENDA, the Enzyme Database:

6.2.1.25

CAS:	95329-17-2

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