| Entry |
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| Name |
benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
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| Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
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| Sysname |
benzoate:CoA ligase (AMP-forming)
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| Reaction(IUBMB) |
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN: R01422]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
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| History |
EC 6.2.1.25 created 1989
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K04105 | 4-hydroxybenzoate-CoA ligase |
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| Genes |
| RPJ: | N234_07060 N234_31305 |
| REH: | H16_A1412(h16_A1412) H16_B1918(h16_B1918) |
| CNC: | CNE_1c14400(bclA) CNE_2c18780(bclA) |
| CUH: | BJN34_07200 BJN34_32120 |
| CTI: | RALTA_A1325 RALTA_B1617 |
| CBW: | RR42_m1521 RR42_s3017 |
| CGD: | CR3_1586(badA) CR3_3376(badA) |
| CCUP: | BKK81_12740 BKK81_26760 |
| CUP: | BKK80_12955 BKK80_29555 |
| CUU: | BKK79_19345 BKK79_35510 |
| COX: | E0W60_03195 E0W60_17010 |
| CCAX: | KZ686_10295 KZ686_17600 |
| BXB: | DR64_3582(bclA) DR64_7554(bclA) |
| AXX: | ERS451415_04891(bclA_4) |
| LIM: | L103DPR2_00827(bclA_2) |
| LIH: | L63ED372_02250(bclA_2) |
| EBA: | ebA2757(bclA) ebA5301(bclA) |
| ABRE: | pbN1_03820(hcl2) pbN1_04230(bclA1) pbN1_17360(bclA2) |
| APET: | ToN1_26720(bclA1) ToN1_39210(hcl2) ToN1_48960(bclA2) |
| AZA: | AZKH_2151(bclA) AZKH_4514(bclA) |
| AZI: | AzCIB_1616 AzCIB_4632 |
| AZD: | CDA09_12090 CDA09_22715 |
| TAK: | Tharo_1132 Tharo_1138 |
| BBT: | BBta_0747 BBta_6637(badA) |
| RPA: | RPA0661(badA) RPA0669(hbaA) |
| RPD: | RPD_0878 RPD_1526 RPD_1534 |
| RPX: | Rpdx1_4117 Rpdx1_4125 |
| VGO: | GJW-30_1_01037(hbaA) |
| SPSE: | SULPSESMR1_02749(hbaA) |
| AHT: | ANTHELSMS3_04347(prpE) |
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| Reference |
1 |
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| Authors |
Hutber, G.N. and Ribbons, D.W. |
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| Title |
Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris. |
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| Journal |
J Gen Microbiol 129:2413-2420 (1983) |
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| Reference |
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| Authors |
Schennen U, Braun K, Knackmuss HJ. |
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| Title |
Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.2.1.25 |
| ExPASy - ENZYME nomenclature database: | 6.2.1.25 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 6.2.1.25 |
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