KEGG   ENZYME: 6.2.1.25
Entry
EC 6.2.1.25                 Enzyme                                 
Name
benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
benzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
Reaction(KEGG)
R01422
Substrate
ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]
Comment
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
History
EC 6.2.1.25 created 1989
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04105  4-hydroxybenzoate-CoA ligase
K04110  benzoate-CoA ligase
K23108  benzoate---CoA ligase
Genes
ATHAT1G65880(BZO1)
MTHDA3224_01560
MIIBTJ40_01805
THISHZT40_02665
ADIB5T_02169
MARLHH196_07215
VFFVITFI_CDS1599
CRZD1345_21875
CHAECH06BL_45340
RPJN234_07060 N234_31305
REHH16_A1412(h16_A1412) H16_B1918(h16_B1918)
CNCCNE_1c14400(bclA) CNE_2c18780(bclA)
CUHBJN34_07200 BJN34_32120
REUReut_A1327
RMERmet_1224(bzdA)
CTIRALTA_A1325 RALTA_B1617
CBWRR42_m1521 RR42_s3017
CGDCR3_1586(badA) CR3_3376(badA)
CCUPBKK81_12740 BKK81_26760
CUPBKK80_12955 BKK80_29555
CUUBKK79_19345 BKK79_35510
CPAUEHF44_15385
COXE0W60_03195 E0W60_17010
CCAMM5D45_06170
CCAXKZ686_10295 KZ686_17600
BUGBC1001_2395
BGFBC1003_1063
BUQAC233_12265
BXEBxe_A1419 Bxe_C0896
BXBDR64_3582(bclA) DR64_7554(bclA)
BPHBphy_1543
BGEBC1002_1980
BPXBUPH_02971
BPYBphyt_2700
BUZAYM40_13865
BFNOI25_2711
BCAIK788_0006461
PSPWBJG93_02470
PARBCJU94_11375
PHSC2L64_05420
PTERC2L65_05205
PGPCUJ91_12165
PCJCUJ87_05105
PTSCUJ90_12230
PCAFDSC91_004077
PMEGFNZ07_26495
PTROG5S35_23215
PGISI6I06_01075
PACPFAZ97_21035
PACSFAZ98_17245
PDIOPDMSB3_3016(bclA)
BRHRBRH_00494
PPKU875_06765
PPNODA70_23835
PPNMLV28_06875
PRBX636_02815
PPULRO07_00960
PSPUNA29_10705
PAPISG18_01135
PVEUC34_17215
POXMB84_21990
PTXABW99_07645
PFGAB870_04255
PNRAT302_14885
PANDDRB87_15915
PFIBPI93_010770
PCOMNTU39_18915
BPTBpet3574
BHOD560_2016(bclA)
BHMD558_2001(bclA)
BHZACR54_04089(bclA_1)
BBROBAU06_05165
BFZBAU07_21260
BPDZBBN53_02645
BGMCAL15_08690
AXYAXYL_05035
AXONH44784_035101
AXNAX27061_4854
AXXERS451415_04891(bclA_4)
ADTAPT56_22200
AISBUW96_14000
ASWCVS48_13515
ACHBDVB37_21295
ADYHLG70_28640
ACHOH4P35_20175
PUDG9Q38_06750
AKATKWG_07570
AMIMMIM_c27210
CDNBN940_14776
PARKLSG25_10610
RFRRfer_0216
RHFEUB48_04930
POLBpro_1624 Bpro_2983
PNAPnap_2948
POSDT070_17695
POOF7R28_12890
PVACHC248_01620(bclA)
ACKC380_20140
VEIVeis_0730
DACDaci_0076
DELDelCs14_0077
DTSBI380_22110
DHKBO996_02615
DLAI6G47_22060
VAPVapar_0089
VPEVarpa_0102
VPDVAPA_1c00910
VBOCKY39_00520
VAMC4F17_18580
CTTCtCNB1_0097
CTESO987_00467
RTARta_22340
OTDJ1M35_05270
LIML103DPR2_00827(bclA_2)
LIHL63ED372_02250(bclA_2)
HYRBSY239_631
HYBQ5W_16405
HYLLPB072_05870
HTNKI616_07605
HCZG9Q37_21430
DIHG7047_17790
DAERH9K75_07735
DRGH9K76_04160
CBAASRAA_0581
PBHAAW51_0206(badA)
SAQAOMP39_14365
SNNEWH46_00425
ATERMW290_08080
LCHLcho_3655
THITHI_0472(badA)
SHDSUTH_01659
EBAebA2757(bclA) ebA5301(bclA)
ABREpbN1_03820(hcl2) pbN1_04230(bclA1) pbN1_17360(bclA2)
APETToN1_26720(bclA1) ToN1_39210(hcl2) ToN1_48960(bclA2)
AZOazo3052(bzdA)
AOAdqs_3186
AZAAZKH_2151(bclA) AZKH_4514(bclA)
AZIAzCIB_1616 AzCIB_4632
AZDCDA09_12090 CDA09_22715
AZRCJ010_18885
TMZTmz1t_3136
TCLTchl_1101 Tchl_1107
TAKTharo_1132 Tharo_1138
DDZDSYM_19340
SURSTAUR_3224
CCROCMC5_025720
PAUUE8A73_045010
NANNO0S08_10320
MESOBSQ44_18050
RPODE0E05_11160
NIYFQ775_02940
KMNHW532_10710
ABAWD5400_06445
BJAblr1077(blr1077)
BJUBJ6T_11070
BJPRN69_05405
BRABRADO6791
BBTBBta_0747 BBta_6637(badA)
BRSS23_67390
AOLS58_06690
BRCBCCGELA001_34230
BICLMTR13_36370
BROBRAD285_6939
BRKCWS35_10155
BOTCIT37_08890
BRQCIT40_30030
BGQX265_34650
BGZXH91_33040
BSYMCIT39_29155
BBETF8237_13035
BARHWN72_46160
BVZBRAD3257_8649(hbaA)
BELBE61_90320
BDGLPJ38_02130
BSEPHAP48_0011945
BQBJ4P68_0015785
BSEIKMZ68_03440
BBANJ4G43_003765
RPARPA0661(badA) RPA0669(hbaA)
RPBRPB_4656
RPCRPC_1016 RPC_1025
RPDRPD_0878 RPD_1526 RPD_1534
RPERPE_0592 RPE_0604
RPTRpal_0728 Rpal_0736
RPXRpdx1_4117 Rpdx1_4125
RBKE0H22_11680
VGOGJW-30_1_01037(hbaA)
TRBHB776_18425
RHZRHPLAN_60910
RBMTEF_07985
LAPACP90_01135
LABRCHH27_19245
LABTFIU93_06225(bclA1)
LAGGB0E33_12635
CAULKCG34_06235
SILSPO3697(badA-1)
JANJann_0669
RPONG3256_16625
SUAMBOO69_15590
SULZC1J03_02525
SMEDJNX03_11420
SPSESULPSESMR1_02749(hbaA)
TOMBWR18_14125
RIDRIdsm_00622(hbaA_1)
AHTANTHELSMS3_04347(prpE)
SAGUCDO87_17715
THAACFI11_22025
OCDFHY55_19220
MALUKU6B_38090
TGLHFZ77_06810
PTPRCA23_c19110
SEDIEBB79_19940
GCEKYE46_09665
SWISwit_0829
SPHDHY78_22550
SPHITS85_01660
SPAPH3Z74_17260
MAGamb2869
MAGXXM1_2792(bclA)
MAGNWV31_19615
NACINUH88_06790
SNEANBZ79_15040
 » show all
Reference
1
  Authors
Hutber, G.N. and Ribbons, D.W.
  Title
Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
  Journal
J Gen Microbiol 129:2413-2420 (1983)
Reference
2  [PMID:2857161]
  Authors
Schennen U, Braun K, Knackmuss HJ.
  Title
Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
  Journal
J Bacteriol 161:321-5 (1985)
DOI:10.1128/JB.161.1.321-325.1985
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.25
IUBMB Enzyme Nomenclature: 6.2.1.25
ExPASy - ENZYME nomenclature database: 6.2.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
BRENDA, the Enzyme Database: 6.2.1.25
CAS: 95329-17-2

DBGET integrated database retrieval system