KEGG   ENZYME: 6.2.1.25Help
Entry
EC 6.2.1.25                 Enzyme                                 

Name
benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
benzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]
Comment
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
History
EC 6.2.1.25 created 1989
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04105  4-hydroxybenzoate-CoA ligase
K04110  benzoate-CoA ligase
Genes
RPJ: N234_07060
REU: Reut_A1327
REH: H16_A1412(h16_A1412) H16_B1918(h16_B1918)
CNC: CNE_1c14400(bclA)
RME: Rmet_1224(bzdA)
CTI: RALTA_A1325 RALTA_B1617
CBW: RR42_m1521
BGL: bglu_2g11460
BUG: BC1001_2395
BGE: BC1002_1980
BPH: Bphy_1543
BPT: Bpet3574
RFR: Rfer_0216
PNA: Pnap_2948
VEI: Veis_0730
DAC: Daci_0076
RTA: Rta_22340
LCH: Lcho_3655
EBA: ebA2757(bclA) ebA5301(bclA)
AZO: azo3052(bzdA)
AZA: AZKH_4514(bclA)
GME: Gmet_2143(bamY)
GLO: Glov_2397
GEO: Geob_0200(bamY)
GEM: GM21_2825
DMA: DMR_19390
BJA: blr1077
BRA: BRADO6791
BBT: BBta_0747 BBta_6637(badA)
BRS: S23_67390
AOL: S58_06690
RPA: RPA0661(badA) RPA0669(hbaA)
RPB: RPB_4656
RVA: Rvan_0044
SIL: SPO3697(badA-1)
JAN: Jann_0669
SWI: Swit_0829
MAG: amb2869
MAGX: XM1_2792(bclA)
SCB: SCAB_8391
AMD: AMED_8609(badA)
PDX: Psed_1491
 » show all
Taxonomy
Reference
1
  Authors
Hutber, G.N. and Ribbons, D.W.
  Title
Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
  Journal
J Gen Microbiol 129:2413-2420 (1983)
Reference
2  [PMID:2857161]
  Authors
Schennen U, Braun K, Knackmuss HJ.
  Title
Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
  Journal
J Bacteriol 161:321-5 (1985)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.25
IUBMB Enzyme Nomenclature: 6.2.1.25
ExPASy - ENZYME nomenclature database: 6.2.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
BRENDA, the Enzyme Database: 6.2.1.25
CAS: 95329-17-2

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