| Entry |
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| Name |
o-succinylbenzoate---CoA ligase;
o-succinylbenzoyl-coenzyme A synthetase;
o-succinylbenzoate:CoA ligase (AMP-forming)
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| Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
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| Sysname |
2-succinylbenzoate:CoA ligase (AMP-forming)
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| Reaction(IUBMB) |
ATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA [RN: R04030]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
AMP [CPD: C00020];
diphosphate [CPD: C00013];
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA [CPD: C03160]
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| History |
EC 6.2.1.26 created 1992
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| Pathway |
| ec00130 | Ubiquinone and other terpenoid-quinone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K01911 | O-succinylbenzoic acid---CoA ligase |
| K14760 | acyl-activating enzyme 14 |
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| Genes |
» show all
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| Reference |
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| Authors |
Heide L, Arendt S, Leistner E. |
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| Title |
Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis. |
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| Journal |
J Biol Chem 257:7396-400 (1982) |
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| Reference |
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| Authors |
Kolkmann R, Leistner E. |
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| Title |
4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis. |
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| Journal |
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| Reference |
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| Authors |
Meganathan R, Bentley R. |
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| Title |
Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.2.1.26 |
| ExPASy - ENZYME nomenclature database: | 6.2.1.26 |
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