KEGG   ENZYME: 6.2.1.33
Entry
EC 6.2.1.33                 Enzyme                                 
Name
4-chlorobenzoate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
4-chlorobenzoate:CoA ligase
Reaction(IUBMB)
4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate [RN:R03932]
Reaction(KEGG)
R03932;
(other) R08117
Substrate
4-chlorobenzoate [CPD:C02370];
CoA [CPD:C00010];
ATP [CPD:C00002]
Product
4-chlorobenzoyl-CoA [CPD:C06387];
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.
History
EC 6.2.1.33 created 1999
Pathway
ec00364  Fluorobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14417  4-chlorobenzoate-CoA ligase
Reference
1  [PMID:7765837]
  Authors
Dunaway-Mariano D, Babbitt PC
  Title
On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.
  Journal
Biodegradation 5:259-76 (1994)
DOI:10.1007/BF00696464
Reference
2  [PMID:1418673]
  Authors
Loffler F, Muller R, Lingens F.
  Title
Purification and properties of 4-halobenzoate-coenzyme A ligase from Pseudomonas sp. CBS3.
  Journal
Biol Chem Hoppe Seyler 373:1001-7 (1992)
DOI:10.1515/bchm3.1992.373.2.1001
Reference
3  [PMID:1610806]
  Authors
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D
  Title
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
  Journal
Biochemistry 31:5605-10 (1992)
DOI:10.1021/bi00139a025
  Sequence
[ag:ABQ44579]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.33
IUBMB Enzyme Nomenclature: 6.2.1.33
ExPASy - ENZYME nomenclature database: 6.2.1.33
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.33
BRENDA, the Enzyme Database: 6.2.1.33
CAS: 141583-20-2

  All links  
Protein sequence (137)   
   UniProt (124)   
   SWISS-PROT (3)   
   PDBSTR (10)   
DNA sequence (239)   
   GenBank (120)   
   EMBL (119)   
3D Structure (9)   
   PDB (9)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (386)   

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