KEGG ENZYME: 6.2.1.33

ENZYME: 6.2.1.33

Entry

EC 6.2.1.33                 Enzyme

Name

4-chlorobenzoate---CoA ligase

Class

Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases

Sysname

4-chlorobenzoate:CoA ligase

Reaction(IUBMB)

4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate [RN:R03932]

Reaction(KEGG)

R03932;
(other) R08117

Substrate

4-chlorobenzoate [CPD:C02370];
CoA [CPD:C00010];
ATP [CPD:C00002]

Product

4-chlorobenzoyl-CoA [CPD:C06387];
AMP [CPD:C00020];
diphosphate [CPD:C00013]

Comment

Requires Mg2+. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.

History

EC 6.2.1.33 created 1999

Pathway

ec00364

Fluorobenzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K14417

4-chlorobenzoate-CoA ligase

Reference

1 [PMID:7765837]

Authors

Dunaway-Mariano D, Babbitt PC

Title

On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.

Journal

Biodegradation 5:259-76 (1994)
DOI:10.1007/BF00696464

Reference

2 [PMID:1418673]

Authors

Loffler F, Muller R, Lingens F.

Title

Purification and properties of 4-halobenzoate-coenzyme A ligase from Pseudomonas sp. CBS3.

Journal

Biol Chem Hoppe Seyler 373:1001-7 (1992)
DOI:10.1515/bchm3.1992.373.2.1001

Reference

3 [PMID:1610806]

Authors

Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D

Title

Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.

Journal

Biochemistry 31:5605-10 (1992)
DOI:10.1021/bi00139a025

Sequence

[ag:ABQ44579]

Other DBs

ExplorEnz - The Enzyme Database:

6.2.1.33

IUBMB Enzyme Nomenclature:

6.2.1.33

ExPASy - ENZYME nomenclature database:

6.2.1.33

UM-BBD (Biocatalysis/Biodegradation Database):

6.2.1.33

BRENDA, the Enzyme Database:

6.2.1.33

CAS:	141583-20-2

DBGET integrated database retrieval system