KEGG   ENZYME: 6.2.1.36Help
Entry
EC 6.2.1.36                 Enzyme                                 

Name
3-hydroxypropionyl-CoA synthase;
3-hydroxypropionyl-CoA synthetase (AMP-forming);
3-hydroxypropionate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
hydroxypropanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate [RN:R09286]
Reaction(KEGG)
Substrate
3-hydroxypropanoate [CPD:C01013];
ATP [CPD:C00002];
CoA [CPD:C00010]
Product
3-hydroxypropanoyl-CoA [CPD:C05668];
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC 6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate.
History
EC 6.2.1.36 created 2009
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K14469  acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15018  3-hydroxypropionyl-coenzyme A synthetase
Genes
RRS: RoseRS_3202
RCA: Rcas_2930
CAU: Caur_0613
CHL: Chy400_0662
CAG: Cagg_3394
CTM: Cabther_B0610
CTS: Ctha_1050
STO: STK_07830
SSO: SSO3203(acsA-10)
SOL: Ssol_0940
SSOA: SULA_0973
SSOL: SULB_0975
SSOF: SULC_0974
SAI: Saci_1184
SID: M164_2161
SII: LD85_2424
SIH: SiH_2103
SIR: SiRe_2035
SIC: SiL_2010
MSE: Msed_1456
MCN: Mcup_0744
AHO: Ahos_2066
 » show all
Taxonomy
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
Reference
2  [PMID:18165310]
  Authors
Alber BE, Kung JW, Fuchs G
  Title
3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation.
  Journal
J Bacteriol 190:1383-9 (2008)
DOI:10.1128/JB.01593-07
  Sequence
[mse:Msed_1456][sto:STK_07830]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.36
IUBMB Enzyme Nomenclature: 6.2.1.36
ExPASy - ENZYME nomenclature database: 6.2.1.36
BRENDA, the Enzyme Database: 6.2.1.36

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