KEGG   ENZYME: 6.2.1.36
Entry
EC 6.2.1.36                 Enzyme                                 
Name
3-hydroxypropionyl-CoA synthase;
3-hydroxypropionyl-CoA synthetase (AMP-forming);
3-hydroxypropionate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
hydroxypropanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate [RN:R09286]
Reaction(KEGG)
R09286
Substrate
3-hydroxypropanoate [CPD:C01013];
ATP [CPD:C00002];
CoA [CPD:C00010]
Product
3-hydroxypropanoyl-CoA [CPD:C05668];
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC 6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate.
History
EC 6.2.1.36 created 2009
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14469  acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15018  3-hydroxypropionyl-coenzyme A synthetase
Genes
PALGHFP57_16695
SANDH3309_14800
POQKZX46_11635
RRSRoseRS_3202
RCARcas_2930
CAUCaur_0613
CHLChy400_0662
CAGCagg_3394
CTMCabther_B0610
CVLJ8C06_12460
CHLOJ8C02_11660
GGRHKW67_05055
CTSCtha_1050
HAKZJ0X25_09315
NAYHYG81_22555
STOSTK_07830
SOHD1869_03850(acs)
SSOSSO3203(acsA-10)
SOLSsol_0940
SSOASULA_0973(acs)
SSOLSULB_0975(acs)
SSOFSULC_0974(acs)
SSHIJ5U23_00295
SCASSACC_31410
SAISaci_1184
SACNSacN8_05775
SACRSacRon12I_05770
SACSSUSAZ_05635
SISLS215_2320
SIAM1425_2157
SIMM1627_2237
SIDM164_2161
SIYYG5714_2284
SINYN1551_0632
SIILD85_2424
SIHSiH_2103
SIRSiRe_2035
SICSiL_2010
SULABFU36_06065
SULEGFS03_11750(acs)
SULOGFS33_03560(acs)
SULLEWF20_05395(acs)
MSEMsed_1456
MEMJMJ1HA_1669
MCNMcup_0744
MHKDFR87_11465(acs)
MPRUDFR88_11030(acs)
MTENGWK48_00965(acs)
MJNMjAS7_2549
AHOAhos_2066
AMANB6F84_01625
ABRIDFR85_11750(acs)
ASULDFR86_01620(acs)
AAMBD1866_05345(acs)
ACIHHS5_08830
SAZOD1868_03325(acs)
CSTYKN1_22620
 » show all
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
Reference
2  [PMID:18165310]
  Authors
Alber BE, Kung JW, Fuchs G
  Title
3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation.
  Journal
J Bacteriol 190:1383-9 (2008)
DOI:10.1128/JB.01593-07
  Sequence
[mse:Msed_1456][sto:STK_07830]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.36
IUBMB Enzyme Nomenclature: 6.2.1.36
ExPASy - ENZYME nomenclature database: 6.2.1.36
BRENDA, the Enzyme Database: 6.2.1.36

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