KEGG   ENZYME: 6.2.1.36Help
Entry
EC 6.2.1.36                 Enzyme                                 

Name
3-hydroxypropionyl-CoA synthase;
3-hydroxypropionyl-CoA synthetase (AMP-forming);
3-hydroxypropionate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
hydroxypropanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate [RN:R09286]
Reaction(KEGG)
Substrate
3-hydroxypropanoate [CPD:C01013];
ATP [CPD:C00002];
CoA [CPD:C00010]
Product
3-hydroxypropanoyl-CoA [CPD:C05668];
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC 6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate.
History
EC 6.2.1.36 created 2009
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14469  acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15018  3-hydroxypropionyl-coenzyme A synthetase
Genes
RRS: RoseRS_3202
RCA: Rcas_2930
CAU: Caur_0613
CHL: Chy400_0662
CAG: Cagg_3394
CTM: Cabther_B0610
CTS: Ctha_1050
STO: STK_07830
SSO: SSO3203(acsA-10)
SOL: Ssol_0940
SSOA: SULA_0973(acs)
SSOL: SULB_0975(acs)
SSOF: SULC_0974(acs)
SAI: Saci_1184
SID: M164_2161
SII: LD85_2424
SIH: SiH_2103
SIR: SiRe_2035
SIC: SiL_2010
MSE: Msed_1456
MCN: Mcup_0744
MHK: DFR87_11465(acs)
MPRU: DFR88_11030(acs)
AHO: Ahos_2066
ASUL: DFR86_01620(acs)
 » show all
Taxonomy
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
Reference
2  [PMID:18165310]
  Authors
Alber BE, Kung JW, Fuchs G
  Title
3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation.
  Journal
J Bacteriol 190:1383-9 (2008)
DOI:10.1128/JB.01593-07
  Sequence
[mse:Msed_1456][sto:STK_07830]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.36
IUBMB Enzyme Nomenclature: 6.2.1.36
ExPASy - ENZYME nomenclature database: 6.2.1.36
BRENDA, the Enzyme Database: 6.2.1.36

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